ライフサイエンスコーパス: a previously unknown

1 ge and cyclize geranylated indolenine (2) to a previously unknown 12-epi-hapalindole U (3), raised th

2 ecular mobility, suggesting the existence of a previously unknown 2D solid-like phase.

3 ich converts geranylgeranyl diphosphate into a previously unknown 5,7-fused bicyclic diterpene, coine

4 ights that resulted in the identification of a previously unknown ability of promysalin to bind iron.

5 Our data therefore highlight a previously unknown action of the myokine irisin, which

6 ro and in vivo inhibitor of XBP1 activation, a previously unknown activity for this widely utilized c

7 stem cell adhesion to FN in the niche ECM as a previously unknown aging mechanism.

8 The receptor was crystallized bound to a previously unknown agonist, benzamidine, opening a new

9 studies revealed the unexpected presence of a previously unknown allosteric site and an unusual dode

10 we used a computational approach to discover a previously unknown allosteric site on 15-LOX.

11 eal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1

12 Here, we describe a previously unknown and potentially useful property of

13 We have identified Emc10 as a previously unknown angiogenic growth factor that is pr

14 Overall, these results demonstrate a previously unknown anorectic action of central TTR in

15 ilitating intracellular growth is to repress a previously unknown anti-virulence factor.

16 Overall, PCZ showed a previously unknown antiviral effect against DENV infec

17 hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a previously unknown Arabidopsis metabolite.

18 ire input for longer duration, demonstrating a previously unknown aspect of Bicoid decoding.

19 anuscript, Michelassi et al. (2017) identify a previously unknown autoinhibited state for Unc13 media

20 Taken together, this report revealed a previously unknown bacteria-bacteria interaction mecha

21 chniques, we discovered Clostridium immunis, a previously unknown bacterial species from this family,

22 arium carbonate (ABC), which transforms into a previously unknown barium carbonate hydrate (herewith

23 iciently disrupt the GK-GKRP interaction via a previously unknown binding pocket.

24 These findings illustrate a previously unknown biological link between proresoluti

25 es exclusively produce 5-nitro-L-tryptophan, a previously unknown biosynthetic intermediate.

26 evolution, of the common pale typica form by a previously unknown black (carbonaria) form, driven by

27 se chain reaction (RT-qPCR), the presence of a previously unknown bornavirus was detected in a contac

28 aling, but they also expose the existence of a previously unknown branch of signaling events that can

29 Our results identifying a previously unknown branch of tetrapyrrole synthesis su

30 identify aerobic respiration by bacteria as a previously unknown but essential process for mosquito

31 autoimmune diabetes pathogenesis and reveals a previously unknown c-Rel-dependent mechanistic differe

32 ol % of metal triflate as catalyst to afford a previously unknown carbotricyclic core sharing an olef

33 They constitute a previously unknown category of large dinosaurian trace

34 ilitated the identification and treatment of a previously unknown cause of human SCID.

35 In addition, a previously unknown CBZ phototransformation product, 3-

36 djuvant induces CD4 CTLs, which kill through a previously unknown CD154-dependent mechanism.

37 Collectively, these novel findings identify a previously unknown cell population potentially utilize

38 nal design of small molecule inhibitors with a previously unknown central urea motif.

39 and sporulation) family have now emerged as a previously unknown class of essential glycosyltranfera

40 osine phosphorylation of EphBs may represent a previously unknown class of mechanism mediating protei

41 re we report on the endogenous production of a previously unknown class of omega-3 PUFA-derived lipid

42 Herein, we report the synthesis of a previously unknown class of polybenzoquinoline-based m

43 We describe here a previously unknown class of potential PLP enzyme inact

44 H2O2-dependent oxidation of monohaloindoles, a previously unknown class of substrate for DHP.

45 Findings identify hBVR as a previously unknown coactivator of Akt1 and as a key me

46 SPARROW uncovers a previously unknown connection between cancer expressio

47 l role of CFIm25 in governing APA and reveal a previously unknown connection between CFIm25 and gliob

48 In summary, our study reveals a previously unknown connection between histone acetylat

49 l roles for yeast CAF-1 subunits and uncover a previously unknown critical function of the middle sub

