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1                                    HuNoV are a major cause of acute gastroenteritis around the world.
2 & AIMS: Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide.
3                Renal ischemia/reperfusion is a major cause of acute kidney injury.
4               Respiratory syncytial virus is a major cause of acute lower respiratory tract infection
5                       Bacterial pneumonia is a major cause of acute lung injury and acute respiratory
6          RATIONALE: Myocardial infarction is a major cause of adult mortality worldwide.
7 ever, senescence has also been implicated as a major cause of age-related disease.
8            Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairme
9         Ischemia-reperfusion injury (IRI) is a major cause of AKI, and previous studies established i
10                  In a mouse model of sepsis, a major cause of ALI, 3-O-beta-d-glycosyl aesculin signi
11 Chronic lung allograft dysfunction (CLAD) is a major cause of allograft loss post-lung transplantatio
12 Chronic injury in kidney transplants remains a major cause of allograft loss.
13  high-risk human papillomaviruses (HPVs) are a major cause of anogenital and oropharyngeal cancers.
14                                              A major cause of autosomal dominant disease is haploinsu
15 ific polysaccharide of Shigella flexneri 2a, a major cause of bacillary dysentery.
16        Campylobacter jejuni, known for being a major cause of bacterial gastroenteritis worldwide, pr
17                      Campylobacter jejuni is a major cause of bacterial gastroenteritis worldwide, pr
18                    Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwi
19 necessarily endocrine cell loss, constitutes a major cause of beta-cell failure in T2D.
20 he majority of the world's population and is a major cause of birth defects.
21    Age-related macular degeneration (AMD) is a major cause of blindness and is associated with comple
22        Primary open-angle glaucoma (POAG) is a major cause of blindness and visual disability.
23 treatments for choroidal neovascularization, a major cause of blindness for patients with age-related
24                 Retinitis pigmentosa (RP) is a major cause of blindness that affects 1.5 million peop
25     Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide.
26 known risk factor for secondary glaucoma and a major cause of blindness worldwide.
27    Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in
28                        Diabetic retinopathy, a major cause of blindness, is characterized by a distin
29 with age-related macular degeneration (AMD), a major cause of blindness.
30 s.Pathological angiogenesis in the retina is a major cause of blindness.
31 ntify new potential targets for treatment of a major cause of blindness.
32                            Ovarian cancer is a major cause of cancer deaths, yet there have been few
33             Human colorectal cancer (CRC) is a major cause of cancer mortality and frequently harbors
34 the most frequent human solid tumors and are a major cause of cancer mortality.
35         Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality.
36 countries, and its metastatic progression is a major cause of cancer-related death.
37 Colorectal cancer metastasis to the liver is a major cause of cancer-related death; however, the gene
38 SIGNIFICANCE STATEMENT Noise overexposure is a major cause of central auditory processing disorders,
39 r significance given that drug resistance is a major cause of chemotherapy failure, the PTX-transport
40                      Measles continues to be a major cause of child mortality globally, and rubella c
41 al disease (DD) due to contaminated water is a major cause of child mortality globally.
42 isease through contaminated water sources is a major cause of child mortality.
43 curs in the first three years of life and is a major cause of childhood blindness.
44 ngenital cytomegalovirus (cCMV) infection is a major cause of childhood deafness.
45 ATIONALE: Lower respiratory tract illness is a major cause of childhood morbidity and mortality.
46         Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated co
47  Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease.
48 nalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worl
49                                  Viruses are a major cause of coccolithophore bloom demise in both te
50                           Rhinovirus (RV) is a major cause of common cold and an important trigger of
51                   Streptococcus pneumoniaeis a major cause of community-acquired pneumonia and septic
52 neumoniae (SP) is a pathogenic bacterium and a major cause of community-acquired pneumonia that could
53                  Alcohol-related traumas are a major cause of death among these subjects.
54         Tuberculous meningitis (TBM) remains a major cause of death and disability in tuberculosis-en
55              Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
56                    Traumatic brain injury is a major cause of death and disability, yet many predicto
57                         Liver metastases are a major cause of death from colorectal cancer.
58                                  Cachexia is a major cause of death in cancer patients.
59                                    Cancer is a major cause of death in children worldwide, and the re
60       Sudden unexpected death in epilepsy is a major cause of death in epilepsy.
61                 Posttransplant malignancy is a major cause of death in orthotopic heart transplant re
62                  CF-related liver disease is a major cause of death in patients with CF.
63                                Metastasis is a major cause of death in patients with EOC, but the und
64 se resulting from iron accumulation is still a major cause of death in patients with thalassemia majo
65                              Cancer remained a major cause of death providing diversified challenges
66                     Prostate cancer (PCa) is a major cause of death since ancient time documented in
67                              Septic shock is a major cause of death worldwide and a considerable heal
68              Cardiovascular disease (CVD) is a major cause of death worldwide.
69  of tuberculosis, is an ancient pathogen and a major cause of death worldwide.
