ライフサイエンスコーパス: a substantial increase in

1 A substantial increase in abundance of the PAO Candidatu

2 ented As(2)O(3)-induced apoptosis and led to a substantial increase in accumulation of oxidized prote

3 ation of GATA-1 activity in G1E cells led to a substantial increase in acetylation of histones H3 and

4 ABT-770 (5) with a sulfone group 13a led to a substantial increase in activity against MMP-9 but was

5 osphatidylinositol 4,5-bisphosphate leads to a substantial increase in adhesion area of the sessile G

6 This represents a substantial increase in Adjudin's selectivity and effi

7 red marrow and may allow, for some patients, a substantial increase in administered activity and thus

8 r, the combined treatment is associated with a substantial increase in adverse effects.

9 d with some caution because this can lead to a substantial increase in aggregation.

10 methacholine, only wild-type mice developed a substantial increase in AHR.

11 ted type 1 diabetic Akita/129 mice exhibited a substantial increase in albumin-to-creatinine ratio (A

12 osphorylation by the LKB1 complex results in a substantial increase in AMPK activity.

13 These changes were associated with a substantial increase in AMPK and Akt phosphorylation a

14 A in transgenic MA, which was accompanied by a substantial increase in angiotensin II-induced constri

15 Despite a substantial increase in antihypertensive and lipid-low

16 gnificant decrease in splenocyte number with a substantial increase in apoptosis and CD95 (Fas/APO-1)

17 ns from the pioglitazone-treated mice showed a substantial increase in apoptotic cells and plaque nec

18 pentalenediide system with N or O results in a substantial increase in aromaticity.

19 Recent studies suggest a substantial increase in ASD prevalence above earlier C

20 at are specific to each ortholog, as well as a substantial increase in asymmetry in the interactions

21 d immunohistochemical analyses both revealed a substantial increase in AT(1) receptor protein content

22 We report a substantial increase in atopy at all ages and in a rem

23 This has resulted in a substantial increase in available habitat and rapid ra

24 Climate change, which generally involves a substantial increase in average temperatures in mounta

25 phate levels in response to prostacyclin and a substantial increase in basal Akt activation.

26 eprived animal, before TRH injection, yields a substantial increase in BAT; while the reverse order y

27 Tax, including Puma and Noxa, culminating in a substantial increase in Bax dimerization.

28 We observed a substantial increase in biofilm density upon the addit

29 to PHLDA2 into one-cell zygotes resulted in a substantial increase in blastocyst development, wherea

30 Isoenergetic replacement does not result in a substantial increase in blood triglyceride concentrati

31 reater energy and power densities along with a substantial increase in both calendar and cycle life.

32 Auditory fear conditioning produced a substantial increase in both CS-elicited spike firing

33 Although oncogenic ras produced a substantial increase in both nucleolar and nucleoplasm

34 ng obligation in EU waters will likely cause a substantial increase in bycatch rates in longliners, a

35 A substantial increase in capacity is needed to interrup

36 Cells overexpressing Radil show a substantial increase in cell adhesion, as well as in i

37 conditions, only elevated temperature led to a substantial increase in cell maintenance costs.

38 ctedly, LRP-1 expression was associated with a substantial increase in cell surface beta(1) integrin

39 In vivo, Sort1(-/-) mice showed a substantial increase in cellular infiltration of neutr

40 However, there is a substantial increase in chondrocyte apoptosis in the c

41 ng RNA-mediated knock-down of BRIP1 leads to a substantial increase in chromosome aberrations, a char

42 media thickness was markedly decreased, with a substantial increase in circumferential wall stress, i

43 anisotropy experiments, however, results in a substantial increase in complex formation, indicating

44 of candidate gene and linkage studies, with a substantial increase in complexity.

45 nd no significant trend in droughts, we show a substantial increase in concurrent droughts and heatwa

46 UVPD and optimized HCD analyses demonstrated a substantial increase in confidence in identification (

47 mutations ranged from very little (R106W) to a substantial increase in conformational sampling (F155S

48 nerve at the neck in rats, which may provide a substantial increase in connections between the contra

49 in risk factors that should have resulted in a substantial increase in coronary heart disease rates (

50 ncreased the rate to 80% to 95%, though with a substantial increase in cost.

