ライフサイエンスコーパス: a substantial increase in

1 A substantial increase in abundance of the PAO Candidatu

2 ented As(2)O(3)-induced apoptosis and led to a substantial increase in accumulation of oxidized prote

3 ation of GATA-1 activity in G1E cells led to a substantial increase in acetylation of histones H3 and

4 osphatidylinositol 4,5-bisphosphate leads to a substantial increase in adhesion area of the sessile G

5 This represents a substantial increase in Adjudin's selectivity and effi

6 red marrow and may allow, for some patients, a substantial increase in administered activity and thus

7 r, the combined treatment is associated with a substantial increase in adverse effects.

8 with narrow follow-up intervals did not show a substantial increase in AEs during TIs.

9 d with some caution because this can lead to a substantial increase in aggregation.

10 ted type 1 diabetic Akita/129 mice exhibited a substantial increase in albumin-to-creatinine ratio (A

11 nd to standard antirejection therapy and had a substantial increase in alloreactive CD8 T cells with

12 osphorylation by the LKB1 complex results in a substantial increase in AMPK activity.

13 These changes were associated with a substantial increase in AMPK and Akt phosphorylation a

14 A in transgenic MA, which was accompanied by a substantial increase in angiotensin II-induced constri

15 Despite a substantial increase in antihypertensive and lipid-low

16 ns from the pioglitazone-treated mice showed a substantial increase in apoptotic cells and plaque nec

17 pentalenediide system with N or O results in a substantial increase in aromaticity.

18 Recent studies suggest a substantial increase in ASD prevalence above earlier C

19 ralar-KO, but not to control, neurons led to a substantial increase in Asp (3-fold) and NAA (4-fold)

20 at are specific to each ortholog, as well as a substantial increase in asymmetry in the interactions

21 d immunohistochemical analyses both revealed a substantial increase in AT(1) receptor protein content

22 Ediacaran to the early Cambrian, suggesting a substantial increase in atmospheric oxygen level from

23 We report a substantial increase in atopy at all ages and in a rem

24 This has resulted in a substantial increase in available habitat and rapid ra

25 Climate change, which generally involves a substantial increase in average temperatures in mounta

26 phate levels in response to prostacyclin and a substantial increase in basal Akt activation.

27 eprived animal, before TRH injection, yields a substantial increase in BAT; while the reverse order y

28 Tax, including Puma and Noxa, culminating in a substantial increase in Bax dimerization.

29 We observed a substantial increase in biofilm density upon the addit

30 to PHLDA2 into one-cell zygotes resulted in a substantial increase in blastocyst development, wherea

31 Isoenergetic replacement does not result in a substantial increase in blood triglyceride concentrati

32 reater energy and power densities along with a substantial increase in both calendar and cycle life.

33 ng obligation in EU waters will likely cause a substantial increase in bycatch rates in longliners, a

34 A substantial increase in capacity is needed to interrup

35 through water-conduction nanochannels led to a substantial increase in carbon dioxide (CO(2)) convers

36 Cells overexpressing Radil show a substantial increase in cell adhesion, as well as in i

37 conditions, only elevated temperature led to a substantial increase in cell maintenance costs.

38 In vivo, Sort1(-/-) mice showed a substantial increase in cellular infiltration of neutr

39 These aberrant behaviors were accompanied by a substantial increase in cFos expression in the VTA-pro

40 However, there is a substantial increase in chondrocyte apoptosis in the c

41 ng RNA-mediated knock-down of BRIP1 leads to a substantial increase in chromosome aberrations, a char

42 media thickness was markedly decreased, with a substantial increase in circumferential wall stress, i

43 by Dehalococcoides at millimolar levels with a substantial increase in cobalamin (~20-fold).

44 anisotropy experiments, however, results in a substantial increase in complex formation, indicating

45 of candidate gene and linkage studies, with a substantial increase in complexity.

46 nd no significant trend in droughts, we show a substantial increase in concurrent droughts and heatwa

47 UVPD and optimized HCD analyses demonstrated a substantial increase in confidence in identification (

48 mutations ranged from very little (R106W) to a substantial increase in conformational sampling (F155S

49 nerve at the neck in rats, which may provide a substantial increase in connections between the contra

50 in risk factors that should have resulted in a substantial increase in coronary heart disease rates (

51 ncreased the rate to 80% to 95%, though with a substantial increase in cost.

