ライフサイエンスコーパス: abnormality

1 l ischemia, and severe=large ischemic region abnormality).

2 with Menetrier-like disease for this cardiac abnormality.

3 pregnancy were complicated by a fetal brain abnormality.

4 apy directed at the specific disease-causing abnormality.

5 We excluded donors with anatomical kidney abnormalities.

6 regions with both structural and functional abnormalities.

7 BMP4 as a potential cause of digital and eye abnormalities.

8 to those with ASD with no identified genetic abnormalities.

9 disorder and bipolar disorder showed similar abnormalities.

10 preceded by atrial dilatation and conduction abnormalities.

11 h microthrombocytopenia and platelet granule abnormalities.

12 syndrome characterized by some of the above abnormalities.

13 , infertility, reduced longevity, and kidney abnormalities.

14 unduscopic changes, and electroretinographic abnormalities.

15 s likely contributing to motor and cognitive abnormalities.

16 ubjects with apparently balanced chromosomal abnormalities.

17 requently associated with neurodevelopmental abnormalities.

18 and characterize their immunologic cellular abnormalities.

19 ed by reproductive, endocrine, and metabolic abnormalities.

20 deficiency associated obesity and metabolic abnormalities.

21 ely to produce offspring with MIA-associated abnormalities.

22 rsed most, but not all, of the immunological abnormalities.

23 and mice, occur in the absence of karyotypic abnormalities.

24 cts of earlier neuropathology and behavioral abnormalities.

25 s with combined immunodeficiency with T-cell abnormalities.

26 , CTNNB1, CDKN1C, ATRX, and chromosome 11p15 abnormalities.

27 mbination with hematologic and morphological abnormalities.

28 ue of baseline LV SUV for subsequent cardiac abnormalities.

29 within the cyst can be analysed for genetic abnormalities.

30 of skeletal, neurological, and immunological abnormalities.

31 s, maximal beta-oxidation, and mitochondrial abnormalities.

32 (NGS) analysis did not detect these genetic abnormalities.

33 nstrating obvious tubular cell morphological abnormalities.

34 rmine AKI status or severe congenital kidney abnormalities.

35 ophthalmologic and neurologic developmental abnormalities.

36 ere negative for Zika virus but had cerebral abnormalities.

37 n 1 (TET1), in depression-related behavioral abnormalities.

38 % of men and women had one or more biomarker abnormalities.

39 ally, and adult mice exhibit no overt tissue abnormalities.

40 , but not with the severity of brain or bone abnormalities.

41 -analysis shows shared and disorder-specific abnormalities.

42 e in variability and functional connectivity abnormalities.

43 ere positive for Zika virus and had cerebral abnormalities, 13 were positive for Zika infection but h

44 uscular dysplasia and extracoronary vascular abnormalities (42% vs. 64%; p = 0.047; and 46% vs. 77%;

45 C abnormalities account for approximately 50% of aHUS case

46 ides a foundation for further study of these abnormalities across human cancers.

47 DS) is associated with early-life behavioral abnormalities, affected individuals are also at high ris

48 enized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodiu

49 age, with progression towards more biomarker abnormalities among individuals who remained cognitively

50 results; 137 (25%) had high-risk cytogenetic abnormalities and 172 (32%) had 1q21 amplification alone

51 ulonephritis was associated with more fundus abnormalities and a screening SDOCT should be considered

52 f Bcl7a in postmitotic neurons elicits motor abnormalities and affects dendritic branching of Purkinj

53 Reversing DNA methylation abnormalities and associated gene silencing, through inh

54 toantibodies have been associated with fetal abnormalities and cerebral folate deficiency-related dev

55 order is complicated by the complex cellular abnormalities and challenges in achieving effective, per

56 e accompanied by striatal dopamine/serotonin abnormalities and cortical excitation-inhibition imbalan

57 ctive gene silencing underlies developmental abnormalities and disease.

58 VEGFR-2 signaling suppressed these vascular abnormalities and enhanced the survival of tumor-bearing

59 as PAH toxicity causes developmental cardiac abnormalities and impaired cardiovascular function.

