ライフサイエンスコーパス: a doubling of

1 A doubling of 25(OH)D3 was associated with 28% lower odd

2 After controlling for risk factors, a doubling of 25(OH)D3 was associated with 30% lower odd

3 was therefore prepared and found to exhibit a doubling of affinity (Ki = 94 microM) relative to pare

4 1.06, 1.55) for cardiovascular mortality and a doubling of albuminuria was associated with an IRR of

5 mRNA and soluble protein levels demonstrate a doubling of alpha-synuclein expression, consistent wit

6 t from organic to inorganic forms and led to a doubling of annual NH(4)(+) export from a 440 hectare

7 y function for the sensitivity of climate to a doubling of atmospheric carbon dioxide levels, and obt

8 er cent to a 60 per cent increase in GPP for a doubling of atmospheric CO2 concentrations in model st

9 per cent for extratropical ecosystems under a doubling of atmospheric CO2 concentrations on the basi

10 heating expected over multiple decades from a doubling of atmospheric CO2).

11 global mean surface temperature response to a doubling of atmospheric CO2, measured by the equilibri

12 A doubling of baseline insulin was associated with a 184

13 Progression of kidney disease was defined as a doubling of baseline serum creatinine level or onset o

14 The primary end point was a composite of a doubling of baseline serum creatinine, development of

15 by a median of only 14% was associated with a doubling of behavioral contrast detection threshold.

16 Preplanned subgroup analysis demonstrated a doubling of benefit compared with sham injections in p

17 A doubling of blood lead was associated with a 1.9-fold

18 function, CtsK-VCL and LysM-VCL mice exhibit a doubling of bone mass.

19 For example, a doubling of BPA concentration was associated with 1-po

20 A doubling of BPA concentration was associated with poor

21 and contractile force in trabeculae revealed a doubling of Ca2+ transient amplitude, with a concomita

22 lic Access Defibrillation trial demonstrated a doubling of cardiac arrest survival in community units

23 A doubling of cash transfers was also associated with ch

24 A doubling of cash transfers was associated with higher

25 ize for each outcome that is associated with a doubling of cash transfers while controlling for a wid

26 ed pits (CCPs) to "necked"/"closed" CCVs and a doubling of CCP/CCV diameter, whereas AP2 depletion ha

27 ve sufficient metabolic resources to support a doubling of cell mass.

28 es within each parasegment, concomitant with a doubling of cell number as the tissue elongates.

29 during and after drug exposure, resulting in a doubling of cell number by 48 h after drug washout.

30 As predicted by the model, a doubling of cell volume resulted in a change in OPL th

31 Nepal, upwind from this site, is recorded by a doubling of chloride concentrations and a fourfold inc

32 In response to a doubling of CO(2), the radiative effect of CO(2) cause

33 of global warming projections in response to a doubling of CO2-from 1.5 degrees C to 4.5 degrees C or

34 increase in stomatal density in response to a doubling of CO2.

35 Idiopathic dilated cardiomyopathy showed a doubling of collagen concentration and a quadrupling o

36 Cortisol lifetime profiles revealed a doubling of cortisol levels over baseline.

37 Preservation by HMPox100% led to a doubling of creatinine clearance after 90 and 120 min

38 nine (n=407, 36%), and severe AKI was either a doubling of creatinine or the requirement of acute ren

39 s common before day 100; 63% of patients had a doubling of creatinine, and 52% had a peak creatinine

40 Here, we describe results showing how a doubling of current atmospheric CO(2) affects the prod

41 This change represented a doubling of curvature at the outer cylindrical surface

42 In this regard, a doubling of cytochrome oxidase activity was observed w

43 Polarimetric measurements showed a doubling of d-glucose mutarotation velocity and HPLC a

44 rate striatal co-grafts were associated with a doubling of DA neuron survival compared with solo mese

45 greater than 1 y delay being associated with a doubling of defect size (adjusted odds ratio (OR) 2.0;

