ライフサイエンスコーパス: a large number of

1 A large number of ABC and SLC transpoters exist; however

2 ed structure with the proper Ni/Cu ratio and a large number of active sites on the surface of hierarc

3 ich highlights the potential for discovering a large number of additional natural riboswitch classes.

4 is for answering many evolutionary problems, a large number of algorithms have been developed.

5 revealing that JMJD6 and U2AF65 co-regulated a large number of alternative splicing events.

6 Although a large number of analytical and numerical models have b

7 d Anopheline genomes led to the discovery of a large number of apparent discrepancies in assembly and

8 trome analyses in CRPC cells have identified a large number of AR target genes involved in proliferat

9 containing full-length FLNC reads, including a large number of AS events associated with rhizome syst

10 y that allows gene expression measurement in a large number of assays.

11 between clock stability, which benefits from a large number of atoms, and accuracy, which suffers fro

12 h experimental characteristics obtained from a large number of back-gated WSe2 devices with various c

13 ytes are readily available for research with a large number of banked lines with associated patient c

14 Furthermore, we observed a large number of binucleated and apoptotic cells-signs

15 Citrus possess a large number of bioactive compounds mainly studied in

16 A large number of bioactive peptides isolated from natur

17 We profiled a large number of biocidal active ingredients (herbicide

18 rld, children continue to be confronted with a large number of biological and psychosocial challenges

19 ds that participate in, and are essential to a large number of biological processes.

20 c activities to the lung and co-expressed in a large number of breast tumors.

21 Consequently, a large number of Btk inhibitors have been developed.

22 creening data have not been available across a large number of cancer cell lines.

23 A large number of cancer drivers have been identified th

24 riptional activities of TP63 isoforms across a large number of cancer types, potentially enabling ide

25 ss rate of these treatments has been low and a large number of cancers, including colorectal cancer r

26 mon, indicating the possibility of detecting a large number of carbonyl metabolites as well as high r

27 Naturally occurring botulism is rare, but a large number of cases could result from unintentional

28 Stochastic Simulation Algorithm expanded to a large number of cell types and scenarios, with the int

29 Assays generally involve a large number of cells and rely on the underlying assum

30 ever, the majority of these methods requires a large number of cells to begin with.

31 tends throughout the cell and is involved in a large number of cellular functions.

32 rophages, which results in the modulation of a large number of cellular genes.

33 Our study involved a large number of centres and detailed protocol with com

34 A large number of chloroplast RNAs was found to be assoc

35 V. parahaemolyticus was created in 2008, and a large number of clones have been identified, causing s

36 Higher eukaryotic genomes are bound by a large number of coding and non-coding RNAs, but approa

37 2/GATA3 and show that they directly regulate a large number of common genes to orchestrate stem versu

38 e fractions of the genome to be sequenced in a large number of compartments.

39 for multi-dimensional systems consisting of a large number of components that interact through a com

40 connectivity information for the analysis of a large number of compounds in complex mixtures, but sta

41 al field, and as such can be expected across a large number of compounds.

42 nity, as it requires simultaneously managing a large number of computational tools.

43 We reviewed a large number of contemporary pregnancy-associated spon

44 However, these spectra generally have a large number of contributions ranging from slow diffus

45 traits with a very small number of cases and a large number of controls.

46 rity of real-life optimization problems with a large number of degrees of freedom are intractable by

47 es due to the mycobacterial genomes encoding a large number of dehydrogenases.

48 ntial miRNA profiles with respect to C, with a large number of deregulated miRNAs shared by both neop

49 patterns of income and access to services in a large number of developing cities, with an emphasis on

50 Although a large number of devices with mesoscopic dimensions hav

51 east 2 alternative conformations, and 2 have a large number of different association modes.

52 salts and potentially enables assessment of a large number of different counter anions, including th

53 tion, is a highly dynamic complex displaying a large number of different enzyme activities.

54 Most plasma membranes comprise a large number of different molecules including lipids a

55 Foods consist of a large number of different nutrients that are contained

56 The near-simultaneous softening of a large number of different q-bosons yields an extended

57 Multicellular organisms contain a large number of different sHsps, raising questions as

58 Studies over the past decade have revealed a large number of disease-related mutations in the MEK1

59 cated as indicators, mediators, or causes of a large number of diseases and disorders.

