ライフサイエンスコーパス: a disintegrin and metalloprotease

1 It is reported here that a disintegrin and metalloprotease 10 (ADAM10) interacts

2 A disintegrin and metalloprotease 10 (ADAM10) is a ubiqu

3 A disintegrin and metalloprotease 10 (ADAM10) is a ubiqu

4 The membrane-anchored metalloproteinase a disintegrin and metalloprotease 10 (ADAM10) is require

5 ed by an initial shedding event catalyzed by A Disintegrin and Metalloprotease 10 (ADAM10).

6 ion of the cellular receptor of alpha-toxin, a disintegrin and metalloprotease 10 (ADAM10).

7 thesis or inhibition of mCD23 cleavage by an a disintegrin and metalloprotease 10 inhibitor, GI254023

8 ne (m)CD23 by the endogenous metalloprotease a disintegrin and metalloprotease 10.

9 n cytoskeleton morphology and recruitment of a disintegrin and metalloprotease 10.

10 The alpha-hemolysin binding to its receptor A-disintegrin and metalloprotease 10 (ADAM10) upregulate

11 One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts

12 A-induced shedding was abrogated by an ADAM (A disintegrin and metalloprotease) 10 and 17 selective i

13 A disintegrin and metalloprotease 12 (ADAM12/meltrin alp

14 e, we describe the identification of ADAM12 (a disintegrin and metalloprotease 12) as a novel marker

15 on was significantly correlated with ADAM12 (A Disintegrin And Metalloprotease 12) expression in thes

16 ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a m

17 of the RGD motif-containing Protein ADAM-15 (a disintegrin and metalloprotease-15) raises the questio

18 ting enzyme type 2 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity i

19 Amino acid polymorphisms within a disintegrin and metalloprotease 17 (Adam17) can accoun

20 A disintegrin and metalloprotease 17 (ADAM17) is a major

21 We have directly shown that A disintegrin and metalloprotease 17 (ADAM17) is a prima

22 The TNF-alpha converting enzyme (TACE), a disintegrin and metalloprotease 17 (ADAM17), has emerg

23 t HER2 trans-activation by IL-1beta required a disintegrin and metalloprotease 17 (ADAM17)-dependent

24 Lastly, a disintegrin and metalloprotease 17 (ADAM17; also known

25 The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF recep

26 ADAM17 (a disintegrin and metalloprotease 17) controls pro- and

27 ADAM17 (a disintegrin and metalloprotease 17) is believed to be

28 Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regul

29 rosis factor alpha-converting enzyme ADAM17 (a disintegrin and metalloprotease 17), which demonstrate

30 vascular smooth muscles, KK stimulates ADAM (a disintegrin and metalloprotease) 17 activity via a PAR

31 ated the metalloprotease-disintegrins ADAMs (a disintegrin and metalloprotease) 17 and 19 as well as

32 A disintegrin and metalloprotease-17 (ADAM17) is a major

33 A disintegrin and metalloprotease-17 (ADAM17) is shown t

34 mice lacking functional ADAM19 (mnemonic for a disintegrin and metalloprotease 19) exhibit severe def

35 en single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene and e

36 A disintegrin and metalloprotease 33 (ADAM33) is a trans

37 2, vascular epithelial growth factor (VEGF), a disintegrin and metalloprotease 33 (ADAM33), and perio

38 We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the

39 alpha(5)beta1 binds a disintegrin and metalloprotease (ADAM) 17, a metalloen

40 odomain of mammalian Jagged is cleaved by an A disintegrin and metalloprotease (ADAM) 17-like activit

41 hedding of HEPCAM at two alpha-sites through a disintegrin and metalloprotease (ADAM) and at one beta

42 Metalloprotease disintegrins (a disintegrin and metalloprotease (ADAM) and metalloprot

43 Catalytically active members of the A Disintegrin And Metalloprotease (ADAM) family of membr

44 of metalloproteases, especially those of the A disintegrin and metalloprotease (ADAM) family, can med

45 membrane-bound precursors by one of several a disintegrin and metalloprotease (ADAM) metalloprotease