52 stimated that, relative to current coverage, a substantial increase in coverage of midwife-delivered

53 orted previously, Orai1 or Orai2 resulted in a substantial increase in CRAC current (I(crac)), but Or

54 All scenarios allow for a substantial increase in crop production, using an area

55 tration of 4 microM) are unlikely to produce a substantial increase in cytotoxic activity.

56 As well as a substantial increase in data and additions to existing

57 In this work, we present for the first time a substantial increase in DEER sensitivity obtained by c

58 old concentration/purification IMB protocol, a substantial increase in detection sensitivity was obse

59 untary food fortification is associated with a substantial increase in dietary intake and biomarker s

60 dramatically enhanced response, resulting in a substantial increase in dorsal ruffling.

61 with incorporation of a single LNA providing a substantial increase in duplex stability.

62 the 21st century indicate the potential for a substantial increase in dust production by the end of

63 tion of sildenafil alone was associated with a substantial increase in EFD score (mean, 7.7 [95% CI,

64 that the method presented here could lead to a substantial increase in efficiency in drug discovery a

65 e protein expressed in Escherichia coli with a substantial increase in efficiency over previous metho

66 th the lowest baseline eGFR group, there was a substantial increase in eGFR seen during follow-up wit

67 A substantial increase in emission intensity with increa

68 C3b deposition was also associated with a substantial increase in erythrocyte membrane stiffness

69 We also observed a substantial increase in extrachromosomal circular (ecc

70 This resulted in a substantial increase in F protein synthesis in infecte

71 ereas LB1-deficient nuclei exhibit primarily a substantial increase in face area.

72 This subsequently leads to a substantial increase in fibrillization.

73 h development and security implications, and a substantial increase in financial resources brought ab

74 re increase of approximately 5 degrees C and a substantial increase in first appearances of mammals t

75 All three lines showed a substantial increase in fitness (a two- to threefold i

76 A substantial increase in food production is needed for

77 in cocultures, while Western blotting showed a substantial increase in GDNF protein.

78 tment of the samples (90 degrees C) promoted a substantial increase in gel strength due to protein de

79 Evidence suggests a substantial increase in global photosynthesis since pr

80 Preliminary results of Phase 2 studies show a substantial increase in growth rate of ACH children af

81 oocytes from KDM1B-deficient females showed a substantial increase in H3K4 methylation and failed to

82 TP inhibitor torcetrapib was associated with a substantial increase in HDL cholesterol and decrease i

83 lipoprotein B-containing particles, leads to a substantial increase in HDL-C levels.

84 d by jogging, and causes rapid breathing and a substantial increase in heart rate.

85 els predicted that vaccination could lead to a substantial increase in hospitalisation because of den

86 to account an increasing coastal population--a substantial increase in hurricane-related losses in th

87 There was a substantial increase in immunostaining intensity of th

88 Electron microscopic tomography estimated a substantial increase in inner:outer membrane ratio, wh

89 ith U1 and the 3' ss with U2AF, resulting in a substantial increase in intron splicing.

90 neovascular glaucoma patient who experienced a substantial increase in IOP associated with severe eye

91 In a companion study, we demonstrated a substantial increase in Kir2.1 protein occurs in beta-

92 ology, genetics, and imaging has resulted in a substantial increase in knowledge about the developmen

93 The treated wash showed a substantial increase in lactic, acetic and succinic ac

94 xpressed in cultures of human glia, supports a substantial increase in late JCV protein (Vp-1) synthe

95 rease in left and right ventricular size and a substantial increase in left ventricular mass.

