ライフサイエンスコーパス: a substantial fraction of

1 A substantial fraction of 5'-ends obtained by this metho

2 d from mouse embryonic stem cells found that a substantial fraction of 5mC in CpG dinucleotides is co

3 ronment, the genetic background accounts for a substantial fraction of abundance of most common micro

4 We show that a substantial fraction of active purifying selection in

5 Our results suggest that a substantial fraction of adult SEZ NSCs is derived from

6 A substantial fraction of adult-generated granule cells

7 lines, and these studies also indicate that a substantial fraction of AGO2 resides in the nucleus.

8 mpact and descriptive, capable of describing a substantial fraction of all known protein folds.

9 nhibitory, pacemaker neurons that constitute a substantial fraction of all preBotC pacemaker neurons.

10 rt hairpin RNA expression plasmids, covering a substantial fraction of all predicted genes in the hum

11 Recent data from Drosophila suggest that a substantial fraction of amino acid substitutions obser

12 We observed that a substantial fraction of amnioserosa cells ingress near

13 cordings during the acute period showed that a substantial fraction of animals were already experienc

14 and prolonged survival, without toxicity, in a substantial fraction of animals.

15 d the appearance of chromosomal fragments in a substantial fraction of anther meiocytes.

16 A substantial fraction of anthropogenic CO(2) emissions

17 rates of synaptic inputs the model generates a substantial fraction of APs in its nodes of Ranvier.

18 (that is, almost complete disintegration) of a substantial fraction of asteroids when they achieve pe

19 l subunits, binds three sites on EBER-1, and a substantial fraction of available L22 is relocalized f

20 A substantial fraction of bacterial and archaeal genomes

21 A substantial fraction of bacterial energy budgets are d

22 t that CNVs contribute pathogenic alleles to a substantial fraction of BBS-affected individuals and h

23 binding assay in a microfluidic device, that a substantial fraction of beta2 integrins on human neutr

24 We estimate that a substantial fraction of binding sites ( approximately

25 were produced for 379 proteins, encompassing a substantial fraction of both protein superfamilies.

26 ng of mESCs revealed that threonine provides a substantial fraction of both the cellular glycine and

27 -dependent ROS production is responsible for a substantial fraction of brain damage at early time poi

28 ells, but in the absence of NHEJ components, a substantial fraction of breaks can be efficiently chan

29 neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal

30 ed protein is silenced due to methylation in a substantial fraction of breast, prostate, lung, and pa

31 rising long-range periodicity that underlies a substantial fraction of C. elegans genomic sequence.

32 t at low exogenous tryptophan concentrations a substantial fraction of C. trachomatis bacteria fail t

33 A substantial fraction of cancers showed high mTOR pathw

34 A substantial fraction of cases will harbor a balanced t

35 a in nonproliferative stroma was observed in a substantial fraction of cases.

36 and the lower IL-2 production that results, a substantial fraction of CD8(+) effector T cells lose C

37 We find that a substantial fraction of cells can become defectively i

38 (ii) that, according to these fluctuations, a substantial fraction of cells may contain only one or

39 roximately 250 megabases, often representing a substantial fraction of cells within a given sample.

40 s not further increase global [Ca(2+)](i) in a substantial fraction of cells, due to a compensatory i

41 l cellulose utilization in systems for which a substantial fraction of cellulase is cell-associated.

42 rmone-binding protein (GHBP) is complexed to a substantial fraction of circulating GH.

43 Of note, a substantial fraction of Clr-a molecules are retained i

44 3, a region of recurrent copy number gain in a substantial fraction of colon cancers.

