ライフサイエンスコーパス: abscission

1 encystment of the germline in promoting GSC abscission.

2 tmitotic genome surveillance and cytokinetic abscission.

3 g, nuclear envelope closure, and cytokinetic abscission.

4 actin coordination are necessary for proper abscission.

5 growth by way of salt ion dilution and organ abscission.

6 naling system known to regulate floral organ abscission.

7 ing relative to Tsg101 and CHMP4B upon virus abscission.

8 ole for ESCRT-II and CHMP6 in ESCRT-mediated abscission.

9 al development, senescence, and floral organ abscission.

10 anonical ESCRT players ESCRT-II and CHMP6 in abscission.

11 of membrane tension as a mechanism to drive abscission.

12 rog2, determine cilium disassembly and final abscission.

13 cting the two daughters immediately prior to abscission.

14 mation, which appeared to be responsible for abscission.

15 to the acquisition of DT, longevity, and pod abscission.

16 mbrane and the midbody microtubules prior to abscission.

17 y distinct RhoGEF required for completion of abscission.

18 plants withdraw nutrients from leaves before abscission.

19 ects the speed of both furrow ingression and abscission.

20 CEP55-Alix and CEP55-Tsg101 complexes during abscission.

21 ude fruit formation, expansion, ripening and abscission.

22 -3-3 but not ARF6 frequently collapse before abscission.

23 cell separation step of cell division called abscission.

24 rchestrates the biochemical preparations for abscission.

25 ehind the forming package, and apparent self-abscission.

26 ational model for ESCRT-mediated cytokinetic abscission.

27 cessing and remodeling of ESCRT filaments in abscission.

28 egulator required for the completion of cell abscission.

29 e for these proteins in cytokinetic membrane abscission.

30 itotic time because of delayed and/or failed abscission.

31 lei being kept apart, furrow ingression, and abscission.

32 cell separation process that leads to organ abscission.

33 ing to dissect the behavior of ESCRTs during abscission.

34 icking regulator that is essential for organ abscission.

35 roles in retroviral budding and cytokinetic abscission.

36 ss of cell adhesion that occurs during organ abscission.

37 can Cep55 target to the midbody and promote abscission.

38 Aurora B and an Aurora B-dependent delay in abscission.

39 ganelles may be responsible for the block in abscission.

40 nt human ESCRT-III (CHMP) proteins inhibited abscission.

41 back together, and to contribute to midbody abscission.

42 R might regulate membrane trafficking during abscission.

43 HED (EVR), that functions as an inhibitor of abscission.

44 ASE1 (SERK1) acts as a negative regulator of abscission.

45 to the anaphase spindle and fails to support abscission.

46 ses anaphase DNA bridge formation and failed abscission.

47 CHMP1 proteins blocked VPS4 recruitment and abscission.

48 onal membranes during furrow progression and abscission.

49 e passenger complex and factors that control abscission.

50 ng AtZFP2 exhibited asynchronous and delayed abscission.

51 as initiated but cells failed to progress to abscission.

52 mechanism explaining drought-triggered leaf abscission.

53 anistic role of water and turgor pressure in abscission.

54 equency of cytokinetic failure and a delayed abscission.

55 s maturation of the intercellular bridge and abscission.

56 eration of the ultimate step of cytokinesis, abscission.

57 5 are all necessary for drought-induced leaf abscission.

58 nserved in regulating drought-triggered leaf abscission.

59 ll events necessary for membrane budding and abscission.

60 on between daughter cells during cytokinetic abscission.

61 ve months elapse from fertilization to fruit abscission.

62 te a MAP kinase cascade that is required for abscission.

63 signaling pathway that controls floral organ abscission.

64 of potential models for ESCRT-mediated virus abscission.

65 and IST1, an ESCRT-III subunit required for abscission.

66 ically expressing INFLORESCENCE DEFICIENT IN ABSCISSION, a predicted signaling ligand for the HAESA/H

67 Later, during septation and abscission, a second GEF-independent mechanism contribut

68 Apical abscission also dismantles the primary cilium, known to

69 Checkpoint failure leads to incomplete abscission and a binucleate outcome.

70 ying defects in mitotic spindles and also in abscission and cell survival.

71 orphisms in this region associated with leaf abscission and cellulose content are suggested to repres

72 and other proteins come together to prevent abscission and form stable intercellular bridges.

