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1 e maintained at control levels when Cx36 was ablated.
2 olds at which phenotype and transmission are ablated.
3 the CaMKII phosphorylation site on RyR2 was ablated.
4 vantage in nuclear layers where neurons were ablated.
5 ll-length Pol was mitochondrial localization ablated.
6 d to alanine, the binding of D1D2 to LRP1 is ablated.
7 0 cells of each population were individually ablated.
8 riatum or hippocampus where CK2alpha is also ablated.
9 the CaMKII site on ryanodine receptor 2 was ablated.
10 this structure as a guide, we systematically ablated a series of proposed intermolecular interactions
11 d by nerve injury or inflammation in mice by ablating a group of adult spinal neurons defined by deve
12 Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOX
14 for maintaining the sAHP when hippocalcin is ablated, a condition that likely impairs PIP2 generation
15 es, deplete presynaptic Ca(2+) channels, and ablate active zone complexes, as analyzed by electron mi
16 une evasion strategy that shows broad immune-ablating activity, we have identified a novel anti-infla
18 ll-mediated antitumor immunity.Significance: Ablating adenosine signaling is found to promote natural
19 %), 67 (89.3%), and 69 (92%) were completely ablated after one, two, and three IRE procedures, respec
20 us and replicon assays using phosphorylation-ablated alanine mutants of these sites showed that Ser-2
22 se oocytes to create the Zurich-3 (ZH3) Prnp-ablated allele on a pure C57BL/6J genetic background.
23 loride concentration late during development ablates alpha1beta glycinergic synapses but spares GABAe
24 al ablation volume and the percentage of the ablated amygdalohippocampal complex between seizure-free
25 ation of a less stable, more dynamic species ablate amyloid formation by increasing the energy barrie
26 organ cadherin levels compared to the Mmp20 ablated and WT mice and, instead of predominantly locati
27 enetically induced lymphoma Gal-1 expression ablated antibody-dependent lymphoma phagocytosis in vitr
28 of depths; the nail material adjacent to the ablated area was rendered porous in appearance presumabl
29 at day 2 showed small white densities in the ablated areas, which appeared to be small intraepithelia
30 itor cells that co-express Sox2 and Bmi1 are ablated, as we observed that ageing in mice started with
31 but not frequency, was reduced when SCs were ablated at E15.5, suggesting that postsynaptic alteratio
33 Mutating the bulge sequence to 5'-ACCCC-3' ablates base stacking in the loop and globally reorients
34 DeltaDC mice in which DCs are constitutively ablated because of expression of the diphtheria toxin al
35 rons or descending serotonergic neurons were ablated before hyperalgesic priming, IL-6- and carrageen
41 0-fold higher than the IC50 were required to ablate both ADP-ribosylation and XRCC1 chromatin binding
42 d a thymidine kinase/ganciclovir paradigm to ablate both dividing NG2(+) cell populations to determin
44 thograde coupling was previously shown to be ablated by a glycine for glutamate substitution at RyR1
47 ells even when its CD4 binding site had been ablated by deletion of a highly conserved aspartic acid
52 rs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle
53 Importantly, all of these associations were ablated by the PAK inhibitor IPA3, suggesting that PAK1
56 Functional analysis reveals these mutations ablate canonical TGFbeta Smad signalling, which is local
60 ion, attenuating scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result i
61 io) to receive either RFA (entire BE segment ablated circumferentially) or a sham endoscopic procedur
62 activation are bidirectionally modulated by ablating CK2 in D1- or D2-positive projection neurons, i
63 e transporter gene (DAT) promoter control to ablate Cnr2 gene in midbrain DA neurons of DAT-Cnr2 cond
65 We now show that Deltaafkp80(-) null mutants ablated d-Arap modifications of LPG as predicted, wherea