70 rtrophy and associated heart fibrosis remain a major cause of death worldwide.
71 ism during the Holocene has been proposed as a major cause of decreased skeletal robusticity (bone st
72                    Cryptosporidium parvum is a major cause of diarrheal illness and was recently pote
73                       Osteoarthritis (OA) is a major cause of disability and morbidity in the aging p
74                            Osteoarthritis is a major cause of disability and there is no current phar
75                      Depressive symptoms are a major cause of disability in bipolar disorder and ther
76 rapy-induced peripheral neuropathy (CIPN) is a major cause of disability in cancer survivors.
77 s (intensive care unit acquired weakness) is a major cause of disability in patients and is currently
78                          Chronic sciatica is a major cause of disability worldwide, but accurate diag
79 cal conditions such as depressive disorders, a major cause of disability worldwide.
80 lues and negatively with diaphragm fibrosis, a major cause of DMD muscle weakness.
81 ession of myeloid cell leukemia-1 (MCL-1) is a major cause of drug resistance in triple-negative brea
82 common hip abnormality in adolescents and is a major cause of early osteoarthritis.
83 ng DWV-B at PCR primer binding sites, may be a major cause of elevated overwinter honeybee loss.
84                 Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeuti
85  are observed in 0.5% of live births and are a major cause of end-stage renal disease, but their gene
86 onary disease (COPD) patients, this virus is a major cause of exacerbations resulting in an increased
87                Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy.
88                                      Because a major cause of failure is lack of immunity to the infe
89  dysfunction is common in MV patients and is a major cause of failure to wean patients from ventilato
90        This condition, termed sarcopenia, is a major cause of falls and of the subsequent increase in
91 mydia trachomatis genital tract infection is a major cause of female reproductive morbidity.
92  transport phenotype in response to hypoxia, a major cause of fetal growth restriction.
93 m in the intestines of animals and birds and a major cause of food-borne gastroenteritis in humans wo
94 gliadins are the most abundant, and are also a major cause of food-related allergies and intolerances
95 nhanced diaphragm force and halved fibrosis, a major cause of functional decline in DMD.
96       Right ventricular (RV) failure remains a major cause of global morbidity and mortality for pati
97                              Malaria remains a major cause of global mortality.
98    Development of transplant vasculopathy is a major cause of graft loss and mortality in solid organ
99 g to cardiac allograft vasculopathy, remains a major cause of graft loss.
100 ackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in childre
101 kin inhabitant Staphylococcus epidermidis is a major cause of healthcare-associated medical device in
102 00 annual cases of Lassa fever (LF), LASV is a major cause of hearing loss in regions of West Africa
103 nflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in children and young adu
104 y, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America.
105                Inadequate target exposure is a major cause of high attrition in drug discovery.
106  tract illness (LRTI) in young children, and a major cause of hospital admissions and health-care uti
107  RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children,
108                                        It is a major cause of hospital-acquired infection; a large nu
109 oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular conseque
110 r-identical segmental duplications (SDs) are a major cause of human disease, often producing phenotyp
111           Talaromyces marneffei infection is a major cause of human immunodeficiency virus (HIV)-rela
112 Established infectious agents continue to be a major cause of human morbidity and mortality worldwide
113 regulate centrosome duplication is therefore a major cause of human preimplantation developmental arr
114 ciated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75%
115  Sustained fluid overload (FO) is considered a major cause of hypertension, heart failure, and mortal
116 ll origin of aldosterone-producing adenomas, a major cause of hypertension, is unknown.
117            Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic s
118 teremia (bacterial bloodstream infection) is a major cause of illness and death in sub-Saharan Africa
119 ssive depletion of these cells is considered a major cause of immunodeficiency.
120 ion caused by biofilm formation, constitutes a major cause of implant failure in dentistry.