45 These data support the hypothesis that a substantial fraction of CR is mediated by antibody (im

46 We observed that the 1D MPS exists in a substantial fraction of dendritic regions in relativel

47 A substantial fraction of disease-causing mutations are

48 Surprisingly, we also find a substantial fraction of DNA hypo-methylated regions in

49 that when a replisome encounters the lesion, a substantial fraction of DNA polymerase (DNAP) and heli

50 on (DOC) preclude prokaryotic consumption of a substantial fraction of DOC in the deep ocean and that

51 scales are found to be highly textured, with a substantial fraction of domains exhibiting the <001> d

52 analysis of rd10 mouse retinas revealed that a substantial fraction of dying cones exhibited necrotic

53 SOX-4 mRNA is shown to be overexpressed in a substantial fraction of each of these lung tumor types

54 However, a substantial fraction of EBV-infected B cells and tumor

55 s using oncolytic therapy is the presence of a substantial fraction of EBV-infected cells that does n

56 A substantial fraction of eIF4E forms nuclear bodies tha

57 Thus, mirtrons surprisingly comprise a substantial fraction of endogenous Dicer substrates in

58 A substantial fraction of eukaryotic genomes consists of

59 containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes.

60 sable elements and their remnants constitute a substantial fraction of eukaryotic genomes.

61 , the spectra begin to show the signature of a substantial fraction of extended chain, the structure

62 Organic aerosol (OA) constitutes a substantial fraction of fine particles and affects bot

63 Secondary organic aerosol (SOA) constitutes a substantial fraction of fine particulate matter and ha

64 By contrast, a substantial fraction of flies genetically null for one

65 Unexpectedly, a substantial fraction of genes induced by loss of SIN3

66 rganisms have established that expression of a substantial fraction of genes is not needed for optima

67 x genes lends support to the hypothesis that a substantial fraction of genes methylated in human canc

68 men with IHC defects could result in missing a substantial fraction of genetic disease.

69 A substantial fraction of GEP transcripts encode product

70 the 3 major subtypes of this malignancy, and a substantial fraction of germinal center B cell-like (G

71 a DMSP demethylase homolog and thereby route a substantial fraction of global marine primary producti

72 irst of two companion articles, we show that a substantial fraction of gluconeogenic carbon leaves th

73 chotogenic action in humans, ketamine blocks a substantial fraction of GluN2C subunit-containing rece

74 Intraepithelial lymphocytes represent a substantial fraction of gut-associated lymphocytes, bu

75 s of histologically normal mammary tissue of a substantial fraction of healthy, cancer-free women.

76 oci for common autoimmune diseases; however, a substantial fraction of heritability remains unexplain

77 We found that a substantial fraction of Hsp70A co-localizes with GlsA,

78 CA mutations and c-MYC elevation co-occur in a substantial fraction of human breast tumors.

79 ly similar to germ-line DNA, indicating that a substantial fraction of human genetic variation arises

80 s associated with Yap activation is found in a substantial fraction of human hepatocellular carcinoma

81 and the PI3K/Akt pathway were coactivated in a substantial fraction of human high-grade tumors.

82 Thus, a substantial fraction of human NSCLCs activates an NRF2

83 pothesis that environmental chemicals induce a substantial fraction of human point mutations has not

84 The existence of pol beta mutations in a substantial fraction of human tumors studied suggests

85 We find that a substantial fraction of human-mouse CRS regions (1) co

86 A substantial fraction of hypothetical open reading fram

87 In healthy humans, a substantial fraction of IgG-positive memory B cells ex

88 inactivation can lead to release sites with a substantial fraction of inactivated channels that exhi

89 These observations imply that a substantial fraction of incident stellar radiation is

90 Calcium imaging confirmed that a substantial fraction of individual endothelial cells r

91 ncing are needed to avoid falsely predicting a substantial fraction of individuals as being at risk f

92 s of their peers are more heterogeneous, but a substantial fraction of individuals consistently contr

93 A substantial fraction of insects and other terrestrial

94 Studies of the transcriptome have shown that a substantial fraction of interspecific differences in g

95 A substantial fraction of introns occupy the same positi

96 We show here that a substantial fraction of IRS-1 is translocated to the n

97 A substantial fraction of ischemic EAA release occurs vi

98 GPGTF homologs constitute a substantial fraction of known proteins: 0.4% of all no

99 Like other herpesviruses, however, a substantial fraction of latently infected cells are re

100 elevant for directing eye movement, we found a substantial fraction of LIP neurons selective for cue

101 We find that a substantial fraction of loci that undergo chromatin ac

102 ocus will increase the variance explained in a substantial fraction of loci, but that allelic heterog

103 , and that this IgM ASC compartment contains a substantial fraction of long-lived plasma cells that d

104 Genome-wide analyses revealed that a substantial fraction of lymphoid and myeloid enhancers

105 family of transposable elements, constitute a substantial fraction of mammalian genomes.