66 with substitution of all tryptophan residues ablating dimerization and self-renewal function complete
67 augments, but a reduction of KIT expression ablates DNMT1 transcription by STAT3 pathway leading to
68 xpressing doxycycline-inducible DOT1L shRNA, ablating DOT1L expression with doxycycline significantly
69 ed glycogen synthase activity was completely ablated during hyperinsulinemic hypoglycemia, and catech
70 demonstrate a new approach for noninvasively ablating each of these pathways and testing their necess
72 However, while IAPs are derepressed in Dnmt1-ablated embryos and embryonic stem cells (ESCs), these E
74 ective ER downregulators (SERDs) are able to ablate ER and thus, theoretically, to prevent survival o
76 ell as those in which P2RY12 was genetically ablated, exhibited significantly diminished movement of
78 e level of exposure to males for control and ablated females and tested for interacting effects on fe
80 espan extension and relative fitness of mNSC-ablated females were maximized under intermediate exposu
82 tensin receptor 1 (Ntsr1) cre-driver mice to ablate floxed Cacna1a in layer VI pyramidal neurons, whi
86 we report that tribbles homologue 2 (TRIB2) ablates forkhead box O activation and disrupts the p53/M
88 mice, in which the Gad1 gene is genetically ablated from 50% of cortical and hippocampal interneuro
89 ggest that there is overall reduced, but not ablated, functionality of TMEM260 and that attenuation o
90 ts is limited by a lack of technologies that ablate gene function within specific mononuclear phagocy
92 tip and water spray was able to effectively ablate >/=95% of biofilm on all types of tested titanium
93 e engineered DNA DSB in fibroblasts that had ablated H2ax did produce clonal, stable GCRs, including
95 nd (223)Ra are used to image, alleviate, and ablate harmful cancerous legions with good specificity v
96 this location, we manipulated native loci to ablate hCDC14A phosphatase activity (hCDC14A(PD)) in unt
97 we used a murine genetic in vivo approach to ablate Hes1 in pancreatic progenitor cells (Ptf1a(+/Cre)
100 ivity, as Foxa3(-/-) HSC fails to repopulate ablated hosts efficiently, implicating for the first tim
101 ial proliferation, which can be abolished by ablating IL-1 signaling or depleting its major cellular
102 the systemic effect of IL-17 by genetically ablating Il-17 in the C57BL/6.NOD-Aec1Aec2, spontaneous
103 Pseudo-reentrant carousels were incorrectly ablated in 5 cases having been misinterpreted as LR.
105 were markedly reduced when dystroglycan was ablated in adult mice, suggesting a role for dystroglyca
107 ssion of neuronal differentiation markers is ablated in both KIF1Bbeta-deficient mouse neuroblasts an
108 x); Osx-Cre mice, in which the Smpd3 gene is ablated in both late-stage chondrocytes and osteoblasts,
109 at leukocyte rolling on P- and L-selectin is ablated in cells lacking O-glycans, with N-glycan trunca
110 , in response to inflammasome activation, is ablated in FABP4/aP2(-/-) macrophages, as well as in FAB
112 re.Socs3 (f/f) mice, in which SOCS3 has been ablated in osteocytes, have high trabecular bone volume
113 ectopically expressing SOX10, and is nearly ablated in Schwann cells by impairing SOX10 function.
117 epair was severely perturbed when Ptpn11 was ablated in stem cells due to a deficit in stem cell prol
119 ecifically, SOX9 induction was significantly ablated in the absence of ROCR, and overexpression of SO
121 homologs 1 and 2 (Ezh1/2) are conditionally ablated in the embryonic epidermal progenitors that give
122 rating a novel mouse model in which PTH1R is ablated in the limb mesenchyme using Prx1Cre transgenic
125 h both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal ligament (PDL)
127 We report that, after a chemical lesion that ablates inner retinal neurons, regenerated retinal bipol
135 vhs carrying the point mutation D215N, which ablates its endoribonuclease activity, to disrupt SG for
136 itution of any canonical HS binding residues ablated Ivt-mediated transduction by AAV2-based vectors.