46 A disintegrin and metalloprotease (ADAM) proteases are i

47 ding to heterodimeric Notch (hNotch) induces a disintegrin and metalloprotease (ADAM) proteolytic rel

48 Using a disintegrin and metalloprotease (ADAM)-17 radiation ch

49 ition of matrix metalloproteinase (MMP)- and a disintegrin and metalloprotease (ADAM)-family zinc met

50 ide evidence that human Tim-3 is a target of A disintegrin and metalloprotease (ADAM)-mediated ectodo

51 The cytoplasmic domain of a disintegrin and metalloprotease (ADAM)10, a transmembr

52 ls with a TLR3 or TLR4 ligand, we identified a disintegrin and metalloprotease (ADAM)15 as a novel TR

53 ll cycle progression, and siRNA knockdown of a disintegrin and metalloprotease (ADAM)17 had a similar

54 As a disintegrin and metalloprotease (ADAM)s have been impl

55 of three candidate alpha-secretase enzymes, a-disintegrin and metalloprotease (ADAM) 9, 10, or 17, i

56 c cells lacking candidate-releasing enzymes (a disintegrin and metalloprotease [ADAM] 9, 10, 12, 15,

57 tments, we determined whether transmembrane "a disintegrin and metalloprotease" (ADAM) proteins are e

58 ding mediated by the cell surface proteases "a disintegrin and metalloproteases" (ADAM)-10 and ADAM-1

59 nstream matrix metalloproteinases (MMPs) and a disintegrin and metalloproteases (ADAMs) and stimulate

60 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs) releases man

61 life-essential molecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated

62 embrane metalloproteases of the ADAM family (a disintegrin and metalloprotease), and the initiation c

63 The ADAMs (a disintegrin and metalloprotease) are a family of glyco

64 The ADAMs (a disintegrin and metalloprotease) are a family of multi

65 ADAMs (a disintegrin and metalloprotease) are a family of prote

66 ADAMs (a disintegrin and metalloproteases) are members of the m

67 Here, we determined which ADAMs (a disintegrin and metalloprotease) can shed various EGFR

68 gulatory region (NRR) that protects an ADAM (a disintegrin and metalloprotease) cleavage site.

69 hedding is largely attributed to a family of a disintegrin and metalloprotease domain (ADAM) metallop

70 transforming growth factor beta receptor II, a disintegrin and metalloprotease domain 17 (ADAM-17), v

71 ion of collagen I, CD45, and CD34 or EGFR or a disintegrin and metalloprotease domain 17 and placed i

72 d with glutamate and GABA neurotransmission: a disintegrin and metalloprotease domain 22 (Adam22) and

73 DAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore,

74 omain membrane proteins (ADAMs) that include A Disintegrin And Metalloprotease domain comprises an in

75 ly of membrane-anchored proteins, containing a disintegrin and metalloprotease domain, is well suited

76 A disintegrin and metalloprotease domain-containing prot

77 been named ADAM because all members contain a disintegrin and metalloprotease domain.

78 , nuclear factor of activated T-cells; ADAM, a disintegrin and metalloprotease domain; OTM, orthodont

79 Endothelial-specific reduction of a disintegrin-and-metalloprotease-domain-10 (Adam10) and

80 ADAM10, a member of a disintegrin and metalloprotease family, is an alpha-se

81 E), a member of the matrix metalloproteinase/a disintegrin and metalloprotease family.

82 shed from the cell surface by proteinases of a disintegrin and metalloprotease family; however, the m

83 Proteolytically active ADAM (named for "a disintegrin and metalloprotease") family molecules hav

84 to the transmembrane metalloprotease ADAM ("a disintegrin and metalloprotease") family.

85 The ADAM (A Disintegrin And Metalloprotease) family is known to ha

86 ase C (PKC) has been attributed to the ADAM (a disintegrin and metalloprotease) family members TACE a

87 enzyme (TACE; ADAM17), a member of the ADAM (a disintegrin and metalloprotease) family of metalloprot

88 g disintegrin-like domain found in the ADAM (a disintegrin and metalloprotease) family of proteins.

89 sheddase activity is attributed to the ADAM (a disintegrin and metalloprotease) family of proteins.

90 metalloprotease, which belongs to the ADAM (a disintegrin and metalloprotease) family.