73 hese results delineate distinct steps during abscission and highlight the central role of the midbody

74 ation of internal biological (leaf-flush and abscission and increased Pc) and environmental (incoming

75 Knockdown of WDR5 impairs abscission and increases the incidence of multinucleated

76 ble to defects in chromosome segregation and abscission and is independent of the effector kinase OSR

77 ted ovary patterning as well as floral organ abscission and lateral organ lamina outgrowth.

78 Floral organ abscission and lateral root emergence are both accompani

79 required for ALIX to function in cytokinetic abscission and retroviral budding, but not in multivesic

80 must be disassembled to allow for the final abscission and separation of the daughter cells.

81 y of riparian vegetation, the timing of leaf abscission and the establishment of invasive riparian sp

82 on, as well as leaf and petal senescence and abscission and, hence, plays a role in virtually every p

83 the midbody in SCCRO-deficient cells during abscission, and its inactivation resulted in phenotypic

84 ssing plants displayed abnormal floral organ abscission, and produced leaves, sepals and petals with

85 arrives at the intercellular bridge, blocks abscission, and subsequently leads to cell death.

86 enabled us to uncover new genes involved in abscission, and their possible contribution to the proce

87 esses including multivesicular body sorting, abscission, and viral budding.

88 ptor KLHL21 mediates the effects of SCCRO on abscission, as it fails to localize to the midbody in SC

89 ne can promote flowering, fruit ripening and abscission, as well as leaf and petal senescence and abs

90 multinucleation, multipolar mitoses, failed abscission, asymmetric segregation of daughter nuclei, f

91 re redundant in function during floral organ abscission, but during lateral root emergence they are d

92 s postmitotic process and delays cytokinetic abscission by keeping the abscission checkpoint active.

93 which EVR modulates the timing and region of abscission by promoting the internalization of other rec

94 The midbody mediates abscission by recruiting many factors, including the Kin

95 ponent and Aurora B substrate CHMP4C enables abscission, bypassing the PKCvarepsilon-Aurora B exit pa

96 delays cytokinetic abscission by keeping the abscission checkpoint active.

97 epsilon signals through Aurora B to exit the abscission checkpoint and complete cell division.

98 an essential signal required to sustain the abscission checkpoint and that ULK3 and CHMP4C are funct

99 on directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at S22

100 The 'NoCut', or Aurora B abscission checkpoint can be activated if DNA is retaine

101 s in the proposed mechanistic pathway of the abscission checkpoint concern factors involved in (1) re

102 This switch is essential for abscission checkpoint exit.

103 The abscission checkpoint in mammalian cells stabilizes the

104 the spindle midzone, which is needed for the abscission checkpoint in other systems.

105 omosome bridges, a phenotype associated with abscission checkpoint signaling failure.

106 he cytokinetic bridge and implicates ALIX in abscission checkpoint signaling.

107 its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chrom

108 New work identifies components of the abscission checkpoint that prevent premature severing of

109 CHMP4C functioned in the Aurora B-dependent abscission checkpoint to prevent both premature resoluti

110 This process is regulated by the abscission checkpoint, a genome protection mechanism tha

111 the cell cycle activate an Aurora B-mediated abscission checkpoint, thereby ensuring that daughter ce

112 response to chromosome bridges via the NoCut abscission checkpoint.

113 nesis timing and plays a central role in the abscission checkpoint.

114 by coordinating midbody resolution with the abscission checkpoint.

115 Abscission completes cytokinesis to form the two daughte

116 Although abscission could be organized from the inside out by the

117 s that require high wind velocities for seed abscission could experience threshold-like reductions in

118 p27(CK-) expression caused a cytokinesis and abscission defect in mouse embryonic fibroblasts.

119 (MPK6) in a mpk3 mutant background all have abscission-defective phenotypes.

120 Disruption of CST suppresses the abscission defects of nev mutant flowers and restores th

121 Abscission defects were accompanied by altered floral mo

122 Further investigation revealed that the abscission delay is primarily due to slower formation of

123 Correction of abscission delays in SCCRO-deficient cells with addition

124 Before the final step of cytokinesis, termed abscission, dividing cells need to ensure that the cleav

125 Interestingly, the disruption of abscission does not appear to result in binucleate cells

126 In mammalian cells, efficient abscission during cytokinesis requires proper function o

127 for multivesicular body biogenesis, membrane abscission during cytokinesis, and retroviral budding.

128 esses including multivesicular body sorting, abscission during cytokinesis, budding of enveloped viru

129 In addition to its role in membrane abscission during cytokinesis, viral budding, endosomal

130 ation, enveloped virus budding, and membrane abscission during cytokinesis.

