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1 ved, but their ability to induce invasion is abrogated.
2 , and its pulsatile translocation is largely abrogated.
3 ost-injection; n=3), which was significantly abrogated (2.3+/-0.5%ID/g at 48h post-injection; n=3) wh
4 s in vivo We conclude that it is possible to abrogate a specific co-chaperone function of Hsp90 witho
5 lines in order to identify new mechanisms to abrogate acquired SR as well as new potential therapeuti
6 how that elimination of the ACT-PLA activity abrogates ACT toxicity in macrophages, particularly at t
12 of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse models of oxygen-indu
13 EGFR2 locus using rAAV1-mediated CRISPR/Cas9 abrogates angiogenesis in the mouse models of oxygen-ind
15 matory monocytes and their derivatives would abrogate anti-myeloperoxidase (MPO) antibody-induced NCG
16 of AML cells both in vitro and in vivo, thus abrogating any potential chemoresistance mechanisms invo
17 logical targeting of apelin cognate receptor abrogates apelin- and endothelial-mediated expansion of
22 a mutation in the TR DNA-binding domain that abrogates binding to DNA and leads to complete loss of c
23 ion of the phospho-deficient Pg-mutant S665A abrogated both cAMP-mediated junctional remodeling and i
24 function for a wild-type polyQ tract that is abrogated by a competing longer polyQ mutation in a dise
27 tivation of the neutrophil NADPH oxidase was abrogated by bacterium-derived proteolysis of galectin-3
28 c capacity of Th17 cells to transfer EAU was abrogated by BET inhibitors in an adoptive transfer mode
29 component of FIV that is Kir independent is abrogated by blocking Ca(2+) -sensitive K(+) channels.
32 is chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and by ph
33 villous trophoblasts, and this induction was abrogated by CH223191, an aryl hydrocarbon receptor (AhR
34 dependent on bacterial CDDL expression, and abrogated by cotreatment with the antibiotic ciprofloxac
35 owth promotion and myelin disinhibition were abrogated by CRMP2 inhibition and largely mimicked in WT
44 uced osteoclast resorptive function, effects abrogated by neutralizing anti-IFN-gamma antibodies.
45 ile in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperactiva
46 ation and ATP production, an effect that was abrogated by phosphocreatine-mediated reactivation of th
47 ed BBB disruption and neuroinflammation were abrogated by pretreatment with the rho kinase inhibitor
48 Such infiltration and tumor regression were abrogated by silencing CCL5 in BECN1-defective tumors.
51 dams provoked pregnancy loss, which could be abrogated by the adoptive transfer of IL-10(+/+) NK cell
52 ar localization of P. pastoris MS (PpMS) was abrogated by the deletion of 107 C-terminal amino acids
54 gnostic impact of chemotherapy resistance is abrogated by the implementation of early response-based
58 dered sterile, it is crucial to discover and abrogate causes as best possible, provide reliable and e
59 sults in reduction of mitochondrial mass and abrogates cellular bioenergetics during degeneration of
60 ivated Cl(-) currents, but unexpectedly also abrogates CFTR-mediated Cl(-) secretion and completely a
61 p53-dependent and -independent mechanisms to abrogate checkpoints that prevent conversion of differen
64 ably, silencing of RNA sensors RIG-I or MDA5 abrogated DC maturation, as well as cytokine responses b
65 etic deletion of Nalp3, which encodes NLRP3, abrogated defects in solute transport during acute perit
66 lmethane treatment restored memory deficits, abrogated development of neurological signs, prevented n
69 g 2 (MSH2), a mismatch repair (MMR) protein, abrogated early inflammation-induced epigenetic alterati
70 c mutS chromosomal alleles that specifically abrogate either regulatory pathway or both, we demonstra
72 expression of either the N- or C-lobe of CaM abrogated estrogen-stimulated transcription of the estro
74 nsfer of wild-type or p110delta(D910A) Tregs abrogated exaggerated neutrophil activity, increased neu
76 called "Affimer" that block IgG binding and abrogate FcgammaRIIIa-mediated downstream effector funct
78 hibitor (CD44v6 peptide) targeting of CD44v6 abrogates fibrogenesis in murine models of lung injury.
