ライフサイエンスコーパス: abortive

1 liferate, we term this type of colonization 'abortive'.

2 quence, CCPs without cargo are almost always abortive.

3 the fate of infection, either productive or abortive.

4 eotide incision repair (NIR) product with an abortive 3'-terminal dC close to the scissile position i

5 Consequently, the abortive 66S pre-rRNPs are prematurely released from the

6 heral and mesenteric lymph nodes, leading to abortive activation and deletion of tyrosinase-specific

7 ndirect pathway CD4(+) T cells, resulting in abortive activation and deletion without detrimental eff

8 at appears to favor tumor survival and drive abortive activation of immune cells.

9 dendritic cell maturation, resulting in the abortive activation of naive CD8(+) T cells, and is depe

10 hemical characteristics of anergy, including abortive activation of Ras-MEK-Erk, increased activation

11 r transgenic CD8 cells are shown to be in an abortive activation state prior to their deletion, showi

12 tion by liver antigens likely contributes to abortive activation, exhaustion, and early death of CD8(

13 The abortive activity of topoisomerases can result in clasto

14 er, abiA alone does not account for the full abortive activity reported for pTR2030.

15 Abortive adenylylation was suppressed at low ATP concent

16 e, and the blocked T-cell progenitors become abortive and die by apoptosis.

17 s of CCP dynamics, including the turnover of abortive and productive CCP species and their relative c

18 ts into the mechanism that controls both the abortive and productive RNA synthesis.

19 -initiation complexes in vitro and represses abortive and productive transcription initiation, as wel

20 omplex, enhances DNA melting, and stimulates abortive and productive transcription.

21 Consistent with the characteristics of both abortive and promoter-proximal sigma(70)-dependent pause

22 as well as helped to clarify a mechanism for abortive and prophylactic drugs.

23 rejoined by TOP2 but on occasion can become abortive and remain unsealed.

24 of the antiprogestin mifepristone (RU486, an abortive) are unknown.

25 pe of replication, therefore, can be termed "abortive," as RSV is capable of entering the cells in th

26 ence of costimulatory signals can lead to an abortive attempt at activation and subsequent anergy.

27 n plating efficiency was observed, with many abortive attempts at cell division apparent in the doubl

28 oposed to be a vinylogous amide derived from abortive beta-deprotonation of the ketimine intermediate

29 ideas, cargo often escapes from a pit before abortive CCP termination or endocytic vesicle production

30 tion to an increase in CCP size, turnover of abortive CCPs increases, and the rate of CCP maturation

31 In contrast, other CCPs (abortive CCPs) are relatively short-lived and disassembl

32 tion to the cytoplasm leads to death through abortive cell cycle induction.

33 ranslocation: productive passage of cargo or abortive channel occlusion by cargo.

34 ranslocation: productive passage of cargo or abortive channel occlusion by cargo.

35 ncovered an excellent candidate for the wild abortive-CMS-encoding gene; like most of the CMS-associa

36 is normal, while the other carries the wild abortive-CMS.

37 etic mutants cause an increased incidence of abortive cohesin deposition events that result in compro

38 auxotrophs, X. nematophila does not exhibit abortive colonization but rather reduced growth and fila

39 Both the open complex and an abortive complex containing a short RNA primer extending

40 With BFA, the association rate of the abortive complex is drastically reduced by a factor of 4

41 on bubble expands at its leading edge in the abortive complex, results that confirm and extend the pr

42 allosteric effect combine to stabilize such abortive complex.

43 gle in the open complex as well as in the +3 abortive complex: a bend of 49 degrees +/- 7 degrees was

44 e to the stability of initially transcribing abortive complexes in T7 RNA polymerase.

45 ributor to the characteristic instability of abortive complexes.

46 eparate sessions: preventive (preceding) and abortive (concurrent) verum acupuncture (VAp and VAa), c

47 plex containing a DNA bubble and enters into abortive cycles of RNA synthesis before escaping the pro

48 ically from the downstream end exhibits less abortive cycling and little perturbation of the final tr

49 Most abortive cycling occurs in the slower phase (>10 s), whe

50 alysis of a transcription cycle analogous to abortive cycling that underlies the sigma(70)-dependent

51 polymerase, which shows dramatically reduced abortive cycling, also transitions to elongation later,

52 likely the primary energetic contributor to abortive cycling.