60 n levels and rescues FTLD-related behavioral abnormalities and retinal degeneration without improving

61 An integrated understanding of these abnormalities and their association with clinical events

62 The relationships between these abnormalities and their incidence, time course, clinical

63 n between imaging markers of neuroanatomical abnormality and poor cognitive and motor outcomes at 2 y

64 MM, predominantly in patients with t(11;14) abnormality and those with a favorable BCL2 family profi

65 d to counteract the effect of each molecular abnormality and to propose potentially efficacious combi

66 (postural imbalance, rigidity, and postural abnormalities) and increasingly reported problems in bas

67 itive for Zika infection but had no cerebral abnormalities, and 11 were negative for Zika virus but h

68 Seventeen patients (71%) had diastolic abnormalities, and 7 patients (29%) met the definition o

69 viability, neurodegeneration, mitochondrial abnormalities, and accumulation of VLCFAs.

70 drome in the current study had severe ocular abnormalities, and all patients had bilateral involvemen

71 erized by congenital heart disease, skeletal abnormalities, and failure to thrive.

72 ditionally, visual problems, musculoskeletal abnormalities, and microcephaly were present in the majo

73 motor phenotypes, minor dopamine metabolism abnormalities, and no signs of dopaminergic neurodegener

74 of characteristic phenotypic and behavioral abnormalities, and prevention of premature death.

75 microcephaly or other central nervous system abnormalities, and timing of infection in infants with c

76 hthalmologic abnormalities, lens and retinal abnormalities, and visual acuity (VA).

77 detect morphological, functional, or tissue abnormalities, and we sought to evaluate the role of CMR

78 ) into those in which -Y was the only clonal abnormality, and all others.

79 critical roles in these disorders; however, abnormalities appear to manifest differently.

80 wt) p53 dysfunction due to nonmutational p53 abnormalities appears to be rather frequent in various A

81 Conduction abnormalities are a common finding after transcatheter a

82 er, genetic and acquired alternative pathway abnormalities are also observed in IC-MPGN.

83 isting hemodynamic instability and metabolic abnormalities are combined with long periods of low cere

84 Neuroendocrine abnormalities are common in Parkinson's disease (PD) and

85 ted in neurological disorders in which sleep abnormalities are common; for example, variation in gene

86 cal ophthalmology because ocular circulation abnormalities are early signs of ocular diseases.

87 e Minimal residual disease (MRD) and genetic abnormalities are important risk factors for outcome in

88 Certain cytogenetic abnormalities are known to adversely impact outcomes in

89 especified vascular risk factors and cardiac abnormalities are more common among patients with PEX th

90 production-spermatogenesis and sperm quality abnormalities are much more difficult to affect positive

91 White matter abnormalities are prevalent in neuropsychiatric disorder

92 Although it is known that gross chromosomal abnormalities are remarkably common in early human embry

93 more important than the associated metabolic abnormalities as the predictor of future liver fat and f

94 es revealed a role for IFN-alpha in vascular abnormalities associated with impaired blood vessel dila

95 tem play important roles in the serious bone abnormalities associated with MDD.

96 ch also predicted higher risks of neurologic abnormalities at 4 mo (OR = 7.67; CI = 4.05, 14.49) and

97 novel, simple and label-free tool to detect abnormalities at an early stage of pregnancy, a GO-pepti

98 To evaluate vascular abnormalities at superficial (SCP) and deep (DCP) capill

99 Survivors without neurological abnormalities before CSE have favourable outcomes.

100 cal or systemic adverse events or laboratory abnormalities between the PfSPZ Vaccine and placebo grou

101 se events (hypotension, syncope, electrolyte abnormalities, bradycardia, or acute kidney injury/failu

102 ystolic blood pressure and more frequent ECG abnormalities but not with higher blood glucose, serum c

103 AC9(-/-) mice exhibit no structural abnormalities but show a significant bradycardia, consis

104 images were reviewed for development-related abnormalities by neuroradiologists.

