ライフサイエンスコーパス: a desired

1 a natural solution allowing the encoding of a desired 3D architecture into the chemical building blo

2 of an intracellular selection process toward a desired activity; and (iii) the characterization of th

3 ning of random peptides and RNA created with a desired amino acid and nucleotide composition, as well

4 ivity of conjugated polymer materials toward a desired analytical target would further benefit their

5 We describe a successful attempt to generate a desired antibody specificity, which was not present in

6 lso play a large part in the suitability for a desired application.

7 abled the isolation of enriched fractions of a desired array without causing significant sample aggre

8 mpare their self-produced speech signal with a desired auditory target and correct for errors.

9 nd then calculate the sample size to achieve a desired average power while controlling FDR.

10 nucleobase conformations of an RNA to match a desired backbone, analogous to fundamental tools that

11 binations of kinetic parameters that produce a desired behavior in a genetic network.

12 efficient of hygroscopic expansion to target a desired behavior such as multimodal locomotion.

13 Several isolates evolved toward a desired behavior under selective pressure.

14 Optimum stimuli can be used to induce a desired behavior without producing undesirable side ef

15 nd construct biological systems that present a desired behavior.

16 sts to train an animal (or human) to produce a desired behavior.

17 o establish the neural patterns that produce a desired behavioral outcome.

18 namic model of a larger device that exhibits a desired behaviour.

19 nd by screening large chemical libraries for a desired biological effect and, conversely, ensuring bi

20 th a metric that may be monitored to enforce a desired bound on accuracy within a user-defined confid

21 distract themselves to cope with waiting for a desired but delayed reward.

22 activation energy and selectively producing a desired but kinetically unfavourable product for the i

23 um complexes with o-alkynylphenols to create a desired cascade triad (coordination, nucleophilic addi

24 A protein or RNA with a desired catalytic activity converts a substrate attach

25 his system to elucidate the connections onto a desired cell type in a high-throughput manner, limited

26 get lentivirus-mediated gene transduction to a desired cell type.

27 rated, systems-level approach for optimizing a desired cellular property or phenotype; and great stri

28 A desired characteristic of candidate antimalarials is r

29 Long-term stability is a desired characteristic of vaccines, especially anthrax

30 for the introduction of de novo activity for a desired chemical reaction.

31 teins to allow chemical-induced proximity of a desired chromatin regulator.

32 ation scheme is a powerful method of finding a desired chromatographic separation based on a small nu

33 E, is a clean approach of gene delivery into a desired chromosomal location, as it is able to insert

34 on (TAR) cloning in yeast is used to isolate a desired chromosomal region or gene from a complex geno

35 (TAR) cloning allows selective isolation of a desired chromosomal region or gene from complex genome

36 sonalized multi-pathway diagrams that depict a desired collection of interacting pathways that emphas

37 The third group displayed a desired combination of diminished general toxicity and

38 st and then is isothermally transformed into a desired, complicated nanocage.

39 ity to prepare noble metal nanostructures of a desired composition, size, and shape enables their res

40 o further enhance heterologous production of a desired compound may be limited by the inherent capaci

41 olic flux, and thereby increase the yield of a desired compound.

42 edonistic synapses can be trained to perform a desired computation by administering reward appropriat

43 ow a color change can be tuned to occur near a desired concentration of analyte.

44 urface is critical for exclusively accessing a desired configuration.

45 interest, a desired spatial resolution, and a desired contrast resolution.

46 d high-performance liquid chromatography had a desired correlation (R(2)=0.9958).

47 stimating the sequencing depth necessary for a desired coverage of protein binding sites.

48 ast bound, the needed exposure time to reach a desired CPE without empirical model inputs.

49 nanocrystal concentration to be adjusted and a desired crystal size to be prepared at full conversion

50 mpossible to rationalize and control to give a desired crystal symmetry, lattice spacing and habit (c

51 listimethate that would be needed to achieve a desired Css,avg and creatinine clearance.

52 for determining the FeTot required to effect a desired %Cvn is presented.

53 With this method, a desired cysteine can be reversibly protected by bindin

54 be difficult to obtain specific labeling of a desired cysteine in proteins with multiple cysteines,

55 e design of the multivalent probe, to target a desired density of binding sites.

56 lts in lower doses of vecuronium to maintain a desired depth of paralysis, and allows a faster recove

57 quantum dots to emit spontaneous photons in a desired direction or can provide an environment where

58 controlled, three-dimensional structures in a desired direction, and expands the current tools avail

59 mine whether the packing can be steered into a desired direction, so to allow topochemical photopolym

60 ve the immune response and/or direct it into a desired direction.