53 Abortive cytokinesis of mononuclear cells contributes to

54 ationship with cleavage furrow formation and abortive cytokinesis.

55 ptic cup formation, and lens development was abortive despite normal Pax6 expression in the lens epit

56 , (3) meiotic plants with autonomous (though abortive) development and (4) meiotic plants lacking aut

57 ctor that prevents infection by inducing the abortive disassembly of capsid cores recognized by its C

58 hibits retroviral infection by promoting the abortive disassembly of incoming retroviral capsid cores

59 tive control and WT rhTRIM5alpha induced the abortive disassembly of viral cores, indicating a role f

60 unrepaired DNA strand breaks resulting from abortive DNA ligation events.

61 (Aptx), a DNA-binding protein that resolves abortive DNA ligation intermediates.

62 rimary neural cells, that aprataxin resolves abortive DNA ligation intermediates.

63 ates at DNA nicks or breaks that result from abortive DNA ligation reactions.

64 When loop B of the TBD is altered, abortive DNA products are observed during leading strand

65 ng model in which end associations represent abortive DNA repair intermediates when the number of tel

66 opo II) poisons such as etoposide can induce abortive DNA strand breaks in which Topo II remains cova

67 The specific factors that trigger abortive DNA synthesis are not characterized.

68 NAD and alpha-Kg suggest the existence of an abortive E:NAD:alpha-Kg complex.

69 g exposure, resulting in long-term memory or abortive effector responses, correlating with T cell-DCs

70 nal axis in unstressed CD-1 mice or have the abortive effects observed with 1.

71 In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic st

72 to recruit p300 during either phase leads to abortive enhancer formation and a lack of target gene ex

73 in a hyperinfection phenotype consisting of abortive epidermal infection events uncoupled from nodul

74 ed recruitment of dynamin and can undergo an abortive event in which clathrin coats separate from the

75 nce system could improve the surveillance of abortive events in French cattle.

76 anti-CD154-induced tolerance resulted in the abortive expansion of the alloreactive, effector T cell

77 programs (i.e., between active, latent, and abortive fates).

78 studies with an inducible L2 mutant revealed abortive formation of the crescent membrane.

79 Abortive Foxp3 expression was caused by production of in

80 Thus, PE prevents the accumulation of abortive genotoxic DNA intermediates arising from strand

81 replication in macrophages is productive or abortive has been a topic of debate.

82 it was proposed that prestin manages only an abortive hemicycle that results in the trapped anion act

83 ion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissue

84 rm of programmed cell death triggered during abortive HIV infection, is associated with the release o

85 he death of these "bystander" cells involves abortive HIV infection.

86 sensor required for CD4 T cell death due to abortive HIV infection.

87 clude A3G and A3F from virions, resulting in abortive HIV replication in nonpermissive human T cells.

88 esidues may prevent undesirable reactions or abortive hydrolysis of the covalently bound enzyme-subst

89 on of primary macrophages lacking emerin was abortive in that viral cDNA localized to the nucleus but

90 ication systems (R-M) (Tock & Dryden, 2005), abortive infection (Abi) (Chopin et al, 2005), Argonaute

91 iction and modification (R/M) system and the abortive infection (Abi) mechanism, AbiR, that impedes b

92 Bacterial abortive infection (Abi) systems are 'altruistic' cell d

93 ding restriction-modification systems (R-M), abortive infection (Abi), Argonaute-based interference,

94 arge fraction of infected cells dies through abortive infection and has a half-life of approximately

95 the productive growth cycle, resulting in an abortive infection and radically restricting viral repli

96 ative estimates of parameters characterizing abortive infection and support the notion that abortive

97 pression to establish quiescence and prevent abortive infection and that the virus usurps a Daxx-medi

98 These cells undergo abortive infection characterized by the cytosolic accumu

99 of RabA2 resulted in an increased number of abortive infection events, including bursting of ITs and

100 tion/modification system LlaI and carries an abortive infection gene, abiA.