105 ion and behavioral disorders and how sensory abnormalities can contribute to the etiology of disorder

106 ther potential causes of white matter signal abnormalities can mimic the changes of toxic leukoenceph

107 en rs1801198 and primary risks of congenital abnormalities, cancer, or Alzheimer disease.Meta-analysi

108 ts suggest that persistent cardiorespiratory abnormalities caused by LT-IH are mediated by epigenetic

109 1 mutant mice have granule and Purkinje cell abnormalities causing subsequent disruptions in postnata

110 e hemimelia (TH), a congenital developmental abnormality characterized by absence of a variable dista

111 currence of retinal pigment epithelium (RPE) abnormalities, choroidal neovascularization, acquired vi

112 These abnormalities contributed to worsening of hyperglycemia

113 elin 1 (ET-1)-mediated vasoconstriction, two abnormalities contributing to vascular dysfunction.

114 contrast to the gray matter, these diffusion abnormalities correlated with cognitive function.

115 ut affecting noncardiac tissues; the cardiac abnormalities could be noninvasively captured by echocar

116 Early identification of vision abnormalities could prevent the development of amblyopia

117 rrelation" has emerged as a new approach for abnormality detection of brain disease.

118 Total number of possible abnormalities did not differ between cases and controls.

119 s whose cardiac comorbidities and structural abnormalities differ.

120 JS with retinal dystrophy, additional brain abnormalities (e.g., heterotopia, Dandy-Walker malformat

121 ung, intestine, and brain, and morphological abnormalities: e.g., disrupted lung alveolarization, atr

122 has focused on the identification of genetic abnormalities, emerging studies increasingly suggest tha

123 ed copy number variations and/or chromosomal abnormalities, emphasizing the importance of detecting a

124 lates an Alzheimer-like profile of biomarker abnormalities even in the absence of other hallmarks of

125 ne system, as evidenced by the severe immune abnormalities exhibited by patients bearing inactivating

126 L2hgdh KO mice exhibit white matter abnormalities, extensive gliosis, microglia-mediated neu

127 y, these results indicate that mitochondrial abnormalities facilitate cyst formation in ADPKD.

128 neural tissues of patients with intracranial abnormalities following intravenous gadolinium-based con

129 to characterize microstructural white matter abnormalities for a deeper understanding of the developm

130 with T2DM demonstrate greater repolarization abnormalities for a given hypoglycemic stimulus despite

131 ll as generalized and focal seizures and EEG abnormalities for patients with gain- and loss-of-functi

132 al defects lead to detrimental mitochondrial abnormalities for unknown reasons.

133 n emotional regulation may represent a trait abnormality for BD and could potentially aid clinical di

134 both basal and learning-dependent molecular abnormalities found in several ASD mice models, includin

135 m cells (HSC) is associated with chromosomal abnormalities, genomic instability, and HSC aging and mi

136 Brain bioenergetic abnormalities have been observed frequently in adults wi

137 FIGSKO mice also develop cognitive abnormalities, i.e. learning impairment and nesting beha

138 ed additional studies to further investigate abnormalities identified on screening, with 32 having in

139 Diffusion tensor imaging abnormalities in a cohort of 97 traumatic brain injury p

140 rocess physiologically salient events, while abnormalities in a temporal pole-medial prefrontal corte

141 in the activation of gelsolin, without which abnormalities in actin polymerisation in the photorecept

142 Previously reported striatal abnormalities in ADHD may be caused by comorbid conduct

143 gical studies reveal a variety of structural abnormalities in astrocytes, such as vacuolization and a

144 We discuss the abnormalities in B cells that occur in HIV infection bot

145 genesis in developing mice led to behavioral abnormalities in both sexes and MRI-detected brain micro

146 A growing body of evidence suggests abnormalities in brain bioenergetics in psychiatric diso

147 Depressed patients show abnormalities in brain connectivity at rest, including h

148 cells expressing this mutation had moderate abnormalities in cell adhesion, migration, proliferation

149 t other pathophysiological processes such as abnormalities in cell metabolism, energy production and

150 fic genetic defects to the associated unique abnormalities in cellular signaling pathways amenable to

151 Abnormalities in certain clinical features of schizophre

152 ate the utility of this method for detecting abnormalities in chondrocyte distribution in mice lackin

153 revealed unprecedented details of glomerular abnormalities in Col4a3 mutants including distorted podo

154 Abnormalities in complement functions occur in many infe

155 s a direct marker of brain neurotransmission abnormalities in complex mental phenomena.