50 These findings reveal a previously unknown cytoplasmic effect of HDAC inhibito

51 PHF11 (plant homeodomain finger 11) encodes a previously unknown DDR factor involved in 5' end resec

52 be modified by visual experience, revealing a previously unknown degree of brain plasticity in respo

53 nctional studies, shows that this site forms a previously unknown determinant of CaV high-affinity ca

54 9b-RhoGAP accelerates RhoA GTP hydrolysis by a previously unknown dual-arginine-finger mechanism, whi

55 the human K326X mutation in vivo and reveal a previously unknown effect of Arhgap29 in murine cranio

56 pment of obesity-associated inflammation via a previously unknown effect of insulin on the IL-10-medi

57 Plexin-B1 for CIL in osteoblasts and reveals a previously unknown effect of Semaphorin signalling on

58 Together, these reveal a previously unknown epigenetic mechanism of cocaine act

59 monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope

60 sults of a laboratory experiment that reveal a previously unknown eruption criterion below which toru

61 for regulation of p31(Comet) and demonstrate a previously unknown event controlling SAC activity.

62 icornavirus host factor that is required for a previously unknown event in the viral life cycle.

63 preimposed orientational patterns represents a previously unknown facet of the interplay between hydr

64 ts reveal neurosteroid estrogen synthesis as a previously unknown factor in the escalation of seizure

65 suggests that alpha-syn arginylation can be a previously unknown factor that facilitates normal alph

66 Localized dysfunction of Treg cells is a previously unknown factor that might contribute to fib

67 ue hydrophobic anchor mechanism that defines a previously unknown family of protein deacetylases.

68 eading toxicity, this approach has uncovered a previously unknown, fast acting, GluN2A-dependent neur

69 on at ~4 angstrom resolution, which revealed a previously unknown form of virion organization.

70 The results demonstrate that Bub3 has a previously unknown function at the kinetochore in acti

71 These findings underscore a previously unknown function for GCN2 phosphorylation o

72 a metastatic to a non-metastatic phenotype, a previously unknown function for ICAM-2.

73 Our findings uncovered a previously unknown function for LYVE-1 and show that t

74 Our results elucidate a previously unknown function for microbial pattern-reco

75 These data suggest a previously unknown function for p190BRhoGAP in control

76 We discovered a previously unknown function for recurved bristles on t

77 Our findings thus reveal a previously unknown function of a common stress mediato

78 topoietic stem-cell migration; this revealed a previously unknown function of BCL11B.

79 RNA 3' end maturation in plants and uncovers a previously unknown function of CPSF73 in snRNA maturat

80 Our findings highlight a previously unknown function of the CSF in promoting sp

81 tination and stability of HDAC2 and uncovers a previously unknown function of USP4 in cancers.

82 nomes and which is due at least partially to a previously unknown function of VP24 in RNA packaging.

83 ontaining protein 2 (MOSPD2), a protein with a previously unknown function, regulates monocyte migrat

84 These findings reveal a previously unknown functional relationship between mem

85 Our studies unveil a previously unknown genetic mechanism of BRAFi resistan

86 rea-specific manner, thereby indicating that a previously unknown genetic program postnatally promote

87 transmission specifically in CRF neurons via a previously unknown Gi-mediated, PKA-dependent postsyna

88 IP-exo) method allowed the identification of a previously unknown high-affinity AICE2 motif at a huma

89 Our results identify TRC8 as a previously unknown Hsp70-independent quality control E

90 We isolated and identified a previously unknown human mitochondrial transcription i

91 ps were determined on the basis of NOEs, and a previously unknown hydrogen-bonding network between Ma

92 These results reveal a previously unknown ICOS-TBK1 signaling pathway that sp

93 Consequently, we report a previously unknown immune subversion mechanism involvi

94 ults identified a VGLL3-regulated network as a previously unknown inflammatory pathway that promotes

95 These results implicate a previously unknown innate-like ability of CD4(+) T cel

96 ese findings permitted the identification of a previously unknown innate-like T cell subset and indic

97 Together, our study unmasks a previously unknown interplay between an E3 ligase and

98 Together, these data suggest a previously unknown interplay between SOD1 acylation, m

99 noids via an oxidation reaction catalyzed by a previously unknown ketolase [4-6].