101 To investigate the role of abortive infection in driving CD4(+) T cell loss in vivo

102 This confirms the importance of abortive infection in driving T cell depletion.

103 at does not express NS2 and NS4 underwent an abortive infection in HAE-ALI.

104 ecimens from atypical lesions may produce an abortive infection in limited cell lines and a cytopathi

105 ubules near masses of dense viroplasm during abortive infection in the absence of the A17 or A14 prot

106 cells, indicating that SAMHD1 contributes to abortive infection in these cells.

107 tap35-infected Sf9 cells during an otherwise abortive infection induced by apoptosis.

108 ellular viral replication centers results in abortive infection of DCs with both VV and MVA.

109 we analyzed the role of both proteins in the abortive infection of human HeLa cells with the poxvirus

110 by replication in hepatocytes and not by the abortive infection of Kupffer cells and the following cy

111 Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4

112 levels, and that SAMHD1 expression promotes abortive infection of this important memory cell subset.

113 ves the infected cell but rather enforces an abortive infection pathway leading to infected cell deat

114 ortive infection and support the notion that abortive infection represents an important mechanism und

115 ing CRISPR-Cas, restriction-modification and abortive infection systems (1-4) .

116 However, the contribution of abortive infection to T cell loss and how quickly aborti

117 rabbit cells tested, vMyxM062-KO conducts an abortive infection, although it initiates viral DNA repl

118 e tissue die through pyroptosis triggered by abortive infection, i.e., infection of resting T cells i

119 In its abortive infection, the gamma(1)34.5 null mutant induces

120 e adsorption inhibition, injection blocking, abortive infection, toxin-antitoxin, and CRISPR-Cas syst

121 rity of CD4(+) T cells in tissue die through abortive infection, where the accumulation of incomplete

122 DNA injection, restriction/modification, and abortive infection.

123 oci and resistance to bacteriophages through abortive infection.

124 inefficiently completed, which results in an abortive infection.

125 on with the viral capsid protein, leading to abortive infection.

126 immunity against bacteriophages by inducing abortive infection.

127 as reverse transcription (RT), resulting in abortive infection.

128 s induces substantial cell death, leading to abortive infection.

129 on were evident in infected pDCs, indicating abortive infection.

130 defense strategy: that both restriction and abortive infections operate during coevolution with phag

131 ing cells have been reported only to exhibit abortive infections with vaccinia virus (VACV).

132 ial sites of infection, potentially limiting abortive infections.

133 identified three transmembrane proteins with abortive infectivity (ABI) domains, elements first descr

134 btained evidence for RNA backtracking during abortive initial transcription and for additional pausin

135 transcription reactions to better understand abortive initiation and promoter escape in vivo.

136 ing-laser excitation, we were able to detect abortive initiation and promoter escape within single im

137 ex at the point where steric clash initiates abortive initiation and sigma(A) dissociation.

138 Abortive initiation assays confirm that ExsA enhances th

139 a transcript is extended to +2 and +3 in an abortive initiation complex.

140 s, and both a downstream shift and increased abortive initiation in reconstituted transcription assay

141 acteristics of in vitro abortive initiation: Abortive initiation increases upon stabilizing interacti

142 ibutions and single-molecule time traces for abortive initiation indicates that, at a consensus promo

143 -molecule DNA nanomanipulation, we show that abortive initiation involves DNA "scrunching"--in which

144 Abortive initiation may be viewed as promoter proofreadi

145 It has not been known whether abortive initiation occurs in vivo.

146 deletion had no effect on promoter binding, abortive initiation or promoter escape, TFIIS-stimulated

147 purification away from excess nucleotide and abortive initiation products so that the purified comple

148 n initiation and elongation; however, longer abortive initiation products were produced in the presen

149 anscribed sequence (ITS) of N25 lengthen the abortive initiation program, resulting in the release of

150 a'omegasigma(70)), we compare productive and abortive initiation rates, short RNA distributions, and

151 In addition, we show that in vivo abortive initiation shows characteristics of in vitro ab

152 emplates, consistent with models attributing abortive initiation to the accumulation of strain in the

153 leading edge and DNA downstream of RNAP upon abortive initiation, and we observe large decreases in d

154 Polymerase structure is permissive for abortive initiation, thereby setting a lower limit on po

155 karyotic RNA polymerase (RNAP) can engage in abortive initiation-the synthesis and release of short (

156 relates with a markedly reduced frequency of abortive initiation.

