ライフサイエンスコーパス: absolute configuration

1 nal stereofidelity and with net retention of absolute configuration.

2 total synthesis, which also established its absolute configuration.

3 tion which enables an accurate assignment of absolute configuration.

4 alkyltin nucleophile, and with retention of absolute configuration.

5 sing the sulfinyl group with the appropriate absolute configuration.

6 e of 5 solidified its (3R,6S,7R,10S,11R,14R) absolute configuration.

7 lic ring systems having defined relative and absolute configuration.

8 the natural products and establishing their absolute configuration.

9 lpha/beta-peptides the beta(3)-residue has S absolute configuration.

10 alkylation selectivity independent of their absolute configuration.

11 ermitted unequivocal assignment of its 2R,3S absolute configuration.

12 ymes may be differentially affected by their absolute configuration.

13 ntum-chemical ECD calculations to assign the absolute configuration.

14 ichroism (ECD) spectra for the corresponding absolute configuration.

15 c separation and aid in the determination of absolute configuration.

16 rrelation allows for the assignment of their absolute configuration.

17 s also established the previously unassigned absolute configuration.

18 viding their chiral pyrrolines with opposite absolute configurations.

19 nd (iii) two rhamnose residues with opposite absolute configurations.

20 yclic cores in enantiopure form with correct absolute configurations.

21 to the CHDA-Gly unit with either of the two absolute configurations.

22 o using the transition rates between various absolute configurations.

23 e use of ECD spectral correlations to assign absolute configurations.

24 Its absolute configuration (3R,5S,6S,7R,11S,14R) is enantiom

25 The absolute configuration (AC) of 2 has been determined by

26 [Graph: see text] In principle, the absolute configuration (AC) of a chiral molecule can be

27 y functional theory (TDDFT) to determine the absolute configuration (AC) of cryptophane derivatives.

28 We report the determination of the absolute configuration (AC) of the new iridoid, prismato

29 has revolutionized the determination of the absolute configurations (ACs) of chiral molecules using

30 The absolute configurations (ACs) of the iridoid natural pro

31 s not possible to unambiguously assign their absolute configurations, although given the absolute (2S

32 In an attempt to rationalize this switch in absolute configuration an investigation of the ambiguous

33 re or si face to solvent, respectively; (2) absolute configuration analysis using vibrational circul

34 of numerous possibilities for assigning the absolute configuration and a predominant conformation.

35 trisubstituted olefins with control of both absolute configuration and alkene geometry.

36 A correlation between the absolute configuration and chiroptical properties of non

37 iral spectra are useful for determination of absolute configuration and conformation of chiral molecu

38 can be used for in situ ICD analysis of the absolute configuration and ee of a wide range of amines.

39 t can be used for in situ CD analysis of the absolute configuration and ee of cyclic and acyclic subs

40 stereodynamic probe for determination of the absolute configuration and enantiomeric composition of c

41 ften provides accurate information about the absolute configuration and enantiomeric composition of t

42 conventional methods for the analysis of the absolute configuration and enantiopurity.

43 sity functional theoretical predictions, the absolute configuration and predominant conformations of

44 od allows for simultaneously determining the absolute configuration and quantity of stereoisomers of

45 ate salts is described, and determination of absolute configuration and racemization barrier is also

46 rates, were used to assess the impact of the absolute configuration and the stereospecific hydrogen b

47 ed the first unambiguous confirmation of its absolute configuration and therefore that of natural (-)

48 lysis, leading to reassignment/assignment of absolute configurations and characterization of a remark

49 troscopy have been utilized to determine the absolute configurations and geometries of two Frater-See

50 quinone antibiotic, the determination of its absolute configuration, and the biological evaluation of

51 e]-1,1'-diol (VANOL) are used to confirm its absolute configuration as (+)(589)-(aR) or (-)(589)-(aS)

52 Its structure including absolute configuration as 8R,9R,10S,13S was established

53 e stereocenters, SynOxC, results in the same absolute configuration as for SynOxA.

54 chiral chemistry, including determination of absolute configuration, as well as in influencing the un

55 b and 12a/12b were separated by HPLC and the absolute configuration assigned by VCD technique in comb

56 However, there exist conflicting absolute configuration assignments arising from electron

57 cts leading to the first total syntheses and absolute configuration assignments of the aglain natural

58 previously reported asymmetric syntheses and absolute configuration assignments of the aglains (+)-po

59 ese new insights provide a fresh look at the absolute configuration assignments of the dSp diastereom

60 cin aglycone, proceeds with the inversion of absolute configuration at C(5) stereogenic center.

61 E, and F confirmed their gross structure and absolute configuration at C7, 8, 10, and 14 but showed t

62 ition of a novel "0.2 ppm rule" allowing the absolute configuration at tetralin C-2 to be determined.