100 tal structures, including the observation of a previously unknown key intermediate structure.

101 The model uncovers a previously unknown large-scale systematic size variati

102 This study therefore identifies a previously unknown layer of antiviral defense that exe

103 The discovery of microRNAs revealed a previously unknown layer of regulation for several bio

104 fic transcription factor by miRNA represents a previously unknown level of developmental regulation i

105 unexpected result that can be interpreted as a previously unknown LFA-1 conformation.

106 ure of the extracellular domain of CASPR2 to a previously unknown ligand, Contactin1 (CNTN1).

107 eature is associated with photoconversion of a previously unknown light-sensitive, blue-shifted photo

108 Altogether, these data unraveled a previously unknown link between an imbalanced stoichio

109 This study has uncovered a previously unknown link between FUS proteinopathy and

110 is issue of the JCI, Kraakman et al. uncover a previously unknown link between hyperglycemia and enha

111 l the identity of key players that establish a previously unknown link between insulin signaling, tra

112 Our data establish a previously unknown link between plastid protein import

113 Our results reveal a previously unknown link between Pro metabolism and pho

114 This study reveals a previously unknown link between the mammary-defining t

115 Here we uncover a previously unknown link between the tricarboxylic acid

116 ion of eIF2alpha phosphorylation and reveals a previously unknown link between translational repressi

117 These findings suggest that a previously unknown link exists between ChREBP and the

118 A previously unknown linkage between glycolysis impairme

119 re we describe and functionally characterize a previously unknown liver-specific enhancer-promoter el

120 d flows in the urethra in vivo and describes a previously unknown long-term neural accommodation phen

121 bly into spherical micelles, which pack into a previously unknown, low-symmetry lyotropic liquid crys

122 , we used BAK1 as molecular bait to identify a previously unknown LRR-RLP required for the recognitio

123 Demonstration of a previously unknown lymphatic endothelial cell progenit

124 quired for transcript degradation, acting in a previously unknown manner.

125 Our study uncovers a previously unknown mechanism by which GOT2 acetylation

126 Our data reveal a previously unknown mechanism by which HCV attenuates t

127 fore, our findings provide new insights into a previously unknown mechanism by which miR-155-3p contr

128 Taken together, our results reveal a previously unknown mechanism by which Myc induces apop

129 ginosa Taken together, our findings identify a previously unknown mechanism by which P. aeruginosa Ex

130 Our findings reveal a previously unknown mechanism by which polyamines may e

131 Here we report a previously unknown mechanism by which rain disperses s

132 endogenous proteolytic activity and defines a previously unknown mechanism by which S. aureus may in

133 The results identify a previously unknown mechanism by which Th17 cells can c

134 Together, these results indicate a previously unknown mechanism for A1R-induced persisten

135 is and Foxp3-E2 variants via enolase-1 shows a previously unknown mechanism for controlling the induc

136 Taken together, these results reveal a previously unknown mechanism for perceiving the afford

137 cers via chromatin looping, which identifies a previously unknown mechanism for regulating the T cell

138 of human osteogenesis imperfecta, and reveal a previously unknown mechanism for splicing "rescue."

139 vely, this study offers the demonstration of a previously unknown mechanism for the beneficial role o

140 These findings identify a previously unknown mechanism for the development of mi

141 Our study uncovers a previously unknown mechanism for the insulin and mTOR

142 of resting membrane potential, demonstrating a previously unknown mechanism for the regulation of exc

143 Together, these data present a previously unknown mechanism for translational shutdow

144 ified Hrd1-mediated BLIMP1 ubiquitination as a previously unknown mechanism in programming DC for CD4

145 In sum, our study uncovers a previously unknown mechanism in which RBF and E2F1 mod

146 Our findings suggest a previously unknown mechanism linking allele-specific e

147 aneptine is an effective antidepressant with a previously unknown mechanism of action.