137 ervations, we used CRISPR/Cas9 technology to ablate Kindlin-2 expression in human MDA-MB-231 and muri
138 as(G12D)p53(L/L) pancreatic cancer models to ablate KLF10 expression and determine the impact of KLF1
139 complex was formed by the reaction of laser-ablated La atoms with acetylene molecules in a molecular
140 enous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it.
143 vity and blood glucose concentrations, while ablating LepRb in PAG neurons augmented glucose mobiliza
144 effectiveness was evident in 66 of 67 (98%) ablated lesions on the first contrast material-enhanced
145 es 393-396 from GII.17.2015 into GII.17.1978 ablated ligand binding and altered antigenicity, definin
146 NA) strands and used synonymous mutations to ablate m(6)A on both strands of the hemagglutinin (HA) s
147 elicited through tail stimulation [5-7] and ablating M-cells abolishes short-latency tail-elicited s
148 ical composition was determined spotwise, by ablating material from various surface locations on a 4
149 ek post-I/R in cardiomyocyte-restricted GRK2 ablated mice (also post-I/R) still demonstrated signific
151 itional skeletal myofiber-specific VEGF gene-ablated mice (VEGF(HSA-/-) ) by providing VEGF(HSA-/-) a
152 ineage neurons preserved in VT3(Lbx1)-neuron-ablated mice is largely sufficient to mediate morphine-s
154 ays in the cold, both sham controls and iBAT-ablated mice stopped shivering and resumed routine physi
157 rated a mouse model in which we specifically ablated Mig-6 in uterine epithelial cells using Sprr2f-c
162 Klf15) loss-of-function strategy was used to ablate nephrocytes and then heart function and the hemol
167 erentiation, we used a Neurog3-Cre allele to ablate Nkx2.2, one of the earliest and most broadly expr
176 This truncated Ig exclusion (TIE) checkpoint ablates PC clones with DeltaV-kappaLCs production and ex
177 ion as well as treatment with SFK inhibitors ablate pDC (but not conventional DC) responses both in v
178 the variation of the cross-section of laser-ablated PDMS channel; (2) the volume of PeT chamber; and
180 , mice were treated with diphtheria toxin to ablate peri-insult generated newborn granule cells, whic
181 regional genetic sympathectomy: BRAINSPAReDT ablates peripheral but not central catecholaminergic neu
182 -brain barrier, which limits its utility for ablating peripheral cells using Cre drivers that are als
184 141 to 160 in full-length Pol did not fully ablate Pol's mitochondrial localization, suggesting that
185 cytotoxicity by a S. cerevisiae mutant with ablated post-transfer editing activity when supplemented
186 cordingly, agonist treatment in Hepa-1 cells ablates potent ER stress-driven Fgf21 expression, and pr
187 by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mo
188 dy used a novel transgenic mouse paradigm to ablate proliferating NG2(+) cells after SCI to better un
192 Moreover, the model shows how attempts to ablate PSs in the viral RNA sequence may result in redun
193 lains why recent experiments that attempt to ablate putative PSs may not see an effect on packaging.
197 ce leads to defective neuronal migration and ablates Reelin stimulation of hippocampal long-term pote
200 wer and accompanied by larger deletions that ablated residual expression from the endogenous OTC gene
204 procedure in male FosLacZ-transgenic rats to ablate selectively Fos-expressing PLC neurons that were
205 ed in vivo: in K310R mutant mice and in mice ablated selectively for nuclear receptor corepressor 1 (
207 ,7-dihydroxytryptamine known to specifically ablate serotonin-neurons markedly decrease serotonin-imm
208 ts in which this ParG temporal regulation is ablated show partition deficient phenotypes as a result
214 onionizing physical energy based modality to ablate solid tumors with high power, or increase local p
215 stabilizing substitution markedly reduced or ablated soluble CD4 (sCD4) induction of non-NAb epitopes
216 ptor potential (TRP) channels to activate or ablate specific neuronal populations using the chemical
223 enome-editing strategies to either repair or ablate target genes, with emphasis on their applications
224 linically relevant parameters can be used to ablate target tissues in a non-tumor-bearing large-anima
225 refore explored the metabolic consequence of ablating TBC1D1 in both resting and contracting skeletal
229 further identify a Tdp2 active site SNP that ablates Tdp2 Mg(2+) binding and catalytic activity, impa
233 oncept, we engineered the vaccine DEKnull to ablate the dominant Bc epitope to partially overcome str
235 t al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantation embryos an
236 dult specific inhibition of tPA activity can ablate the ocular dominance shift in Lynx1 KO mice.