63 activity revealed the importance of the (S) absolute configuration at the 2-position for binding aff

64 Thus, eight more analogues with different absolute configuration at the chiral center of the aroma

65 The absolute configuration at the new chiral centers was ass

66 The absolute configuration at the original thymine C5 and C6

67 the relationship between chemical shift and absolute configuration at the phosphorus center of H-pho

68 obtained by asymmetric synthesis, and their absolute configurations at both phosphorus and C-5 carbo

69 The absolute configurations at C24 and its influence on the

70 ts convincingly prove that the assignment of absolute configuration based on vibrational chiroptical

71 he case of an optically pure enantiomer, its absolute configuration can be determined.

72 xample of using VCD carbonyl multiplets, the absolute configuration could be reliably predicted, stre

73 tural requirements for woody odor, including absolute configuration, critical methyl substitution, an

74 d method for the complete identification and absolute configuration determination of all 12 pentose i

75 DDFT methods, is negative demonstrating that absolute configurations determined from TDDFT calculatio

76 VCD is the more reliable technique to assign absolute configuration due to the larger functional and

77 can be used for in situ determination of the absolute configuration, ee, and total concentration of m

78 P)- or (M)-, of this helical folding and the absolute configuration, either (R)- or (S)-, of the chir

79 assay for simultaneous determination of the absolute configuration, enantiomeric composition and con

80 r instantaneous in situ determination of the absolute configuration, enantiomeric composition and tot

81 lutions and allows fast determination of the absolute configuration, enantiomeric composition, and ov

82 hat allow instantaneous determination of the absolute configuration, enantiomeric excess and concentr

83 re isolated by enantioselective HPLC and the absolute configuration established by DFT simulation of

84 ESI, or CDESI and QTOF-MS/MS experiments and absolute configurations established by quantum mechanica

85 idues and in which all residues are of the d-absolute configuration, except for fucose and rhamnose w

86 A compound with a shorter tether and (3R,4S) absolute configuration exhibited high activity with a K(

87 ture of C-35 acetoxy epimers indicated a 35R absolute configuration for 2.

88 n natural products was used to determine the absolute configuration for both thiaplakortones C and D

89 ylidene carbene insertion, with retention of absolute configuration, from a diastereomerically pure k

90 ly crystallized racemic jasmonic acid, whose absolute configuration had only been inferred from deriv

91 e of heterocyclic scaffold but with opposite absolute configuration has also been accomplished by mak

92 The absolute configuration has been assigned by comparison o

93 e araiosamines has been developed, and their absolute configuration has been assigned.

94 streptophenazine G has been revised, and its absolute configuration has been determined to be 1'S,2'R

95 lactomycin (1), as well as assignment of the absolute configuration, has been achieved exploiting a c

96 ospironucleoside intermediates of the proper absolute configuration have been made available from ena

97 to the enantiopure molecular cages of which absolute configurations have been assigned by ECD spectr

98 containing amino acid residues with opposite absolute configurations have long been a source of inter

99 key construction was the installation of (S) absolute configuration in m-hydroxyphenylalanine using a

100 In addition, the absolute configuration inferred from CD spectra of the t

101 ly attributable to either conformation or to absolute configuration is identified.

102 which is a semiconserved element because its absolute configuration is virus-dependent.

103 olecule-including assigning its relative and absolute configurations-is paramount, enabling one to un

104 The absolute configuration of (+)-2 was also determined to (

105 The absolute configuration of (+)-2 was determined to be (R,

106 Through this synthesis, the absolute configuration of (+)-frondosin A was establishe

107 The absolute configuration of (+)-verticillol (4) was revise

108 The absolute configuration of (-)-2 was determined by compar

109 Also, the absolute configuration of (-)-diastereomer has been inde

110 Inversion of the absolute configuration of (S)-2,3,4,9-tetrahydro-1H-carb

111 on C(1) allows for easy determination of the absolute configuration of 1,6,7-trisubstituted 2,3-dihyd

112 C- and GC-MS analyses was used to assign the absolute configuration of 1.

113 A (1), B (2), and D (4) was executed and the absolute configuration of 2 and 4 was determined.

114 The absolute configuration of 2 was assigned by (1)H NMR ana

115 The (-)-(1R,5R)/(+)-(1S,5S) absolute configuration of 4b inferred from the TDDFT cal

116 The absolute configuration of 6 was confirmed via spectrosco

117 The absolute configuration of 9-epixylogranatin A (1) was de

118 pies are evaluated for the assignment of the absolute configuration of a highly flexible natural comp

119 The absolute configuration of a key intermediate and that of

120 rst ever case study of the assignment of the absolute configuration of a molecule based on the isoneo

121 Additionally, we report the first proof of absolute configuration of a natural ladderane.

122 The absolute configuration of acylfulvene analogues has a si

123 Determination of the absolute configuration of all obtained sugars was feasib

124 olution for an unambiguous assignment of the absolute configuration of bound molecules.

