ライフサイエンスコーパス: aberration

1 herapies active against the unique molecular aberration.

2 43 patients, and 32 (74%) had a PI3K pathway aberration.

3 x allows spherical lenses to avoid spherical aberration.

4 se was limited to patients with PI3K pathway aberration.

5 ing patient samples and study their genomics aberrations.

6 ological processes and their disease-related aberrations.

7 terparts, such as wide field of view and low aberrations.

8 of cytolytic activity, and fewer chromosomal aberrations.

9 cant differences in all analyzed chromosomal aberrations.

10 Adaptive optics can correct for optical aberrations.

11 lent, astigmatism, safety indices nor ocular aberrations.

12 ronuclei formation and numerical chromosomal aberrations.

13 ough the post-acquisition correction of lens aberrations.

14 ird of RPS15-mutant cases also carrying TP53 aberrations.

15 utations, isolated or associated with clonal aberrations.

16 including repeat instability and chromosomal aberrations.

17 ly to lamin A/C and induces profound nuclear aberrations.

18 nt for TP53 wild-type neuroblastoma with ALK aberrations.

19 lso observe biases in chromosome copy number aberrations.

20 herapy on the prognostic role of cytogenetic aberrations.

21 arbitrarily shaped objects introduce optical aberrations.

22 ity analysis and presence of somatic genetic aberrations.

23 the delivery optics and is limited by ocular aberrations.

24 ed to identify known and unknown chromosomal aberrations.

25 on forks, engendering structural chromosomal aberrations.

26 y to form cell-cell contacts and chromosomal aberrations.

27 viding a systems-level view of these genetic aberrations.

28 e (BMF), immunodeficiency, and developmental aberrations.

29 or have the ability to detect cancer somatic aberrations.

30 wever, is degraded by sample-induced optical aberrations.

31 the disparities in these aspects to genetic aberrations.

32 aired HR and the accumulation of chromosomal aberrations.

33 ally actionable, metastasis-specific genomic aberrations.

34 cers with a less extensive burden of genetic aberrations.

35 specific metastases may share common genomic aberrations.

36 sister chromatid exchange, gross chromosomal aberrations, 53BP1 foci, and micronuclei.

37 Translocation t(11;14) as the most prevalent aberration (59%) led to an improved CR rate after high-d

38 ignificantly higher frequency of copy number aberrations (67%) than other subgroups (P = 0.02), parti

39 Using spherical aberration-aberration corrected scanning transmission el

40 These aberrations accompany increased unspliced (intron-retain

41 this resource, we find that most chromosomal aberrations accumulate late during breast tumorigenesis,

42 ion methodology that corrected the chromatic aberration across the entire image field to within 10 nm

43 psed/refractory disease at study entry, TP53 aberration, advanced Rai stage, and high beta-2 microglo

44 al to hematopoietic stem cell functions, its aberrations affect AML evolution, biology, and therapy r

45 Copy number aberrations affected a mean of only 0.5% of PTNFL genome

46 cell death response and enhanced chromosomal aberrations after PhIP treatment, while ATM and DNA-PK i

47 gned to evaluate the changes in higher-order aberrations after wavefront-guided ablation with IntraLa

48 orrected for color distortions and chromatic aberrations, also matching the chromatic response of hum

49 However, such somatic aberration and its association with prognostic factors h

50 l endpoints (DNA repair kinetics, chromosome aberration and mutation formation, survival) across a ra

51 m (i.e., 28 days) protection against corneal aberration and retinal injury after pilocarpine delivery

52 The 4th order HOAs (spherical aberration and secondary astigmatism) and the HOA root m

53 a nonlinear guide star to determine optical aberrations and a deformable mirror to correct them.

54 emonstrated a correlation between epigenetic aberrations and adverse effects of space relevant irradi

55 vity in mouse cells is known to cause genome aberrations and cellular senescence, although the molecu

56 river captures the inherent clusters of gene aberrations and constructs the background distribution t

57 resulted in increased numbers of chromosome aberrations and gammaH2AX foci in non-transformed MCF10A

58 differ in the incidence of high-risk genetic aberrations and in DNA methylation profile, preserved fr

59 among tumours with somatic NF-kappaB pathway aberrations and LMP1-overexpression, suggesting that NF-

60 put data have unraveled many novel molecular aberrations and network alterations in tumors.

