ライフサイエンスコーパス: aboral

1 ontrols the homeobox gene patterning of oral/aboral and proximal/distal domains within the first bran

2 ub-networks, including endomesodermal, oral, aboral, and apical.

3 showed that, by postgastrulation, cells from aboral areas of the preingression embryo developed lower

4 also come from lateral, aboral-lateral, and aboral areas.

5 The oral/aboral asymmetry in veg1 allocations was also demonstrat

6 fates along both the animal-vegetal and oral-aboral axes of sea urchin embryos.

7 with respect to the animal/vegetal and oral/aboral axes of the embryo.

8 irst known molecular determinant of the oral-aboral axis (the embryonic dorsoventral axis), and is cr

9 cell polarity and patterning along the oral-aboral axis are disrupted.

10 ion of ectoderm and polarization of the oral-aboral axis in Lytechinus pictus depends on cellular int

11 yonic regions and the patterning of the oral-aboral axis in Nematostella We also show functionally th

12 ere founder cells are specified and the oral-aboral axis is determined, and to activate the CyIIIa ge

13 is established during oogenesis and the oral-aboral axis is specified sometime after fertilization.

14 in concert to pattern tissues along the oral-aboral axis of the polyp.

15 The oral-aboral axis of the sea urchin embryo is specified condit

16 on resulted in embryoids that displayed oral-aboral axis patterning in the absence of endoderm.

17 Effective entrainment of the oral-aboral axis requires that the embryos remain immobilized

18 with reference to earlier work on both oral-aboral axis specification and P3A2 and used to develop a

19 op a testable model of the mechanism of oral-aboral axis specification in the sea urchin embryo.

20 viously established interactions on the oral/aboral axis to generate a GRN model encompassing the 2D

21 lly along the axis perpendicular to the oral-aboral axis, the directive axis.

22 opment of radialized embryos lacking an oral-aboral axis.

23 ng biradial symmetry organized along an oral-aboral axis.

24 formation and differentiation along the oral-aboral axis.

25 external comb rows, which run along the oral-aboral axis.

26 meres as well as interactions along the oral-aboral axis.

27 polarization of the ectoderm along the oral-aboral axis.

28 ommitment and differentiation along the oral-aboral axis.

29 ents control axial patterning along the oral-aboral axis.

30 and foot along a single axis called the oral-aboral axis.

31 tivity is spatially modulated along the oral-aboral axis.

32 identical quadrants organized along the oral-aboral axis.

33 mbryos, specification of the secondary (oral-aboral) axis occurs via nodal, expression of which is en

34 symmetrical around their longitudinal (oral-aboral) axis.

35 alterations in the specification of the oral/aboral boundary of the jaw.

36 propose that ectoderm is first specified as aboral by broadly expressed activators, including SpOtx,

37 t role in gastrulation: during gastrulation, aboral cells become more columnar and oral cells less co

38 regulator of morphogenetic movements in the aboral compartments of the ectoderm, endoderm and mesode

39 d- to late-gastrula stage, PMCs utilize oral-aboral cues from the ectoderm for the first time.

40 ic cues that distinguish the future oral and aboral domains of the early embryo.

41 henceforth expressed exclusively, in oral or aboral domains, presaging the mesodermal cell types that

42 , a positive inductive signal to specify the aboral ectoderm and a negative suppressive signal to ina

43 tomeres and is critical for specification of aboral ectoderm and for ectoderm patterning, presumably

44 the CyIIIa gene, expressed in the embryonic aboral ectoderm and on the Endo16 gene, expressed in the

45 ry studies to be expressed in either oral or aboral ectoderm by 24 h are included, though universally

46 formation is a prerequisite for induction of aboral ectoderm by lithium and for normal ectoderm patte

47 and inhibited the formation of endoderm and aboral ectoderm cell types.

48 pressor activity at the proximal G-string in aboral ectoderm cells.

49 ne and more generally the differentiation of aboral ectoderm cells.

50 by repressing LpS1 gene transcription in non-aboral ectoderm cells.

51 ur results suggest that SpOtx is involved in aboral ectoderm differentiation by activating aboral ect

52 uitous transcription activator that promotes aboral ectoderm differentiation.