106 A substantial fraction of marine plastic debris originat

107 rochlorococcus and Synechococcus account for a substantial fraction of marine primary production.

108 Our results demonstrate that a substantial fraction of MART-1(27-35) epitope-specific

109 Without Prm1, a substantial fraction of mating pairs arrest with their

110 A substantial fraction of MHC-associated peptides from E

111 tic nerve fibers and reversed in larvae with a substantial fraction of misprojecting fibers.

112 nal repeat (LTR) retrotransposons constitute a substantial fraction of most eukaryotic genomes and ar

113 three new RGC types that together constitute a substantial fraction of mouse RGCs, provide insights i

114 A substantial fraction of mutations that arise in the ce

115 The downside of mutagenesis is that a substantial fraction of mutations will destroy gene/ge

116 A substantial fraction of nascent proteins delivered int

117 A substantial fraction of NBS-deficient fibroblasts rein

118 ings confirm that eukaryotic life depends on a substantial fraction of ncDNA and also make a predicti

119 uli and subsequent rewards, the responses of a substantial fraction of neurons in the primary visual

120 A substantial fraction of newly born neurons die before

121 Rather, a substantial fraction of nitrate consumption must be su

122 Further analysis indicated that a substantial fraction of Nkx3.1 target genes are also d

123 However, a substantial fraction of NOA heritability remains undef

124 n phosphorylation, and provide evidence that a substantial fraction of nonactivated visual pigments b

125 recessive beneficial mutations may comprise a substantial fraction of noncoding DNA divergence obser

126 Hyponatremia occurs in a substantial fraction of nonelite marathon runners and

127 PET led to change in intended management in a substantial fraction of nonprostate cancer patients.

128 istone variants replace the core histones in a substantial fraction of nucleosomes, affecting chromat

129 nerative disorder that has been diagnosed in a substantial fraction of older male fragile X premutati

130 ccurs in continental margin sediments, where a substantial fraction of organic carbon escapes oxidati

131 By the end of this experiment, a substantial fraction of organic matter remained in ide

132 Atmospheric aerosols often contain a substantial fraction of organic matter, but the role o

133 f interaction in these networks accounts for a substantial fraction of our bias to see faces.

134 ndogenous retroelements-viruses that make up a substantial fraction of our genomes-as an important so

135 lysis confirmed elevated L-MYC expression in a substantial fraction of OvCas, including nine of nine

136 However, a substantial fraction of participants consistently enga

137 A substantial fraction of patients (28%) did not require

138 patients with diabetes from nephropathy, but a substantial fraction of patients develop progressive d

139 y' therapeutic strategy for the treatment of a substantial fraction of patients diagnosed with this i

140 Although mainly an endocrine disease, a substantial fraction of patients have gastrointestinal

141 Currently, a substantial fraction of patients with AML fail to resp

142 ase led to changes in intended management in a substantial fraction of patients with prostate or othe

143 A substantial fraction of PERK-deficient beta-cells disp

144 Our results show that there is a substantial fraction of phosphosites that can play cri

145 A substantial fraction of PICA-resistant T cells express

146 the methanol extract, and for both extracts a substantial fraction of PM oxidative potential was ass

147 A substantial fraction of polymorphic sites mediated rep

148 These findings suggest that a substantial fraction of postmenopausal breast cancer m

149 A substantial fraction of pre-tRNASerUGAM contains too f

150 Moreover, we found that these motifs span a substantial fraction of previously uncharacterized hum

151 allele frequencies (MAFs) of 0.1-1% explain a substantial fraction of prostate cancer risk in men of

152 , 5%, and 5%, respectively), suggesting that a substantial fraction of prostate cancers (estimated at

153 that at moderate transmembrane bias values, a substantial fraction of protein translocation events a

154 In all three cases, a substantial fraction of protomers can be found in a "t

155 ave revealed that immune repertoires contain a substantial fraction of public clones, which may be de

156 te of nonsynonymous evolution, implying that a substantial fraction of replacements of conservative a

157 When a substantial fraction of rhodopsin in a rod photorecept

158 adaptation after illumination that bleaches a substantial fraction of rhodopsin.