157 racking and arrest in a process analogous to abortive initiation.

158 initiation shows characteristics of in vitro abortive initiation: Abortive initiation increases upon

159 e of C-terminal positive charges, results in abortive insertion of this transmembrane domain by the S

160 nontemplate strands is a major force driving abortive instability (although collapse from the downstr

161 l enzyme) results in substantially increased abortive instability and is likely the primary energetic

162 The results suggest that abortive instability is a by-product of the mechanistic

163 in RNA polymerases that dramatically reduce abortive instability.

164 mb site-2 (NNI2) lead to the accumulation of abortive intermediates three-five nucleotides in length.

165 lication in most mammalian cells but have an abortive-late phenotype, in that the block to replicatio

166 hat antigen presentation within the liver is abortive, leading to T cell tolerance or apoptosis.

167 e that repairs A5'pp5'DNA ends formed during abortive ligation by classic 3'-OH/5'-PO4 ligases, is al

168 d in repair of A5'pp5'DNA ends formed during abortive ligation by classic ligases, is highly effectiv

169 Abortive ligation during base excision repair (BER) lead

170 onsequence of ligase failure by removing the abortive ligation product, i.e. the 5'-adenylate (5'-AMP

171 in the removal of adenylates that arise from abortive ligation reactions that take place at incised a

172 This could explain why LIG3 is less prone to abortive ligation than LIG1.

173 enerate and/or exacerbate DNA damage through abortive ligation that produces chemically adducted, tox

174 tion of full-size transcripts by suppressing abortive loss of short RNAs.

175 these data suggest a possible role of K8 in abortive lytic DNA replication occurring in early stages

176 express late viral proteins and thus had an abortive lytic form of EBV infection.

177 rly after viral entry but that this burst of abortive lytic gene expression is terminated with the su

178 onsequence of a latent infection rather than abortive lytic infection.

179 results show that the SL mutant induces an "abortive" lytic infection in humanized mice that is comp

180 be considered for future pediatric trials of abortive migraine therapeutics.

181 analyze and compare polyadenylated RNAs from abortive MOCV infections of several cell lines and a hum

182 e expression level of chitinase 1 and caused abortive molting in the insects.

183 Our results indicate that the abortive nature of initial synthesis is caused, at least

184 verting double-strand break repair away from abortive NHEJ and toward homologous recombination.

185 Additionally, POLRMT+TFB2M makes 2-mer abortives on LSP, but longer RNAs are observed only with

186 does not necessarily derive from the use of abortive or newborn animals with ultrathin hides, but co

187 placebo interventions (preventive, PAp, and abortive, PAa, placebo acupuncture; placebo cetirizine p

188 ism of brefeldin A (BFA) that conducts to an abortive pentameric Arf1-Mg(2+)-GDP-BFA-Sec7 complex.

189 patible crosses showed even distributions of abortive phenotypes over time, suggesting that host agei

190 The lifetime distribution of abortive pits calculated from our model agrees well with

191 of Met282 that results from formation of an abortive Pol beta-gapped DNA-dATP complex is consistent

192 /=12 years of age with labor and delivery or abortive pregnancy outcome between 2005 and 2013.

193 some traffic jams that block initiation, and abortive (premature) termination of stalled ribosomes.

194 ver, there is no evidence of an uncoupled or abortive process in the deamination reaction, as indicat

195 bing complexes, with a resulting decrease in abortive product release.

196 the scrunched open complex exhibits reduced abortive product synthesis, suggesting that scrunching a

197 nter forward translocation are fast, whereas abortive-product dissociation and RNAP-active-center rev

198 ribonucleoside triphosphate concentrations, abortive-product release is rate-limiting (i.e., abortiv

199 tive-product release is rate-limiting (i.e., abortive-product synthesis and RNAP-active-center forwar

200 We observe small, but reproducible and abortive-product-length-dependent, decreases in distance

201 eotide RNA but causes accumulation of longer abortive products between 9 and 13 nucleotides.