53 xists for spec genes despite their conserved aboral ectoderm expression.

54 ded together with Otx sites for specifically aboral ectoderm expression.

55 w that SpGsc is a repressor that antagonizes aboral ectoderm fate specification and promotes oral ect

56 tx redirected nonaboral ectoderm cells to an aboral ectoderm fate.

57 on factor SpOtx is required for endoderm and aboral ectoderm formation during sea urchin embryogenesi

58 not overcome the inhibition of endoderm and aboral ectoderm formation, suggesting that SpOtx functio

59 of beta-catenin's functions in endoderm and aboral ectoderm formation.

60 f beta-catenin, have defects in endoderm and aboral ectoderm formation.

61 e early embryo and in all tissues except the aboral ectoderm in later embryos.

62 fic features disappear and expression of the aboral ectoderm marker spec1 encompasses the whole of th

63 aboral ectoderm-specific gene expression and aboral ectoderm morphology, but with C-cadherin present,

64 e CyIIIa cytoskeletal actin gene outside the aboral ectoderm of the embryo.

65 nism underlying the known dependence of oral-aboral ectoderm polarity on intercellular signaling.

66 cohorts of independently activated oral and aboral ectoderm regulatory genes, and we predict yet uni

67 in the sea urchin embryo, and indirectly, of aboral ectoderm specification as well.

68 pOtx mRNA developed into epithelial balls of aboral ectoderm suggesting that SpOtx redirected nonabor

69 ry network analysis to the adjacent oral and aboral ectoderm territories over the same period.

70 ole is to establish CyIIIa expression in the aboral ectoderm territory as the blastomere founder cell

71 l ectoderm-specific genes in the prospective aboral ectoderm territory, are needed for correct spatia

72 ion which accompanies differentiation of the aboral ectoderm, and that a negative regulatory region n

73 s), which are fated to give rise to oral and aboral ectoderm, developed into polarized embryoids that

74 showed that in addition to expression in the aboral ectoderm, the proximal G-string mutation caused e

75 is transcribed exclusively in the embryonic aboral ectoderm, under the control of 2.3 kb cis-regulat

76 SpOtx plays a key role in the activation of aboral ectoderm- and endoderm-specific gene expression a

77 Strongylocentrotus purpuratus embryogenesis, aboral ectoderm-specific expression of spec2a relies on

78 Coexpressing SpOtx with C-cadherin restored aboral ectoderm-specific gene expression and aboral ecto

79 tein reduced the expression of endoderm- and aboral ectoderm-specific genes and inhibited the formati

80 boral ectoderm differentiation by activating aboral ectoderm-specific genes and that modulating its e

81 markers, although we previously showed that aboral ectoderm-specific genes can be induced by 25 mM l

82 The truncated PDGF receptor-beta caused the aboral ectoderm-specific genes LpS1 and LpC2 to be repre

83 d for correct spatial expression of oral and aboral ectoderm-specific genes.

84 Expression of the aboral ectoderm-specific LpS1 gene in Lytechinus was use

85 erm, resulted in polarized expression of the aboral ectoderm-specific LpS1 protein, but global expres

86 The aboral ectoderm-specific LpS1-alpha and -beta genes of L

87 somere-derived embryoids did not express any aboral ectoderm-specific markers, although we previously

88 controlling the expression of the sea urchin aboral ectoderm-specific spec genes.

89 is believed to direct the activation of the aboral ectoderm-specific Spec2a gene and more generally

90 icated as a transcriptional activator of the aboral ectoderm-specific Spec2a gene.

91 rogressive confinement of hyalin mRNA to the aboral ectoderm.

92 purpuratus is expressed specifically in the aboral ectoderm.

93 e constructs were expressed primarily in the aboral ectoderm.

94 ween TGFbeta-expressing endodermal cells and aboral ectoderm.

95 o cause expression of the spec2a gene in the aboral ectoderm.

96 late and for the activation of spec2a in the aboral ectoderm.

97 B, which bilaterally separates the oral from aboral ectoderm; (3) the vegetal lateral CB, which bilat

98 rovide new information on development of the aboral end in buds.