61 ising metabolic cost per unit of distance in a desired direction.

62 erior colliculus (SC) is thought to generate a desired displacement command specifying the amplitude

63 microbubble was generated and positioned at a desired distance from the membrane of a Xenopus oocyte

64 served in a simulation, rather than assuming a desired distribution has been generated.

65 ency of recombinational targeting leading to a desired DNA change can be as high as 20% of cells.

66 plant transformation method, plantlets with a desired DNA change were regenerated in <6 weeks.

67 Under favorable conditions, a desired DNA fragment or gene in the size range up to a

68 eminivirus replicons to generate plants with a desired DNA sequence modification.

69 llows not only selection for transmission of a desired, donor-derived differential region but also se

70 physician to titrate sedative medications to a desired effect and thereby reduce the risks associated

71 so penetrate the brain parenchyma to achieve a desired effect within the brain.

72 mulus shapes better than others at achieving a desired effect?

73 talyst surface and the targeted synthesis of a desired enantiomer requires the implantation of chiral

74 echanism for immediate vessel disappearance, a desired endpoint for treating vascular lesions.

75 investigate the potential for introgressing a desired engineered gene into a pest population by link

76 es to facilitate isolation of cells in which a desired engineering outcome has occurred.

77 that produces high affinity antibodies with a desired epitope coverage profile, resulting in the gen

78 Developing electromagnetic pulses to produce a desired evolution in the presence of such variation is

79 ntify interventions that force a cell toward a desired expression state.

80 free drug from the covalently bound form in a desired fashion.

81 ic organ, cellular and sub-cellular level is a desired feature of a drug carrier system.

82 the platform to force yeast cells to express a desired fixed, or time-varying, amount of a reporter p

83 lem of designing a flow sculpting device for a desired fluid flow shape remains a challenge.

84 lii) either had to determine the location of a desired food item or a property of a non-food item (le

85 n source to deflect electromagnetic waves at a desired frequency, ranging from millimeter-wave to far

86 n a synthetic device and can be tailored for a desired frequency.

87 When engineering biological systems, a desired function must be achieved in a context that is

88 an fold into structures capable of eliciting a desired function.

89 evant assays to identify proteins possessing a desired function.

90 ral (AAV) libraries that can be selected for a desired function.

91 rmation of a given fiber network to optimize a desired function.

92 s the efficient isolation of antibodies with a desired functional characteristic without prior knowle

93 For skin gene therapy, introduction of a desired gene into keratinocyte progenitor or stem cell

94 ive, switchable control of the expression of a desired gene to a preselected level in any suitable ce

95 is the drive system, which serves to spread a desired genotype into the targeted field population.

96 Reduced phytic acid content in seeds is a desired goal for genetic improvement in several crops.

97 lls directed against a target autoantigen is a desired goal of experimental approaches for the treatm

98 Although the reduction of clinical stroke is a desired goal, the current research design of embolic p

99 e to carry out a behavior necessary to reach a desired goal.

100 to plan and enact a sequence of tasks toward a desired goal.

101 m for constructing a potential function with a desired ground state.

102 ulate the growth kinetics in order to select a desired growth mode are briefly addressed.

103 his could lead to unexpected deviations from a desired growth pathway.

104 ive in vitro axonal extension over 5 mm with a desired growth rate of approximately 1 mm/day.

105 trol the arrangement and binding strength of a desired guest.

106 "center of mass" of large shapes: ants learn a desired heading toward a point on a distant shape as t

107 in predictions while keeping specificity in a desired high range.

108 s choice of a TE may allow the production of a desired hybrid metabolite.

109 as a tool to identify critical components of a desired immune response.

110 ver antigens to these sites and to stimulate a desired immune response.

111 cific DNA sequences and subsequently trigger a desired intracellular response.

112 ontrolling the assembly of these chains with a desired length.

113 negative rate of the screening algorithm to a desired level (5% in this study) is achieved.

114 ower with false discovery rate controlled at a desired level and is robust to the unimodal distributi

115 the optimal environmental factors to achieve a desired level of cellular function.

116 imating the depth of sequencing required for a desired level of coverage and demonstrating that more

117 otein-binding sites, while still maintaining a desired level of false positive calls.

118 ht the key design criteria needed to achieve a desired level of public health benefit.