202 characteristically unstable, yielding short abortive products on the path to elongation.

203 s was observed as reduced production of long abortive products.

204 tive synthesis after undergoing the shortest abortive program.

205 In vitro, CTL-expressed Ag induced an abortive proliferative response in specific B lymphocyte

206 beta7 on naive B cells, which resulted in an abortive proliferative response.

207 tumor Ag in the lymph node and underwent an abortive proliferative response.

208 DNA containing epsilonC lesions, forming an abortive protein-DNA complex; such binding not only shie

209 It provokes abortive recombination and compromises DNA repair in a m

210 ell proliferation, such as DNA repair and/or abortive reentry into the cell cycle, which can occur as

211 ure of injured peripheral axons mimicked the abortive regeneration typically seen after CNS injury.

212 ade after a spinal cord injury results in an abortive regenerative response.

213 may lead to hyper forward translocation and abortive release at VLAT positions.

214 s indicated that a significant proportion of abortive replicases continue RNA synthesis to the end of

215 To determine the impact of abortive replication at different stages of the viral li

216 ellular and viral membranes under normal and abortive replication conditions.

217 viruses, is not likely to be responsible for abortive replication of RSV during reinfection.

218 our knowledge, this is the first evidence of abortive replication of RSV in vivo.

219 release in the lung, but it does not prevent abortive replication of the virus.

220 Their repression results in abortive replication with the accumulation of dense mass

221 RF3 or TV-norovirus chimeric RNA resulted in abortive replication without the production of infectiou

222 l gene expression program with some lytic or abortive replication.

223 esponding to Ag and costimulation undergo an abortive response characterized by impaired clonal expan

224 dually and collectively in productive versus abortive responses, new potential therapeutic targets ca

225 riad of potential signaling pathways linking abortive ribosome synthesis to cell-cycle regulators may

226 These observations and the lack of abortive RNA in initiation from short-lived ribosomal pr

227 ctive RNA synthesis 2-5-fold by altering the abortive RNA pattern, decreasing the abundance of the me

228 The GreB-refractive nature of short abortive RNA production may reflect a minimum length req

229 se inhibition leading to the accumulation of abortive RNA products correlated with the amplification

230 rtive synthesis and increases full-length to abortive RNA ratio relative to full-length (FL) Rpo41.

231 tional changes provide a basis to understand abortive RNA synthesis during early stages of initiation

232 f promoter binding, bending and melting, and abortive RNA synthesis.

233 ly unstable, leading to the release of short abortive RNA transcripts.

234 evels in the presence of GreB, which rescues abortive RNAs (</=15 nucleotides) associated with backtr

235 g the levels of short (2-5 nt) and very long abortive RNAs (16-20 nt).

236 That the very long abortive RNAs are unaffected by GreB suggests that they

237 The different length-distributions of abortive RNAs released from OCs with different lifetimes

238 e of the medium (6-10 nt) to long (11-15 nt) abortive RNAs without changing the levels of short (2-5

239 ed nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatch

240 negative breast cancer cell lines undergo an abortive S phase and apoptotic cell death due to loss of

241 k3 can bypass the arrest and proceed into an abortive S phase followed by apoptosis.

242 s and achieve bipolar attachment, leading to abortive segregation and fragmentation of incompletely r

243 eletion of 1-270 amino acids (DN270) reduces abortive synthesis and increases full-length to abortive

244 The mechanisms of abortive synthesis and promoter escape during initiation

245 ntify a sequence element that modulates both abortive synthesis and the formation of arrested elongat

246 -rich region does not affect the kinetics of abortive synthesis up to the formation of 8-nucleotide R

247 ts after i.v. AML induction, consistent with abortive T cell activation and peripheral tolerance.

248 part by the activity of regulatory T cells, abortive T-cell activation and T-cell anergy.

249 s to a propagation of errors that results in abortive termination of protein synthesis.

250 ch collision with a trailing ribosome causes abortive termination of the stalled ribosome.