80 single amino acid substitutions in DAXX that abrogate formation of the complex to explore ATRX-depend
82 involving FAK and mutant EGFR, EGFRvIII, and abrogated gains in secreted proteases, MMP-2 and MMP-9,
83 f function via GATA4 germline mutations that abrogated GATA4 interactions with a coactivator, MED12,
86 am pathways, using small-molecule inhibitors abrogates GNA13-induced TIC phenotypes, rendering cells
87 n of both phoP and Sant_4061 is necessary to abrogate growth of this bacterium in an insect host.
90 H3K9ac at hepcidin-associated chromatin and abrogates hepcidin suppression by erythropoietin, iron d
92 the depletion or inactivation of Akt or Skp2 abrogated Hippo signal deficiency-induced liver tumorige
95 re overload in mice lacking SRC-2 induces an abrogated hypertrophic response and decreases sustained
96 A-mediated HIF2alpha knockdown in BeWo cells abrogated hypoxia-associated decreases in PlGF secretion
99 -AS1, or one IFNG enhancer-associated lncRNA abrogates IFNG expression by memory T cells, indicating
100 grin ligation with an RGD-containing peptide abrogated IL-13-enhanced contraction, with no further ef
103 e that the IL-1 receptor antagonist anakinra abrogates IL-22 production and reduces tumor growth in a
106 intron to express a foreign circRNA sequence abrogates immune activation, and mature human circRNA is
114 ts of radiotherapy and STING agonists can be abrogated in humans by a translational strategy involvin
116 ulation of mTORC1 signaling by DNA damage is abrogated in many cancer cells, thus mTORC1 signaling re
117 ession and prostaglandin E2 release could be abrogated in metastatic breast cancer cells by inhibitio
118 ling is active in mouse ESCs grown in 2i but abrogated in serum by ERK-dependent phosphorylation.
121 tive effect of DNGR-1 deletion is completely abrogated in the absence of bone marrow-derived IL-10.
122 ing INS-1E cells, respectively, and this was abrogated in the presence of an irisin-neutralizing anti
124 ersely, blocking TNFalpha receptor signaling abrogated induction of MCP-1, implicating it in the anti
126 sulting in an impaired thrombopoiesis and an abrogated inositol 1,4,5-triphosphate receptor-dependent
127 Here we identify a mutation in HPV16 E2 that abrogates interaction with ChlR1, and we show that ChlR1
129 viruses encoding full-length NSs completely abrogated intranuclear filament formation in infected ce
131 sely, LKB1-overexpression in LKB1-null cells abrogated invasion, migration and mammosphere-formation.