131 ESCRT pathway and is required for efficient abscission during HeLa cell cytokinesis.

132 siRNA strategies reduced cell retraction and abscission during late-stage cytokinesis, causing multin

133 unction disassembly and acto-myosin-mediated abscission, during which the centrosome is retained whil

134 erval between cleavage furrow ingression and abscission, during which the midbody microtubule bundle

135 sure model (IP-CELC) was used to investigate abscission effects on seed dispersal kernels and plant p

136 h as benzyladenine and metamitron, acting as abscission enhancers.

137 its the midbody ring (MR) upon completion of abscission even in apparently symmetrically dividing cel

138 lates both spatially and temporally with the abscission event suggests a direct role for these protei

139 defect in late cytokinesis, just before the abscission event.

140 aspects from topologically related cellular abscission events.

141 During this period, Plk1 phosphorylates the abscission factor Cep55 in trans and prevents its untime

142 negatively regulates Cep55 to ensure orderly abscission factor recruitment and ensures that this occu

143 In this study, we show how abscission factor recruitment is controlled by the Polo-

144 r bridge but almost completely abolishes the abscission failure phenotype.

145 ing the phosphorylation of Borealin leads to abscission failure, as does expression of a non-phosphor

146 tent with destabilization of the midbody and abscission failure.

147 exhibited midbody formation consistent with abscission failure.

148 Moreover, studies of abscission frequently involve the examination of events

149 ess-related developmental processes, such as abscission, fruit ripening, and senescence.

150 activity in vitro, but the role of ESCRTs in abscission has been undefined.

151 owever, how ESCRT-III is activated to set on abscission has not been resolved.

152 bscission mutants inflorescence deficient in abscission (ida) and blade-on-petiole1 (bop1)/bop2 and a

153 f HAESA (HAE) and INFLORESCENCE DEFICIENT IN ABSCISSION (IDA) is induced in cauline leaf abscission z

154 organ separation, INFLORESCENCE DEFICIENT IN ABSCISSION (IDA), suggesting that signalling through IDA

155 tion mutations in Inflorescence Deficient in Abscission (IDA), which encodes a predicted secreted sma

156 ed by the peptide INFLORESCENCE DEFICIENT IN ABSCISSION (IDA), which signals through the leucine-rich

157 hich involves the INFLORESCENCE DEFICIENT IN ABSCISSION (IDA)-derived peptide and its receptors, HAES

158 acetic acid (IAA) in regulating floral organ abscission in Arabidopsis (Arabidopsis thaliana).

159 Furthermore, the ability to study leaf abscission in Arabidopsis opens up a new avenue to tease

160 e the steps required for the first embryonic abscission in Caenorhabditis elegans Our findings indica

161 n immunodeficiency virus 1, and for membrane abscission in cytokinesis.

162 n contrast, cytokinesis is arrested prior to abscission in differentiating male germ cells that are i

163 Mutations in SERK1 dominantly rescue abscission in flowers without functional NEVERSHED (NEV)

164 e evolution and ovary senescence and pedicel abscission in fruits that were not pollinated under cont

165 in early dry season, and is followed by net abscission in late dry season that coincides with increa

166 linked components of the timer that controls abscission in multiple physiological situations.

167 port a key role for IAA in the regulation of abscission in planta and reveal, to our knowledge for th

168 required for proper midbody organization and abscission in polarized cortical stem cells and has a cr

169 B and the ESCRT-III subunit CHMP4C to delay abscission in response to chromosome missegregation.

170 via tandem MIT domains, and thereby, delays abscission in response to lagging chromosomes, nuclear p

171 reveals greatly delayed fission kinetics in abscission in which a population of cells with persisten

172 int that delays progression from anaphase to abscission in yeast was activated by both UFBs and chrom

173 The results confirm that nonrandom seed abscission increased dispersal distances, particularly f

174 o physical feedbacks: (i) although nonrandom abscission increased the initial acceleration of seeds f

175 nd speed increased; and (ii) while nonrandom abscission increased the mean dispersal length, it reduc

176 of ethylene during the very early stages of abscission induction was investigated in fruitlet popula

177 tification of isoprene as an early marker of abscission induction.

178 contrast, Boi2 is specifically required for abscission inhibition in cells with chromatin bridges.

179 abscission, is necessary and sufficient for abscission inhibition.