156 Data also suggest that abnormalities in connecting white matter pathways and fu

157 Abnormalities in dendritic spines are manifestations of

158 nopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-prolifer

159 , they provide a framework for understanding abnormalities in disease.

160 These results suggest that cognitive abnormalities in disorders like schizophrenia in which g

161 c dysfunction; 3) prognostic implications of abnormalities in E/A and E/e'; 4) special scenarios of t

162 cific deletion of Evc2 phenocopied the tooth abnormalities in Evc2 mutants.

163 s (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates.

164 Findings of structural abnormalities in frontal and temporal lobes, amygdala, a

165 These oxotremorine-induced abnormalities in Gnal(+/-) mice were replicated by oxotr

166 Autonomic nervous system testing revealed no abnormalities in heart rate and blood pressure variabili

167 These data support the idea that abnormalities in heparan sulfate content and distributio

168 Structural abnormalities in hippocampal volume and shape are found

169 d to be a powerful technique for identifying abnormalities in human tissue.

170 euronal layer that resembles cerebral cortex abnormalities in humans.

171 n of TNF-alpha normalized neurodevelopmental abnormalities in infected mice, providing evidence that

172 nition of developmental delays and cognitive abnormalities in iron-deficient neonates, and literature

173 right ventricular (RV) filling and ejection abnormalities in IUGR young adult baboons using cardiac

174 the development of cortical and behavioural abnormalities in MIA-affected offspring.

175 o fixed airflow obstruction and radiological abnormalities in moderate to severe asthma.

176 dentate nuclei (DNs) functional connectivity abnormalities in multiple sclerosis (MS) to explore thei

177 hese findings suggest that the mitochondrial abnormalities in mutant Hsp27-induced neuropathies may b

178 Our objective was to examine whether abnormalities in neuroimaging measures of amyloid and ne

179 This promoted myelin clearance but led to abnormalities in nonmyelinating and myelinating SCs in t

180 s is a potential biomarker for the metabolic abnormalities in obesity.

181 describe clinically relevant neuroendocrine abnormalities in Parkinson's disease to highlight their

182 overlapping phenotypes of inhibitory control abnormalities in patients with ASD and OCD.

183 Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/P

184 Addiction is characterized by abnormalities in prefrontal cortex that are thought to a

185 ly with magnetic resonance imaging (MRI) and abnormalities in regional CBF are present in many neurop

186 Earliest abnormalities in regions with normally appearing retinal

187 he most widely replicated neurophysiological abnormalities in schizophrenia and are linked to underly

188 Abnormalities in signalling pathways required for postna

189 STATEMENT Psychiatric diseases are linked to abnormalities in specific white matter (WM) pathways, an

190 ma-aminobutyric acidergic systems as well as abnormalities in synaptic plasticity and neural connecti

191 lled in a study of cerebrospinal fluid (CSF) abnormalities in syphilis underwent the mental alternati

192 ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and pref

193 The abnormalities in the ileal enteroendocrine cells appear

194 in the mother and there are commonly ocular abnormalities in the newborn.

195 pplication and oil/gas wells correlated with abnormalities in the Northeast, Southeast, and western r

196 The expression of NCOR1DeltaID ameliorated abnormalities in the peripheral blood indices, and corre

197 ative stress, mitochondrial DNA instability, abnormalities in the regulation of mitochondrial dynamic

198 Transmission electron microscopy revealed abnormalities in the ultrastructure of mutant SGNs as ea

199 isorder (ADHD) is associated with structural abnormalities in total gray matter, basal ganglia, and c

200 work describes early postnatal developmental abnormalities in visual and olfactory sensory systems in

201 its in neurite density appear fundamental to abnormalities in white matter integrity in early psychos

202 Widespread abnormalities in white matter microstructure were also s

203 lip of the epiphysis, is the most common hip abnormality in adolescents and is a major cause of early

204 fasciculations often present as the initial abnormality in ALS, an early harbinger of dysfunction an

205 Hyperammonemia is a consistent abnormality in cirrhosis that results in impaired skelet

206 otein synthesis and corrects dendritic spine abnormality in Fmr1 knockout mice.