135 diated phosphorylation sites in beta-catenin abrogated its AJ localization and compromised epithelial
138 on into the growth factor domain of uPA that abrogates its binding to uPAR (Plat(GFDhu/GFDhu)) to inv
139 coccal protease SspB inactivates galectin-3, abrogating its stimulation of oxygen radical production
140 onstrated that depletion of CBL/CBL-B or LNK abrogated JAK2 ubiquitination, extended JAK2 half-life,
141 rmore, deficiency in either NLRP11 or RNF19A abrogates K48-linked ubiquitination and degradation of T
143 increases, whereas targeted DNMT1 depletion abrogates KIT signaling cascade through Sp1/miR-29b netw
144 P deubiquitinates NALP7 and STAMBP knockdown abrogates LPS or Pam3CSK4-induced increases in NALP7 pro
145 ronic pharmacological dynein inhibition also abrogates Mbp mRNA distribution and dramatically decreas
146 ermore, depletion of p115 RhoGEF levels also abrogated MCP1- or BI-induced Rac1-NFATc1-cyclin D1-CDK6
149 T1 inhibition, and MARCKS or LAMC2 knockdown abrogated migration and invasion induced by AKT1 inhibit
153 omerular necrosis and crescent formation and abrogated monocyte, macrophage, and dendritic cell incre
154 ma membrane, increased drug sensitivity, and abrogated MPP1-dependent hematopoietic progenitor cell r
161 h the CSF-1 receptor antagonist PLX5622, and abrogated neuronal-microglial communication in CX3C rece
162 motor coordination, and working memory, and abrogated neutrophil infiltration into the injured brain
164 eptor's activity using a chemical antagonist abrogated not only the alterations in PPARgamma-regulate
165 the phytaspase cleavage sites in prosystemin abrogated not only the phytaspase-mediated processing of
166 epleting Kapalpha.Kapbeta1 by RanGTP further abrogates NPC barrier function, whereas adding back Kapb
167 dicate that R742A as well as D113R mutations abrogate nuclear localization of PpMS and its ability to
168 regulators, and disruption of actin dynamics abrogates nuclear transport, preventing NLS (nuclear loc
175 eraction between C-terminal module and PIF3, abrogates PHYB nuclear accumulation, photobody biogenesi
176 and IPA-3) that act via different mechanisms abrogated PKD1 phosphorylation at Ser(203), 2) siRNA-med
178 ronate (PLN-alen), but not free alendronate, abrogated PLN-induced tumor growth and increased progres
179 ection by blocking viral DNA replication and abrogating postreplicative intermediate and late gene tr
182 ow that overexpression of certain chaperones abrogates protein aggregation and protects a UPR mutant
184 Silencing thioredoxin-interacting protein abrogated reactive oxygen species accumulation in EZH2 s
188 ble, and the consequent ability to precisely abrogate specific MMP activity could contribute to the f
190 nd we identify a specific Zwilch mutant that abrogates Spindly and dynein recruitment in vivo and Spi
191 Silencing of PECAM-1 or key ER stress genes abrogated SS regulation of VCAM-1 transcription and mono
192 that mutation of these OH-interface residues abrogates starvation-induced up-regulation of autophagy
193 SPR/Cas9 nuclease genome editing, display an abrogated stretch-stimulated actin reinforcement respons
196 of GLS1 expression, in the presence of Gln, abrogated TGF-beta1-induced expression of profibrotic ma
198 mplex, a coactivator of transcription, which abrogate the ability to carry out most of these sterol-d
200 We found that one of these inhibitors can abrogate the Aha1-induced ATPase stimulation of Hsp90 wi
201 ogenases prevent nitrotyrosine formation and abrogate the cytotoxicity of RNS against phoQ Salmonella
202 fe seizures influence them, and the means to abrogate the ensuing cognitive problems.SIGNIFICANCE STA
203 rabine, and the ability of ATR inhibition to abrogate the G2 cell cycle checkpoint both contributed t
204 example of a strategy used by adenovirus to abrogate the host DDR and show how viruses can modify ce
205 tivity acquired through a common mutation to abrogate the migration of CD8+ T cells to the tumor.
206 the PTEN-null fibroblasts was sufficient to abrogate the observed increase in colony forming activit
209 hibition of the mechanotransductive pathways abrogated the ability of CAFs to deform the matrix and s
211 ion of anti-NKp46 antibodies to TIL cultures abrogated the ability of these regulatory ILCs to suppre
212 the CT26 model, depletion of CD8(+) T cells abrogated the activity of ADCs when used alone or in com
213 In contrast, depletion of endogenous SF3B1 abrogated the apoptotic effects, but not the G2/M cell c
218 A mixture of bacterial protease inhibitors abrogated the effect of MET-1 effects on DRG neuron rheo
220 Exogenous administration of HX, GSN, or AAT abrogated the effects of IL-1beta and osteoarthritic syn
221 an alpha5beta1 inhibitor into murine airways abrogated the exaggerated bronchoconstriction induced by
222 downregulated most cytokines and proteases, abrogated the formation of pro- but also anti-inflammato
224 in microvascular perfusion in both legs and abrogated the greater glucose uptake in the exercised co
225 ssion of a PP1c cysteine mutant (C127S-PP1c) abrogated the H2S effect on eIF2alpha phosphorylation.