96 enesis in brown adipose tissue is defined by a substantial increase in levels of mitochondrial reacti

97 naling in the liver was also associated with a substantial increase in lipoprotein lipase activity in

98 influenza infection has been associated with a substantial increase in local and systemic IFN-gamma c

99 In contrast, there was a substantial increase in long-term mortality after a sp

100 art disease (CHD) and stroke has resulted in a substantial increase in longevity, with subsequent gro

101 A substantial increase in LRP-1 expression was observed.

102 mmatory cells in lungs of IKTA mice revealed a substantial increase in macrophages and lymphocytes, i

103 The Cbl double deficiency resulted in a substantial increase in marginal zone (MZ) and B1 B ce

104 to 52 weeks) treatment with Mab G6-31 led to a substantial increase in median survival.

105 siRNA-mediated knockdown of TPC2 also caused a substantial increase in melanin content in both MNT-1

106 one, ovarian suppression was associated with a substantial increase in menopausal symptoms, sexual dy

107 This nanoribbon also displays a substantial increase in molar circular dichroism relat

108 A substantial increase in molecular complexity occurred

109 onic fatigue syndrome, but our findings show a substantial increase in mortality from suicide.

110 ild-moderate in severity, is associated with a substantial increase in mortality in patients with acu

111 All cities showed a substantial increase in mortality risk associated with

112 HCV infection is associated with a substantial increase in mortality.

113 In contrast, males that showed a substantial increase in mPOA DA during precopulatory i

114 A substantial increase in MPs was observed in CNS tissue

115 istological grade of rejection on day 5, and a substantial increase in MST (27.5 days).

116 These novel muscle-specific CRMs result in a substantial increase in muscle-specific gene transcrip

117 a genetic defect can be accomplished without a substantial increase in mutational burden.

118 SLIP-GC-deficient mice experienced a substantial increase in mutations at G:C base pairs at

119 Concurrently, there was a substantial increase in neo-oligodendrogenesis as mani

120 Interestingly, we observed a substantial increase in Neto2 Ser-409 phosphorylation

121 We specifically show that 27-OHC induces a substantial increase in NF-kappaB binding to the BACE1

122 one of the SCR systems were found to lead to a substantial increase in NH(3) emissions after operatio

123 lity with age in culture was associated with a substantial increase in NMDA-R current, concomitant in

124 t among the elderly (increased by 2%) due to a substantial increase in nonvaccine types (NVTs).

125 ageing of the world's population is causing a substantial increase in number of people affected.

126 is a highly energetic event, which requires a substantial increase in nutrient metabolism.

127 voltage fluctuation conditions that include a substantial increase in overall membrane conductance.

128 The hot solid shows a substantial increase in oxygen disorder around the lam

129 aused a 4-fold increase in p53 that preceded a substantial increase in p53 transcripts by more than 2

130 A substantial increase in papillary thyroid carcinoma (P

131 nd show that increasing convenience produces a substantial increase in parking for passenger pickup/d

132 he midst of an opioid crisis that has led to a substantial increase in patients at risk for this visi

133 In AIH/AISC we noted a substantial increase in peripheral blood-derived CD4(+

134 Concomitantly, there is a substantial increase in phosphorylation likely tied to

135 Plasma analyses showed a substantial increase in plasma values of tumor necrosi

136 A substantial increase in political and financial invest

137 ned consistently small by LSA standards, and a substantial increase in population size is obvious onl

138 us missense variant in KCNT1, which produced a substantial increase in potassium channel current.

139 This results in a substantial increase in power conversion efficiency co

140 strate advantages of the approach, including a substantial increase in power over competing methods.

141 e in future Abeta imaging studies, providing a substantial increase in power over currently used SUVr

142 We demonstrate a substantial increase in power to detect SCZ associatio

143 Our findings show a substantial increase in practice consultation rates, a

144 2 diabetes in all age groups might result in a substantial increase in prevalence of diabetes-related

145 These 4 early surgery trials showed a substantial increase in procedures in the early surger

146 tiple challenges including the necessity for a substantial increase in production to meet the needs o

147 evidence by health care decision makers, and a substantial increase in public and private funding for

148 B(12) deprivation also caused a substantial increase in reactive oxygen species, which

149 e mono-N-oxide analogue 17a did indeed cause a substantial increase in reactivity of the mustard unit

150 Although thrombophilia is associated with a substantial increase in relative risk of venous thromb

151 induced LigA and LigB expression and caused a substantial increase in released LigA.