60 A large number of distal enhancers and proximal promoter

61 ven suitable for sequencing approaches, with a large number of distinct and highly penetrant causal v

62 The ability to visualize directly a large number of distinct molecular species inside cell

63 llow low-barrier folding pathways that visit a large number of distinct structures.

64 We processed a large number of DNA-protein complexes retrieved from t

65 orkflow for the measurement of CCS values of a large number of drug or drug-like molecules in nitroge

66 A large number of drugs can induce prolongation of cardi

67 Yet, how a large number of effector proteins are selectively recr

68 RNAs bound to CBP in vivo include a large number of eRNAs.

69 rent positions within those genes, requiring a large number of evolutionary parameters that have to b

70 The M1 family of metalloproteases represents a large number of exopeptidases that cleave single amino

71 oth charged and neutral systems and captures a large number of experimental observations.

72 n mechanism in STKR1 kinases that reconciles a large number of experimental studies and sheds light o

73 Such analyses can produce a large number of false positive predictions, suggesting

74 ithout multi-testing correction can generate a large number of false positives while multi-testing co

75 Alarmingly, a large number of fatalities have been linked to overdos

76 sizes may be more or less important and thus a large number of features extracted might end up being

77 n include machine learning methods utilizing a large number of features, including molecular informat

78 A large number of fluorescent dyes were loaded into Alb

79 A large number of follicular helper T (Tfh) cells were a

80 o extensive gene splicing that gives rise to a large number of functional and nonfunctional isoforms.

81 wdsourcing project to annotate and reanalyse a large number of gene expression profiles from Gene Exp

82 subjective in analysis, and unable to screen a large numbers of gene fusions.

83 Intriguingly, a large number of genes coding for ionotropic and metabo

84 The identification of a large number of genes essential for serum resistance i

85 This screen also yielded a large number of genes expressed in a lamina-specific m

86 lysis revealed predominant downregulation of a large number of genes involved in proliferation and ap

87 MIA strongly upregulates expression of a large number of genes involved in translation initiati

88 ofiles in rhd6, modulating the expression of a large number of genes related to cell wall composition

89 omparative transcriptome analysis identified a large number of genes related to the vascular tissue f

90 In addition to identifying a large number of genes required for palate development,

91 in dynamically regulating the expression of a large number of genes upon temperature shifts.

92 costs; and additionally, there usually exist a large number of genes whose methylation level cannot b

93 s sites with distinct features and regulates a large number of genes with cooperative function in reg

94 ufficiency of CUX1 altered the expression of a large number of genes, including cell cycle regulators

95 genome-wide alterations in the expression of a large number of genes, many of which exhibited tempora

96 SFPS regulates pre-mRNA splicing of a large number of genes, of which many are involved in r

97 ven a small number of biological samples yet a large number of genes, this problem suffers from the d

98 tep towards developing "activator drugs" for a large number of genetic disorders where mutations have

99 n sequencing (NGS) technique have identified a large number of genetic variants including copy number

100 Here we identified a large number of genetic variants that are associated w

101 association studies (GWAS) have highlighted a large number of genetic variants with potential diseas

102 ic effect is rather complex, attributable to a large number of genetic variants, and many variants fu

103 eeded the discovery of the genetic basis for a large number of genodermatoses and continue to provide

104 Reconstructing and analyzing a large number of genome-scale metabolic models is a fun

105 We identified a large number of genomic elements that superficially re

106 Such draft genomes consist of a large number of genomic fragments (scaffolds), whose p

107 d genome scale loss-of-function screening in a large number of genomically annotated cancer cell line

108 There are a large number of germline DMRs that have not yet been a

109 During spermatogenesis, a large number of germline genes essential for male fert

110 atistical framework, graph-GPA, to integrate a large number of GWAS datasets for multiple phenotypes

111 lum Finally, we quantified the expression of a large number of Helicobacter pylori genes and found hi

112 Over the past two decades, a large number of highly diverse systems have been studi

113 Furthermore, by analyzing a large number of human antibody sequences and structure

114 ysine methyltransferases are associated with a large number of human diseases, including cancer.

115 rkable reports that intranasal OT influences a large number of human social behaviors should be viewe

116 By analyzing imputed data for a large number of human traits, we empirically derive a

117 Due to the testing of a large number of hypotheses and relatively small sample

118 Across a large number of ICUs, patients were exposed to high so

119 hypothesis of schizophrenia is supported by a large number of imaging studies that have identified a

120 Photochemical reactions are essential to a large number of important industrial and biological pr

121 ly to treat infections, there continue to be a large number of inappropriately prescribed antibiotics

122 s recent genome sequencing projects revealed a large number of indels in various cancer types.

