ライフサイエンスコーパス: Zucker rat

1 ion and contractile dysfunction of the obese Zucker rat.

2 insulin resistance in the genetically obese Zucker rat.

3 se pathway) in the vascular tissues of obese Zucker rats.

4 ected from fatty (ZF) and lean (ZL, control) Zucker rats.

5 t increased glucose disposal by 88% in obese Zucker rats.

6 or body weight in either Long-Evans or fatty Zucker rats.

7 vely correlated with creatinine clearance in Zucker rats.

8 bular abnormalities are accelerated in obese Zucker rats.

9 ntake, and extended the observation to fatty Zucker rats.

10 n NPY receptor subtypes in obese versus lean Zucker rats.

11 mildly hyperglycemic hyperinsulinemic obese/Zucker rats.

12 ot significantly different in lean and obese Zucker rats.

13 ance of single fibers from obese versus lean Zucker rats.

14 Spontaneously breathing male Zucker rats.

15 as absent in leptin receptor-deficient obese Zucker rats.

16 sly breathing lean (n = 9) and obese (n = 9) Zucker rats.

17 ryngeal wall tissue strain in lean and obese Zucker rats.

18 served in neurones from lean, but not obese, Zucker rats.

19 ions after an oral glucose challenge in male Zucker rats.

20 ed in isoflurane-anesthetized lean and obese Zucker rats.

21 d hyperinsulinemia in leptin-resistant obese Zucker rats.

22 ZDF rats but not from insulin-sensitive lean Zucker rats.

23 h fasting or in free-feeding Wistar or obese Zucker rats.

24 on metabolism was investigated in male obese Zucker rats.

25 fusion rates were then examined in the obese Zucker rats.

26 e Zucker rats (type II diabetes) versus lean Zucker rats.

27 opment of muscle insulin resistance in obese Zucker rats.

28 take and body weight in lean, but not obese, Zucker rats.

29 thetized, 10-14 week old male lean and obese Zucker rats.

30 in target tissues of insulin-resistant obese Zucker rats.

31 sensitivity and reduced body weight in obese Zucker rats.

32 fold in obese Zucker rats compared with lean Zucker rats (0.21+/-0.06 versus 0.08+/-0.03 mm(2), P<0.0

33 ean (n = 16, fa/+) and obese (n = 15, fa/fa) Zucker rats (12 weeks of age).

34 ricular nucleus (PVN) were examined in obese Zucker rats (18 weeks old).

35 rsisted through day 14 in the obese and lean Zucker rats (202.27+/-98.86 versus 35.71+/-20.54 bromode

36 mal area was markedly increased in the obese Zucker rats 7 days after injury (0.058+/-0.024 versus 0.

37 enes in untreated and losartan-treated obese Zucker rats, a model of obesity, insulin resistance, and

38 e [SHPTP-2]) in liver homogenates from obese Zucker rats after TNF-alpha blockade.

39 in the diet (50 micromol/kg of diet) to male Zucker rats ages 6-7 weeks for 9 months (prevention grou

40 d decreased TSH and T4 in Sprague-Dawley and Zucker rats, an effect that was only transitory.

41 ficantly lower in the obese relative to lean Zucker rats and ARC proNeuropeptide Y (proNPY) mRNA leve

42 on was examined in the kidney of young adult Zucker rats and compared with age-related changes in ren

43 ssue (BAT) towards metabolic improvements in Zucker rats and DIO mice (DIOs).

44 1 and provide metabolic benefits of FGF21 in Zucker rats and DIOs.

45 In obese Zucker rats and high-fat-fed rodents, in which muscle mi

46 d the oxidative stress in fatty livers of Ob Zucker rats and improved survival following lethal ische

47 channel is specific to GR neurones of obese Zucker rats and that the presence of this channel couple

48 eek-old fa/fa rats compared with age-matched Zucker (+/+) rats, and hepatic glycogen was dramatically

49 and food intake in Sprague-Dawley and obese Zucker rats, and enabled us to study the role that NT pl

50 In lean, fatty and diabetic Zucker rats, and endothelial insulin receptor knockout m

51 a model of 70% hepatectomy in obese and lean Zucker rats, and obese Zucker rats pretreated with recom

52 Obese Zucker rats are insulin-resistant, diabetic and hyperlep

53 lining cells (SLCs) in fatty livers of obese Zucker rats are more susceptible to ischemia/reperfusion

54 hypothesized that fatty livers of obese (Ob) Zucker rats are oxidatively stressed and oxidative stres

55 ncreases in longevity, suggesting that obese Zucker rats are particularly sensitive to energy restric

56 Obese Zucker rats are susceptible to increased hepatic ischemi

57 rinking H2O) and untreated groups, with lean Zucker rats as controls.