180 at sites of polarized growth, and acts as an abscission inhibitor during cytokinesis in response to c

181 The effects of SCCRO on abscission involve its role in neddylation and localizat

182 Drought-triggered abscission is a strategy used by plants to avoid the ful

183 egulating developmentally timed floral organ abscission is conserved in regulating drought-triggered

184 Floral abscission is controlled by the leucine-rich repeat rece

185 of ESCRT function in C. elegans, cytokinetic abscission is delayed but can be completed, suggesting t

186 We propose that cytokinetic abscission is driven by an ESCRT-III fission complex, wh

187 e specific molecular changes associated with abscission is hampered by contamination from neighboring

188 f any, during cleavage-furrow ingression and abscission is poorly understood.

189 Abscission is the consequence of a specialized layer of

190 Abscission is the final step of cytokinesis and results

191 Abscission is the process by which plants shed unwanted

192 SCRT machinery necessary for mediating viral abscission is unclear.

193 Cell separation, or abscission, is a highly specialized process in plants th

194 r bud growth and targets Boi2 to the site of abscission, is necessary and sufficient for abscission i

195 sumed that midbody microtubules scaffold the abscission machinery.

196 d cleavage furrow and guides the assembly of abscission machinery.

197 h an extremely relevant phenomenon, fruitlet abscission, may occur as a response to both endogenous a

198 ells occurs via an actomyosin-based membrane abscission mechanism that is regulated by nucleotide cyc

199 surface wind environment, independent of the abscission mechanism.

200 Genetic analyses of abscission mutants have defined ethylene-independent det

201 ed further by crossing reporter lines to the abscission mutants inflorescence deficient in abscission

202 We show that abscission occurs in two stages.

203 ruited to the narrow constriction site where abscission occurs.

204 Plant cell signaling triggers the abscission of entire organs, such as fruit, leaves and f

205 mber of the genetic components that regulate abscission of floral organs, including a pair of related

206 d that binucleated cells arise by incomplete abscission of progeny cells followed by fusion.

207 ion of multinucleated cells caused by failed abscission of the cleavage furrow after telophase.

208 lymerization and remodeling, participates in abscission of the intercellular membrane bridge connecti

209 step of cell division, usually ends with the abscission of the two daughter cells.

210 s suggest that SEPT9 plays multiple roles in abscission, one of which is regulated by the action of C

211 or SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of

212 he absence of chromatin and that it promotes abscission, perhaps by facilitating midbody microtubule

213 e midbody and that MITD1 participates in the abscission phase of cytokinesis.

214 membrane fusion event that occurs during the abscission phase of cytokinesis.

215 eased expression of HAE as well as a delayed abscission phenotype.

216 els supporting the fruitlets with the lowest abscission potential (central fruitlet), indicating that

217 RECEPTOR-LIKE KINASE1, act as inhibitors of abscission, potentially by modulating HAE/HSL2 activity.

218 gated in fruitlet populations with different abscission potentials due either to the natural correlat

219 In this study, different abscission potentials were obtained within the apple fru

220 plex drives membrane fission, completing the abscission process.

221 ate in the leaf abscission zones through the abscission process.

222 the peptide IDL1, a signal known to regulate abscission processes via the receptor kinases HAESA and

223 ncrease in HAE) observed in flowers when the abscission program is initiated.

224 tructures at the intercellular bridge during abscission progression.

225 The midbody directs the final membrane abscission reaction and has been proposed to attach the

226 Transcriptomic evidence indicated that abscission-related ABA is biologically active, and its i

227 Seven novel abscission-related genes were identified, four of which

228 d to probe a microarray, and a population of abscission-related transcripts was studied in detail.

229 Apple (Malus domestica) fruitlet abscission represents an interesting model system to stu

230 Control of abscission requires Eph kinase activity, and Src and cit

231 Abscission requires membrane traffic and microtubule dis

232 nner to bring about secondary ingression and abscission, respectively.

233 n cytokinesis, with a delay in daughter cell abscission revealed by a fluorescence-bleaching assay.

234 ar development, programmed cell death, organ abscission, senescence, and plant responses to their bio

235 Abscission shares several features with cell polarizatio

236 n contrast, quantitative analysis of midbody abscission showed inheritance of the midbody remnant by

237 is gaseous hormone and the generation of the abscission signal within the fruit.

238 aturation to date and may help elucidate how abscission sites are positioned and regulated.

239 ns-anillin and RhoA-localized to presumptive abscission sites in mature midbodies, where they may reg

240 mutants, hws loses its delayed floral organ abscission ("skirt") phenotype, suggesting epistasis.

241 abidopsis thaliana) where the promoter of an abscission-specific polygalacturonase gene (At2g41850/AR

242 ous membrane fission events required for the abscission stage of cytokinesis and for a series of "rev

243 s during multivesicular body biogenesis, the abscission stage of cytokinesis, and enveloped virus bud

244 ntralumenal endosomal vesicle formation, the abscission stage of cytokinesis, and enveloped virus bud

245 rovesicles, enveloped virus budding, and the abscission stage of cytokinesis.

