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1 tate DNA replication in the context of BRCA2 abrogation.
2 f sim1a cannot be rescued by RA biosynthesis abrogation.
4 on of WDHD1 reduced E7-induced G1 checkpoint abrogation and rereplication, demonstrating a novel func
6 cells were destroyed not by frank G2-M phase abrogation but rather by initiating a cumulative genotox
7 mouse model to an extent just shy of disease abrogation, but this remarkable observation has not been
8 NaPB-treated astroglial supernatants and its abrogation by anti-TrkB blocking antibody suggest that N
11 tochondrial accumulation is indicated by its abrogation by dominant-negative HRES-1/Rab4(S27N) mutati
12 rence only in the presence of plasma and its abrogation by heat inactivation, EDTA, and eculizumab.
14 lls, and notably show that specific microRNA abrogation can disrupt the wild-type cellular phenotype
15 rrb transcript repression, cell-cell contact abrogation, cell survival in suspension, STAT3 phosphory
17 effect was attenuated by shRNA-mediated MUC4 abrogation, further implying that these nicotine-mediate
18 tants and targeted RNA interference-mediated abrogation in Drosophila to uncover molecular pathways a
26 sm of p53 induction, thought to be caused by abrogation of 40S biogenesis and continued 60S biogenesi
28 liver taurine production and associates with abrogation of a growth hormone/insulin-like growth facto
29 physical security of memory devices, prompt abrogation of a memory device which stored a large numbe
31 y inducing expression of IKZF1, resulting in abrogation of adhesion and self-renewal, cell cycle arre
34 Grp78(f/f) murine uteri also corresponded to abrogation of AKT activation within the endometrium.
35 isib-mediated inhibition of PI3Kdelta led to abrogation of Akt phosphorylation in patient CLL cells a
36 ereby negating their use as anti-infectives, abrogation of alkaline signalling has, therefore, been p
37 nd airway T(H)2 cytokine levels and complete abrogation of allergen-induced airway eotaxin-2/CCL24 an
38 ion in primary exocytosis (SG-PM fusion) and abrogation of almost all sequential SG-SG fusion, togeth
41 n (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRN
46 induces the re-expression of E-cadherin via abrogation of autocrine EGFR signaling pathway in prosta
50 the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the
52 lated alpha-DG on muscle fibers and possibly abrogation of binding from molar excess of overexpressed
55 oietic progenitors and its deletion leads to abrogation of both adult and fetal hematopoiesis, target
56 a (AML); they are silenced in human AML, and abrogation of both genes in mice leads to rapid postnata
60 I, BCMA, and BAFF-R expression on CLL cells; abrogation of CD40 expression in MVECs; or suppression o
66 veral recent studies have indicated that the abrogation of checkpoints in tumourigenesis through the
73 ly shown mediates their premature attrition; abrogation of CTLA-4-mediated coinhibition can reduce Bi
75 at KLLN interacts with DBC1, with consequent abrogation of DBC1 inhibition of SUV39H1, a H3K9 methylt
78 elated with transmission efficiency, and the abrogation of direct contact between infected and naive
81 urora kinase-A expression is correlated with abrogation of DNA damage-induced apoptotic response and
86 T(H)2 phenotype HDM model as demonstrated by abrogation of eosinophils and neutrophils in the airways
88 ession and LXA(4) formation, while estradiol abrogation of epithelial wound healing was completely re
89 cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implic
92 generated a Fan1 knockout mouse model, with abrogation of Fan1 expression confirmed by quantitative
94 nal and genital anatomy and also resulted in abrogation of female-specific regulation of these genes.
97 al p53 (ATp53) mutations often result in the abrogation of full-length p53 expression, but concomitan
98 ibition rescued the gamma-H2AX induction and abrogation of G2 phase as induced by Wee1 inhibition in
99 of infiltrating leukocytes was unaltered by abrogation of gal-3, but reduced expression of YM1 (P=0.