229 oth inhibition of AMPK and IL-1R8 deficiency abrogated the positive effects of IL-37 on exercise perf
234 sion, inhibited individual cell-motility and abrogated the stem-like phenotype of breast cancer cells
236 ated neutralization of galectin-10 partially abrogated the suppressive function of the eosinophils.
238 he wild-type F427 residue, the K33S mutation abrogates the ability of ectopically expressed GPC to me
239 humans, and genetic deletion of the receptor abrogates the ability of GDF15 to decrease food intake a
240 rasitic helminth infection in mice, and also abrogates the ability of mice to regulate brown fat and
241 Importantly, a T239D or F240D substitution abrogates the activity of GSDMD consisting of amino acid
242 ipitation analysis confirmed that clofibrate abrogates the binding of nuclear factor-kappaB to the PT
243 Thus, deletion of CD36 or Nox2 from PVM abrogates the deleterious vascular effects of Abeta, whe
245 ' end of the single guide RNA (sgRNA), which abrogates the function of CRISPR-transcriptional activat
246 in any one of the Ndc80p interaction regions abrogates the Ndc80 complex's ability to bind two Dam1 r
250 racerebroventricular injection of clodronate abrogates the reactive oxygen species production and cer
252 armacological inhibition of the MAPK pathway abrogates the stimulus-dependent recruitment of Integrat
253 ctivation of AMPKalpha2, but not AMPKalpha1, abrogates the tumor attenuation caused by UBE2O loss, wh
254 tiple myeloma PC migration toward CCL3 while abrogating the multiple myeloma PC migratory response to
255 neuroblastoma cells, with the E138K mutation abrogating the neurovirulence and neuroinvasiveness of J
256 ing the quorum sensing (QS) mechanism and so abrogating the virulence of the pathogen Streptococcus p
258 g animals under axenic conditions completely abrogates their abnormal phenotype, even upon high-fat d
259 elopment of tertiary lymphoid structures and abrogates their prognostic value in patients with lung c
261 etter screening and preventive strategies to abrogate these toxic effects and improve patient care.
266 mutations found in multiple myeloma patients abrogate this cytotoxicity, indicating a survival advant
267 ys with human kinesin-5 (Eg5) only partially abrogated this behavior, indicating that Cin8 binds micr
268 th standard of care, eculizumab specifically abrogated this histomolecular rejection phenotype and as
275 in fibroblasts, yet targeted tph1b mutations abrogating this response do not disrupt fin regeneration
279 silencing Hsp70/90 expression in tumor cells abrogates tumor-induced muscle catabolism and wasting in
281 mutation of any component of the T1SS system abrogated type VI secretion activity under nutrient-limi
282 le-like fibriforms, but this association was abrogated upon microtubule-disassembly agents, resulting
284 y, we showed that this cytotoxicity could be abrogated using CME inhibitors or antioxidants, attestin
285 nectin through anion-exchange chromatography abrogated V2-independent gp120-alpha4beta7 binding.
288 ntiacanthamoebal chemotherapy by potentially abrogating virulence-enhancing properties of bacterial e
290 By hardening the wall, the increased pH abrogates wall loosening required for cell expansion and
291 ant mouse model and that this enhancement is abrogated when mAgrin is in molar excess relative to lam
294 ors since LKB1-silencing and AMPK-inhibition abrogated, while LKB1-overexpression and AMPK-activation
296 iectomized female mice, while the effect was abrogated with estradiol supplementation, suggesting tha
297 es late Na(+) current, two effects that were abrogated with NaV1.5 mutants mimicking phosphorylation
299 Xist-dependent Polycomb recruitment, in turn abrogating Xist-mediated gene silencing and reversing Xi
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