152 of the predonation value, largely because of a substantial increase in renal blood flow.

153 interest in Amazonian fires, accompanied by a substantial increase in research in the subject.

154 bstantial risk of urinary retention nor with a substantial increase in residual urine volume.

155 st susceptible, PUSA population (Asia-II-7), a substantial increase in resistant ratios was observed

156 sults indicate that hippocampal neurons show a substantial increase in responsiveness to task-relevan

157 in the early processing steps, brings about a substantial increase in ribosomal protein mRNA.

158 ing 20 mg/day or more of corticosteroids had a substantial increase in risk even after adjustment for

159 Nevertheless, there is a substantial increase in risk of suicide compared with

160 these nine LOF variants was associated with a substantial increase in risk of T2D (OR = 7.22; P = 0.

161 rowth to stationary phase (SP) all result in a substantial increase in RpoS abundance and activity.

162 BCL11A knockdown was associated with a substantial increase in S/G2-phase human HSCs after en

163 am time available at XFELs and should enable a substantial increase in sample throughput at these fac

164 ether with a 2D template spectrum results in a substantial increase in sensitivity, evidenced by 50-1

165 tly elevated in NAFLD, which correlated with a substantial increase in serum FGF21.

166 al infrastructure in Exmouth Gulf will cause a substantial increase in shipping traffic with the risk

167 of Delta values of 0.28 to 0.70 osmolal and a substantial increase in sigmaD/<D>.

168 Blocking Has1p expression causes a substantial increase in snoRNPs associated with 60S-90

169 These studies were enabled by a substantial increase in solubility compared to previou

170 All three variants showed a substantial increase in specificity for 8-oxoG.C relat

171 s beta-strands of FGF-1 are shown to provide a substantial increase in stability.

172 Rodents injected with NP had a substantial increase in STAT3 tyrosine phosphorylation

173 an increase in mortality and morbidity, with a substantial increase in stroke and systemic thromboemb

174 US enlisted Marines have experienced a substantial increase in suicide rates.

175 vent exchange and desolvation), resulting in a substantial increase in surface area from 725 to 2,749

176 Previous studies revealed a substantial increase in surface oxygen content after e

177 ules and clouds is less frequent, leading to a substantial increase in surface shortwave forcing.

178 significantly lower all-cause mortality and a substantial increase in survival for both men and wome

179 f alpha-GalCer-treated NOD mice, followed by a substantial increase in T cells.

180 tion from grassland to shrubland resulted in a substantial increase in terrestrial C sequestration.

181 However, a substantial increase in the 2MeH3K9 mark was found on

182 adenosine analogues (Figure 2) brought about a substantial increase in the A(3)-AdoR binding affinity

183 ormation encoded by neuronal firing; and (2) a substantial increase in the ability of both single neu

184 A substantial increase in the abundance of [M + Na](+) a

185 -CD19 BBzeta T cells and was associated with a substantial increase in the abundance of the most pro-

186 step in the replication cycle, resulting in a substantial increase in the accumulation of replicon-s

187 Thus it results in a substantial increase in the accuracy of statistical es

188 -constrained experimental conditions demands a substantial increase in the acquisition speed of high

189 lease of cytochrome c into the cytoplasm and a substantial increase in the activities of caspase-9 an

190 This resulted in a substantial increase in the amount of F protein expres

191 This reduction in error resulted in a substantial increase in the amount of genetic variatio

192 Training led to a substantial increase in the amount of information tran

193 o oxygenic photosynthesis, which resulted in a substantial increase in the amount of oxygen in the at

194 POPE/POPS monolayers, but only SPM promoted a substantial increase in the amount of the high phase o

195 on of methionine residues in CaM-DA produced a substantial increase in the amplitude of the extended

196 In mlc/NT3 mice, there is a substantial increase in the amplitudes of monosynaptic

197 analyses of data from Medicare claims showed a substantial increase in the care of hospitalized patie

198 plex to a region of DNA, but it also induces a substantial increase in the catalytic turnover number

199 rotein surface coordinates, which results in a substantial increase in the computational efficiency o

200 the assembly of the liquid crystals promotes a substantial increase in the condensation rate of silic