159 small subset of lowland TMF trees examined, a substantial fraction of Rubisco was inactive.

160 on of Nxf2 causes depletion of germ cells in a substantial fraction of seminiferous tubules in aged m

161 c and nuclear proteins; indeed, we show that a substantial fraction of SIRT5 is extramitochondrial.

162 que--an external observer also still can see a substantial fraction of sky through the flock.

163 Wnt pathway activation occurred in a substantial fraction of Stage I NSCLCs, which was rare

164 Thus, the chemical composition of a substantial fraction of submicrometer particles will n

165 We found that there is a substantial fraction of subtelomeric DNA containing re

166 n suggested, quite generally, to account for a substantial fraction of such multifactorial inherited

167 nal domain is important for activity against a substantial fraction of sumoylated targets.

168 and intermittent rates up to 250 Hz, leaving a substantial fraction of synaptic receptors occupied pe

169 A substantial fraction of synaptic sites contain AMPAR m

170 I1 and EWSAT1 repressed gene expression, and a substantial fraction of targets that were repressed by

171 t of TCRs is dispensable for activation when a substantial fraction of TCRs are stably engaged.

172 reassignment events, we detected recoding in a substantial fraction of the >1700 environmental sample

173 During the Deepwater Horizon disaster, a substantial fraction of the 600,000-900,000 tons of re

174 xidation and 2) chain shortening contributes a substantial fraction of the acetyl-CoA used for fatty

175 bservational analysis, it is documented that a substantial fraction of the anomalous Northwest Pacifi

176 A substantial fraction of the anti-single-stranded DNA a

177 oantibody-transgenic mice, it was noted that a substantial fraction of the B cells that had avoided D

178 etrameric antigen labeling demonstrated that a substantial fraction of the B-cell repertoire can be m

179 metry breaking, the energy scale of which is a substantial fraction of the bandwidth.

180 Importantly, we find that a substantial fraction of the bases within MCSs (approxi

181 to adults, and maintained cannabis prices at a substantial fraction of the black market price.

182 he results confirm previous conclusions that a substantial fraction of the carbon content indicated b

183 Our results indicate that a substantial fraction of the cell population was able t

184 etwork model of plant primary walls in which a substantial fraction of the cellulose surface is surro

185 Balaur can securely outsource a substantial fraction of the computation to the public

186 , with CodY stimulating and CovRS repressing a substantial fraction of the core genome, including man

187 , labeled severe asthma, are responsible for a substantial fraction of the disease burden.

188 mitotic recombination events can account for a substantial fraction of the earliest oncogenic events

189 conferred surprisingly large effects (often a substantial fraction of the entire phenotypic differen

190 notably slow (seconds to tens of seconds) in a substantial fraction of the events.

191 Because a substantial fraction of the free energy of ligand bind

192 , Delta11q, Delta13p and Delta14p) represent a substantial fraction of the full-length expression lev

193 Accordingly, a substantial fraction of the genes in most bacteria and

194 Comparative genomics shows that a substantial fraction of the genes in sequenced genomes

195 This suggests that a substantial fraction of the genetic code has a stereoc

196 o insulin processing and secretion; however, a substantial fraction of the genetic contribution remai

197 A substantial fraction of the genome is transcribed in a

198 ately equal frequency ("dual haplotypes") in a substantial fraction of the genome likely reflects the

199 A substantial fraction of the genome of most eukaryotes,

200 Here we show that, although a substantial fraction of the genome shows some degree o

201 ty and Myc target gene regulation can rescue a substantial fraction of the growth defect in myc(-/-)