121                                              A major cause of inaccurate examinations of pathological
122 ) gene of respiratory syncytial virus (RSV), a major cause of infant hospitalization, encodes a virop
123 tening complex clinical disorder and remains a major cause of infection-related deaths in the intensi
124             Because implantation defects are a major cause of infertility in women, identifying these
125 colitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella diseas
126                                  Glaucoma is a major cause of irreversible blindness worldwide.
127                      Diabetic retinopathy is a major cause of irreversible vision loss.
128    Age-related macular degeneration (AMD) is a major cause of irreversible vision loss.
129         Antibody-mediated rejection (AMR) is a major cause of kidney allograft loss.
130         Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment of in
131     The latter is increasingly recognized as a major cause of late graft loss, for which we have few
132 ent is an important mediator of chronic AMR, a major cause of late graft loss.
133 Chronic graft-versus-host disease (cGVHD) is a major cause of late mortality following allogeneic bon
134                  Streptococcus pneumoniae is a major cause of life-threatening infections.
135                    Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosup
136         Hepatitis C virus (HCV) infection is a major cause of liver cirrhosis and hepatocellular carc
137  Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide.
138                   Hepatitis C virus (HCV) is a major cause of liver disease, affecting over 2% of the
139 r (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide.
140 nic bacteria such as Haemophilus influenzae, a major cause of lower respiratory tract diseases, must
141 beta-tubulins are increasingly recognized as a major cause of malformations of cortical development (
142     Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality.
143                      Preeclampsia represents a major cause of maternal mortality and morbidity worldw
144 develop an analytical approach that corrects a major cause of measurement inaccuracy inherent in conv
145 e extensive horizontal genetic exchange, are a major cause of meningitis and septicaemia worldwide.
146               Serogroup Y (MenY) strains are a major cause of meningococcal disease.
147                       Although disasters are a major cause of mental health problems and typically af
148                               Corneal ulcer, a major cause of monocular blindness in developing count
149 Staphylococcus aureus (MRSA) continues to be a major cause of morbid conditions and death.
150                Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and
151                  Acute cellular rejection is a major cause of morbidity after lung transplantation.
152 nfection after renal transplantation remains a major cause of morbidity and death, especially infecti
153          Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogenei
154 d Epstein-Barr virus (EBV) infections remain a major cause of morbidity and mortality after allogenei
155  Chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after allogenei
156 nvasive pneumococcal disease continues to be a major cause of morbidity and mortality among children
157 roup of red blood cell disorders, considered a major cause of morbidity and mortality among genetic d
158 ter congenital heart surgery is frequent and a major cause of morbidity and mortality among infants.
159                      Cervical cancer remains a major cause of morbidity and mortality among women, es
160                                       AKI is a major cause of morbidity and mortality and an importan
161 dysregulated tissue repair responses and are a major cause of morbidity and mortality because they af
162 lure (HF) is increasing in prevalence and is a major cause of morbidity and mortality despite advance
163                          Peritonitis remains a major cause of morbidity and mortality during chronic
164  is increasing in prevalence and constitutes a major cause of morbidity and mortality globally.
165 easonal respiratory tract infections and are a major cause of morbidity and mortality in adults and c
166          One example is acute renal failure, a major cause of morbidity and mortality in cancer patie
167                  Portal hypertension (PH) is a major cause of morbidity and mortality in chronic live
168      Damage to the gastrointestinal tract is a major cause of morbidity and mortality in graft-versus
169                    Pneumocystis pneumonia is a major cause of morbidity and mortality in immunocompro
170 influenza virus type 3 (PIV3) infections are a major cause of morbidity and mortality in immunocompro
171                               Infections are a major cause of morbidity and mortality in kidney allog
172 Environmental pollution is now recognized as a major cause of morbidity and mortality in low- and mid
173                                   Anaemia is a major cause of morbidity and mortality in low-income c
174                    Cardiovascular disease is a major cause of morbidity and mortality in patients wit
175              Pneumocystis pneumonia (PCP) is a major cause of morbidity and mortality in patients wit
176                           Lung immaturity is a major cause of morbidity and mortality in premature in
177 e development of Acute Chest Syndrome (ACS), a major cause of morbidity and mortality in SCD patients
178  Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatr
179 Hemorrhagic shock (HS) due to trauma remains a major cause of morbidity and mortality in the United S
180              Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant p
181              Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant p
182 le illness caused by dengue virus (DENV) and a major cause of morbidity and mortality in tropical and
183                              Tuberculosis is a major cause of morbidity and mortality in women of chi
184 festation of ischemic heart disease, remains a major cause of morbidity and mortality worldwide and i
185                   Coronary artery disease is a major cause of morbidity and mortality worldwide, and
186 ying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide.
187              Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide.
188                        Heart failure (HF) is a major cause of morbidity and mortality worldwide.
189 VTE), which is a common vascular disease and a major cause of morbidity and mortality worldwide.
190 ella, Cytomegalovirus, and Herpesviruses are a major cause of morbidity and mortality worldwide.