123 ng sites between pairs of DNA sequences from a large number of independent loci.

124 complaints, and depression) was predicted by a large number of indicators of working conditions in bo

125 detection of single action potentials across a large number of individual neurons in a large field-of

126 to principles that can be used to influence a large number of individuals to participate in such act

127 sleeping patterns using mobile phone data of a large number of individuals.

128 enefits but are meaningful when performed by a large number of individuals.

129 lly mapped the response of CD4(+) T cells to a large number of input cytokine combinations that drive

130 d by both a high-dimensional phase space and a large number of instabilities are ubiquitous among com

131 electron microscopy (TEM), we observed that a large number of intact IBDV virions were arranged in a

132 coupled receptors (GPCRs), and they scaffold a large number of interaction partners.

133 hich a single neuronal stem cell can produce a large number of interneurons with similar functional c

134 ntation site, the subcutaneous site requires a large number of islets to achieve engraftment success

135 carbons were positively identified including a large number of isomeric compounds, both aliphatics an

136 In general, CIIIPRX genes encode a large number of isozymes with ranges of in vitro subst

137 dPCR has demonstrable reproducibility across a large number of laboratories without calibration.

138 We identify a large number of layer-specific accessible sites, and s

139 means that a small number of diagnoses share a large number of links, while most diagnoses show limit

140 lly, we observed the increased abundances of a large number of lipids, which are potentially related

141 ion studies of tumor samples have identified a large number of lncRNAs associated with various types

142 dy a mobile lab was used to repeatedly visit a large number of locations ( approximately 1800), defin

143 We describe an approach, sampling a large number of loci across the genome from functional

144 To date, a large number of long non-coding RNAs (lncRNAs) have be

145 rapid leukemic proliferation when there were a large number of LSCs, while a small number of LSCs req

146 rediction of the likely HLA restriction, and a large number of M. tuberculosis T cell epitopes enable

147 This analysis of a large number of male rectal specimens tested for GC an

148 hub sensory neuron/interneuron, integrating a large number of male-specific synaptic inputs and conv

149 mice receiving intraperitoneal saline stored a large number of mature granulocytes expressing a high

150 Although there are a large number of MCTPs found in the plant lineage, biol

151 A large number of MDD patients do not respond to the cur

152 lung microcirculation in mice, we show that a large number of megakaryocytes circulate through the l

153 show that for complex samples there will be a large number of metabolites where traditional DDA appr

154 st a major nAChR-binding mechanism shared by a large number of MG antibodies and the possibility to t

155 A large number of microbial metabolites have been detect

156 intestinal tract of mammals is colonized by a large number of microorganisms including trillions of

157 ncing have led to whole-genome sequences for a large number of microorganisms, enabling the applicati

158 A large number of miR-122 targets were found to be speci

159 While a large number of miRNAs have already been annotated, th

160 Applying our framework to a large number of model and real-world networks, we find

161 ull uncertainty space of the model generates a large number of model variants that are equally accept

162 This has uncovered a large number of models which are compatible with the c

163 titude of marine organisms and were used for a large number of molecular machines.

164 bers of the Apocynaceae plant family produce a large number of monoterpenoid indole alkaloids (MIAs)

165 tected a few important miRNAs that regulated a large number of mRNAs in the control group but not in

166 trophic event, such as chromothripsis, where a large number of mutations instead occur simultaneously

167 nal seeding, in which a single clone evolved a large number of mutations prior to migrating to the li

168 eurons of the maxillary palp (MP-OSNs) using a large number of natural odor extracts to identify nove

169 and anterior cingulate cortex (ACA) contain a large number of neurons activated during PS hypersomni

170 s critical for learning and memory, contains a large number of neurons that develop in the early post

171 CLAM recovered a large number of novel RNA regulatory sites inaccessibl

172 mics at atomic resolution simultaneously for a large number of nuclear sites.

173 We identified a large number of O-glycosites distributed on most envel

174 Fitting such models with a large number of observations involves a prohibitive co

175 nostic signatures, suggesting that including a large number of omic biomarkers may provide substantia

176 A large number of organic contaminants are commonly foun

177 edicted protein-protein association data for a large number of organisms.

178 bles them to modulate their interaction with a large number of other molecules.