61 r ability to recapitulate underlying genomic aberrations and primary tumor biology.

62 agine supplementation restored the metabolic aberrations and proliferation defect caused by glutamine

63 s of protein expression with DNA copy number aberrations and signatures of post-transcriptional regul

64 SMYD5 depletion resulted in chromosomal aberrations and the formation of transformed cells that

65 pediatric AMKL cases for the aforementioned aberrations and to study their clinical characteristics

66 nonperturbative 3D chemical imaging with low aberration, and the concentration profiles measured with

67 ne for lensing and compensation of spherical aberration, and the other carpet cloak, both at 532 nm v

68 ace lens doublet corrected for monochromatic aberrations, and an image sensor.

69 ions, diluting the signals of clone-specific aberrations, and complicating estimation of clone-specif

70 ncreased cytotoxicity, chromosome structural aberrations, and error-prone mutagenic DNA repair follow

71 the efficacy, safety, predictability, ocular aberrations, and flap thickness predictability of Visuma

72 as, a subset feature large-scale chromosomal aberrations, and highly conserved molecular signatures f

73 ect driver mutations, chromosome copy number aberrations, and mutation signatures.

74 Large vitreous length, higher-order aberrations, and surgical interface haze may contribute

75 tine metabolic risk factors; these metabolic aberrations appear to precede the development of fatty l

76 Chromosomal aberrations are a hallmark of human cancers, with comple

77 on, showing that the majority of copy number aberrations are acquired at the earliest stages of tumor

78 senchymal TNBC, especially when PI3K pathway aberrations are identified.

79 OA is possible in a few eyes, spherical-like aberrations are increased in majority of the treated eye

80 DNA methylation aberrations are now known to, almost universally, accomp

81 ients that shows a role of complex karyotype aberrations as an independent prognostic factor for surv

82 mechanism in the development of postsynaptic aberrations associated with neurodegenerative disorders.

83 ression profiles with numbers of chromosomal aberrations (based on single-nucleotide polymorphism arr

84 Karyotyping for the detection of chromosomal aberrations, based on measuring the ratio of expression

85 Spherical aberration becomes a limiting factor for achieving resol

86 ignificant difference in induction of ocular aberrations but with potential advantage for Visumax reg

87 S, and GCTB have few and recurrent molecular aberrations but, paradoxically, can have variable natura

88 be utilized for the analysis of chromosomal aberrations by comparing gene expression levels between

89 Centrosome aberrations (CA) and abnormal mitoses are considered bea

90 through numerical simulations, how chromatic aberration can be exploited to obtain spectral informati

91 ices can be fabricated; thus, the problem of aberration can be obviated simply by selecting a chip ma

92 We studied whether these cytogenetic aberrations can be used for risk group stratification.

93 These data indicate that annotating rare aberrations can reveal important cancer signalling pathw

94 Chromosomal aberrations (CAs) in blood lymphocytes have been shown t

95 ined stable thereafter and posterior corneal aberrations changed constantly over 12 months.

96 The number of copy number aberration changes and biallelic inactivation of tumor s

97 By comparing the cells' DNA copy number aberration (CNA) landscapes with those of the primary tu

98 orefractory disease, we examined copy-number aberrations (CNAs) in circulating tumor cells (CTCs) fro

99 ent with childhood-onset melanoma had a FISH aberration compared with 4 patients with adult-onset mel

100 fficiency and 2-fold decrease in chromosomal aberrations, compared to those in iPS cells induced only

101 ified underlying disease-modifying molecular aberrations contributing to disease initiation and progr

102 ed through synchrotron-based diffraction and aberration corrected electron microscopy.

103 ion limit, comparable to that obtained using aberration corrected instruments.

