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2 ) in mouse Gp78 isoform 2 that forms part of a highly conserved 41-amino acid region containing 14-3-
3 -amino group of a specific lysine present on a highly conserved acceptor protein domain, resulting in
9 cluding two papain-like proteases (PLPs) and a highly conserved ADP-ribose-1''-phosphatase (ADRP) mac
12 from an artemisinin ABPP equivalent confirms a highly conserved alkylation profile, with both endoper
14 a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of t
16 d with the disease in the pedigree, affected a highly conserved amino acid residue, and was predicted
20 phaCPs and hnRNP E proteins), are encoded by a highly conserved and broadly expressed gene family.
24 Epithelial-mesenchymal transition (EMT) is a highly conserved and fundamental process in developmen
28 nt of the Trm8/Trm82 holoenzyme that effects a highly conserved and specific (m(7)G46) methylation of
31 PAT family reveals PfDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs.
33 binding site had been ablated by deletion of a highly conserved aspartic acid at position 385, which,
34 pproaches identified Asp93, which is part of a highly conserved AspGlu dyad found in all dual domain
38 irth (neurogenesis) within the hypothalamus, a highly conserved brain region involved in hyperactivit
39 are present only in angiosperms and possess a highly conserved C-terminal region containing linear m
43 g combined with mutational analysis revealed a highly conserved catalytic dyad as well as conserved s
44 he 17b human monoclonal antibody recognizing a highly conserved CD4-induced epitope on gp120 involved
45 acterial phage shock protein (Psp) system is a highly conserved cell envelope stress response require
47 d panneuronal responses to visual stimuli in a highly conserved central brain region in the fruit fly
51 ng zoysiagrass, rice and sorghum genomes and a highly conserved collinearity in the gene order was ob
52 of commensal fungi are mediated by mannans, a highly conserved component of fungal cell walls, since
53 re, we provide evidence for the existence of a highly conserved, continuous, PC-specific epitope sequ
55 stal structure of the decaheme MtrC revealed a highly conserved CX8C disulfide that, when substituted
57 tantly, ROS also inactivate Sb9 by oxidizing a highly conserved cysteine pair (P1-P1' in rodents and
61 Growth arrest specific gene two (GAS2) is a highly conserved cytoskeleton-associated protein whose
62 An allosteric sodium ion was found bound to a highly conserved D2.50 residue in inactive GPCRs, wher
65 tes directly to autoinhibition by precluding a highly conserved dipole-enhanced hydrogen bond between
72 sual case in which an equivalent mutation in a highly conserved domain of yeast and mammalian Erks ca
73 ork mapped the immunosuppressive activity to a highly conserved domain, termed the immunosuppressive
77 Poly (ADP-ribose) polymerase-1 (PARP1) is a highly conserved enzyme focused on the self-repair of
78 (sulfide quinone oxidoreductase) protein is a highly conserved enzyme involved in H2S metabolism.
79 Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evolved a second, unrelat
81 ds through a coordinated movement of CDRs to a highly conserved epitope encompassing a hydrophobic gr
82 g and transgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream o
84 d from isoforms LRRC8C and LRRC8E to uncover a highly conserved extracellular region preceding the se
86 clamp loader clade, RarA protein is part of a highly conserved family of DNA metabolism proteins.