246 ate Orc6 is necessary during mitosis for the abscission stage of cytokinesis.

247 membrane of infected cells; and the membrane abscission step in cytokinesis.

248 The ESCRT pathway helps mediate the final abscission step of cytokinesis in mammals and archaea.

249 avenue to tease apart mechanisms involved in abscission that have been difficult to separate from flo

250 membrane-remodeling and fission event termed abscission that occurs after chromosome segregation, cle

251 ed proplatelets in vitro to undergo repeated abscissions that yield circulating platelets.

252 ated as the driving force for mammalian cell abscission, that is, fission of the intercellular membra

253 The final stage of cytokinesis is abscission, the cutting of the narrow membrane bridge co

254 During cytokinetic abscission, the endosomal sorting complex required for t

255 (ESCRT) proteins have a critical function in abscission, the final separation of the daughter cells d

256 Cytokinetic abscission, the final stage of cell division where the t

257 a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the

258 evolutionarily conserved role in cytokinetic abscission, the final step of cell division where daught

259 In somatic cells, abscission, the physical separation of daughter cells at

260 r proliferation and then at midbodies during abscission, thereby helping ensure the ordered progressi

261 lls links postmitotic genome surveillance to abscission timing and that Chk1 integrates this and othe

262 ), a human ESCRT-III subunit, is involved in abscission timing.

263 tering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular

264 soidal blood vessels, which undergo repeated abscissions to yield circulating PLTs.

265 ent in the abscission checkpoint that delays abscission until chromatin is cleared from the intercell

266 ch suggested a model whereby CHMP4C inhibits abscission upon phosphorylation by Aurora B.

267 Nonrandom abscission was investigated using models of three seed r

268 ew genes are known to be essential for organ abscission, we conducted a screen for mutations that alt

269 es proper chromosome segregation by delaying abscission when chromatin is trapped between dividing ce

270 ivision, particularly during cytokinesis and abscission, when 2 daughter cells partition through coor

271 SCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a componen

272 midbody formation consistent with successful abscission, whereas those from 3 day-old cardiomyocytes

273 final step of cytokinesis in animal cells is abscission, which is a process leading to the physical s

274 cipal function being to localize the site of abscission, which physically separates two daughter cell

275 tive imaging of ESCRT-III during cytokinetic abscission with biophysical properties of ESCRT-III comp

276 follow apical mitoses of NSCs; coordinating abscission with delamination from the apical membrane; t

277 coordinates the activity of ESCRT-III during abscission with earlier events in the final stages of ce

278 ctivity specifically within the floral organ abscission zone (AZ).

279 nfirmed the expression of these genes in the abscission zone and revealed other places of expression

280 d location of the trans-Golgi network in nev abscission zone cells are rescued by a mutation in EVR,

281 a variety of cell types, such as trichomes, abscission zone cells, peripheral root cap cells, and xy

282 HAESA-LIKE2, may be deregulated in nev serk1 abscission zone cells.

283 ata permitted a detailed characterization of abscission zone development and the identification of ke

284 , auxin, and cell wall-remodeling enzymes in abscission zone formation.

285 llow deposition of lignin that initiates the abscission zone in the seed-pedicel junction.

286 transcriptionally up-regulated in the floral abscission zone just before cell separation.

287 It is unknown how expression of IDA in the abscission zone leads to HAESA activation.

288 tingly, transmission electron micrographs of abscission zone regions from wild-type and nev flowers r

289 The other mutation eliminated the flower abscission zone, providing "jointless" fruit stems that

290 leading to the downstream activation of the abscission zone.

291 n detachment requires cell separation within abscission zones (AZs).

292 They are found in heartwood, sapwood, and in abscission zones and can be induced by various stresses,

293 We have also found that the abscission zones of nev serk1 flowers are enlarged compa

294 and HAE continues to accumulate in the leaf abscission zones through the abscission process.

295 ABSCISSION (IDA) is induced in cauline leaf abscission zones when the leaves become wilted in respon

296 After organ shedding, enlarged abscission zones with obscured boundaries are found in n

297 xtension or remodeling, such as young stems, abscission zones, or developing vasculature, showing goo

298 adventitious rooting in hypocotyls, and leaf abscission zones.

299 e identity of the trans-Golgi network in nev abscission zones.

300 s prematurely, nev evr flowers show enlarged abscission zones.