104 Aberration corrected scanning transmission electron micr

105 ure characterized by means of powder XRD and aberration corrected scanning transmission electron micr

106 By using aberration corrected scanning transmission electron micr

107 t catalysts are quantitatively studied using aberration corrected scanning transmission electron micr

108 rce microscopy (PFM), and is corroborated by aberration-corrected atomic-resolution scanning transmis

109 neutron reflectivity, x-ray reflectivity and aberration-corrected electron microscopy confirm that th

110 Using aberration-corrected environmental transmission electron

111 Here we use aberration-corrected environmental transmission electron

112 Aberration-corrected high-angle annular dark-field scann

113 nations by X-ray absorption spectroscopy and aberration-corrected high-angle annular dark-field scann

114 ctive optics to demonstrate planar chromatic-aberration-corrected lenses.

115 We elucidate their behavior using aberration-corrected Lorentz transmission electron micro

116 ined with a parallelized and computationally aberration-corrected optical coherence tomography system

117 tile titania nanorods was investigated using aberration-corrected scanning transmission electron micr

118 liated ZrTe5 thin flakes from the studies of aberration-corrected scanning transmission electron micr

119 oscopy (TEM) techniques, including spherical aberration-corrected scanning transmission electron micr

120 through homotopy group theory and spherical aberration-corrected scanning transmission electron micr

121 Using aberration-corrected scanning transmission electron micr

122 eport a combined investigation of SYCO using aberration-corrected scanning transmission electron micr

123 properties determined on an atomic level by aberration-corrected scanning transmission electron micr

124 Aberration-corrected scanning transmission electron micr

125 Using aberration-corrected scanning transmission electron micr

126 Aberration-corrected scanning transmission electron micr

127 Atomic-resolution imaging in an aberration-corrected scanning transmission electron micr

128 Atomic mappings via aberration-corrected scanning transmission electron micr

129 ed iron (FeN4), was directly visualized with aberration-corrected scanning transmission electron micr

130 dered manganite Bi0.35Sr0.18Ca0.47MnO3 using aberration-corrected scanning transmission electron micr

131 e-off can be defeated, we apply in situ, and aberration-corrected scanning, transmission electron mic

132 ol of a sub-A sized electron probe within an aberration-corrected STEM.

133 yer MoS2 sheet as directly observed using an aberration-corrected transmission electron microscope (T

134 ion and sensitivity of the latest generation aberration-corrected transmission electron microscopes a

135 ges by means of cathodoluminescence mapping, aberration-corrected transmission electron microscopy im

136 BaCo2O5.5 (delta = 0) structure evidenced by aberration-corrected transmission electron microscopy.

137 n of the excitation light for depth-resolved aberration correction of two-photon excited fluorescence

138 and a novel multi-actuator adaptive lens for aberration correction to achieve near diffraction limite

139 We discuss impending challenges, including aberration correction, and also examine current issues a

140 ports imply that the sheer number of somatic aberrations could trigger an immune-response, our data s

141 L had either unique or more frequent genomic aberrations (del13q14, del17p, gain8q24, and gain18q21)

142 Leiomyomas with HMGA2 aberrations displayed highly significant up-regulation o

143 al phenotype was observed only for the G308E aberration, drastically damaging both the redox properti

144 n recognition of pathogens and physiological aberration, drives activation of caspase-1, pyroptosis,

145 cation of multiple mutations and chromosomal aberrations driving the progression of myeloid malignanc

146 S, there is an additional problem of optical aberration due to refractive index mismatch between the

147 single crystals suggest that excitation beam aberrations due to the presence of the aqueous phase are

148 However, it is unclear when aberrations emerge in the disease process and if such de

149 t standard for genome-wide screening of such aberration events.

150 l concerns, including the effects of optical aberrations, field dependence in the imaging system, flu

151 Here, we use aberration-free remote focusing to diagonally sweep a na

152 ature of the focusing scheme also enables an aberration-free scattering lens.

153 in Amazon NBE but do find NBE sensitivity to aberrations from long-term mean climate.