46 vy chain (MHC) promoter led to approximately a doubling of DGAT activity and TG content and reduction

47 e higher maternal choline intake also led to a doubling of dimethylglycine in cord plasma (P = 0.002)

48 ersal evolution and their interaction led to a doubling of distance spread by cane toads in our model

49 W m(-2) per 100% percent cloud fraction for a doubling of droplet concentrations and associated incr

50 ETS exposure resulted in a doubling of ELF GSH levels, which was blocked in the M

51 between prenatal PFHxS and TGs z-score [for a doubling of exposure, beta=0.11; 95% confidence interv

52 and 1.2 (95% CI: 0.3, 2.1) ng/mL higher with a doubling of exposure, respectively].

53 in bFGF mRNA during this period, followed by a doubling of expression by 48 hours, at which time bFGF

54 r and body weight and ultimately resulted in a doubling of fat mass in males and females.

55 the range of 50 to 400 mug/d indicated that a doubling of folic acid intake resulted in an increase

56 result in a 1.5-times increase and 7.5 g in a doubling of frataxin protein concentration.

57 ude a reduction in connections between MSNs, a doubling of FSI inhibition to D2 MSNs, an increase in

58 net emissions by 0.16 Pg of carbon per year, a doubling of fuel efficiency for cars and light trucks

59 There was a doubling of GH secretion, resulting from an increase o

60 ssion of Nkx6.1 in class 3 cells resulted in a doubling of glucagon mRNA, with no effect on Pdx1 leve

61 tivated brown adipose tissue as evidenced by a doubling of glucose uptake, and increased beta-oxidati

62 opulation has doubled in size, necessitating a doubling of health and social services to maintain cov

63 Granulocytic differentiation resulted in a doubling of HGE binding and enhanced infection consist

64 , including elevated histone acetylation and a doubling of histone H1.

65 The effect of UVC RL resulted in a doubling of inactivation rates over X-ray irradiation

66 ed a threefold increase of GIP-R protein and a doubling of insulin secretion to 16.7 mmol/l glucose/1

67 , glucose tolerance did not change, owing to a doubling of insulin sensitivity.

68 Myocardial infarction was associated with a doubling of intensive care unit time (3.5 days among p

69 In 2010, Winnipeg, Canada, experienced a doubling of invasive pneumococcal disease (IPD) rates,

70 ultivated land area globally has been due to a doubling of irrigated land.

71 ession of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adip

72 of Sox9(+) Neurog3(TA.LO) progenitors, with a doubling of its mitotic index relative to normal Neuro

73 the glycerol-deficient line, probably due to a doubling of [K(+)] accumulating during stress.

74 satory elevation of caspase-9 expression and a doubling of levels of direct IAP binding protein with

75 in immunodeficient mice, leading to at least a doubling of liver repopulation efficiencies.

76 y active glucocorticoid receptor resulted in a doubling of luciferase activity.

77 ork) cohort, COPD status was associated with a doubling of lung cancer incidence, no apparent overdia

78 ng would be disrupted by hyperoxia, we found a doubling of lung EC-SOD protein in newborn rats expose

79 e of nonzein proteins, and as a consequence, a doubling of lysine levels.

80 addition of elesclomol to paclitaxel yielded a doubling of median PFS (112 v 56 days) and a 41.7% ris

81 atients younger than 70 years can now expect a doubling of median survival to 5 years, a 20% chance o

82 2-yl]-2,5-diphenyl tetrazolium bromide), and a doubling of mitotic activity combined with the presenc

83 associated with excess mortality, with about a doubling of mortality in both sexes.

84 e 6 months following ACS predicted more than a doubling of mortality over 6.7 years of follow-up.