91 ther, our results demonstrate that IFT88 has a highly conserved function within the primary cilia of
93 Trace amine-associated receptor 1 (TAAR1) is a highly conserved G-protein-coupled receptor bound by e
96 -related oncogene; also known as DCUN1D1) is a highly conserved gene that functions as an E3 in neddy
98 dy, two basic amino acids, R128 and R129, in a highly conserved GKYLQRRLQ motif were determined to be
100 bstitutions (p.Glu117Val and p.Glu117Gly) at a highly conserved glutamic acid residue located in the
101 llular form of the prion protein (PrP(C)) is a highly conserved glycoprotein mostly expressed in the
102 We identified murein lipoprotein (MLP), a highly conserved gram-negative outer membrane protein,
103 ant (OR 0.58; 95% CI 0.36-0.94; P = .028) in a highly conserved haplotype region surrounding the LCT
106 the conformation of the heme and changes in a highly conserved helix I motif that is associated with
108 l domain are facilitated by the Bam complex, a highly conserved heteroligomer that plays a general ro
109 or the periplasm of bacteria is mediated by a highly conserved heterotrimeric membrane protein compl
111 cytochrome b561), and abolished by mutating a highly conserved His residue (H292L) predicted to coor
112 al, and mass spectrometry analyses show that a highly conserved His, immediately N-terminal to His(nu
113 enesis and biophysical studies revealed that a highly conserved histidine (His(113)) functions as a p
114 nally, all types of neurons are specified in a highly conserved histogenic order, although its signif
119 esidues adjacent to Asn-110 and Asn-137 form a highly conserved hydrophobic cleft interacting with th
121 vel neutralizing monoclonal antibody targets a highly conserved internal fusion loop in the glycoprot
123 the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell
125 s of mechanistic target of rapamycin (mTOR), a highly conserved kinase within a nutrient-sensing path
126 Specifically, three-toed sloths possess a highly conserved, low-diversity foregut community with
127 haploinsufficiency for LOX or are located at a highly conserved LOX catalytic domain, which is relati
129 nonstructural protein 3 (nsP3) that contains a highly conserved MacroD-type macrodomain at the N term
131 on is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome.
136 factor (SRF)-mediated gene transcription is a highly conserved mechanism that connects dynamic reorg
140 respectively) envelope glycoproteins contain a highly conserved, membrane-proximal endocytosis motif
141 ults demonstrate the selective inhibition of a highly conserved metabolic enzyme that contains identi
143 on that encodes a substitution of valine for a highly conserved methionine (p.Met184Val) in both affe
144 we show that a homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is assoc
145 nuclear receptor and major drug target, has a highly conserved minor splice variant, GRgamma, which
148 the R128A or R129A mutation introduced into a highly conserved motif ((123)GKYLQRRLQ(131)) reduced t
149 s physically interact with tankyrase through a highly conserved motif at their N terminus, and mutati
151 n inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of pepti
153 Rs) from diverse animal phyla and identified a highly conserved motif, which we termed the "hydrophob
156 The target of rapamycin complex 1 (TORC1) is a highly conserved multiprotein complex that functions i
157 d by removal of the GPI-modification signal, a highly conserved N-glycan or the deletion of predicted
158 elated voltage-gated potassium channels have a highly conserved N-linked glycosylation site in the fi
161 mediated by the hypothalamic-pituitary axis, a highly conserved neurohormonal cascade that culminates
162 an ortholog of the mammalian neuropeptide Y, a highly conserved neuromodulator that stimulates food-s
163 rates thyrotropin-releasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal
164 Interestingly, this regulation required a highly conserved NF-kappaB-binding site but not a pred
167 The m.7551A > G mutation is localized at a highly conserved nucleotide(A37), adjacent (3') to the
170 eport the identity of swip-13, which encodes a highly conserved ortholog of the human atypical MAP ki
171 tion of the hedgehog (Hh) signaling pathway, a highly conserved pathway best understood for its role
177 neurotoxicity in HIV-infected macrophages is a highly conserved phenotype of macrophage-tropic HIV st
178 in Drosophila demonstrated the importance of a highly conserved phenylalanine for Pur-alpha's unwindi
181 ed by cAMP-dependent protein kinase (PKA) at a highly conserved phosphorylation site and by cyclin-de
182 roliferating cell nuclear antigen (PCNA) via a highly conserved PIP box motif within the kinase domai
183 tural and functional domains; in particular, a highly conserved pore-loop sequence that determines th
