ライフサイエンスコーパス: Zucker diabetic fatty rat

1 ntary rodent clamp studies were performed in Zucker Diabetic Fatty rats.

2 nes and glucose uptake in skeletal muscle in Zucker diabetic fatty rats.

3 rat hepatocytes and from bicarbonate in male Zucker diabetic fatty rats.

4 cids, or by study of lipid-laden islets from Zucker diabetic fatty rats.

5 pression is increased in both ob/ob mice and Zucker diabetic fatty rats.

6 d islets of obese, leptin-unresponsive fa/fa Zucker diabetic fatty rats.

7 sis and lipotoxicity complicating obesity in Zucker diabetic fatty rats.

8 EBP-1c was 3.4 times higher than in lean +/+ Zucker diabetic fatty rats.

9 ction mutation in the leptin receptor, as in Zucker diabetic fatty rats.

10 uvate carboxylase ASO had similar effects in Zucker Diabetic Fatty rats.

11 tests in both C57BL/6J mice and high-fat fed Zucker diabetic fatty rats.

12 receptor is up-regulated by about 20-fold in Zucker Diabetic Fatty rats; 2) Adenovirus-mediated overe

13 se drugs on diabetes, NAC or AG was given to Zucker diabetic fatty rats, a laboratory model of type 2

14 , on metabolic and hemodynamic parameters in Zucker diabetic fatty rats, a model of type 2 diabetes.

15 beta-cell function normally observed in the Zucker diabetic fatty rat and preserved the ability of t

16 ulin signaling in the muscles of the treated Zucker diabetic fatty rats and diet-induced obese mice.

17 imilar to those in renal biopsy specimens of Zucker diabetic fatty rats and patients with advanced di

18 ed from adipocytes obtained from normal lean Zucker diabetic fatty rats (+/+) and incubated for 0, 3,

19 lipid-cultured 832/13 cells and islets from Zucker diabetic fatty rats by addition of a membrane per

20 th-old and 18-month-old lean wild-type (+/+) Zucker diabetic fatty rats by adenovirus gene transfer.

21 ot significantly altered in young-adult male Zucker diabetic fatty rats compare to their lean counter

22 In adipocytes of obese Zucker diabetic fatty rats (fa/fa) with defective leptin

23 We show that Zucker diabetic fatty rats (fa/fa), which are known to e

24 he antidiabetic effect of TGZ in prediabetic Zucker Diabetic Fatty rats involves prevention of lipoto

25 Thus far, lipotoxic diabetes of fa/fa Zucker diabetic fatty rats is the only proven lipodegene

26 oxyradical levels in Zucker lean control and Zucker diabetic fatty rat islets by digital imaging micr

27 Oral administration of MB06322 to Zucker diabetic fatty rats led to a dose-dependent decre

28 f the lead prodrug, MB06322 (30, CS-917), to Zucker Diabetic Fatty rats led to dose-dependent inhibit

29 Intravenous administration of 4.4 to Zucker diabetic fatty rats led to rapid and robust gluco

30 glycemia when dosed at 3 mg/kg bid po in the Zucker diabetic fatty rat model of type 2 diabetes.

31 ilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (

32 rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes

33 blood glucose levels of both normal mice and Zucker diabetic fatty rats predominantly through suppres

34 eracting site into nephrotic Buffalo Mna and Zucker Diabetic Fatty rats reduced proteinuria through t

35 mpathetic branch of the stellate ganglion in Zucker diabetic fatty rats revealed an elevated resting

36 In the Zucker diabetic fatty rat, the glucosylceramide synthase

37 undertaken in STZ-induced diabetic rats and Zucker diabetic fatty rats using the tumor necrosis fact

38 idate the relevance of our findings in vivo, Zucker diabetic fatty rats were gavaged daily with water

39 Gastrostomized Zucker diabetic fatty rats were submitted to intraperito

40 eptozotocin-induced diabetic rats and type 2 Zucker diabetic fatty rats were treated by intravitreal

41 r the up-regulation of circulating leptin in Zucker Diabetic Fatty rats, which are nonresponsive to l

42 s from lipoapoptosis, we treated prediabetic Zucker Diabetic Fatty rats with 200 mg/kg per day of TGZ

43 In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutation

44 ic and renal changes in the partially inbred Zucker Diabetic Fatty Rat (ZDF/Drt-fa), a model that clo

45 etic levels of plasma glucose and insulin in Zucker diabetic fatty rats (ZDF).

46 ubstrate metabolism were measured in 10 male Zucker diabetic fatty rats (ZDF, fa/fa) and 10 lean litt

47 val in a genetically leptin-resistant model (Zucker Diabetic Fatty rats, ZDF).

48 dipose tissue, skeletal muscle, and liver of Zucker diabetic fatty rats (ZDFs).