1 riedel-Crafts cyclizations to cis- and trans-abietanes.

2 t similar preferences for cyclization to cis-abietanes.

3 e-activity relationship perspective, the new abietane 5 having cyano groups at C-2 and C-13 and a phe

4  cyclizations of iminolactones, favors trans-abietanes as the only observable diastereomer.

5 ty of this strategy allows us to propose the abietane C7-C8 cleavage as a possible biosynthetic pathw

6 , stereodivergent synthesis of cis- or trans-abietanes, demonstrates the dramatic influence of ZrCl 4

7  on the cleavage of the C7-C8 double bond of abietane diterpenes, is the only one yet reported for sy

8 mpassed genes coding for enzymes involved in abietane diterpenoid biosynthesis and others with activi

9  signaling, including methyl salicylate, the abietane diterpenoid dehydroabietinal, the lysine catabo

10  Here we show that dehydroabietinal (DA), an abietane diterpenoid, is an activator of systemic acquir

11                                              Abietane diterpenoids are major constituents of conifer

12 d to formation of miltiradiene, precursor of abietane diterpenoids in C. forskohlii.

13 osed of resin acids derived largely from the abietane family of diterpene olefins as precursors which

14 he C13 isopropyl group characteristic of the abietane family of diterpenes.

15        Optimizing the cyclizations for trans-abietanes has identified ZrCl 4 as an exceptional Lewis

16 ene synthase that acts on CPP to produce the abietane olefin miltiradiene, but also their subcellular

17 indicating that miltiradiene is the relevant abietane olefin precursor.

18 -7a as a key step in the biosynthesis of the abietane resin acid constituents (1b-4b) of conifer oleo

19 al rearranged 5(6-->7) or 6-nor-5(6-->7)abeo-abietane skeleton, which exhibit promising biological ac

20 he C13 isopropyl group characteristic of the abietane structure.

21 ynthetic pathways, particularly for the abeo-abietane tri-epoxide lactone triptolide.