51 orted previously, Orai1 or Orai2 resulted in a substantial increase in CRAC current (I(crac)), but Or

52 All scenarios allow for a substantial increase in crop production, using an area

53 s with antigen-encoding plasmids resulted in a substantial increase in CTL activity and antibody prod

54 tration of 4 microM) are unlikely to produce a substantial increase in cytotoxic activity.

55 As well as a substantial increase in data and additions to existing

56 In this work, we present for the first time a substantial increase in DEER sensitivity obtained by c

57 old concentration/purification IMB protocol, a substantial increase in detection sensitivity was obse

58 untary food fortification is associated with a substantial increase in dietary intake and biomarker s

59 dramatically enhanced response, resulting in a substantial increase in dorsal ruffling.

60 with incorporation of a single LNA providing a substantial increase in duplex stability.

61 the 21st century indicate the potential for a substantial increase in dust production by the end of

62 tion of sildenafil alone was associated with a substantial increase in EFD score (mean, 7.7 [95% CI,

63 that the method presented here could lead to a substantial increase in efficiency in drug discovery a

64 e protein expressed in Escherichia coli with a substantial increase in efficiency over previous metho

65 omal DSB we show that loss of Brca2 leads to a substantial increase in error-prone repair by homology

66 C3b deposition was also associated with a substantial increase in erythrocyte membrane stiffness

67 in the Clock gene are subfertile and exhibit a substantial increase in estrous cycle duration as reve

68 We also observed a substantial increase in extrachromosomal circular (ecc

69 This resulted in a substantial increase in F protein synthesis in infecte

70 ereas LB1-deficient nuclei exhibit primarily a substantial increase in face area.

71 This subsequently leads to a substantial increase in fibrillization.

72 h development and security implications, and a substantial increase in financial resources brought ab

73 re increase of approximately 5 degrees C and a substantial increase in first appearances of mammals t

74 All three lines showed a substantial increase in fitness (a two- to threefold i

75 in cocultures, while Western blotting showed a substantial increase in GDNF protein.

76 tment of the samples (90 degrees C) promoted a substantial increase in gel strength due to protein de

77 Preliminary results of Phase 2 studies show a substantial increase in growth rate of ACH children af

78 oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to

79 TP inhibitor torcetrapib was associated with a substantial increase in HDL cholesterol and decrease i

80 lipoprotein B-containing particles, leads to a substantial increase in HDL-C levels.

81 hough restricted activity is associated with a substantial increase in health care utilization, older

82 d by jogging, and causes rapid breathing and a substantial increase in heart rate.

83 els predicted that vaccination could lead to a substantial increase in hospitalisation because of den

84 to account an increasing coastal population--a substantial increase in hurricane-related losses in th

85 to HIV-1, viral Tat, or viral gp120 leads to a substantial increase in IL-8 production.

86 There was a substantial increase in immunostaining intensity of th

87 Electron microscopic tomography estimated a substantial increase in inner:outer membrane ratio, wh

88 lling of human cervical cancer cells induced a substantial increase in intracellular Ca2+ ([Ca2+]i) b

89 ith U1 and the 3' ss with U2AF, resulting in a substantial increase in intron splicing.

90 neovascular glaucoma patient who experienced a substantial increase in IOP associated with severe eye

91 In a companion study, we demonstrated a substantial increase in Kir2.1 protein occurs in beta-

92 ology, genetics, and imaging has resulted in a substantial increase in knowledge about the developmen

93 xpressed in cultures of human glia, supports a substantial increase in late JCV protein (Vp-1) synthe

94 enesis in brown adipose tissue is defined by a substantial increase in levels of mitochondrial reacti

95 naling in the liver was also associated with a substantial increase in lipoprotein lipase activity in

96 influenza infection has been associated with a substantial increase in local and systemic IFN-gamma c

97 In contrast, there was a substantial increase in long-term mortality after a sp

98 art disease (CHD) and stroke has resulted in a substantial increase in longevity, with subsequent gro

99 A substantial increase in LRP-1 expression was observed.

100 mmatory cells in lungs of IKTA mice revealed a substantial increase in macrophages and lymphocytes, i

101 The Cbl double deficiency resulted in a substantial increase in marginal zone (MZ) and B1 B ce

102 to 52 weeks) treatment with Mab G6-31 led to a substantial increase in median survival.