189 cinate dehydrogenase complex (complex II) is a highly conserved protein complex composed of the SDH1
191 s an ABCB1 auxin transporter and Dw1 encodes a highly conserved protein involved in the regulation of
194 Proliferating cell nuclear antigen (PCNA) is a highly conserved protein necessary for proper componen
195 XPhi uses an infection strategy that targets a highly conserved protein of Gram-negative bacteria ess
200 id of secretome phage display, we identified a highly conserved protein that specifically binds and i
204 nts, indicating that CdiA-CT(EC536) exploits a highly conserved protein-protein interaction to promot
205 pocampus.Finally, we confirm that Lhx2 binds a highly conserved putative enhancer of Dmrt5, suggestin
206 of Haemophilus influenzae LpoA (HiLpoA) has a highly conserved, putative substrate-binding cleft bet
207 lyzed by O-acetylserine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependen
208 in organization, and both subclasses contain a highly conserved Rab-binding domain at their C termini
211 associated (CA) HIV-1 DNA and RNA, targeting a highly conserved region in HIV-1pol, with sensitivitie
212 ucleotide polymorphisms, one of which was in a highly conserved region of a gene encoding a sensor ki
213 inkage at multiple sites near the D1 domain, a highly conserved region of bacterial flagellins that i
215 sed the recently solved crystal structure of a highly conserved region of the Drosophila orthologue o
216 phorylation of a single tyrosine (p*Y504) in a highly conserved region of the fibronectin type III (F
218 A RNA interference construct, designed to a highly conserved region of these genes, was used to tr
219 TLR13 has recently been identified to sense a highly conserved region within bacterial 23S rRNA.
220 gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lip
221 ome remodeling deacetylase (NuRD) complex is a highly conserved regulator of chromatin structure and
227 ar, the p.Thr270Ala missense variant affects a highly conserved residue in the DBL homology domain, w
230 persistent PKD1 phosphorylation at Ser(203), a highly conserved residue located within the PKD1 N-ter
232 dentified a single novel missense variant in a highly conserved residue of FLNC (filamin C; p.V2297M)
233 mouse model with an RNase H2 AGS mutation in a highly conserved residue of the catalytic subunit, Rna
235 causes a missense mutation (p.Arg2024Gln) in a highly conserved residue that is essential for carbamo
238 tion responsible encodes the substitution of a highly conserved residue, which lies outside the benza
242 cribe the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential
244 coded protein associates with rRNA and plays a highly conserved role in the maturation of the 60S rib
245 tion in zebrafish cloche mutants, indicating a highly conserved role in vertebrate vasculogenesis and
246 tural accessions of this species, indicating a highly conserved role of this protein in controlling o
249 o the complex by engaging the latter through a highly conserved segment adjacent to the helical HID s
253 at a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defi
254 sp/Glu-rich hypervariable region followed by a highly conserved sequence comprising two potential HXH
259 ng identified a germline mutation (S631G) at a highly conserved serine residue in the uncharacterized
264 tivates the unfolded protein response (UPR), a highly conserved signaling cascade that functions to a
265 f intragenic suppressors, all located within a highly conserved six amino acid tether region of ISP-1
266 ious GAS M-Prts have shown that they contain a highly conserved sortase A-dependent cell wall-anchore
273 e fine specificity is strongly influenced by a highly conserved substitution that regulates receptor
276 r the stability of the fold, forming part of a highly conserved symmetrically repeating hydrogen-bond
281 AZ-bound transcription factors, and contains a highly conserved TIF[F/Y]XG motif that defines the lar
282 RIZ homology domain containing 8 (PRDM8) as a highly conserved transcription factor that is abundant
283 this resilience is linked to the activity of a highly conserved transcription factor, nuclear factor
286 function of elongation factor 4 (EF-4/LepA), a highly conserved translational GTPase, has remained el
287 ce lacking the p75(NTR) death domain (DD) or a highly conserved transmembrane (TM) cysteine residue (
289 h results from cis/trans isomerization about a highly conserved Trp-Pro imide bond in a region of the
292 we identify Abl-mediated phosphorylation of a highly conserved Tyr residue in the P + 1 loop of prot
294 methyl group of dTMP apparently clashes with a highly conserved tyrosine residue, preventing the form
296 ajor histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical
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