119 for the isolation of sequences that exhibit a desired level of stability.

120 ame RNA molecule to reduce the error rate to a desired level, and they also enable accurate quantific

121 ngineer any intron to increase expression to a desired level, and to explore the mechanism of IME by

122 educe the uncertainty in period estimates to a desired level.

123 se discovery rate (FDR) can be controlled at a desired level.

124 hile controlling the false discovery rate at a desired level.

125 f logarithms of likelihood ratios (logLR) to a desired level.

126 an be designed by precycling an electrode in a desired Li- or Na-based electrolyte, and that ionic tr

127 hanges in gene expression in the presence of a desired ligand.

128 hat the motor system computes and implements a desired limb trajectory, an intermediary control proce

129 dology to move selected single live cells to a desired location on a flat substrate, such as a patter

130 t possible to precisely position the line at a desired location.

131 only start working after they are placed in a desired location.

132 the control process of moving the carton to a desired location.

133 indows (of 10 m/z) within the ion trap until a desired mass range has been covered.

134 Glass is a desired material for many microfluidics applications.

135 ycloserine has the therapeutic properties of a desired medication for ASDs; specifically, a medicatio

136 through space to direct an addressee towards a desired mental state.

137 ative strategy to increase the production of a desired metabolite.

138 lt casting is impossible or does not achieve a desired microstructure, and has long been pursued for

139 trieving, transporting, and repositioning to a desired microwell on the array.

140 ate the expected number of new variants with a desired minimum frequency to be discovered in a new da

141 that is used to selectively transmit ions of a desired mobility.

142 fic epitopes on the target molecule to exert a desired modulation of biological function.

143 al validation on a cobalt-C3N4 catalyst with a desired molecular configuration, which possesses compa

144 thermodynamics closely approximating that of a desired motif is numerically calculated from directly

145 od of activity of an oligonucleotide against a desired mRNA target is sequence motif content dependen

146 eaction flux data onto the collage to obtain a desired multi-pathway diagram.

147 he need to screen a large random library for a desired mutant plant.

148 ters of the protein Hamiltonian to fold into a desired native structure.

149 ions to those correlated with recognition of a desired new base to create enzymes that recognize and

150 le means to provide sufficient quantities of a desired NP while using inexpensive renewable resources

151 However, if a desired nucleic acid sequence could be translated in v

152 rolyzed in a controlled fashion to introduce a desired number of carboxylic acid groups to the intern

153 Next, a desired number of substructures are joined together by

154 of requesting or drawing their attention to a desired object or food.

155 species' metabolisms will integrate to reach a desired outcome is a difficult problem that has been s

156 These results show that achieving a desired outcome often necessitates roundabout steps.

157 a system works where allograft rejection is a desired outcome rather than an unforeseen consequence.

158 es knowing whether a past action resulted in a desired outcome.

159 tegy, even when it is beneficial, to achieve a desired outcome.

160 pically tuned manually to subjectively match a desired output.

161 With a desired P1 group in place a variety of heterocyclic an

162 Furthermore, the method selects for a desired particle size and produces a monodisperse agen

163 thesize an electromagnetic metamaterial with a desired permittivity, using as building blocks only tw

164 The CWER needed to attain a desired PFP level does not depend on the correlation a

165 At present, the change from a desired phenotype (e.g. altered expression of a specif

166 thod of library generation and selection for a desired phenotype directly in a mammalian system can b

167 to identify those individuals which express a desired phenotype or genotype.

168 eu to numerically expand CAR(+) T cells with a desired phenotype, for the addition of interleukin (IL

169 can be manipulated to modulate cells towards a desired phenotype.

170 -1-mediated gene transcription) resulting in a desired phenotypic cellular change (inhibit LEF-1-driv

171 llow, to isolate dominant mutant clones with a desired phenotypic change.

172 can deploy a given subset of them to produce a desired phenotypic outcome without undesired cross tal

173 s can be designed to produce structures with a desired physical property rather than a specific shape

174 s more than what is required for reaching to a desired point in 3D space.

175 ither selectivity over other drug targets or a desired polypharmacology.

176 Thus, the ability to select for a desired population of cells within a recipient would b

177 By locally feeding carbon precursors to a desired position of a substrate composed of an optimiz

178 ioester and a nucleophilic 1,2-aminothiol at a desired position to examine their polymerization produ

179 nd perhaps unexpected amino acid variants at a desired position.

180 ional mutations to introduce a single Cys at a desired position.