201 ering RNA targeting in A549 cells results in a substantial increase in the degree of endoreduplicatio

202 ation of mesothelial ultrastructure revealed a substantial increase in the density of microvilli in D

203 These improvements resulted in a substantial increase in the detection and identificati

204 iod before screening) and more the result of a substantial increase in the detection of small tumors

205 ower, and (3) multivariate methods may offer a substantial increase in the discovery of genetic varia

206 pi stacking and lamellar spacing, leading to a substantial increase in the efficiency of bulk heteroj

207 lted in the structural remodeling of KIF and a substantial increase in the elastic modulus of the net

208 Compared with their unlocked counterparts, a substantial increase in the emission yield is also obs

209 xpressing cancer cells with RETRA results in a substantial increase in the expression level of p73, a

210 ease in fatty acid (FA) oxidation as well as a substantial increase in the expression of PPARalpha an

211 istration of the drug a decade ago, there is a substantial increase in the failure rate of oral milte

212 Furthermore, EM analysis revealed a substantial increase in the frequency of large gaps be

213 gin vivoandin vitro Finally, we demonstrated a substantial increase in the helicity of this region in

214 ta suggest that ibrutinib is associated with a substantial increase in the incidence and severity of

215 Between 2000 and 2009, a substantial increase in the incidence of NAS and mater

216 Adolescence is characterised by a substantial increase in the incidence of tuberculosis,

217 r pharmacologic suppression of FasL produced a substantial increase in the influx of tumor-rejecting

218 The higher efficiency reflects a substantial increase in the k(pol) value (compare 25 v

219 we demonstrate that the mutations result in a substantial increase in the level of binding to non-na

220 very low-fluence rate white light, there was a substantial increase in the level of transcripts encod

221 xtend the life span of HDFs, they also cause a substantial increase in the levels of endogenous p16(I

222 c differential expression analysis, we found a substantial increase in the levels of the neurotrophin

223 Interim methadone maintenance results in a substantial increase in the likelihood of entry into c

224 The results show a substantial increase in the mass sensitivity compared

225 after multiple courses of BG/TMZ, providing a substantial increase in the maximum tolerated dose of

226 se in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated

227 se in the percentage of myelinated axons and a substantial increase in the mean g-ratio of myelinated

228 for Disease Control and Prevention reported a substantial increase in the number of acute hepatitis

229 Recent immigration trends suggest a substantial increase in the number of Americans with c

230 uction of glycinergic and GABAergic ACs with a substantial increase in the number of cholinergic ACs

231 as a high priority, the past decade has seen a substantial increase in the number of clinical studies

232 expanded the applications of CT, leading to a substantial increase in the number of CT examinations

233 The redesigned rrnDB brings a substantial increase in the number of genomes describe

234 ) are required for gene silencing, providing a substantial increase in the number of identified compo

235 ion in colon and mesenteric lymph nodes, and a substantial increase in the number of infiltrating neu

236 ent to enhanced primary expansion, there was a substantial increase in the number of LCMV-specific me

237 ion in contraction of CD8 T cells, there was a substantial increase in the number of memory CD8 T cel

238 A substantial increase in the number of older adults is

239 ns, the organ donor shortage has resulted in a substantial increase in the number of patients who und

240 In the last year, there has been a substantial increase in the number of research studies

241 report an update of the VDJdb database with a substantial increase in the number of T-cell receptor

242 ion of Ly-6C(high) monocytes correlated with a substantial increase in the numbers of CD11b(+) DC in

243 e complications and wound infection, without a substantial increase in the operative time.