58 sal and lateral (perifomical) areas of obese Zucker rats, as compared to lean rats.

59 lucose tolerance of obese, insulin resistant Zucker rats at the 20 mg/kg dose level and had no effect

60 week-old male lean (Fa/Fa) and obese (fa/fa) Zucker rats before and after a meal.

61 e measured in the livers of Ob and lean (Ln) Zucker rats before and after treatment with high-dose TO

62 2 is downregulated in the glomeruli of obese Zucker rats before the onset of proteinuria.

63 2 vs. 7.0 +/- 1.0 mumol g(-1)) in obese male Zucker rats, both intact and castrated.

64 othalamic neurons of lean Sprague-Dawley and Zucker rats, but is ineffective on neurons of obese Zuck

65 a highfat diet), and genetically obese fa/fa Zucker rats by quantifying the permeability coefficient

66 In both obese and lean Zucker rats, cell proliferation peaked in the media at 3

67 on decreases with advancing age in the obese Zucker rat, clusterin mRNA expression was examined in th

68 ointimal area was increased >2-fold in obese Zucker rats compared with lean Zucker rats (0.21+/-0.06

69 o release 5-HT at the MH is reduced in obese Zucker rats, consistent with their blunted responsivenes

70 The lean and obese Zucker rats demonstrated distinct capillary-level flow d

71 Endovascular stenting studies in Zucker rats demonstrated increased heparanase expression

72 hat glucose-receptive (GR) neurones of obese Zucker rats exhibit abnormal electrophysiological respon

73 nflammatory tone in soleus muscle from obese Zucker rats fed a 2DG-supplemented diet.

74 he citrus extract were followed in the obese Zucker rats fed with the HFD.

75 We studied fatty Zucker rats given rosiglitazone maleate (50 micromol/kg

76 Inbred lean Zucker rats (>26 generations) served as donors and recip

77 Obese Zucker rats had lower alpha-MSH and dynorphin A(1-17) pe

78 Obese Zucker rats had significantly decreased regenerative cap

79 in lean Zucker rat hearts, whereas, in obese Zucker rat hearts, muscle carnitine palmitoyltransferase

80 n of all PPAR-alpha -regulated genes in lean Zucker rat hearts, whereas, in obese Zucker rat hearts,

81 se in alpha-MSH in the PVN seen in the obese Zucker rat in the present study suggest that reduced act

82 obese insulin-resistant and type 2 diabetic Zucker rats, in streptozotocin-induced type 1 diabetic S

83 The genetically obese Zucker rats injected with NT69L (1 mg/kg) had a signific

84 t the enhanced energetic efficiency of obese Zucker rats involves blunted serotonergic release within

85 t the enhanced energetic efficiency of obese Zucker rats is associated with a reduced capacity of act

86 dy suggests that insulin resistance in obese Zucker rats is tissue specific and that signaling from a

87 as increased in select nephrons of the obese Zucker rat kidney and in 24-mo-old F344 rat kidney as as

88 Obese Zucker rats, known to possess a mutation in the gene for

89 wo potentially pathogenic forces, we studied Zucker rats (leptin receptor wild type, +/+; heterozygou

90 IL-6 pretreatment of steatotic Zucker rat liver isografts dramatically reduces mortalit

91 endothelial cell necrapoptosis in steatotic Zucker rat liver isografts, which is prevented by in vit

92 ocirculation, which is impaired in steatotic Zucker rat liver transplants.

93 Steatotic Zucker rat livers and livers from alcohol-fed rats were

94 istered through the portal vein of steatotic Zucker rat livers before and after cold ischemic storage

95 muscle of obese Zucker rats (OZR; with lean Zucker rats (LZR) as controls), we determined indices of

96 a obtained from gastrocnemius muscle of lean Zucker rats (LZRs) and obese Zucker rats (OZRs) were ana

97 s in arterial pressure (AP) compared to lean Zucker rats (LZRs).