91 erting enzyme), a member of the ADAM family (a disintegrin and metalloprotease-family) of proteases,

92 genetically deficient in various ADAMs (for a disintegrin and metalloprotease) identified tumor necr

93 Polymorphic variation in ADAM33 (A Disintegrin And Metalloprotease) is strongly associate

94 ADAMDEC1 (Decysin-1) is a putative ADAM (a disintegrin and metalloprotease)-like metalloprotease

95 ADAMs (a disintegrin and metalloproteases) mediate several impo

96 Here we show that receptor cleavage by ADAM (A Disintegrin And Metalloprotease) metalloproteases prom

97 Recent studies suggest that serum levels of a disintegrin and metalloprotease protein-12 (ADAM-12) c

98 MDC-L (ADAM 28), a member of the ADAM (a disintegrin and metalloprotease) protein family, is ex

99 ADAM (a disintegrin and metalloprotease) proteins bind integri

100 ies of the disintegrin-like domains of ADAM (a disintegrin and metalloprotease) proteins.

101 the length of VWF is regulated by ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin

102 A disintegrin and metalloprotease with a thrombospondin

103 ADAMTSs (a disintegrin and metalloprotease with thrombospondin do

104 ADAMTS13 (a disintegrin and metalloprotease with thrombospondin mo

105 The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin mo

106 ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin mo

107 Aggrecanase-1 (ADAMTS-4) is a member of the a disintegrin and metalloprotease with thrombospondin mo

108 oorly active 29/31-kDa form of VEGF-C by the A disintegrin and metalloprotease with thrombospondin mo

109 These results identify A disintegrin and metalloprotease with thrombospondin mo

110 A disintegrin and metalloprotease with thrombospondin mo

111 established in a pilot approach, identifying a disintegrin and metalloprotease with thrombospondin mo

112 ey pericytes rapidly activated expression of a disintegrin and metalloprotease with thrombospondin mo

113 set out to investigate the role of ADAMTS-5 (a disintegrin and metalloprotease with thrombospondin mo

114 ma-21 encodes ADT-2, a member of the ADAMTS (a disintegrin and metalloprotease with thrombospondin mo

115 A disintegrin and metalloprotease with thrombospondin mo

116 or a circulating plasma VWF metalloprotease, A Disintegrin and Metalloprotease with Thrombospondin mo

117 ADAMTS-12 (a disintegrin and metalloprotease with thrombospondin mo

118 ADAMTS13 belongs to the "a disintegrin and metalloprotease with thrombospondin re

119 The hypothesis that increased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin re

120 These proteins belong to the ADAMTS (a disintegrin and metalloprotease with thrombospondin re

121 endothelial cell (HUVEC)-released ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin re

122 related to a severe deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin ty

123 (TTP), but how therapy affects the level of a disintegrin and metalloprotease with thrombospondin ty

124 The Sp-EBR1 ortholog has the same ADAMTS (a disintegrin and metalloprotease with thrombospondin ty

125 ed from the endothelial surface by ADAMTS13 (a disintegrin and metalloprotease with thrombospondin ty

126 ns in protein C, protein S, antithrombin and A Disintegrin and Metalloprotease with Thrombospondin ty

127 L, (2) serum creatinine >2.25 mg/dL, and (3) a disintegrin and metalloprotease with thrombospondin ty

128 ura (TTP) by identifying naturally processed A Disintegrin And Metalloprotease with ThromboSpondin ty

129 n patients with diabetes, impaired ADAMTS13 (a disintegrin and metalloprotease with thrombospondin ty

130 mmunoglobulin G (IgG) autoantibodies against A Disintegrin And Metalloprotease with ThromboSpondin ty

131 The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin ty

132 chulman syndrome [USS]) severe deficiency of a disintegrin and metalloprotease with thrombospondin ty

133 c cleavage of von Willebrand factor (VWF) by A disintegrin and metalloprotease with thrombospondin ty

134 tl encodes a metalloprotease similar to the "a disintegrin and metalloprotease with thrombospondin" (

135 n at sites of vascular injury, and ADAMTS13 (a disintegrin and metalloprotease with thrombospondin)is