85 LTF (P = 0.005, hazard ratio [HR] = 2.4 for a doubling of MTV), DM and OS (P < 0.001 for both, HR =

86 dependent kinase 2, which was accompanied by a doubling of myocytes in the S and G(2) phases of the c

87 nematodes is developing rapidly with almost a doubling of newly described species in the past five y

88 Botulinum toxin results in a doubling of NMJ density.

89 accompanied by increases in eNOS protein and a doubling of NO production.

90 A doubling of NT-proBNP was associated with a relative h

91 also associated with a delay in onset, with a doubling of onset time observed in the WAP-TGFalpha/Mu

92 s (1971 to 1994), the past 6 years have seen a doubling of overall activity for the whole basin, a 2.

93 Remarkably, a doubling of p300 levels was associated with the de nov

94 from 45% to 84% (p = 0.001) and resulted in a doubling of participants providing compressions of bot

95 ial database has expanded considerably, with a doubling of patients exposed in the clinical trial env

96 whereas the membrane-bound portion mediated a doubling of phytoene synthesis rates.

97 or women; the relative risks associated with a doubling of plasma 25-hydroxyvitamin D were 1.15 (95%

98 layer counting uncertainty, our record shows a doubling of precipitation since 1840 CE, with recent

99 a life-time risk approaching 4% and predict a doubling of prevalence by 2030.

100 and diminishing land resources forecast that a doubling of productivity is critical in meeting agricu

101 15-PGDH null colons and is concomitant with a doubling of prostaglandin E(2) in 15-PGDH null colonic

102 repared during the day show more robust LTP (a doubling of PS amplitude), a difference persisting in

103 preoperative serum PSA level (odds ratio for a doubling of PSA levels, 1.9; 95% confidence interval,

104 Except of a doubling of putrescine, nicotine treatment also did no

105 A doubling of RC would still result in net STI preventio

106 The primary family of aptamers showed a doubling of relative fluorescence intensity at saturat

107 ned regularly with increasing Hb levels from a doubling of risk at Hb <10 g/dl to a 61% decrease at 1

108 Consanguinity was associated with a doubling of risk for congenital anomaly (multivariate

109 Conrad et al. reported a doubling of RNA polymerase II (Pol II) occupancy at X-

110 m reproductive rate of bacteria doubles with a doubling of rrn copy number, and the efficiency of car

111 ment of ascites, encephalopathy, or varices; a doubling of serum bilirubin to 2.5 mg/dL or greater; a

112 During follow-up, a doubling of serum creatinine or ESRD occurred in all p

113 h 10 muM intracellular concentration) led to a doubling of Shigella intracellular migration velocity

114 tnership for Health intervention resulted in a doubling of smoking cessation quit rates.

115 AED in communities is associated with nearly a doubling of survival after out-of-hospital cardiac arr

116 ally limited tumor progression, resulting in a doubling of survival in the p48-Cre;LSL-Kras(G12D);Trp

117 A doubling of syndecan-1 was associated with an increase

118 r with antibodies to CD3 and CD28 and led to a doubling of T-cell yield by 5 days.

119 Compound 32 caused a doubling of the activated partial thromboplastin time

120 uble transitions on adsorption isotherms and a doubling of the adsorption capacity.

121 iNOS inhibitor 1400W (1 microM) resulted in a doubling of the amiloride-sensitive Na+ current in GFP

122 obal-mean surface temperature in response to a doubling of the atmospheric carbon dioxide concentrati

123 lobal mean temperature change in response to a doubling of the atmospheric carbon dioxide concentrati

124 disease have evolved in recent decades with a doubling of the average patient age and an increased p

125 ular alterations were associated with nearly a doubling of the average survival time in the RAD-treat

126 e time to the primary composite end point of a doubling of the base-line serum creatinine concentrati

127 The primary outcome was the composite of a doubling of the base-line serum creatinine concentrati

128 for those with normal ALT at the baseline or a doubling of the baseline ALT for those with elevated A

129 Among the four racial and ethnic groups, a doubling of the calcium score increased the risk of a

130 retinoblastoma tumor suppressor protein, and a doubling of the cell number.