238 s, inhibition of SRC and PKCdelta completely ablated the ability of MDA-7/IL-24 to reduce the Bcl-x(L
239 hat disrupted the pTRS1 interaction with PKR ablated the ability of pTRS1 to antagonize PKR activatio
240 otein in vitro, this modification completely ablated the activity of LLO, and this inhibitory effect
241 e of pancreatic ductal adenocarcinoma (PDAC) ablated the development of salivary biomarker profile.
242 r a C3/C4 dorsal column SCI that bilaterally ablated the dorsal corticospinal tract (CST) containing
243 dismutase and catalase mimetic EUK-134 also ablated the effects of hypoxia on BKCa channel currents
245 e addition of calcium to the motility assays ablated the impact of phosphorylation on maximal sliding
246 with an IFNAR-neutralizing antibody after MI ablated the interferon response and improved left ventri
247 Using a conditional targeting approach, we ablated the major CLP gene Irf6 only in the late embryon
248 Raising growth temperature to 37 degrees ablated the positive influence of some mutations on the
249 ree independent inhibitors of Hsp70 function ablated the protective effects of NAC, suggesting that N
253 drugs (DREADDs)-mediated synaptic silencing ablates the food intake and body weight reduction follow
257 Aicardi-Goutieres syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the
264 Taken together, our study demonstrated that ablating the NLRP3 gene significantly reduced neuroinfla
265 at the collected particles were continuously ablated; the time for complete ablation of 193 ng of suc
266 plement receptor 3-expressing phagocytes and ablates their bactericidal capacities by catalyzing unre
267 ficient to maintain adult NSC quiescence and ablating them leads to NSC activation and subsequent dep
269 nterfering RNA, TGF-beta, and IL-6 treatment ablated these proresolution effects in primary human mac
274 ncreased ETC activity, co-treatment with HKL ablated this response and vastly enhanced the rate of ap
275 GFP) mice in which Tregs can be specifically ablated through administration of diphtheria toxin, we d
279 sonance imaging and histological staining of ablated tissue were subsequently performed as a part of
283 o dobutamine, whereas expression of phosphor-ablated TnI alone had little effect on the acceleration
284 Cre) to target the mandibular epithelium, we ablated transcription factor Islet1, resulting in a dist
285 Thus, there is a need for a mechanism to ablate transferred T cells after tumor eradication is co
286 he broad use of these inhibitors as tools to ablate tumor-associated macrophages that enable malignan
288 In 13 (33%; 95% CI: 18, 47) of 40 completely ablated tumors, intrahepatic tumor recurrence was observ
290 cm; mean SUVmax, 22.7; range, 9.5-77.1) were ablated using radiofrequency (n = 16) or microwave (n =
292 oyed an inducible mouse KO that specifically ablates Utx in satellite cells (SCs) and demonstrated th
293 (HSA-/-) ) by providing VEGF(HSA-/-) and non-ablated (VEGF(f/f) ) littermates with running wheels for
294 r-generated periodic gratings were virtually ablated via a computational process based on a two-step
295 ns of many antidepressants at SERT have been ablated via knock-in substitution (SERT Met172) without
296 ISPR technology in SaOs2 cells significantly ablated vitamin D mediated inhibition of calcification.
297 rdia (FAT) is extremely difficult to map and ablate when it is difficult to induce and nonsustained.
300 r loss of both proteins to greatly reduce or ablate XRCC1 chromatin binding following H2O2 treatment.
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