191                             These tumors are a major cause of morbidity and mortality, and medical th
192            Oral squamous cell carcinomas are a major cause of morbidity and mortality, and tobacco us
193 s with SCD, CNS complications continue to be a major cause of morbidity and mortality, with no eviden
194   Obesity and its metabolic consequences are a major cause of morbidity and mortality.
195 poietic stem cell transplantation (HSCT) are a major cause of morbidity and mortality.
196 gnitive deficits increase the risk of falls, a major cause of morbidity and mortality.
197  diseases (NMDs), cardiac disease represents a major cause of morbidity and mortality.
198 rhythmia encountered by cardiologists and is a major cause of morbidity and mortality.
199 s and dissections of the thoracic aorta, are a major cause of morbidity and mortality.
200                Bloodstream infections remain a major cause of morbidity and mortality.
201           Abdominal aortic aneurysm (AAA) is a major cause of morbidity and mortality; however, the m
202    Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in W
203  of sudden cardiac death in young adults and a major cause of morbidity caused by chronic heart failu
204                        Glomerulonephritis is a major cause of morbidity in patients with SLE.
205                        Zoonotic diseases are a major cause of morbidity, and productivity losses in b
206 Enterobacteriaceae, and Candida species, are a major cause of morbidity, mortality, and healthcare co
207                                    Sepsis is a major cause of morbidity, mortality, and increased med
208 on childhood infection of the middle ear and a major cause of morbidity.
209              Traumatic brain injury (TBI) is a major cause of mortality and morbidity with limited th
210                           Atherosclerosis is a major cause of mortality and morbidity, which is mainl
211 static progression in prostate cancer and is a major cause of mortality and morbidity.
212                                 Influenza is a major cause of mortality and morbidity.
213                                Metastasis is a major cause of mortality and remains a hurdle in the s
214            Progressive metastatic disease is a major cause of mortality for patients diagnosed with m
215                Sudden cardiac death (SCD) is a major cause of mortality in adult congenital heart dis
216 tunistic pathogen Pseudomonas aeruginosa are a major cause of mortality in cystic fibrosis (CF) patie
217                       Haematoma expansion is a major cause of mortality in intracranial haemorrhage r
218 cardial infarction (PMI), even though PMI is a major cause of mortality in patients undergoing urgent
219                             Breast cancer is a major cause of mortality in women.
220 spectrum of alcoholic liver disease (ALD) is a major cause of mortality with limited therapies availa
221 s of end-stage chronic liver disease signify a major cause of mortality worldwide.
222                        Seasonal influenza is a major cause of mortality worldwide.
223                     West Nile virus (WNV) is a major cause of mosquito-borne illness in the United St
224 lium causes mucostasis and likely represents a major cause of mucus plugging in asthma.
225                             Parasites can be a major cause of natural selection on hosts, which conse
226           Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality.
227               Group B Streptococcus (GBS) is a major cause of neonatal sepsis and meningitis.
228                        Multiple sclerosis is a major cause of neurological disability, which accrues
229                                    Stroke is a major cause of neurological morbidity and mortality.
230 sition leads to pulmonary hypertension (PH), a major cause of newborn mortality associated with prete
231                             Liver disease is a major cause of non-AIDS-related deaths, and as a resul
232 ommon sexually transmitted infection that is a major cause of noncervical anogenital and oropharyngea
233 in-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infection.
234                        With sepsis remaining a major cause of obstetric mortality, we aimed to look a
235                               Sarcoidosis is a major cause of ocular or periocular inflammation.
236 ise from high levels of oxidative stress and a major cause of oxidative stress is ionizing radiation.
237                 Spontaneous preterm birth is a major cause of perinatal morbidity and mortality.
238                 Congenital heart defects are a major cause of perinatal mortality and morbidity, affe
239                            Despite its being a major cause of peripheral nerve damage in leprosy pati
240 in more than 100 countries, where it remains a major cause of peripheral neuropathy and disability.
241                                              A major cause of peripheral neuropathy is a copy number
242 s are recalcitrant to antibiotic therapy and a major cause of persistent and recurrent infections.