103 siRNA-mediated knockdown of TPC2 also caused a substantial increase in melanin content in both MNT-1

104 one, ovarian suppression was associated with a substantial increase in menopausal symptoms, sexual dy

105 pression by unliganded TR is associated with a substantial increase in methylation of H3 lysine 9 (H3

106 A substantial increase in molecular complexity occurred

107 onic fatigue syndrome, but our findings show a substantial increase in mortality from suicide.

108 All cities showed a substantial increase in mortality risk associated with

109 HCV infection is associated with a substantial increase in mortality.

110 In contrast, males that showed a substantial increase in mPOA DA during precopulatory i

111 A substantial increase in MPs was observed in CNS tissue

112 istological grade of rejection on day 5, and a substantial increase in MST (27.5 days).

113 a genetic defect can be accomplished without a substantial increase in mutational burden.

114 SLIP-GC-deficient mice experienced a substantial increase in mutations at G:C base pairs at

115 splantation into immunodeficient mice showed a substantial increase in myeloid and B cell engraftment

116 and a nuclear [Ca2+] delay, CCh also evoked a substantial increase in NADH autofluorescence.

117 Interestingly, we observed a substantial increase in Neto2 Ser-409 phosphorylation

118 We specifically show that 27-OHC induces a substantial increase in NF-kappaB binding to the BACE1

119 lity with age in culture was associated with a substantial increase in NMDA-R current, concomitant in

120 t among the elderly (increased by 2%) due to a substantial increase in nonvaccine types (NVTs).

121 ageing of the world's population is causing a substantial increase in number of people affected.

122 is a highly energetic event, which requires a substantial increase in nutrient metabolism.

123 voltage fluctuation conditions that include a substantial increase in overall membrane conductance.

124 The hot solid shows a substantial increase in oxygen disorder around the lam

125 aused a 4-fold increase in p53 that preceded a substantial increase in p53 transcripts by more than 2

126 A substantial increase in papillary thyroid carcinoma (P

127 he midst of an opioid crisis that has led to a substantial increase in patients at risk for this visi

128 In AIH/AISC we noted a substantial increase in peripheral blood-derived CD4(+

129 Concomitantly, there is a substantial increase in phosphorylation likely tied to

130 Plasma analyses showed a substantial increase in plasma values of tumor necrosi

131 A substantial increase in political and financial invest

132 xylic acid and hydroxyl groups, resulting in a substantial increase in polymer surface energy from 42

133 ned consistently small by LSA standards, and a substantial increase in population size is obvious onl

134 us missense variant in KCNT1, which produced a substantial increase in potassium channel current.

135 This results in a substantial increase in power conversion efficiency co

136 strate advantages of the approach, including a substantial increase in power over competing methods.

137 Our findings show a substantial increase in practice consultation rates, a

138 2 diabetes in all age groups might result in a substantial increase in prevalence of diabetes-related

139 tiple challenges including the necessity for a substantial increase in production to meet the needs o

140 Isolated natural killer cells showed a substantial increase in proliferation and cytotoxicity

141 evidence by health care decision makers, and a substantial increase in public and private funding for

142 e mono-N-oxide analogue 17a did indeed cause a substantial increase in reactivity of the mustard unit

143 Although thrombophilia is associated with a substantial increase in relative risk of venous thromb

144 induced LigA and LigB expression and caused a substantial increase in released LigA.

145 of the predonation value, largely because of a substantial increase in renal blood flow.

146 bstantial risk of urinary retention nor with a substantial increase in residual urine volume.

147 st susceptible, PUSA population (Asia-II-7), a substantial increase in resistant ratios was observed

148 sults indicate that hippocampal neurons show a substantial increase in responsiveness to task-relevan

149 in the early processing steps, brings about a substantial increase in ribosomal protein mRNA.