207 The skeletal sites showing the greatest abnormality in the carpal-tarsal osteolysis syndromes ar

208 studies have failed to demonstrate a primary abnormality in the eosinophil lineage.

209 These abnormalities include intestinal lymphangiectasia, mesen

210 mes as well as patients with other metabolic abnormalities including patients with chronic kidney dis

211 order (ASD) is associated with physiological abnormalities, including abnormal redox and mitochondria

212 ation exhibited morphological and functional abnormalities, including increased mitochondrial superox

213 Morphant embryos displayed cardiac abnormalities, including pericardial edema and heart fai

214 oderma, small stature, sparse hair, skeletal abnormalities, increased risk of osteosarcoma, and decre

215 or, anemia complicating pregnancy, placental abnormalities, infection during labor, maternal readmiss

216 itial management of evolving coronary artery abnormalities is essential, necessitating an increased f

217 ng singleton pregnancies without chromosomal abnormalities lasting >/=20 weeks in Denmark from 1978 t

218 nstrated that mitotic arrest and segregation abnormalities lead to cell death through mitotic catastr

219 The structural and mineralization abnormality led to slight reduction in apparent modulus,

220 ar surface pathologies, neuro-ophthalmologic abnormalities, lens and retinal abnormalities, and visua

221 Eye abnormalities may be the only initial finding in congeni

222 values to detect pediatric liver mechanical abnormalities may not allow detection of mild disease an

223 cantly influence white matter and that these abnormalities may signify an early feature of the diseas

224 The synaptic abnormalities mediated by IL-1beta and the clinical and

225 abetes, TEPP-46 treatment reversed metabolic abnormalities, mitochondrial dysfunction and kidney path

226 Ventricular abnormalities, namely ependymitis and choroid plexitis w

227 ent or mass effect, and homogenous T2 signal abnormality not significantly exceeding the T1 enhanceme

228 A condensed cis-Golgi was the first abnormality observed upon Munc18-1 or SNAP-25 loss withi

229 PEVAC is an isolated, perifoveal, aneurysmal abnormality, occurring in otherwise healthy patients who

230 Lid and periocular abnormalities, ocular surface pathologies, neuro-ophthal

231 Both RPGR and Gelsolin knockout mice show abnormalities of actin polymerisation and mislocalisatio

232 , typically caused by genetically determined abnormalities of cardiac desmosomes, which leads to deta

233 ults are therefore essential for translating abnormalities of human WM and effects of DBS to rodent m

234 Abnormalities of mucus viscosity play a critical role in

235 ccur with or without accompanying functional abnormalities of other organ systems, particularly skele

236 At baseline, tractional abnormalities of the CB were diagnosed in 58 out of 263

237 Tractional abnormalities of the CB were identified with spectral-do

238 Still, we found no evidence of morphologic abnormalities of the dopaminergic cells in mutant brains

239 Abnormalities of the endosomal-lysosomal network (ELN) a

240 beta-Thalassemia is associated with several abnormalities of the innate immune system.

241 We also correlate initial abnormalities of the nervous system found on imaging wit

242 Although structural abnormalities of the right ventricle predominate, it is

243 about myocardial structure and composition, abnormalities of which form the direct, pathophysiologic

244 e more frequent in Down syndrome, suggesting abnormality of adaptive immunity.

245 ual event rates increased with the extent of abnormality of myocardial perfusion.

246 Results In areas with no or minimal abnormalities on CT images, small areas of increased att

247 AC at baseline, and fewer than half have any abnormalities on FT.

248 cerbations, greater evidence of small airway abnormality on CT, lower interleukin-15 concentrations,

249 drome, developmental delay, and epileptiform abnormality on electroencephalogram (EEG) before withdra

250 The presence of structural abnormalities or antihypertensive medication also correl

251 y of any degree, and (3) no structural brain abnormalities or metabolic conditions that could explain

252 Eyes with vitreoretinal interface abnormalities or that had undergone vitrectomy were excl

253 ily in those who have epilepsy, neurological abnormalities, or both before the episode of CSE.