154 joint analysis of different types of genomic aberrations from multiple biopsies taken from the same p

155 y capacity of lymphoma B cells with TNFRSF14 aberrations had clinical relevance, associating with hig

156 DNA methylation aberrations have been implicated in acquired resistance

157 In cancer, genetic aberrations have been traditionally thought to disrupt t

158 Therefore, sensory aberrations help construct a vicious cycle in post-traum

159 ing reduced neurogenesis, increased synaptic aberrations, higher metabolic stress, and augmented infl

160 bsent in generalized anxiety disorder, these aberrations highlight a unique sensory pathology of post

161 ral corneal thickness (CCT) and higher-order aberrations (HOAs) over a 6 mm pupil, were assessed befo

162 Genomic aberrations identified were enriched for genes implicate

163 nia, predisposition to MDS with chromosome 7 aberrations, immunodeficiency, and progressive cerebella

164 xpression are known to promote physiological aberrations implicated in MDD.

165 We sought to identify the genetic aberration in 4 related patients with CID, early-onset a

166 (ER)-chromatin binding and function, yet its aberration in endocrine-resistant (Endo-R) breast cancer

167 Amplification of Mcl-1 is a common genetic aberration in human cancer whose overexpression contribu

168 The current study examined this rearing aberration in human development.

169 sphodiesterase-6 (PDE6) provokes a metabolic aberration in rod cells that promotes the pathological c

170 Loss of PAX2 is the earliest known molecular aberration in the FTE occurring in serous carcinogenesis

171 Objective: To identify patterns of aberration in the PI3K and interactive pathways that mig

172 een thought to arise from distinct mutations/aberrations in "driver" oncogenes.

173 360 cancer genes and genome-wide copy number aberrations in 413 and 170 ILBC samples, respectively, a

174 ics research has ushered in the discovery of aberrations in a third category: gain-of-novel-function

175 outcome parameters of recurrent cytogenetic aberrations in AMKL, samples and clinical data of patien

176 ysis of glioblastoma (GBM) reveals pervasive aberrations in apoptotic signaling pathways that collect

177 ASD showed common "epimutations." Acetylome aberrations in ASD were not attributable to genetic diff

178 Overall and chromosome specific aberrations in blood lymphocytes may be a unique set of

179 increased frequency of chromosomal aberrations in blood lymphocytes was significantly assoc

180 on stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells.

181 mic studies have identified multiple somatic aberrations in breast cancer, including copy number alte

182 first comprehensive catalogue of chromosomal aberrations in cancer GEMMs.

183 he regulatory disruptions related to genomic aberrations in cancers.

184 atients with calpainopathy and single-allele aberrations in CAPN3.

185 egulated in newborn Jag1(Ndr/Ndr) mice, with aberrations in cholangiocyte polarity, but these defects

186 re the prognostic value of recurrent genetic aberrations in diagnostic bone marrow (BM) specimens fro

187 activity, is one of the most common genetic aberrations in endometrioid endometrial cancer.

188 oli sprouts (BSp) on neutralizing epigenetic aberrations in estrogen receptor-alpha (ERalpha) leading

189 ls of the signaling axis, connecting genetic aberrations in FLT3, tyrosine kinase 2 (TYK2), platelet-

190 te maintenance of stem cell populations, and aberrations in functional stem cell numbers are associat

191 ach reveals oncogenic activity for rare gene aberrations in genes including NAD Kinase (NADK), which

192 Tackling aberrations in glucose-stimulated insulin release such a

193 ity of UTX regulated genes do not experience aberrations in H3K27me3 or H3K4me3, implicating alternat

194 r molecule of the human immune response, and aberrations in IgG glycosylation are linked to various d

195 somes shortly after the pff treatment causes aberrations in intracellular processing of pff seeds con

196 urden of genomic copy number alterations and aberrations in known oncogenic drivers were all highly c

197 lopment were affected by culture, with fewer aberrations in Natur-IVF embryos.

198 rom the central nervous system and potential aberrations in neurological diseases.