150 sured from (2)H relaxation experiments, show a substantial increase in rigidity at lower pH (<DeltaS(

151 ing 20 mg/day or more of corticosteroids had a substantial increase in risk even after adjustment for

152 plus a history of heavy alcohol abuse led to a substantial increase in risk for cirrhosis (odds ratio

153 th the common ESR1 c.454-397CC genotype have a substantial increase in risk of MI.

154 Nevertheless, there is a substantial increase in risk of suicide compared with

155 these nine LOF variants was associated with a substantial increase in risk of T2D (OR = 7.22; P = 0.

156 rowth to stationary phase (SP) all result in a substantial increase in RpoS abundance and activity.

157 BCL11A knockdown was associated with a substantial increase in S/G2-phase human HSCs after en

158 am time available at XFELs and should enable a substantial increase in sample throughput at these fac

159 The combination of the two tests provided a substantial increase in sensitivity and positive predi

160 ether with a 2D template spectrum results in a substantial increase in sensitivity, evidenced by 50-1

161 tly elevated in NAFLD, which correlated with a substantial increase in serum FGF21.

162 agonism and demonstrate, for the first time, a substantial increase in SHP-1 activity during antagoni

163 of Delta values of 0.28 to 0.70 osmolal and a substantial increase in sigmaD/<D>.

164 Blocking Has1p expression causes a substantial increase in snoRNPs associated with 60S-90

165 All three variants showed a substantial increase in specificity for 8-oxoG.C relat

166 s beta-strands of FGF-1 are shown to provide a substantial increase in stability.

167 Rodents injected with NP had a substantial increase in STAT3 tyrosine phosphorylation

168 an increase in mortality and morbidity, with a substantial increase in stroke and systemic thromboemb

169 The results of this study suggest a substantial increase in substance use in the acute pos

170 US enlisted Marines have experienced a substantial increase in suicide rates.

171 ules and clouds is less frequent, leading to a substantial increase in surface shortwave forcing.

172 significantly lower all-cause mortality and a substantial increase in survival for both men and wome

173 A substantial increase in Survivin expression was found

174 f alpha-GalCer-treated NOD mice, followed by a substantial increase in T cells.

175 tion from grassland to shrubland resulted in a substantial increase in terrestrial C sequestration.

176 However, a substantial increase in the 2MeH3K9 mark was found on

177 adenosine analogues (Figure 2) brought about a substantial increase in the A(3)-AdoR binding affinity

178 ormation encoded by neuronal firing; and (2) a substantial increase in the ability of both single neu

179 A substantial increase in the abundance of [M + Na](+) a

180 step in the replication cycle, resulting in a substantial increase in the accumulation of replicon-s

181 Thus it results in a substantial increase in the accuracy of statistical es

182 -constrained experimental conditions demands a substantial increase in the acquisition speed of high

183 lease of cytochrome c into the cytoplasm and a substantial increase in the activities of caspase-9 an

184 This resulted in a substantial increase in the amount of F protein expres

185 This reduction in error resulted in a substantial increase in the amount of genetic variatio

186 Training led to a substantial increase in the amount of information tran

187 o oxygenic photosynthesis, which resulted in a substantial increase in the amount of oxygen in the at

188 POPE/POPS monolayers, but only SPM promoted a substantial increase in the amount of the high phase o

189 on of methionine residues in CaM-DA produced a substantial increase in the amplitude of the extended

190 In mlc/NT3 mice, there is a substantial increase in the amplitudes of monosynaptic

191 e two most rapid phases were associated with a substantial increase in the binding of 8-anilino-1-nap

192 analyses of data from Medicare claims showed a substantial increase in the care of hospitalized patie

193 plex to a region of DNA, but it also induces a substantial increase in the catalytic turnover number

194 rotein surface coordinates, which results in a substantial increase in the computational efficiency o

195 the assembly of the liquid crystals promotes a substantial increase in the condensation rate of silic

196 ering RNA targeting in A549 cells results in a substantial increase in the degree of endoreduplicatio

197 ation of mesothelial ultrastructure revealed a substantial increase in the density of microvilli in D

198 These improvements resulted in a substantial increase in the detection and identificati

199 iod before screening) and more the result of a substantial increase in the detection of small tumors