202 Unexpectedly, the results also imply that a substantial fraction of the hemoglobin has associated

203 ealed that heparinase III treatments removed a substantial fraction of the heparan sulfate bound to t

204 variants in coding regions of genes explain a substantial fraction of the heritability of common dis

205 sharing between CAC and CAD/MI suggests that a substantial fraction of the heritable risk for CAD/MI

206 axis of the neutron star, demonstrating that a substantial fraction of the high-energy electrons resp

207 human genome reference (NCBI Genome GRCh37)-a substantial fraction of the human genome's remaining u

208 at non-protein-encoding transcripts comprise a substantial fraction of the human RNA population.

209 gree of elevation of FMR1 mRNA suggests that a substantial fraction of the increased message in the p

210 In this study we show that a substantial fraction of the input CTL develop into mem

211 over-represented pseudomotif patterns occupy a substantial fraction of the intergenic regions.

212 ed kilometers, indicating that plumes convey a substantial fraction of the internal heat escaping fro

213 k the tissue extract by selectively removing a substantial fraction of the intracellular protein comp

214 A substantial fraction of the lesions (84 [38.2%] of 220

215 ng finding that in normal brain development, a substantial fraction of the lipids incorporated into c

216 PE) or Pro-Pro-Glu (PPE) motifs, account for a substantial fraction of the M. tuberculosis genome cod

217 o endogenous retroviruses (ERVs), comprising a substantial fraction of the mammalian genome.

218 Repetitive DNA elements account for a substantial fraction of the mammalian genome.

219 SLAM family markers to isolate HSCs excludes a substantial fraction of the marrow HSC compartment.

220 A substantial fraction of the metazoan transcriptome und

221 It is concluded that a substantial fraction of the missense variants observed

222 A substantial fraction of the mutant PyrR proteins did n

223 d and inserted in the TTS membrane, and that a substantial fraction of the mworks as conductive Ca2+

224 Reperfusion accounts for a substantial fraction of the myocardial injury occurrin

225 Inhibitory neurons make up a substantial fraction of the neurons in the preBotzinge

226 We show that for much of the world ocean a substantial fraction of the nitrate taken up is genera

227 n to the McDonald-Kreitman test to show that a substantial fraction of the nucleotide divergence in t

228 ering at approximately 200 degrees C, before a substantial fraction of the oleate capping group evapo

229 Our results imply that a substantial fraction of the Oort cloud comets, perhaps

230 enetically informative, this subset retained a substantial fraction of the original taxonomic diversi

231 A substantial fraction of the packaged nucleic acid, eit

232 , a process known as parallel evolution, and a substantial fraction of the parallel mutations were si

233 ma cells that were prone to spontaneous EMT, a substantial fraction of the pericytes associated with

234 was exposed to light bright enough to bleach a substantial fraction of the photopigment.

235 ulated data show that our method can recover a substantial fraction of the phylogenetic structure eve

236 A substantial fraction of the PMK active site is occupie

237 ations well beyond the unfolding transition, a substantial fraction of the polypeptides ( approximate

238 are found throughout biology and account for a substantial fraction of the protein in a cell.

239 motif sites are found in promoter regions of a substantial fraction of the protein-coding genes in th

240 A substantial fraction of the proteome is intrinsically

241 equatorial region, the Na(+) pressure can be a substantial fraction of the proton pressure.

242 sm targeted in this study, it is likely that a substantial fraction of the PTP superfamily can be sen

243 overlooked, which could explain the fate of a substantial fraction of the PyC mobilized annually.

244 Although the fAOSLO corrects a substantial fraction of the rat eye's aberrations, dir

245 Thus, in this setting, a substantial fraction of the RB sequence is unnecessary

246 actors explored, only aspirin dose explained a substantial fraction of the regional interaction.

247 n in the absence of HLA-DQ8 and CD4 T cells, a substantial fraction of the RIP-B7.1mII(-/-) mice deve

248 e hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in

249 hat thin filament compliance may account for a substantial fraction of the sarcomere's elasticity.