148 These data identify a previously unknown mechanism of bacterial-guided neutr

149 he surface of the skin; thus, this points to a previously unknown mechanism of barrier immunity.

150 is in postsynaptic neurons (Purkinje cells)--a previously unknown mechanism of neural circuit develop

151 diabetes induced neuropathic pain and define a previously unknown mechanism of pain, regulated by end

152 Our results reveal a previously unknown mechanism of unconscious memory due

153 Taken together, this work identifies a previously unknown mechanism regulating multiple aspec

154 The regeneration of axons relies on a previously unknown mechanism that involves the regulat

155 We describe a previously unknown mechanism that may contribute to ra

156 study establishes lysine fatty acylation as a previously unknown mechanism that regulates the Ras fa

157 g translational fidelity, which may serve as a previously unknown mechanism to improve fitness in res

158 Together, our data identify a previously unknown mechanism to maintain centromere id

159 ve recognition of CD1a by the TCR represents a previously unknown mechanism whereby alphabeta T cells

160 Here we report a previously unknown mechanism whereby NiV provides a no

161 Taken together, our data identify a previously unknown membrane-interacting surface of Ysc

162 These results reveal a previously unknown metabolic component to postthymic T

163 biochemical analyses of these genes lead to a previously unknown metabolic link between TDA/acid res

164 These data reveal a previously unknown metabolic versatility of photoferro

165 ch carbamazepine resists biodegradation, and a previously unknown microbial biodegradation was predic

166 We identified a previously unknown missense substitution in ADGRE2 (al

167 We identified a previously unknown mitochondrial fission arrest phenot

168 This study identifies TRIM21 as a previously unknown modulator of Toxoplasma gondii resi

169 o Aalpha-chain frameshift variants, yielding a previously unknown molecular basis for the pathogenesi

170 hanistically, we have found that HDAC6 forms a previously unknown molecular complex with STAT3, assoc

171 We have identified a previously unknown molecular link between folate avail

172 We report a previously unknown molecular mechanism by which folate

173 :SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-

174 itro, we demonstrate that not cell death but a previously unknown morphogenetic event transforms the

175 his food texture discrimination depends upon a previously unknown multidendritic (md-L) neuron, which

176 Here, we unveil a previously unknown, multilayered regulation of epithel

177 We found a previously unknown murine leukemia virus infection in

178 In whole genome sequencing a previously unknown mutation c.197G>T p.G66V in CHCHD10

179 than 1,000 molecular differences, including a previously unknown, Mycobacterium tuberculosis-specifi

180 Abundant pollination by a previously unknown native moth in experimental and res

181 e bacterial infections likely resulting from a previously unknown negative interference between dieta

182 s Noco2, suggesting that mRNA splicing plays a previously unknown negative role in plant immunity.

183 nal NMR experiments, we were able to uncover a previously unknown network of interactions that stabil

184 Furthermore, we investigated a previously unknown neural circuit originating from sep

185 Here we identify a previously unknown neuron type in the songbird brain t

186 lized hydridosilylenes 3 was accomplished by a previously unknown NHC-induced fragmentation of silano

187 Taken together, these findings reveal a previously unknown, nonredundant role for Elmo1 in con

188 Our results reveal a previously unknown nucleotide-sensing mechanism for co

189 These findings identify a previously unknown oncogenic property of the spatially

190 a molecule can be changed by the ligand set, a previously unknown option with these metals due to the

191 g fimS inversion, our method also identifies a previously unknown pair of 5' UTR inverted repeats tha

192 (18)F-FLT biodistribution over time revealed a previously unknown path of cellular recovery of haemop

193 tes proliferate in situ during AH, providing a previously unknown pathogenic mechanism and new avenue

194 These results demonstrate a previously unknown pathological adaption in a key node

195 Together, this study defines a previously unknown pathway by which S. aureus epicutan

196 A previously unknown pathway can selectively degrade mit

197 of dc-Si via an intermediate dh-Si phase is a previously unknown pathway of solid-state amorphizatio

198 e recently discovered that obesity activates a previously unknown pathway that promotes both excessiv

199 cation in eastern North America, evidence of a previously unknown pathway to domestication in northea

200 d with phosphatidylethanolamine (PE) through a previously unknown pathway.