251 s, ribosome collisions selectively stimulate abortive termination without fine-tuning of kinetic rate

252 an S-adenosylmethionine (AdoMet)-binary and abortive ternary complex containing 8-hydroxyquinoline,

253 2 s(-1) for the dissociation of ADP from the abortive ternary complex, ERK2.Ets.ADP.

254 in, show perturbations upon formation of the abortive ternary complex, which are qualitatively simila

255 Thus, we define a pathway of abortive Th1 cell development that results in the specia

256 ells and helper-deficient CD8(+) T cells are abortive, these cells can differentiate into effectors a

257 is not exclusively due to a futile cycle of abortive TLS followed by exonucleolytic reversal.

258 Furthermore, the transition from abortive to productive elongation is kinetically limitin

259 ote the transition of RNA polymerase II from abortive to productive elongation.

260 of 6 and 7 nucleotides and a lower ratio of abortive to productive initiation events was observed fo

261 rising independently of DNA replication from abortive top1 activity or oxidative stress.

262 and in mouse post-mitotic neurons following abortive TOP2 activity.

263 engaging the diverse DNA damage triggers of abortive Top2 reactions.

264 phosphodiesterase-2, an enzyme that repairs 'abortive' TOP2-induced DSBs, in individuals with intelle

265 ydrolyzes 5'-tyrosine-DNA adducts that mimic abortive Top2cc.

266 DNA phosphodiesterase-1 protects cells from abortive topoisomerase I (Top1) activity by hydrolyzing

267 DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potentia

268 hydrolyzing 5'-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) cleavage complexes to a

269 ence of topoisomerase poisons, can result in abortive topoisomerase-induced DNA strand breaks.

270 Atoh1 in hair cells is likely caused by the abortive trans-differentiation of supporting cells into

271 re than 5-fold without affecting the rate of abortive transcript stimulation.

272 pe RNAP in promoter-dependent transcription, abortive transcript synthesis, transcript elongation or

273 ncrease in the ability of TFIIB to stimulate abortive transcription ('superstimulation').

274 al to maintain genomic integrity and prevent abortive transcription and translation initiation.

275 The detailed characterizations include abortive transcription assays, RNAP/promoter complex sta

276 y RNA in real time without interference from abortive transcription byproducts.

277 unpolyadenylated transcripts, probably from abortive transcription elongation.

278 nclude that oocyte maturation signals induce abortive transcription events in which FCP-1 may recycle

279 the active center, an increased frequency of abortive transcription in runoff assays, and both a down

280 nerated as byproducts of RNA degradation and abortive transcription initiation.

281 ts in the TFIIB 'linker domain' to stimulate abortive transcription was systematically quantitated us

282 Abortive transcription, the premature release of short t

283 ogram, resulting in the release of very long abortive transcripts (VLATs) 16-19 nucleotides long.

284 ed nucleic acid probes, we directly detected abortive transcripts in bacteria.

285 Abortive transcripts may have functional roles in regula

286 The trailing complex can bind and make abortive transcripts when the leading complex is between

287 or mapping single ends cannot, such as short abortive transcripts, bicistronic messages and overlappi

288 ant in preventing the premature synthesis of abortive transcripts, suggesting its involvement in a ge

289 AP promoter association or the production of abortive transcripts.

290 te the production of very short (< or =5 nt) abortive transcripts.

291 ne and five Ds derivatives generated through abortive transposition events.

292 dministration may have potential as an acute abortive treatment for convulsive seizures in emergency

293 harmacokinetics trial data of drugs used for abortive treatment of migraine submitted to the FDA from

294 l challenge in pediatric trials of drugs for abortive treatment of migraine.

295 vels of incorrectly processed viral ends and abortive two-long-terminal-repeat circles.

296 The round cells were characteristic of an abortive viral infection.

297 y caspase-1-mediated pyroptosis triggered by abortive viral infection.

298 In summary, following an abortive VZV infection, RMs developed an adaptive immune

299 hesus macaques (RMs) with VZV resulted in an abortive VZV infection.

300 e-production state increases, short-lived or abortive waves due to ROS-induced ROS release coexist wi