250 er, this general approach is ineffective for a substantial fraction of the small GTPase family in whi

251 nd PAHs, although small in magnitude, can be a substantial fraction of the SOA from anthropogenic hyd

252 subsurface interface geometries suggest that a substantial fraction of the southernmost 500 kilometre

253 At this rate, a substantial fraction of the stars in a large elliptica

254 Using transcriptome analysis, we found that a substantial fraction of the T3 target genes display a

255 ch of the DNA lies flat on the surface, with a substantial fraction of the thymine bases chemisorbed.

256 the 960 cm(-1) framework mode indicate that a substantial fraction of the titanol groups recondense

257 and progression through the re-sequencing of a substantial fraction of the total collection of human

258 mula: see text] in physiological conditions, a substantial fraction of the total gating energies in s

259 ion in which dissolved methane accounted for a substantial fraction of the total methane generated fr

260 Leaves constitute a substantial fraction of the total resistance to water

261 This core set of genes captures a substantial fraction of the transcriptional output of

262 bilaterian evolution, collectively regulate a substantial fraction of the transcriptome.

263 nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability ar

264 e restricted to the use of models comprising a substantial fraction of the unknown structure.

265 However a substantial fraction of the variance in overall outcom

266 erences in the rate of recombination explain a substantial fraction of the variation in levels of nuc

267 ss, in most areas LUR models still explained a substantial fraction of the variation of concentration

268 visual experience occurs during the day when a substantial fraction of the visual pigment in our phot

269 single-cell experiment with microelectrodes, a substantial fraction of the voltage is lost at the int

270 ms crystalline fibrils a few nm across, with a substantial fraction of their glucan chains at the sur

271 Antiretroviral therapy for HIV represents a substantial fraction of these additional costs, becaus

272 However, a substantial fraction of these patients does not wean f

273 We found that a substantial fraction of these sequences are either mis

274 loops that control rhythmic transcription of a substantial fraction of these transcriptomes, yielding

275 A substantial fraction of this energy budget is devoted

276 ectodomain III (EDIII) of the E protein, and a substantial fraction of this population was interdomai

277 A substantial fraction of this population-based sample o

278 global carbon sink over recent decades, with a substantial fraction of this sink probably located in

279 long the same rostrocaudal gradient predicts a substantial fraction of this variation in neuron numbe

280 erminal half of the F helix appears to spend a substantial fraction of time in a partially unfolded s

281 ing copy-number variation (CNV), constitutes a substantial fraction of total genetic variability and

282 Corridor region, and very likely account for a substantial fraction of total NOx emissions from elect

283 e measurements show that sulfate constitutes a substantial fraction of total particle mass in both en

284 Furthermore, a substantial fraction of treated cells are unable to co

285 r dichroism (CD) spectroscopy confirmed that a substantial fraction of TRIF exists as polyproline II

286 Here, we demonstrate that a substantial fraction of TSAd is found in the T cell nu

287 ty of p53 for tumor regression, we find that a substantial fraction of tumors progress to a Wnt-indep

288 arker only if it correlated with response in a substantial fraction of tumors.

289 le exceptions, very few genes are mutated in a substantial fraction of tumors.

290 A substantial fraction of unannotated 3' ends of RNA are

291 A substantial fraction of units preferred finer spatial

292 Here, we find that a substantial fraction of V2R(+) VSNs does not express t

293 Thus, a substantial fraction of variation generated is static

294 al dileucine-like motif: without this motif, a substantial fraction of VGLUT2 redistributes to the pl

295 unostaining and live imaging, we showed that a substantial fraction of Vif localized to the nucleus,

296 ies show a preponderance of HCV over HBV and a substantial fraction of viral marker-negative cases.

297 At baseline, a substantial fraction of women had a steady partner, wo

298 A substantial fraction of women in this study would have

299 This study is the first to find that a substantial fraction of women with early-stage breast

300 ferences in TAS1R3 transcription account for a substantial fraction of worldwide differences in human