199 , and zf-AD domains of ENBA1, in addition to aberrations in noncoding regions, especially in BamHI A

200 Previously, diagnosis focused solely on aberrations in oral structures, largely without empirica

201 Aberrations in PRKCQ were found to occur in 20% of tumor

202 ation pathways of NF-kappaB, which result in aberrations in production of various proinflammatory cyt

203 , we found that complete Foxc1 loss leads to aberrations in proliferation, neuronal differentiation a

204 These results suggest that aberrations in psoriatic Mo-MDSCs prevent proper suppres

205 -negative breast cancers acquire copy number aberrations in short punctuated bursts in the earliest s

206 insight into early functional and structural aberrations in striatal connectivity that may predispose

207 hese results further intimate neurometabolic aberrations in stuttering in brain circuits subserving s

208 These data indicate that aberrations in the chromatin regulator gene BRPF1 cause

209 Aberrations in the genes encoding these proteins result

210 Similar aberrations in the metabolic profile were observed alrea

211 However, because of chromatic aberrations in the objective lens, this approach lacks t

212 Importance: Molecular aberrations in the phosphatidylinositol-3-kinase (PI3K)

213 s the mesenchymal subtype frequently harbors aberrations in the phosphoinositide 3-kinase (PI3K) path

214 available, archived tissue was evaluated for aberrations in the PI3K pathway.

215 nts and that they are associated with common aberrations in the RUNX1 gene.

216 chromosome dynamics, but instead result from aberrations in the spatial organization of the phragmopl

217 s are important determinants of CB activity, aberrations in their signaling could lead to sleep apnea

218 Aberrations in this pathway underlie the aforementioned

219 s significant induction of gross chromosomal aberrations in thyroidal TPC-1 cells following overexpre

220 review the broad roles played by epigenetic aberrations in tumor initiation and evolution and their

221 Examples of frequent aberrations included PTEN loss in hepatocellular (57% of

222 is is a pathologic process driven by genomic aberrations, including changes in nucleotide sequences.

223 phil granulocytes, and complex developmental aberrations, including mild skeletal anomalies, neurocog

224 Genomic aberrations increase with age, highlighting the infant p

225 characterized by immunogenic and a metabolic aberrations, indicating that targeting these processes m

226 proteins together with lamin A/C for nuclear aberrations induced by Cofilin/ADF loss.

227 Aberrations introduced by refractive index inhomogeneity

228 The compensation of defocus aberrations is also used for the measurement of three-di

229 to quantify how a tumor's burden of genetic aberrations is distributed among coexisting clones, geno

230 ibition and characterized by various genomic aberrations known to elevate D-cyclin levels and describ

231 Unusual interaction behaviors and perceptual aberrations, like those occurring in schizotypy and schi

232 Nek7 deficiency leads to telomere aberrations, long-lasting gammaH2AX and 53BP1 foci, and

233 rying cancer-specific genetic and epigenetic aberrations may enable a noninvasive 'liquid biopsy' for

234 Features of these aberrations might determine whether NAFLD progresses to

235 ological relevance of SPAG5 gene copy number aberrations, mRNA transcript expression, and protein exp

236 Two recurrent cytogenetic aberrations, namely del(17p), affecting TP53, and del(11

237 d CBFA2T3/GLIS2 and NUP98/KDM5A as recurrent aberrations, occurring in similar frequencies as RBM15/M

238 We hypothesized that genetic aberration of the EGFR pathway would identify patients b

239 urate at wavelength measurements of residual aberrations of a refractive X-ray lens using ptychograph

240 ved particularly strong associations between aberrations of chromosomes 12, 13, 17 and risk of SCC (O

241 as carcinogenic exposures or cancer related aberrations of DNA maintenance machinery.

242 To study aberrations of early development in TSC, we generated in

243 veloped severe anemia and exhibited profound aberrations of erythrocyte morphology and membrane stabi

244 U1 in normal cells phenocopies the metabolic aberrations of malignant cells.

245 e production, and mtDNA depletion as well as aberrations of mitochondrial fusion and fission proteins

246 We identified enrichment for genomic aberrations of multiple negative regulators of the NF-ka

247 sociated with the development of significant aberrations of neural differentiation.

248 Cell lines mirrored the proteomic aberrations of primary tumors, in particular for intrins

249 vels, which was not a result of proportional aberrations of T-cell subsets.