201 cognizing the same glycolipid, we identified a previously unknown pattern of V gene usage (TRAV17, TR

202 We have discovered that GAS uses a previously unknown peptide-mediated intercellular sign

203 he presumably uniformly fluidic ER membrane, a previously unknown phenomenon.

204 exhibits significant nanostructure, which is a previously unknown physical component of the host-Cand

205 Taken together, our results unmask a previously unknown player in central regulation of glu

206 We identified a previously unknown population of choline acetyltransfe

207 We report the identification in mouse of a previously unknown population of multipotent stem/prog

208 ing RNAs are regulated by DUSP11 and defines a previously unknown portal for small RNA-mediated silen

209 ncode RNA-binding proteins, thus delineating a previously unknown post-transcriptional regulatory sub

210 ing the underlying mechanisms, we identified a previously unknown postsynaptic current during neurotr

211 We report a previously unknown poxvirus infection in 2 patients, 1

212 a challenging case history and treatment of a previously unknown poxvirus rash illness in a renal tr

213 tients (28.6%), (68)Ga-DOTATATE PET/CT found a previously unknown primary tumor, and detected primary

214 es downregulated in ASD, and hsa_can_1002-m, a previously unknown, primate-specific miRNA that is dow

215 Overall, our results define a previously unknown principle in neuroscience; thalamic

216 These results illuminate a previously unknown program of liver regeneration after

217 In conclusion, our study identifies a previously unknown protective SMA modifier in humans,

218 We show that a previously unknown protein, termed as Charon, function

219 Our study identifies a previously unknown proteolytic activity of PLA2 that i

220 We report that a previously unknown, quorum-sensing-controlled LysR-typ

221 A previously unknown, rather unusual, memory response pa

222 via a dehydrogenase in Pfam family PF00107, a previously unknown reaction; 2) phosphorylation of d-t

223 We conclude that Krtap5-5 is a previously unknown regulator of cytoskeletal function

224 These results identify SMAD4 as a previously unknown regulator that restricts non-canoni

225 This RNA-based silencing represents a previously unknown regulatory means to control this ma

226 r study identifies lysine fatty acylation as a previously unknown regulatory mechanism for the Ras fa

227 of the activation of IRF3 but also identify a previously unknown regulatory mechanism independent of

228 In conclusion, our findings reveal a previously unknown regulatory role for LRRK2 in CX3CR1

229 Our study uncovers a previously unknown relationship between oxygen-sensiti

230 d with GSL and AA concentrations, suggesting a previously unknown relationship between plants and end

231 Our study uncovers a previously unknown relationship between these two ubiq

232 These studies revealed a previously unknown relationship between two nonadjacen

233 Our work identifies a previously unknown requirement for a GAP in DLP functi

234 ion during neural crest migration and define a previously unknown requirement for EF1alpha1 methylati

235 a and pax7b zebrafish mutants, we identified a previously unknown requirement for Pax7 in xanthophore

236 Our study reveals a previously unknown requirement for the BMP4 prodomain

237 findings indicate that preterm birth may be a previously unknown risk factor for HF.

238 roteins identified in other quaranjaviruses, a previously unknown RNA segment (segment 7) encoding a

239 These studies reveal a previously unknown role for bidirectional Notch signal

240 These results elucidate a previously unknown role for blood-derived non-classica

241 These findings support a previously unknown role for CNS astrocytes in energy b

242 These data uncover a previously unknown role for DYRK1A in lymphopoiesis, a

243 Here we identify a previously unknown role for FSH in this signaling casc

244 the MHV68 lytic replication cycle and define a previously unknown role for Hsc70 in facilitating MHV6

245 Thus, we have identified a previously unknown role for IL-1beta in facilitating I

246 Thus, we have identified a previously unknown role for Itch in regulating IL-17-m

247 These findings support a previously unknown role for Mop in endosomal trafficki

248 Our aggregate data identify a previously unknown role for MSC-derived EVs in the reg

249 These findings suggest a previously unknown role for MTHFD2 in cancer cell prol

250 Thus our data identify a previously unknown role for Nr4a2 in the regulation of

251 Our results reveal a previously unknown role for nuclear actin filaments in

252 Furthermore, we identify a previously unknown role for OX40L in steady-state bone

253 ial cues for NK cell organization and reveal a previously unknown role for S1P in positioning cells w

254 This study unveils a previously unknown role for Srp1 and Sts1 in cotransla

255 ensory feedback architecture and constitutes a previously unknown role for the antennae.

