ライフサイエンスコーパス: abnormal karyotype

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1 uble antisense transfected cells with highly abnormal karyotype.

2 both accounted for 76% of all cases with an abnormal karyotype.

3 ally delayed, three died, and two others had abnormal karyotype.

4 A total of 48/66 (72.7%) cases had an abnormal karyotype.

5 found in 36 of 158 successive patients with abnormal karyotypes.

6 ors by Southern blot analysis, and three had abnormal karyotypes.

7 tes were similar in patients with or without abnormal karyotypes.

8 In 14 cancers with abnormal karyotypes, 65% (123 of 188) of the chromosomal

9 L cases including 29 normal karyotype AML, 8 abnormal karyotype AML and 8 AML without karyotype infor

10 shared between the normal karyotype AML and abnormal karyotype AML.

11 nd 4) established from these colonies had an abnormal karyotype and altered morphology, but were not

12 lls, and a strong correlation exists between abnormal karyotype and tumorigenicity.

13 Mayo Clinic patients with abnormal karyotypes and FISH-detected IgH translocation

14 fore and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells.

15 rom 2 large cohorts of patients with MM with abnormal karyotype, and then validated it in 2 independe

16 The engrafted human cells exhibited the same abnormal karyotype as primary cells in a portion of the

17 ologies was completely reliable to detect an abnormal karyotype, but the best protocol for an interpr

18 We obtained data for the details of all abnormal karyotypes by reason for referral and assessed

19 The abnormal karyotype correlated with shorter time to first

20 alyzed 1,054 adult patients with MDS with an abnormal karyotype from the Spanish Registry of MDS.

21 We propose that cells with abnormal karyotypes generate a signal for their own elim

22 tively high frequency of cells with the same abnormal karyotype (>5-10%; presumably of clonal origin)

23 ics had CNA, whereas 40% of patients with an abnormal karyotype had additional CNA detected by SNP ar

24 However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromo

25 Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of patients with AML, ho

26 Overall, 103 of 169 (61%) patients had an abnormal karyotype, including 31 with del(6q), 29 with 1

27 udies have shown that pluripotent cells with abnormal karyotypes may grow faster, differentiate less

28 ts, 29 (48%) had secondary AML, 30 (50%) had abnormal karyotypes (monosomy 5 and/or 7 in 15 [25%]), a

29 Conversion from normal to abnormal karyotype occurred at a constant rate after ini

30 er International Prognostic Score (P = .01), abnormal karyotype (P = .05), the presence of excess bla

31 linical parameters linked to poor prognosis, abnormal karyotype (P =.002) and high serum beta(2)-micr

32 isease, incomplete blood count recovery, and abnormal karyotype pre-HCT, MRD-positive HCT was associa

33 0 and one in 40 samples having an undetected abnormal karyotype, respectively.

34 erations at 12q14-15 and in one case with an abnormal karyotype that included double minute chromosom

35 In multivariable analysis, an abnormal karyotype, the presence of FLT3-internal tandem

36 Given the potential of cells with abnormal karyotypes to become cancerous, do pathways tha

37 ary cells, but the specific contributions of abnormal karyotypes to cancer, a disease characterized b

38 ndem duplication in 447 AML patients with an abnormal karyotype treated in Medical Research Council (

39 An abnormal karyotype was found in 21.5% and 35.7% of cases

40 Abnormal karyotypes were detected in 37% of our patients

41 Because the odds are very low that an abnormal karyotype will surpass the viability of a norma

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