254 medication, gastrointestinal AE, laboratory abnormality, or AE leading to discontinuation of the dru

255 ith deletion carriers without any radiologic abnormalities (P < .005, P < .002, and P < .004, respect

256 orrelated with the presence of CB tractional abnormalities (P = .002).

257 In general, RPE abnormalities paralleled photoreceptor degeneration, alt

258 These abnormalities persisted to 120 days after injury.

259 chemoreceptor feedback to cardiorespiratory abnormalities present in diseases in which the carotid b

260 tory CTs to identify functional small airway abnormality (PRM(FSA)) and emphysema (PRM(EMPH)) in the

261 al disability with or without seizures, gait abnormalities, problems of social behavior, and other va

262 is suitable to quantify qualitative walking abnormalities related to CNS circuit dysfunction across

263 The saccadic abnormalities related to DN involvement were independent

264 The etiology of these abnormalities remains to be determined.

265 hizophrenia, but it is unclear whether these abnormalities represent a cause or consequence of these

266 en perfusion-weighted and diffusion-weighted abnormalities serves as an indicator of the penumbra.

267 has been achieved in targeting some genetic abnormalities, several challenges and limitations exist

268 ing domain in PfHDP resulted in food vacuole abnormalities similar to that seen with a cysteine prote

269 es of its loss include neurofilament network abnormalities, specifically accumulation and bundling of

270 Our analysis integrates TERT abnormalities, telomerase activity and genomic alteratio

271 gory 2 had significantly more ocular surface abnormalities than patients in category 1, including a g

272 knockout (KO) mice have more severe skeletal abnormalities than those of Cx43-KO mice.

273 ere aortic valve diseases are common cardiac abnormalities that are associated with poor long-term su

274 ents with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and

275 astic leukemia (ALL) and to identify genetic abnormalities that drive disease in these patients.

276 onucleotide incorporation is a primary mtDNA abnormality that can result in pathology.

277 The greater the conduction abnormality the greater the discordance of LV filling fo

278 Insulin insensitivity and adipokine abnormalities (the hallmarks of type 2 diabetes mellitus

279 s complicates interpretation of the observed abnormalities: they may be cascade effects of earlier ne

280 tal outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and the

281 e elicits profound structural and functional abnormalities throughout the primary visual pathway.

282 ctrum disorder (ASD) and other developmental abnormalities to construct a genome-wide map of large SV

283 detected abnormal macular thinning and flow abnormalities undetected by biomicroscopy.

284 espondence between SD-OCT thinning and mfERG abnormalities was shown in 67% of the eyes with ETDRS <2

285 This abnormality was corrected by restoring ADAMTS13 activity

286 No abnormality was observed during color Doppler US.

287 tablish the pathogenic significance of these abnormalities, we inhibited mitochondrial fragmentation

288 Abnormalities were blocked by the mTORC1 inhibitor sirol

289 merase chain reaction screening for relevant abnormalities were centrally reviewed and were informati

290 arts, with evidence that metabolic substrate abnormalities were compensated for by increased mitochon

291 High-risk cytogenetic abnormalities were defined as del(17p), t(4;14), and/or

292 high risk for ASD, reciprocal neuroanatomic abnormalities were found and determined to be associated

293 One or more structural abnormalities were found in all 45 (100%) hemiplegic sho

294 These NAc abnormalities were limited to patients with non-GBD.

295 nd tangles were noted in 3 eyes, and macular abnormalities were noted in 3 eyes.

296 Optic nerve and retinal abnormalities were the most frequent findings.

297 The areas of atrial abnormality were consistent among patients, most commonl

298 bphl mice revealed cardiac conduction system abnormalities with aberrant atrioventricular conduction

299 sults in neuronal destruction and behavioral abnormalities with differential immune-mediated involvem

300 These abnormalities, with the exception of hyperglycemia, were