244 Overexpression of AtADS2 resulted in a substantial increase in the percentage of glycerolipid

245 CAS expression led to a substantial increase in the phosphotyrosine content of

246 e Ppao and should be suspected when there is a substantial increase in the Ppao without a concomitant

247 eline, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension

248 eline, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension

249 s recommended for hypertension treatment and a substantial increase in the proportion of adults consi

250 ensitive troponin assays will likely lead to a substantial increase in the proportion of detectable t

251 There was a substantial increase in the proportion of esophagectom

252 he expanded use of MTBDRplus DST resulted in a substantial increase in the proportion of new cases id

253 rn blot analysis of injured brains confirmed a substantial increase in the protein levels of these fa

254 d-type and spink5(R820X/R820X) mice revealed a substantial increase in the proteolytic processing of

255 h 5 mm methyl-beta-cyclodextrin (MCD) caused a substantial increase in the rate of agonist-evoked por

256 scale genome sequencing is poised to provide a substantial increase in the rate of discovery of disea

257 A decrease in alkyl chain length resulted in a substantial increase in the rate of flip-flop manifest

258 we demonstrate that depletion of CALM causes a substantial increase in the ratio of "open" clathrin-c

259 d sulfate reduction, and were accompanied by a substantial increase in the relative abundance of Desu

260 ing prion infection of the OSE could lead to a substantial increase in the release of prion infectivi

261 on of the IFN-stimulated gene signature with a substantial increase in the release of proinflammatory

262 rare R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheim

263 isease stages 3 to 5 and are associated with a substantial increase in the risk of ESRD and ACM befor

264 sers of biologic agents are unlikely to have a substantial increase in the risk of hematologic malign

265 the medications examined was associated with a substantial increase in the risk of severe illness amo

266 lecules and trapped reagent ions, results in a substantial increase in the sensitivity of LIAD analys

267 of 6.68 and 7.29, respectively, resulting in a substantial increase in the sensitivity of the assay.

268 n severe reactions, MCA can be documented by a substantial increase in the serum tryptase level above

269 Twist1-Jagged1 double heterozygotes exhibit a substantial increase in the severity of craniosynostos

270 on is approximately 25%, and this results in a substantial increase in the signal-to-noise ratio allo

271 IFN-gamma induced a substantial increase in the spatial proximity between

272 ions, and half-life measurements demonstrate a substantial increase in the stability of most mRNA spe

273 enomic integrity in these cells is linked to a substantial increase in the stability of RAD51 at DNA

274 This paper shows that a substantial increase in the throughput of the TOF MS-b

275 analyzing genetic variation data have led to a substantial increase in the understanding of genetic v

276 Between 2006 and 2010, we found a substantial increase in the use of broad-spectrum anti

277 for people with Down's syndrome have led to a substantial increase in their longevity.

278 n nanopore sequencing technology have led to a substantial increase in throughput and sequence qualit

279 The Dm-dNK-expressing mice showed a substantial increase in thymidine-phosphorylating acti

280 pecificities and myeloid cell proliferation, a substantial increase in TLR7 expression caused fatal a

281 t decrease, whereas knockdown of S6K2 caused a substantial increase in TNF-alpha and TRAIL (TNF-relat

282 n aboveground large wood pools, resulting in a substantial increase in total system carbon.

283 A substantial increase in toxicity (EC(50) approximately

284 density (BMD), surprisingly caused mainly by a substantial increase in trabecular bone mass, resultin

285 drastic reduction in the B1 B-cell pool and a substantial increase in transitional and marginal zone

286 sported in the mug/h/cm(2) range, presenting a substantial increase in transport capacity in comparis

287 We also demonstrated MVA-NP+M1 activated a substantial increase in TRM cells exhibiting effector

288 We also demonstrated MVA-NP+M1 activated a substantial increase in TRM cells exhibiting effector

289 enome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR =

290 The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in

291 800 nm) revealed that laser treatment caused a substantial increase in tumor temperature, from 37 deg

292 sensitivity (1 ppb) can be achieved through a substantial increase in turn-on emission fluorescence

293 slation on all three stop codons, to provide a substantial increase in unnatural amino acid incorpora

294 V12 in double-negative thymocytes and caused a substantial increase in usage of TRAV12 in Tcrd recomb

295 f randomized controlled data, there has been a substantial increase in use of percutaneous mechanical

296 is associated with increased body weight and a substantial increase in waist circumference.

297 We find a substantial increase in water-use efficiency in temper

298 er consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber,

299 d adoption of longer season cultivars caused a substantial increase in yield ranging from 13% to 38%

300 rediction method for hybrid yield and showed a substantial increase in yield through genomic hybrid b