179 ecent study of transport and diamagnetism in a large number of overdoped La2-xSrxCuO4 (LSCO) films sh

180 Our Wide-Open system identified a large number of overdue datasets, which spurred admini

181 The discovery of a large number of p53 target genes, which confer p53's t

182 Although a large number of PAINS have been classified, often on t

183 Within only two synaptic layers, a large number of parallel information channels emerge,

184 te transition kernel to estimate in parallel a large number of parameters, split across partitioned d

185 ed screens prohibits experimental testing of a large number of parameters.

186 This modification is mediated by a large number of parasite proteins that are exported to

187 ual intermittent collective displacements of a large number of particles known as 'avalanches'.

188 orks by spreading the target material across a large number of partitions.

189 Unfortunately, there are still a large number of patients and malignancies that do not

190 tio, in HIV disease progression by analyzing a large number of patients in 3 cohorts with different H

191 drome that causes morbidity and mortality in a large number of patients with cancer.

192 laria transmission globally in recent years, a large number of people remain at risk and hence the ga

193 A large number of peptides are generated during the proc

194 A large number of plants have been tested and exploited

195 methods, our assay is able to rapidly detect a large number of polymerase errors at base resolution o

196 onjunction with biomonitoring data to narrow a large number of possible chemical combinations down to

197 analysis to check the purity with respect to a large number of possible contaminant elements.

198 rning a sparse model, where only a subset of a large number of possible predictors is used, and train

199 A large number of potential aging-associated interventio

200 cores (computerized algorithm used to select a large number of potential confounders) and by comparin

201 s represent a cell-cell interaction hub with a large number of potential incoming and outgoing signal

202 ghly symmetrical cavitands are sorted out of a large number of potentially feasible products, which r

203 Using real data, we validate a large number of predictions for long-range contacts in

204 first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their deriv

205 Histological data reveal that a large number of pretectal cells in the superficial and

206 ues when such values exist, and they provide a large number of previously unavailable values.

207 Molecular network reconstruction identified a large number of previously unidentified metabolite cla

208 In the cht7 mutant, a large number of programmed responses failed to readjus

209 Collagen contains a large number of proline residues, so the cis/trans iso

210 lular quantification analyses, we identified a large number of prominent cell groups expressing high

211 The library screening yielded a large number of promising biparatopic lead candidates,

212 type IVB secretion system (T4BSS) to export a large number of protein substrates into the cytoplasm

213 By screening the interaction between a large number of proteins and four types of NPs, the pr

214 Here, we show that MKK3 interacts with a large number of proteins critical for cell growth and

215 we provide evidence that HPr interacts with a large number of proteins in Escherichia coli We demons

216 n how GlcNAc-1-phosphotransferase recognizes a large number of proteins that lack a common structural

217 trometry on the cellular sheddings show that a large number of proteins, both membrane and intracellu

218 complex, requiring the sequential action of a large number of proteins.

219 In recent years, a large number of publications has appeared on photoregu

220 There are a large number of published studies with deposited datas

221 icant computational resources and results in a large number of questionable clusters.

222 show that nanopores can absorb and eliminate a large number of radiation-induced defect clusters.

223 A large number of radiomic features are different betwee

224 the feasible flux space allowed us to obtain a large number of randomly mutated cells simulated at di

225 Our data suggest that the use of a large number of rapidly evolving species-specific prot

226 arity level of 80%, supporting the view that a large number of rare and minute marine species may hav

227 aracterization of functional phenomena using a large number of related phenotype measures, which can

228 Using a large number of repeated measurements we show statisti

229 Its measurement normally requires a large number of repetitions of the same short sound st

230 nts allow for fast and reliable screening of a large number of reported halogenated natural products,

231 Although a large number of reviews and books on biologically acti

232 We find that a large number of RNA fragments in plasma (63%) and urin

233 of 1,225 clinical HCC samples revealed that a large numbers of RNA binding proteins (RBPs) are dysre

234 es and can thus be used for the screening of a large number of samples for high-throughput applicatio

235 vestigation of the biological variability on a large number of samples in a time and cost efficient m

236 clones with CRISPR-mediated genomic edits in a large number of samples is made possible by next gener

237 Analysis of a large number of samples requires an efficient, rapid a

238 y DERs that permits genome-scale analyses in a large number of samples, (ii) introducing a flexible s

239 the method is time-consuming when analyzing a large number of samples.

240 speed of analysis allows its application for a large number of samples.

241 aluable tool in breeding programs, analyzing a large number of samples.