101 of type IA p110alpha PI3K and Akt by gem and abrogation of gem-induced upregulation of IL-1Ra by inhi
102 ith a mechanistic rationale based chiefly on abrogation of gemcitabine-induced G2-M checkpoint activa
103 D40L Ab, and CTLA4-Ig is associated with the abrogation of germinal centers and depletion of short-li
112 sitron emission tomography showed a complete abrogation of hepatic binding of labeled Myrcludex B in
113 ing extrinsic stimuli, and they suggest that abrogation of Hmga2 function in the microenvironment can
119 NF-alpha and IL-10, (iv) a reduction but not abrogation of IL-10 and TNF-alpha by Tat-stimulated macr
120 sular macrophages (SCMsmall ef, Cyrillic) or abrogation of IL-18 signaling dramatically impairs the A
122 ode Schistosoma mansoni Here, we report that abrogation of IL-4 receptor alpha (IL-4Ralpha) signaling
125 ha-synuclein and ubiquitinated proteins, and abrogation of inflammatory responses and neuronal loss w
126 ved in the double-layer infection model, and abrogation of iNOS expression prevented the C. sakazakii
127 solated from betaGlud1(-/-) mice resulted in abrogation of insulin release evoked by glutamine combin
128 Knockdown of Axl expression resulted in abrogation of invasive and transendothelial migratory ab
130 murine models, we found that the conditional abrogation of IRE1alpha in bone marrow cells increases b
132 hways in a replication-dependent manner, and abrogation of IRF-3 function enhanced virus-mediated inj
133 hways in a replication-dependent manner, and abrogation of IRF-3 function enhanced virus-mediated inj
136 rway epithelium differentiation and that the abrogation of its function contributes to lung carcinoge
140 of PRMT5-mediated KLF4 methylation leads to abrogation of KLF4 accumulation, which, in turn, attenua
142 ts in the cleavage of the signal peptide and abrogation of leukotoxin-induced cytolysis of target cel
144 hat has been delineated in this study is the abrogation of lytic activity of lysozyme by a novel glyc
145 graft dysfunction and structural damage with abrogation of macrophage and dendritic cell infiltration
147 lactosamine (GalNAc) salvage pathway induced abrogation of MAL-II and PNA epitopes in Jurkat cells.
148 and sensitization to tamoxifen, resulting in abrogation of mammary tumor growth and progression.
149 /NO and VISTA caused additive or synergistic abrogation of MDSC-mediated suppression of B-cell respon
151 romerization in vivo, leading to a selective abrogation of memory impairments caused by exposure to T
153 vitro and in vivo We found that concomitant abrogation of metallothioneins 1 and 2 results in activa
156 ver, PIM-1 overexpression led to significant abrogation of miR33b- or MLN2238-induced cell death.
157 e cell periphery and ROS production, whereas abrogation of MLCK using specific siRNA significantly in
159 CD154(-/-) H-2(d) strains, and by selective abrogation of MPER restimulated, H-2(d)-restricted prime
160 nhibitor and rapamycin uniformly resulted in abrogation of mTOR inhibition-induced AKT activation in
162 Here, we demonstrate the rapid and potent abrogation of MYC gene transcription by representative s
163 f STAT6 to the TGF-beta promoter by NaB, and abrogation of NaB-induced expression of TGF-beta in sple
168 icularly, in the isolated mouse spinal cord, abrogation of neurotransmission derived by both V1 and V
170 responses, are particularly relevant to the abrogation of new relapsing disease activity observed in
173 creas and that overexpression may lead to an abrogation of normal cytokinesis, indicating that it sho
174 ke ligands Dll1 and Dll3 and NOTCH activity; abrogation of NOTCH activity restored LDN-enhanced myelo
181 ty of A2B5-defined glioma TPCs; as such, the abrogation of PAR1-dependent signaling pathways may prov
183 IFN-gamma expression concomitantly with the abrogation of PD-L1 expression in CMFs under homeostasis
184 ety of imatinib and test the hypothesis that abrogation of PDGFRA signaling can ameliorate the manife
186 MUNE are responsive to SMN restoration, and abrogation of phenotype can be achieved even after sympt
188 ion of both EGFR and PDGFR was necessary for abrogation of PI3 kinase pathway activity in the mixed p
193 and leading to more efficient DNA repair and abrogation of programmed cell death under salinity and g
195 naling molecules to lipid rafts, followed by abrogation of protein tyrosine phosphorylation of ZAP70,
196 of T cell proliferation was associated with abrogation of proximal TCR signaling by inhibiting recru