99 rical, expression of both genes in the bud's aboral end is initially asymmetrical, appearing first on

100 Axial patterning of the aboral end of the hydra body column was examined using e

101 During regeneration of the aboral end, expression of manacle precedes that of shin

102 To determine if the aboral expression of LvTbx2/3 is linked between germ lay

103 ve, and the initial polarization of oral vs. aboral fate is manifested in a redox differential, the b

104 Lewis rat small bowel xenotransplants (n=7), aboral free ends of Thierry-Vella loops constructed from

105 affect survival of lipolytic activity during aboral gastrointestinal transit.

106 ly developing echinoids, the secondary (oral-aboral) larval axis is established after fertilization b

107 oral area, but a few also come from lateral, aboral-lateral, and aboral areas.

108 nist drug treatments result in an absence of aboral markers, a shift in the expression boundaries of

109 analyzed the regulatory linkages within the aboral NSM gene regulatory network.

110 nic mesoderm and is downstream of Gcm in the aboral NSM gene regulatory network.

111 egulatory genes that later contribute to the aboral NSM regulatory state.

112 age, is asymmetrically inactivated in future aboral nuclei.

113 ian Nematostella vectensis, the primary oral-aboral (O-Ab) axis first develops during the early embry

114 indicated that asymmetry was about the oral/aboral (O/A) axis.

115 The oral-aboral (OA) axis in the sea urchin is specified by the T

116 he initial asymmetry that specifies the oral-aboral (OA) axis of the sea urchin embryo has long been

117 Previous studies have shown that oral-aboral (OA) polarity correlates with a mitochondrial gra

118 ry (animal-vegetal) (AV) and secondary (oral-aboral) (OA) axes of sea urchin embryos are established

119 , subsequently, became refined solely to the aboral ones during skeletogenesis.

120 reased cell apoptosis, especially within the aboral (or caudal) domain of the BA1, resulting in hypop

121 on of the embryonic mouth, tentacles, combs, aboral organ, and putative sensory cells.

122 s, such as coloration, length, and number of aboral papillae, which are highly variable and can be af

123 regulatory genes involved in euechinoid oral-aboral patterning of nonskeletogenic mesodermal and ecto

124 At this time, some aboral PMCs migrate into the adjacent oral quadrant to a

125 Surprisingly, no blastema developed at the aboral pole after stolon removal.

126 equently, micromeres are formed first at the aboral pole and later at the oral pole.

127 l processes, was initially recognized at the aboral pole during the third day of development.

128 ession boundaries of oral markers toward the aboral pole, and changes in the position of differential

129 NvecGrl1 transcripts are detected around the aboral pole, considered the equivalent to the head-formi

130 late-gastrula stages, when some PMCs from an aboral quadrant migrate to the adjacent oral quadrant.

131 ion of the oral ectoderm begins with an oral-aboral redox gradient, which is interpreted by the cis-r

132 ssion of Gsc and other genes in the proximal aboral region of the developing mandible.

133 and part of a feedback loop locking down the aboral regulatory state.

134 e side facing the inside tends to become the aboral side.

135 her rate of respiration than the prospective aboral side.

136 Nodal and its target Gsc each rescue oral-aboral specification and patterning when expressed asymm

137 essed in the oral territory, is required for aboral specification.

138 distribution of LvTbx2/3 was observed in the aboral territories of all three germ layers.

139 indicates that expression of LvTbx2/3 in the aboral territories of each germ layer is a common aspect

140 fied signaling interactions between oral and aboral territories.

141 These defects were not observed aboral to the obstruction.

142 tivity of the ileal muscles, 0-5 cm oral and aboral to the site of resection, were examined at 5 and

143 cells of Cajal (ICC) decreased oral, but not aboral, to the site of obstruction.

144 We found different patterns of aboral-to-oral Cnox-2 expression among polyp polymorphs,

145 archenteron up to the foregut region, while aboral veg1 clones contributed only small numbers of hin

146 ntly contributed more cells to endoderm than aboral veg1 clones.

147 l-vegetal and at 45 degree angle to the oral-aboral (ventral-dorsal) axis.

148 ion of nodal and entrains OA polarity toward aboral when confined to half of the embryo via 2-cell st