243                                    Stress is a major cause of poor health and mortality in humans and
244             Intimal hyperplasia (IH) remains a major cause of poor patient outcomes after surgical re
245          Surgical-site infections (SSIs) are a major cause of postoperative morbidity and mortality.
246   Noncompressible torso hemorrhage (NCTH) is a major cause of potentially survivable trauma death.
247                H9N2 avian influenza virus is a major cause of poultry production loss across Asia lea
248 y its ability to limit breakdown of elastin, a major cause of premature aging, following UVB exposure
249 ng against a generalized T cell paralysis as a major cause of protracted immune suppression from seps
250       Gender-based violence (GBV) represents a major cause of psychological morbidity worldwide, and
251                      Acute tubular damage is a major cause of renal failure, especially at the early
252                                              A major cause of resistance is changes in the amino acid
253                                   Smoking is a major cause of respiratory conditions.
254 tory syncytial virus (RSV) infections remain a major cause of respiratory disease and hospitalization
255  RNA virus of the Paramyxoviridae family and a major cause of respiratory disease in children.
256              Human metapneumovirus (HMPV) is a major cause of respiratory disease in infants, the eld
257          Swine influenza A viruses (IAV) are a major cause of respiratory disease in pigs and humans.
258 respiratory distress syndrome (ARDS) remains a major cause of respiratory failure in critically ill p
259                              Inflammation is a major cause of respiratory impairment during Pneumocys
260  pigmentosa GTPase regulator (RPGR) gene are a major cause of retinitis pigmentosa, a blinding retina
261 e conclude that mitochondrial dysfunction is a major cause of reversible neurological deficits in neu
262                       Lung complications are a major cause of rheumatoid arthritis-related mortality.
263                                   Ragweed is a major cause of seasonal allergy, affecting millions of
264 rtunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients.
265                                       RSV is a major cause of serious lower respiratory tract infecti
266  Human respiratory syncytial virus (HRSV) is a major cause of serious respiratory tract infection.
267 FV), a member of the family Bunyaviridae, is a major cause of severe human disease worldwide and show
268                    Pseudomonas aeruginosa is a major cause of severe infections that lead to bacterem
269 Typically, the disease is progressive and is a major cause of severe liver cirrhosis and hepatocellul
270 spiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in inf
271                     Staphylococcus aureus is a major cause of skin and soft tissue infection.
272 in-resistant Staphylococcus aureus (MRSA) is a major cause of skin and soft tissue infections.
273    Infectious agents have been identified as a major cause of specific types of human cancers worldwi
274 oxide (N2O) is a powerful greenhouse gas and a major cause of stratospheric ozone depletion, yet its
275              Ventricular tachycardia (VT) is a major cause of sudden cardiac death.
276  one of the most common cardiomyopathies and a major cause of sudden death in young athletes.
277 vascular autonomic dysfunction in seizure is a major cause of sudden unexpected death in epilepsy.
278                       Rhinoviruses (RVs) are a major cause of symptomatic respiratory tract infection
279  polymorphonuclear leukocyte recruitment, is a major cause of the decline in respiratory function in
280                       Motorised transport is a major cause of the greenhouse gas emissions that are t
281 s of P. falciparum infection could have been a major cause of the high levels of G6PD polymorphism se
282 ypically elicited by bacterial LPS, which is a major cause of the high mortality associated with bact
283               Progressive tissue fibrosis is a major cause of the morbidity and mortality associated
284  potentially help to avert clonal evolution, a major cause of therapeutic resistance and disease rela
285                                              A major cause of this decline is habitat loss due to agr
286     Their use in breeding and aquaculture is a major cause of this.
287           Nonvalvular atrial fibrillation is a major cause of thromboembolic events.
288 SOD1(2SH), is dynamic and hypothesized to be a major cause of toxicity in vivo.
289 ributes to impaired insulin action, which is a major cause of type 2 diabetes.
290         Respiratory syncytial virus (RSV) is a major cause of upper and lower respiratory tract infec
291 (EoE) has emerged over the past 2 decades as a major cause of upper gastrointestinal morbidity.
292 Critical limb ischemia (CLI) continues to be a major cause of vascular-related morbidity and mortalit
293                        Human noroviruses are a major cause of viral gastroenteritis, and it is import
294                                       HBV is a major cause of viral hepatitis, liver cirrhosis, and h
295        Choroidal neovascularization (CNV) is a major cause of vision loss in chronic central serous c
296 atment strategy for neovascular eye disease, a major cause of vision loss in diabetic retinopathy and
297              DR is a common complication and a major cause of vision loss in patients with diabetes m
298 D) and related macular dystrophies (MDs) are a major cause of vision loss.
299    Age-related macular degeneration (AMD) is a major cause of visual impairment that affects the cent
300                   Colorectal cancer (CRC) is a major cause of worldwide morbidity and mortality.

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