242 Using a large number of sequencing datasets, we demonstrate ho

243 tb growth through a cumulative inhibition of a large number of Ser- and Cys-containing enzymes partic

244 mize HHV-8 transmission, and households with a large number of siblings should receive additional cou

245 integrated microfluidic platform to analyze a large number of single cells in parallel.

246 By recording simultaneously from a large number of single neurons in alert mice viewing m

247 In this study, we identified a large number of single-nucleotide polymorphisms (SNPs)

248 ve sites, we first predict the CO binding at a large number of sites and select four exhibiting CO bi

249 ensity functional theory calculations reveal a large number of sites at the interface between the Co

250 a population change of 15% or less requires a large number of sites to be surveyed, which might be u

251 of morphological and densitometric traits at a large number of sites within the axial skeleton of adu

252 ents with anti-SRP(+) and anti-HMGCR(+) Abs, a large number of small fibers corresponding to both atr

253 We show that a large number of small proteins could in fact be coded

254 A large number of software tools and pipelines developed

255 growth advantage, cancer genomes accumulate a large number of somatic mutations resulting from norma

256 Furthermore, a large number of soybean WRKY genes were responsive to

257 Since this process is complex and involves a large number of species and physical phenomena, a comp

258 organisms have been observed and analysed in a large number of species, however the study of how the

259 ved the assay throughput to allow testing of a large number of specimens in a single run.

260 3-D and of representative cross-sections of a large number of specimens.

261 ferentiating epidermal keratinocytes express a large number of structural and antimicrobial proteins

262 to understand this complex material we bring a large number of structural and magnetic techniques to

263 A large number of studies during the past 2 years have a

264 A large number of studies have extensively addressed the

265 This has led to a large number of studies on improving the retention of

266 ithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of >/=10%.

267 nces in sequencing technologies have enabled a large number of studies to characterize the taxonomic

268 We found that KRCV-1 quickly acquired a large number of substitutions in its genome during rep

269 Having a large number of sufficiently abundant T cell clones is

270 s sickle (SS) red blood cells (RBCs) express a large number of surface receptors that mediate cell ad

271 id (RNA) potentially present in the semen of a large number of survivors of Ebola virus disease (EVD)

272 Icosahedral viral capsids are made of a large number of symmetrically organized protein subuni

273 of PVP in identifying causative variants on a large number of synthetic whole exome and whole genome

274 Analysis of T cell reactivity revealed a large number of T cell epitopes.

275 A large number of T cells populate the skin.

276 ocusing on the center of this area, we found a large number of taste responsive cells ranging from na

277 ally available plastomes and can accommodate a large number of taxa.

278 expression of ID1, it induced expression of a large number of terminal differentiation genes.

279 However, there remain a large number of TFs ( approximately 800) with no high-

280 the context of plant cell division in which a large number of TGN-derived membrane vesicles fuse wit

281 ative trait loci or 'cerQTL', and found that a large number of them were unexplored in conventional e

282 A large number of these clusters are enriched in binding

283 eved through aliovalent doping, to introduce a large number of titanium vacancies that act as interca

284 Seq analysis is still rapidly evolving, with a large number of tools available for each of the three

285 To achieve accurate results in practice, a large number of trainable parameters are often require

286 ional regulation in vivo because it involves a large number of transcripts that are physically seques

287 virus (HCV) infection, but this still leaves a large number of treatment failures secondary to the em

288 or of the TRN and the dLGN, we reconstructed a large number of TRN neurons that were retrogradely lab

289 rotensin receptor 1 (NTR1) has been shown in a large number of tumor entities such as pancreatic or c

290 ork permits and freedom from deportation for a large number of undocumented immigrants.

291 Our annotation has identified a large number of unique gene ontology terms related to

292 Furthermore, the presence of a large number of unknown features, which cannot be read

293 drate active enzymes, our new method reveals a large number of unknown proteins, supporting the notio

294 tructures by noncovalent forces has provided a large number of unprecedented supramolecular assemblie

295 onal neural network models and apply them to a large number of varied existing biomedical named entit

296 Strikingly, we resolve a large number of very high quality (Q approximately 1 x

297 fractionated viral metagenomic data generate a large number of viral contigs with missing host inform

298 e population is amplified and used to create a large number of virtual populations.

299 Influenza A(H7N9) viruses have caused a large number of zoonotic infections since their emerge

300 Bats host a large number of zoonotic viruses, including several vi