200 ower, and (3) multivariate methods may offer a substantial increase in the discovery of genetic varia

201 pi stacking and lamellar spacing, leading to a substantial increase in the efficiency of bulk heteroj

202 lted in the structural remodeling of KIF and a substantial increase in the elastic modulus of the net

203 Compared with their unlocked counterparts, a substantial increase in the emission yield is also obs

204 g ours) of 1.5-2 mm/y global sea level rise; a substantial increase in the estimates of 20th century

205 xpressing cancer cells with RETRA results in a substantial increase in the expression level of p73, a

206 y demonstrated that toxin A at 1 hour caused a substantial increase in the expression of both CRH rec

207 ent with mitomycin C or UV light also caused a substantial increase in the expression of PblA and Pbl

208 ease in fatty acid (FA) oxidation as well as a substantial increase in the expression of PPARalpha an

209 istration of the drug a decade ago, there is a substantial increase in the failure rate of oral milte

210 Furthermore, EM analysis revealed a substantial increase in the frequency of large gaps be

211 gin vivoandin vitro Finally, we demonstrated a substantial increase in the helicity of this region in

212 Between 2000 and 2009, a substantial increase in the incidence of NAS and mater

213 r pharmacologic suppression of FasL produced a substantial increase in the influx of tumor-rejecting

214 The higher efficiency reflects a substantial increase in the k(pol) value (compare 25 v

215 we demonstrate that the mutations result in a substantial increase in the level of binding to non-na

216 very low-fluence rate white light, there was a substantial increase in the level of transcripts encod

217 xtend the life span of HDFs, they also cause a substantial increase in the levels of endogenous p16(I

218 cytoma cells attached to fibronectin induced a substantial increase in the levels of paxillin protein

219 c differential expression analysis, we found a substantial increase in the levels of the neurotrophin

220 Interim methadone maintenance results in a substantial increase in the likelihood of entry into c

221 The results show a substantial increase in the mass sensitivity compared

222 after multiple courses of BG/TMZ, providing a substantial increase in the maximum tolerated dose of

223 se in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated

224 se in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated

225 ence of the nonimmobilizer although there is a substantial increase in the microscopic viscosity for

226 Recent immigration trends suggest a substantial increase in the number of Americans with c

227 uction of glycinergic and GABAergic ACs with a substantial increase in the number of cholinergic ACs

228 as a high priority, the past decade has seen a substantial increase in the number of clinical studies

229 expanded the applications of CT, leading to a substantial increase in the number of CT examinations

230 The redesigned rrnDB brings a substantial increase in the number of genomes describe

231 ) are required for gene silencing, providing a substantial increase in the number of identified compo

232 ion in colon and mesenteric lymph nodes, and a substantial increase in the number of infiltrating neu

233 ent to enhanced primary expansion, there was a substantial increase in the number of LCMV-specific me

234 ion in contraction of CD8 T cells, there was a substantial increase in the number of memory CD8 T cel

235 A substantial increase in the number of older adults is

236 Correspondingly, we observed a substantial increase in the number of P1CTL in anti-4-

237 ns, the organ donor shortage has resulted in a substantial increase in the number of patients who und

238 In the last year, there has been a substantial increase in the number of research studies

239 in keratinocyte viability is accompanied by a substantial increase in the number of sub-G1 cells, nu

240 ion of Ly-6C(high) monocytes correlated with a substantial increase in the numbers of CD11b(+) DC in

241 e complications and wound infection, without a substantial increase in the operative time.

242 Overexpression of AtADS2 resulted in a substantial increase in the percentage of glycerolipid

243 CAS expression led to a substantial increase in the phosphotyrosine content of

244 e Ppao and should be suspected when there is a substantial increase in the Ppao without a concomitant

245 eline, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension

246 eline, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension

247 s recommended for hypertension treatment and a substantial increase in the proportion of adults consi

248 ensitive troponin assays will likely lead to a substantial increase in the proportion of detectable t

249 There was a substantial increase in the proportion of esophagectom

250 he expanded use of MTBDRplus DST resulted in a substantial increase in the proportion of new cases id