256 In this study, we report a previously unknown role for the cytoplasmic promyelocy

257 Our data reveal a previously unknown role for the gut microbiota in infl

258 We describe a previously unknown role for the Hippo pathway in myeli

259 ssion and the splicing of PTC7 and establish a previously unknown role for the SWI/SNF complex in the

260 ially accessible chromatin regions suggested a previously unknown role for the Zic family of transcri

261 Together, these results reveal a previously unknown role for transcription factor IIH i

262 nserved across phyla, and this study reports a previously unknown role for VGLUT as an acid-extruding

263 Here, we reveal a previously unknown role for Zic2 in the migration of f

264 We have discovered a previously unknown role of a post-translational modifi

265 Therefore, these findings reveal a previously unknown role of Cav1.2 channels within the

266 This underscores a previously unknown role of DNA damage repair in the pa

267 Our results uncover a previously unknown role of ErbB4 in regulating cortico

268 Taken together, these data demonstrate a previously unknown role of HDAC11 as a negative epigen

269 These findings uncover a previously unknown role of IL-27 in regulating Treg fu

270 Overall, our study reveals a previously unknown role of lipin1 in skeletal muscle r

271 These results demonstrate a previously unknown role of the S1P signalling pathway

272 tutions in Ubc13-deficient strains uncovered a previously unknown role of Ubc13 in controlling the ac

273 ected plant recognition strategy for AMF and a previously unknown signaling link between symbiosis an

274 Thus, our study has uncovered a previously unknown signaling module (ARK2-PUB9) that i

275 rt that pathogen-secreted proteases activate a previously unknown signalling pathway in Arabidopsis t

276 of sea ice and sea ice-influenced ocean are a previously unknown significant source of atmospheric o

277 G6P was found to bind to a previously unknown site adjacent to the canonical site

278 These findings support a previously unknown skin immune response based on T cel

279 A previously unknown species of MCC, which consists of M

280 Homo naledi is a previously-unknown species of extinct hominin discover

281 The results demonstrate a previously unknown specificity of calcineurin isoforms

282 genome sequencing revealed a new mutation in a previously unknown splice enhancer of the DGAT1 gene.

283 to prior studies, we find that CcdA samples a previously unknown state where only one of the disorde

284 anges in Smo dynamics in cilia and highlight a previously unknown step in Hh pathway activation.

285 emonstrate that Dph7 is an enzyme catalyzing a previously unknown step in the diphthamide biosynthesi

286 sence of cytoskeletal tension generation, as a previously unknown strategy to maintain stemness in 3D

287 The stic2 locus identified a previously unknown stromal protein that interacts phys

288 Our results suggest a previously unknown structural feature of Lin28 targets

289 These results reveal a previously unknown subcortical mechanism of rapid inhi

290 Here we describe a previously unknown subset of phenotypically naive huma

291 nd lung defense against oxidative stress, as a previously unknown substrate of Pla.

292 These results identify Ce-Punctin as a previously unknown synaptic organizer and show that pr

293 Our data demonstrate a previously unknown synergy between AngII and BAFF in i

294 Collectively, our study uncovers a previously unknown tightly coupled positive feedback s

295 Thus, we establish a previously unknown translaminar inhibitory circuit in

296 In this work, we describe a previously unknown trigger, interactions with lipid me

297 Taken together these data suggest a previously unknown two-molecule sensing mechanism in w

298 a low-luminosity active galactic nucleus or a previously unknown type of extragalactic source.

299 Our findings identify a previously unknown viral strategy of immune evasion.

300 ion and synaptic ribbon formation and reveal a previously unknown yet critical role of L-type voltage