98 e enhanced energetic efficiency of the obese Zucker rats may not be associated with attenuated seroto

99 The obese Zucker rat model may be an ideal diabetic model to furth

100 1 overexpression in a well-established fatty Zucker rat model of I/R followed by orthotopic liver tra

101 ovements in insulin action after RYGB in the Zucker rat model.

102 In the obese Zucker rats, neither AICAR nor insulin stimulated whole-

103 activity within the skeletal muscle of obese Zucker rats (OZR) is impaired.

104 Using the in situ cremaster muscle of obese Zucker rats (OZR; with lean Zucker rats (LZR) as control

105 Adult obese Zucker rats (OZRs) have reduced sympathetic responses to

106 muscle of lean Zucker rats (LZRs) and obese Zucker rats (OZRs) were analysed to investigate flow dis

107 sed regenerative capacity compared with lean Zucker rats (PCNA, BrdU, mitotic index, regenerated live

108 omy in obese and lean Zucker rats, and obese Zucker rats pretreated with recombinant interleukin 6 (r

109 Obese and lean Zucker rats received intravenous (IV) injections of glyc

110 Male lean Zucker rats received water (control, n = 8) or meldonium

111 of MC4-R with food restriction and in obese Zucker rats reflects receptor upregulation secondary to

112 ipose tissue by 54 and 49% in obese and lean Zucker rats, respectively.

113 Similarly, obese (fa/fa) Zucker rats showed 43-98% increases in MC4-R in the same

114 Compared with the lean controls, obese Zucker rats showed significant glomerular matrix expansi

115 performed on obese (fa/fa) and lean (Fa/fa) Zucker rats that had been treated orally with BWA1433 or

116 keletal muscle insulin resistance, the obese Zucker rat, to test the effect of oral administration of

117 performed using steatotic liver grafts from Zucker rats transplanted into lean recipients.

118 omics analysis of fasting plasma from obese, Zucker rats treated with XN revealed decreases in produc

119 us regular Sprague-Dawley rats and (2) obese Zucker rats (type II diabetes) versus lean Zucker rats.

120 ithin cardiomyocytes of obese, but not lean, Zucker rats upon fasting.

121 nd GVSK degraded collagen I when perfused in Zucker rat ventral skin and formed higher molecular weig

122 clamp, whole body glucose disposal in obese Zucker rats was only 22% of that observed in lean animal

123 mia and reperfusion injury in fatty and lean Zucker rats was used.

124 Renal clusterin mRNA levels in the obese Zucker rat were 2.5-fold higher by 3 mo of age and fourf

125 First, +/+ and +/- Zucker rats were compared metabolically.

126 Lean and obese Zucker rats were either fed ad libitum or fasted overnig

127 In two experiments in which diabetic fatty Zucker rats were injected subcutaneously twice daily for

128 Female lean Zucker rats were injected with adenoviral/human PKC-zeta

129 (30 min or 24 hr) livers from obese and lean Zucker rats were perfused ex vivo for 90 min with oxygen

130 Seven-week-old male obese Zucker rats were randomized to losartan-treated (100 mg/

131 Three groups of genetically obese Zucker rats were studied: RYGB, sham surgery pair-fed (P

132 Obese (Ob) and lean (Ln) Zucker rats were subjected to 90 min of in vivo partial

133 Seven-week-old female obese and lean Zucker rats were treated with DZ (150 mg/kg/d) or vehicl

134 d in diabetes, aorta and carotid arteries of Zucker rats were used for immunostaining, Western blotti

135 neuropeptide Y (NPY) receptors in the obese Zucker rat which has an increased synthesis and release

136 ation in Y5 'feeding' receptors in the obese Zucker rat which is known to possess a hyperactive arcua

137 othelial function in insulin-resistant fatty Zucker rats, which display hypertension and abnormal end

138 om normal rats but not in corneas from fa/fa Zucker rats, which lack functional leptin receptors.

139 s studies have shown that treatment of obese Zucker rats with the adenosine receptor antagonist 1,3-d

140 ed perfusion, treatment of genetically obese Zucker rats with the HO-1 inducer cobalt protoporphyrin

141 Treatment of insulin resistance in Zucker rats with the insulin-sensitizing drug rosiglitaz

142 mproved hepatic insulin sensitivity in obese Zucker rats without altering the tyrosine phosphorylatio

143 rotein levels compared with the control lean Zucker rat (ZL).