197 ering SHH signaling and eye development upon abrogation of ptch1 in zebrafish for which in vivo compl
203 ng titers compared with palivizumab, whereas abrogation of receptor binding led to a drastic reductio
205 ut conditions, and nonagreement as a greater abrogation of responsibility when that decision was made
211 t and might favor JCV brain invasion through abrogation of sialic acid binding with peripheral cells,
212 inhibition of lymphocyte activation through abrogation of signal 3-cytokine transduction emerges as
215 ting motif for TMEM106B and demonstrate that abrogation of sorting to lysosomes rescues TMEM106B-indu
216 nserved upstream region of the OPN gene, and abrogation of Sox9 in HSCs significantly decreased OPN p
220 ncluding elevated osmoticum, suggesting that abrogation of stomatal function reflects a mechanical ch
221 idues caused the loss of protein solubility, abrogation of substrate binding, increased cell death, a
230 lls lacking C/EBPbeta showed nearly complete abrogation of TDB/TDM responsiveness, but also failed to
231 ody blocking this cytokine resulted from the abrogation of Teff suppression; however, T1D-derived iNK
232 aring low-affinity T cell receptors, and the abrogation of TGF-beta receptor expression led to failed
233 cer to evaluate the effect of cell-intrinsic abrogation of TGF-beta signaling in self/tumor-specific
235 tumor formation and progression by targeted abrogation of TGF-beta1 expression in metastatic cells i
239 /fl) B6-transplanted recipients and observed abrogation of the deleterious effect of a HSD in the abs
240 e that had already experienced EAE symptoms, abrogation of the disease in 90% of the animals was appa
241 The tolerant state was associated with (1) abrogation of the donor-specific antibody response, (2)
242 -251) and CRE (-308) sites led to a complete abrogation of the effect of TX on GLT-1 promoter activit
243 nhibitors, E64d plus pepstatin A, results in abrogation of the ES-62-mediated suppression of LPS-driv
245 enome repair machinery, with nearly complete abrogation of the hypomutation phenomenon in individual
247 adjuvanticity is ascertained by significant abrogation of the immunity after systemic depletion of p
251 257-mediated inhibition of Mps-1 resulted in abrogation of the mitotic checkpoint, premature progress
253 inase-dependent mechanism); and (v) complete abrogation of the normal pro-apoptotic effect of dexamet
254 Treatment with anti-IFN-gamma led to an abrogation of the NP-specific IgG2c Ab induced by P. cha
256 ervations provide a possible explanation for abrogation of the p53-mediated apoptotic pathway in mela
257 , in complementary loss of function studies, abrogation of the PAR2-Gq-calcium signaling arm failed t
261 e, disrupting cell polarity through combined abrogation of the polarity protein Pard6gammab and Lamin
262 have recently demonstrated a p53-independent abrogation of the postmitotic checkpoint by HPV E6 that
265 d by genomic instability, TP53 mutation, and abrogation of the TP53-mediated senescence program.
266 the prospective forebrain and combinatorial abrogation of their activity results in incomplete segre
270 ated to the kinetics of MPR upregulation and abrogation of this event abolished the combined effect o
273 pendent group 2 ILC (ILC2) response and that abrogation of this response impairs re-epithelialization
276 -alpha by inflammatory granulocytes leads to abrogation of tolerance at the FMI and fetal rejection.
278 gic inhibition of KDM1A resulted in complete abrogation of tumor growth in an AML xenograft model har
279 est possible novel molecular targets for the abrogation of tumor microenvironment immunosuppression.
286 Taken together, our results suggest that abrogation of viral mRNA cap methylation can serve as an
289 l after DNA damage relies on DNA repair, the abrogation of which causes genomic instability and devel
293 rocess of spreading through the species, and abrogation or modification of Rec8 function is possibly
294 we termed "p53 potentiation with checkpoint abrogation" (PPCA)] displayed therapeutic benefits in pr
295 d increased functional CXCR4 protein and its abrogation reduced epidermal growth factor receptor (EGF
297 er cells from the apoptotic effects of HSP90 abrogation, restoring blood vessel formation in two prec
298 6 played a role in E7-mediated G1 checkpoint abrogation under hypoxic condition, and the function cou
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