181 red number of subjects and arrays to achieve a desired power at a specified significance level.

182 from more extensive data to be correct with a desired probability, delivers an accurate estimate of

183 hich essential enzymes divert flux away from a desired product, as well as in the production of polyk

184 intermediate and improve the final titers of a desired product.

185 pregulated to produce a significant yield of a desired product.

186 variability in a population of cells follow a desired profile.

187 echanism also decelerates DNA translocation, a desired property for sequencing and gene detection, al

188 n some cases, be achieved by optimization of a desired protein in isolation, methods have been develo

189 rvested, transfected, and induced to express a desired protein or selection of proteins to have medic

190 al cell lines expressing specific amounts of a desired protein simply by fluorescent activated cell s

191 r the facile site-selective glycosylation of a desired protein with variously sized glycans.

192 , and allyl-containing tyrosine analogs into a desired protein.

193 te, they effectively discover genes based on a desired quantile of differential gene expression.

194 that can dramatically affect the fidelity of a desired quantum operation or measurement.

195 hich can be used to transform materials into a desired quantum state.

196 ict the rate-determining transition state of a desired reaction in presence of the optimal arrangemen

197 ity of a phosphine ligand that best promotes a desired reaction outcome is often non-intuitive, and t

198 and modification of their properties towards a desired reactivity is, at best, complex.

199 he calculation of intraocular lens power for a desired refractive target can be challenging and compl

200 Yet, safe, effective pill retention within a desired region of the GI remains an elusive goal.

201 mized and is very straightforward, providing a desired reproducibility in measurements, while not req

202 nd hence a drying end point determination to a desired residual moisture level.

203 o determine the optimal sequencing depth for a desired resolution.

204 olymer and crosslinker components to achieve a desired response at the site of action, which imparts

205 ol both the activation and the inhibition of a desired response function (protein activity or spine v

206 ing a broadband low-loss optical device with a desired response.

207 e them in a logical manner before initiating a desired response.

208 of mild model-engineered feedback to achieve a desired response.

209 ation, nor is it practical to wait years for a desired response.

210 times possible to tune the regiochemistry to a desired result by modifying reaction conditions.

211 ccuracy of the classifier and thereby choose a desired risk of error.

212 ivery system for silencing and/or expressing a desired RNA for therapeutic purposes.

213 nic myelogenous leukemia and GIST has become a desired route to regulatory approval of an increasing

214 in a metabolic pathway for the production of a desired secondary metabolite.

215 For the multicolor assay, a desired selection substrate was used simultaneously wi

216 ions for the design of novel inhibitors with a desired selectivity profile (e.g. targeted at multiple

217 y can be utilized to identify molecules with a desired selectivity profile without access to the trad

218 It was confirmed that the search for a desired separation rarely requires a large number of c

219 t a computational method that takes as input a desired sequence profile and calculates the individual

220 rtificial transcription factors that bind to a desired sequence.

221 me mutants to activate component moieties of a desired set of larger molecules, thus yielding a libra

222 anoscale pi-conjugated polymer structures of a desired shape by a simple self-assembly process presen

223 The design for a desired shape is made by raster-filling the shape with

224 A desired shape, drawn on the canvas, is then produced b

225 e elution buffer to produce a pH gradient of a desired shape.

226 ential of a cell, calculating the current of a desired simulated component using an appropriate model

227 e targeting of specific foreign sequences to a desired site in DNA.

228 swelling of the particles to microgels with a desired size and deformability.

229 hesize nanowires directly on substrates with a desired size and density.

230 HA polymers of a desired size are constructed by controlling the reacti

231 Maximizing the production of a desired small molecule is one of the primary goals in

232 to select aptamers with binding affinity to a desired small molecule.

233 epsilon-amine, (ii) Fmoc-SPPS elongation of a desired solubilizing sequence, and (iii) in-solution r

234 ch enable normal-hearing listeners to select a desired sound source out of a sound mixture.

235 (ii) multilayered slabs designed to achieve a desired spatial Green's function.

236 ical history to derive a region of interest, a desired spatial resolution, and a desired contrast res

237 control the contact angles, thereby imposing a desired spatio-temporal stiffness variation to the pho

238 engineer the formation of micro emulsions to a desired specification.

239 at ensures the identification of clones with a desired specificity by properly positioning the random

240 rithms for finding metabolic pathways, given a desired start and target compound, that conserve a giv

241 n) nodes is required to steer the network to a desired state within a relatively small time window.