251 of cells at G(2)M-phase and correlated with a substantial increase in the protein levels of the cycl

252 rn blot analysis of injured brains confirmed a substantial increase in the protein levels of these fa

253 d-type and spink5(R820X/R820X) mice revealed a substantial increase in the proteolytic processing of

254 h 5 mm methyl-beta-cyclodextrin (MCD) caused a substantial increase in the rate of agonist-evoked por

255 A decrease in alkyl chain length resulted in a substantial increase in the rate of flip-flop manifest

256 ever, termination products accumulate due to a substantial increase in the rate of nonproductive enzy

257 cement in translesion DNA synthesis reflects a substantial increase in the rate of the conformational

258 we demonstrate that depletion of CALM causes a substantial increase in the ratio of "open" clathrin-c

259 d sulfate reduction, and were accompanied by a substantial increase in the relative abundance of Desu

260 ing prion infection of the OSE could lead to a substantial increase in the release of prion infectivi

261 on of the IFN-stimulated gene signature with a substantial increase in the release of proinflammatory

262 (<5% of total RT in gradient fractions) and a substantial increase in the retention of CA.

263 rare R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheim

264 isease stages 3 to 5 and are associated with a substantial increase in the risk of ESRD and ACM befor

265 sers of biologic agents are unlikely to have a substantial increase in the risk of hematologic malign

266 lecules and trapped reagent ions, results in a substantial increase in the sensitivity of LIAD analys

267 of 6.68 and 7.29, respectively, resulting in a substantial increase in the sensitivity of the assay.

268 n severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above

269 Twist1-Jagged1 double heterozygotes exhibit a substantial increase in the severity of craniosynostos

270 on is approximately 25%, and this results in a substantial increase in the signal-to-noise ratio allo

271 IFN-gamma induced a substantial increase in the spatial proximity between

272 ions, and half-life measurements demonstrate a substantial increase in the stability of most mRNA spe

273 enomic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA

274 A substantial increase in the stability of the contact r

275 thesis of IFN-gamma, and was associated with a substantial increase in the synthesis in the lungs of

276 This paper shows that a substantial increase in the throughput of the TOF MS-b

277 Between 2006 and 2010, we found a substantial increase in the use of broad-spectrum anti

278 for people with Down's syndrome have led to a substantial increase in their longevity.

279 n nanopore sequencing technology have led to a substantial increase in throughput and sequence qualit

280 The Dm-dNK-expressing mice showed a substantial increase in thymidine-phosphorylating acti

281 pecificities and myeloid cell proliferation, a substantial increase in TLR7 expression caused fatal a

282 t decrease, whereas knockdown of S6K2 caused a substantial increase in TNF-alpha and TRAIL (TNF-relat

283 n aboveground large wood pools, resulting in a substantial increase in total system carbon.

284 A substantial increase in toxicity (EC(50) approximately

285 density (BMD), surprisingly caused mainly by a substantial increase in trabecular bone mass, resultin

286 drastic reduction in the B1 B-cell pool and a substantial increase in transitional and marginal zone

287 sported in the mug/h/cm(2) range, presenting a substantial increase in transport capacity in comparis

288 enome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR =

289 We detected a substantial increase in tubular apoptosis in IL-15-/-

290 800 nm) revealed that laser treatment caused a substantial increase in tumor temperature, from 37 deg

291 immunized with TP-DC early after BMT showed a substantial increase in tumor-specific IFN-gamma produ

292 sensitivity (1 ppb) can be achieved through a substantial increase in turn-on emission fluorescence

293 slation on all three stop codons, to provide a substantial increase in unnatural amino acid incorpora

294 V12 in double-negative thymocytes and caused a substantial increase in usage of TRAV12 in Tcrd recomb

295 f randomized controlled data, there has been a substantial increase in use of percutaneous mechanical

296 is associated with increased body weight and a substantial increase in waist circumference.

297 We find a substantial increase in water-use efficiency in temper

298 d adoption of longer season cultivars caused a substantial increase in yield ranging from 13% to 38%

299 rediction method for hybrid yield and showed a substantial increase in yield through genomic hybrid b

300 ain in a maize-based diet is associated with a substantial increase in zinc absorption.