250 hese include altered cell cycle checkpoints, aberrations of the centrosome, and failed chromatid cohe

251 ulmonary surfactants, indicating IVI-induced aberrations of the pulmonary surfactant system might pla

252 or analyzing either a single type of genomic aberration or individual biopsies.

253 , as well as an improvement in the spherical aberration (P = .018), coma (P = .23) and total higher o

254 r hypermethylation than those without either aberration (P = 0.046).

255 .018), coma (P = .23) and total higher order aberrations (P = .31).

256 e shows that driver genes exhibit consistent aberration patterns across multiple-omics in tumors.

257 ed on the number of drug matches and genomic aberrations per patient, we found that high scores were

258 deficiency is associated with developmental aberrations, progressive BMF with myelodysplastic featur

259 These aberrations progressively increase over time and may com

260 replication fork instability and chromosomal aberrations provoked by aldehyde-induced BRCA2 haploinsu

261 growth in the oral cavity may be a result of aberrations ranging from microbial dysbiosis and salivar

262 Coma aberrations remained unchanged (P = 0.07) while the chan

263 he cross-talk between epigenetic and genomic aberrations remains limited.

264 The genomic aberrations reported in this study warrant further inves

265 nt therapeutic target to normalize metabolic aberrations responsible for poor prognosis in ovarian ca

266 It is revealing that many chromosomal aberrations, some associated with malignancies, are pres

267 provided converging evidence for structural aberrations specific to the microstructurally defined me

268 ole-genome sequencing, clustering of genetic aberrations, subclone combinatorics, and mutational sign

269 cells (hPSCs) frequently acquire chromosomal aberrations such as aneuploidy in culture.

270 d by continued reduction in corneal haze and aberrations, suggesting ongoing remodeling of the cornea

271 The high-risk cytogenetic aberrations t(4;14), t(14;16), and del(17p13) conferred

272 ing has shed light on the underlying genetic aberrations that drive tumorigenesis.

273 ed a tremendous amount regarding the genetic aberrations that govern disease development in AML.

274 Cancer cell lines carrying genetic aberrations that impair the Hippo signaling pathway show

275 sive breast cancers and describe the genetic aberrations that inactivate its expression.

276 hes between media and sample cause spherical aberrations that often limit penetration depth and resol

277 Efforts to identify genetic aberrations that predispose tumors to metastasis have be

278 senting cells, we hypothesized that TNFRSF14 aberrations that reduce HVEM expression could alter the

279 ged cytokinin sensitivity, and developmental aberrations that were previously shown to be associated

280 ng the functional activities of each genomic aberration to be targeted is crucial in devising effecti

281 is necessary for deleting cells with mitotic aberrations to limit aneuploidy.

282 stronomical telescopes to combat atmospheric aberrations, to improve image quality of fluorescence mi

283 Significantly, however, pre-GOE atmospheric aberrations toward more reducing conditions-featuring a

284 alysed the associations of SPAG5 copy number aberrations, transcript expression, and protein expressi

285 M divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outc

286 Numerical centrosome aberrations underlie certain developmental abnormalities

287 d cells lacking CYREN accumulate chromosomal aberrations upon damage induction, specifically outside

288 Presence of PI3K pathway aberration was associated with a significant improvement

289 Among 2,045 molecular aberrations was the involvement of 302 distinct genes.

290 ss of blast cells, and various developmental aberrations, we identified three homozygous loss-of-func

291 Overall, the BCa cell line genomic aberrations were concordant with those found in BCa pati

292 These aberrations were mutually exclusive.

293 These structural aberrations were reflected in their functional behavior,

294 ff-axis pupil and the principle of chromatic aberration (where different wavelengths come to focus at

295 AN proteins led to an increase in centromere aberrations, whereas enhancing chromosome missegregation

296 g efficiency, 4-fold increase in chromosomal aberrations, whereas overexpression of Delta133p53 with

297 tical systems, which limits image speed, and aberrations, which restrict the image volume.

298 is IAA-sensing ability induces morphological aberrations with consequences for plant fitness.

299 We further associated chromatin aberrations with gene expression changes from a larger c

300 r acquired, which in some cases is caused by aberrations within the growth factor signaling pathways.