242 ering engineered and natural systems towards a desired state, a framework to control complex self-org

243 is to induce the network to transition into a desired state, or set of states.

244 nodes and the minimum time required to reach a desired state.

245 en) nodes to steer a complex network towards a desired state.

246 was the number of patients needed to achieve a desired statistical power.

247 ons strategies forcing a set of targets into a desired steady state.

248 network in order to force it to converge to a desired steady-state distribution of gene regulation.

249 eated using colloids that self-assemble into a desired structure by means of a programmable recogniti

250 A user specifies a desired structure, and the system automatically genera

251 trands to fold one long scaffold strand into a desired structure, has provided access to megadalton-s

252 ences is searched for sequences that fold to a desired structure.

253 the ability to control the system to obtain a desired structure.

254 for designing proteins that self-assemble to a desired symmetric architecture.

255 discover which nanoparticle designs lead to a desired system behavior.

256 meric zinc finger proteins that can regulate a desired target gene through cooperative DNA recognitio

257 he initial surface so the evolution leads to a desired target pattern.

258 s used to discover peptides or proteins with a desired target property-most often, affinity for a tar

259 on of epoetin can maintain the hematocrit in a desired target range, with an average weekly dose of e

260 or generating single-stranded DNA (ssDNA) of a desired target sequence in bacterial cells.

261 ary pressure either to favor the cleavage of a desired target sequence or to disfavor the cleavage of

262 ose native cleavage site is a close match to a desired target sequence, followed by small-scale engin

263 CR reactions to identify droplets containing a desired target sequence.

264 l systems, and allows bringing the system to a desired target state even when this state is not direc

265 quantum mechanical system can be steered to a desired target state in the presence of relaxation.

266 be used to bias the helix population toward a desired target.

267 to an episodic memory that allows it to find a desired target.

268 framework permits reprogramming a network to a desired task, as well as rescuing networks from the br

269 es drug-protein interactions associated with a desired therapeutic effect.

270 enes vaccine immunization regimens to elicit a desired therapeutic effect.

271 cation model based on drugs with and without a desired therapeutic effect.

272 ce both the duration and expression level of a desired therapeutic gene in KC, by linking its express

273 distribution, confirming its high quality as a desired therapeutic.

274 arget gene in vivo in a selected site and at a desired time.

275 kinetic prevention of protein adsorption in a desired timescale is shown.

276 near filter that maximizes the projection of a desired tissue (ischemic tissue) while it minimizes th

277 ed non-coding elements (CNEs) likely to have a desired tissue-specificity based on the expression of

278 hylactic antibodies against Ft by suggesting a desired topology for binding of the antibody to intern

279 bited not only potent CB1R activity but also a desired tPSA value over 90 A(2), a threshold considere

280 bility of several of these proteins might be a desired trait as part of a mechanism enabling Chlamydo

281 ncomycin, metronidazole, and fidaxomicin) is a desired trait in such probiotic species, we screened s

282 eased copy of each gene and/or operon has on a desired trait or phenotype.

283 ave like a trajectory controller but only if a "desired trajectory" is the goal of the task.

284 or control is that the motor system computes a "desired trajectory" when reaching to a spatial goal.

285 difference between a current trajectory and a desired trajectory (DJ) that does not change during ad

286 This strategy does not enforce a desired trajectory, but uses feedback more intelligent

287 ular patterning, direct an island to move in a desired trajectory, or merge several islands into a la

288 tain the highest enantiomeric excess (ee) of a desired transformation.

289 he ionizable hydrophobic block, which led to a desired transition pH based on standard curves.

290 o enrich HIV-1-based lentiviral vectors with a desired transmembrane protein.

291 ved, then adjust command strength to achieve a desired travel distance.

292 s aminoacylate an amber suppressor tRNA with a desired unnatural amino acid, but no natural amino aci

293 y complicate engineering the biosynthesis of a desired "unnatural product" but may also open addition

294 ., for regulation that achieves or maintains a desired, useful end.

295 such as liposomes and polymers, can achieve a desired vaccine response.

296 y along a single Si nanowire can be tuned to a desired value (between crystalline and amorphous limit

297 over, its Poisson's ratio can be designed at a desired value, e.g. positive, or negative, or zero.

298 airway pressure that would place the lung at a desired volume on its P-V curve.

299 ocompatible material that can be inflated to a desired volume using biocompatible effervescent chemic

300 livery system enables addition and mixing of a desired-volume droplet with the levitated drop.