131 15 patients, 46.7% had equal to or more than a doubling of the central scotoma area in response to a

132 uring the period of kinocilium migration was a doubling of the centrioles' confinement area taking pl

133 dSe aerogels exhibit twice the surface area, a doubling of the complex viscosity for 5 wt % aerogel-P

134 ower than expected without an epidemic), and a doubling of the crude death rate because of HIV/AIDS,

135 ancement of the cycling stability leading to a doubling of the cycle life.

136 ions are subsequently combined and result in a doubling of the DeltaG value of unfolding.

137 for obesity, the past few decades have seen a doubling of the diabetes mellitus incidence with an in

138 a superior primary outcome, as compared with a doubling of the dose of an inhaled glucocorticoid, as

139 an inhaled glucocorticoid, as compared with a doubling of the dose of the inhaled glucocorticoid (pr

140 ns continue, the subcontinent may experience a doubling of the drought frequency in the coming decade

141 level; HR = 1.45 (1.11-1.89; P = 0.006) for a doubling of the esRAGE level.

142 e local field size on age at diagnosis, with a doubling of the expected field diameter between ages a

143 The transfection resulted in a doubling of the expression of Galpha13 protein in thes

144 o fluorophores for transduction resulting in a doubling of the extinction coefficient and improving t

145 infected mice developed frank diarrhea with a doubling of the fecal water content.

146 The model projects nearly a doubling of the frequency of category 4 and 5 storms b

147 ytes, at 2-yr follow-up there was on average a doubling of the frequency of naive CD4(+) T cells at t

148 The faster growth rates are accompanied by a doubling of the frequency of transport of short microt

149 from small to large individuals resulted in a doubling of the generation time.

150 Second, we observed a doubling of the glucose contribution to brain metaboli

151 Waquoit Bay, MA, USA), we observed more than a doubling of the groundwater-associated nitrogen flux t

152 Thus, a doubling of the group size was associated with a fourf

153 ministration to hypothyroid rats resulted in a doubling of the HCN2/beta-actin mRNA ratio.

154 on and that CK flux does not increase during a doubling of the heart rate-blood pressure product by d

155 epresentative data from 1980 to 2012 suggest a doubling of the incidence and prevalence of diabetes d

156 duce a significant decrease in lifespan, and a doubling of the incidence of premature coronary artery

157 A doubling of the intensity of cyclophosphamide (or ifos

158 ase in the fraction of monomer to 30-40% and a doubling of the intersubunit distance.

159 nitrogen and phosphorus fertilization rates, a doubling of the irrigated land area, and an 18% increa

160 Nine patients had at least a doubling of the logMAR visual acuity in their right ey

161 ct whereas use of CTLA4-Ig alone resulted in a doubling of the median graft survival compared with co

162 h relapsed and then newly diagnosed MM, with a doubling of the median survival as a direct result.

163 Irrespective of duration of breast-feeding, a doubling of the mercury concentration in cord blood wa

164 om single to double valency, consistent with a doubling of the molecular brightness of mCherry-tagged

165 nimum hospital caseloads necessary to detect a doubling of the mortality rate were 64 cases for crani

166 first 9 months of the scheme, there has been a doubling of the number of HLA-000 mismatched kidneys t

167 ansition was observed that may correspond to a doubling of the number of oligomer subunits.

168 ve S-nitrosothiol formation at Cys-81 led to a doubling of the oxidoreductase activity of MIF.

169 glucagon, and growth hormone concentrations, a doubling of the plasma glucose levels inhibited EGP by

170 atmospheric CO2 to a trajectory that avoids a doubling of the preindustrial concentration.

171 The results imply roughly a doubling of the probability of an El Nino event occurr

172 hreshold at approximately 20% bone loss with a doubling of the probability ratios of CHD compared to

173 ldren had significant cognitive deficits and a doubling of the rate of developmental delay during the

174 Recent publications suggest a doubling of the rate of diagnosis of patients with gen

175 d with increased serum creatinine levels and a doubling of the rate of hyperkalemia (18.7%, vs. 9.1%

176 N deprivation elicited a doubling of the rate of NDA2-dependent CEF, with littl

177 d this figure could rise to nearly 86% under a doubling of the region's population.

178 Capacitors 1 microm2 show a doubling of the remanent polarization at voltages high

179 f the 95% confidence interval indicated that a doubling of the risk could not be ruled out.

180 allele in the PS-1 gene was associated with a doubling of the risk for late-onset Alzheimer's diseas

181 It was associated with almost a doubling of the risk in the highest quintile as compar

182 /neonatal complications were associated with a doubling of the risk of developing a psychotic disorde

183 It is associated with a doubling of the risk of developing breast carcinoma, e

184 obese subjects, high levels of pro-NT denote a doubling of the risk of developing obesity later in li

185 Female sex is associated with a doubling of the risk of Fidelis lead failure.

186 a normal body-mass index, obese subjects had a doubling of the risk of heart failure.

187 f 6 or 7 were each associated with more than a doubling of the risk of stroke.

188 rat whole-lung total polar lipids leading to a doubling of the saturation index.

189 Losartan reduced the incidence of a doubling of the serum creatinine concentration (risk r

190 The risk of a doubling of the serum creatinine concentration was 33

191 chronic kidney disease, which was defined as a doubling of the serum creatinine level, a diagnosis of

192 as a composite of end-stage renal disease or a doubling of the serum creatinine level.

193 of muscle stem cell turnover, accounting for a doubling of the signal from satellite cell and progeny

194 HR) = 1.74 (95% CI 1.25-2.41; P = 0.002) for a doubling of the sRAGE level; HR = 1.45 (1.11-1.89; P =

195 The use of a clearing agent led to a doubling of the tetrazine tumor uptake and a 125-fold

196 of a metalloproteinase inhibitor results in a doubling of the time required for human monocytes to c

197 tion, increases in each nIF mRNA resulted in a doubling of the total amount of nIF mRNA, as well as a

198 integrated nutrition curriculum resulted in a doubling of the total hours of required instruction in

199 oli lysate revealed improved peptide scores, a doubling of the total number of peptides, and a 30% in

200 duction in fishing mortality has resulted in a doubling of the total population biomass compared with

201 ed by the P2(1)/c space group which involves a doubling of the unit cell along the [0 1 0] direction.

202 Moreover, the A118C mutation caused a doubling of the V(max) value, whereas the S123C, E131C

203 itamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin

204 induces an increase in L-Asp transport with a doubling of the Vmax and no change in Km (4.5 micronM)

205 e activation kinetics of SCN5A, resulting in a doubling of the window current.

206 eenland show a strong seasonality as well as a doubling of their rate of occurrence over the past 5 y

207 < 0.001, HR = 1.6 and 1.7, respectively, for a doubling of TLG).

208 ease in 15-F2t-IsoP (95% CI: 3.2, 14.7), and a doubling of toenail As was associated with a 1.7% incr

209 However, in contrast with expectations, a doubling of toenail As was associated with a 2.3% decr

210 de polymorphism (SNP) R757C in TAS1R3 led to a doubling of umami ratings of 25 mmol MPG/L.

211 iate-adjusted estimates of associations with a doubling of urinary As suggested an 8.8% increase in 1

212 Complexin mutants exhibit a doubling of vesicle fusion in the absence of extracell

213 Most neurons showed more than a doubling of visually evoked firing rate as the animal

214 bited no significant change in Km but showed a doubling of Vmax to 87 +/- 6 pmol TC/mg protein/min (P

215 marked reductions in fertility, resulted in a doubling of world population between 1960 and 2000.

216 ion, which in Drosophila is achieved through a doubling of X-linked transcription in males.

217 Such band structure engineering results in a doubling of zT in p-type PbTe to above 1.5 at 773 kelv