125 The first total synthesis and absolute configuration of bruguierol C are reported.

126 are increasingly employed for assigning the absolute configuration of chiral molecules through compa

127 rometers, allow for the determination of the absolute configuration of chiral secondary alcohols by d

128 the isoneoamphilectane carbon skeleton, the absolute configuration of compound 5 was established as

129 This synthesis confirms the absolute configuration of crocagin A and provides access

130 is was explored to tentatively elucidate the absolute configuration of cryptomoscatone E3, a polyketi

131 rrect structure and the determination of the absolute configuration of cystobactamid 919-2.

132 sor 39 was separated by chiral HPLC, and the absolute configuration of each enantiomer was determined

133 Further determination of the absolute configuration of each product helped rebuild th

134 The absolute configuration of embellicine A (1) was determin

135 was developed to qualitatively determine the absolute configuration of enantioenriched secondary alco

136 sidual dipolar couplings or to determine the absolute configuration of enantiotopic NMR signals is di

137 or rules cannot be safely used to assign the absolute configuration of even these simple derivatives.

138 illator approach, thus establishing the full absolute configuration of gymnocin-B.

139 The absolute configuration of haliclamide thus is 2S, 9S, 14

140 d the ability of this methodology to set the absolute configuration of multiple stereocenters in a si

141 The absolute configuration of namalide was established, and

142 The absolute configuration of natural (+)-cladoacetal A was

143 m sector and helicity rules to determine the absolute configuration of optically active alpha,beta-un

144 pode of carvone led to a reassignment of the absolute configuration of peribysin E.

145 pectra data analysis were used to define the absolute configuration of phaeophytins 12 (13(2)R, 17R,

146 The planar structure and (3R,6S,7R) absolute configuration of pustulosaisonitrile-1 were ded

147 The absolute configuration of rearrangement products was ini

148 determination of enantiomeric purity and/or absolute configuration of remotely chiral primary alcoho

149 ient utilization in the determination of the absolute configuration of secondary alcohols.

150 The absolute configuration of sphenostylisin C (3) was estab

151 The relative and absolute configuration of stagonolide D was established

152 The absolute configuration of stereogenic sulfoxide acceptor

153 ted by chiral column chromatography, and the absolute configuration of the 2-position was assigned by

154 that of analogues in order to determine the absolute configuration of the active natural flavonoidal

155 of the desymmetrization process, whereas the absolute configuration of the alpha-amino stereocenter g

156 ective total synthesis and assignment of the absolute configuration of the architecturally challengin

157 The absolute configuration of the asbestinin subclass was co

158 The absolute configuration of the asymmetric C(alpha)-atom o

159 s enantiospecific, hence correlated with the absolute configuration of the bile steroid rather than i

160 Here, we report the full structure and absolute configuration of the borolithochromes, enigmati

161 It establishes the correct absolute configuration of the C-6 hydroxyl function in e

162 nd amides showed strong consistency with the absolute configuration of the carbinol and amine moietie

163 The absolute configuration of the carbon stereogenic center

164 The absolute configuration of the cardamom peroxide is repor

165 ty, its central double bond geometry and the absolute configuration of the chiral centers were not de

166 The absolute configuration of the chlorocyclopropane ring in

167 allows the unambiguous determination of the absolute configuration of the conformationally flexible

168 The absolute configuration of the corresponding cyclocarbony

169 ectra to computationally simulated ones, the absolute configuration of the enantiomeric pair (6R, 12a

170 e biocatalytic transamination and assign the absolute configuration of the enantiomeric products.

171 The absolute configuration of the enantiomers of these fire

172 ve coupling is demonstrated to depend on the absolute configuration of the Evans chiral auxiliary emp

173 ies also support the experimentally obtained absolute configuration of the final adducts.

174 The absolute configuration of the imino-aldol adducts has be

175 ace is reported and analyzed in terms of the absolute configuration of the lipid tail carbinols at pH

176 The absolute configuration of the major (-)-(R) enantiomer o

177 and tetrahydrofuran and also to predict the absolute configuration of the major stereoisomers derive

178 The resultant absolute configuration of the mandelalide A macrolide wa

179 hesis of garcibracteatone, which allowed the absolute configuration of the natural compound to be det

180 This allowed to determine the absolute configuration of the natural product and to pla

181 The absolute configuration of the natural product was determ

182 The stereochemistry and absolute configuration of the natural sesterterpenolide

183 CD spectra that have been used to assign the absolute configuration of the new fulleropyrrolidines.

184 acterize and determine the assignment of the absolute configuration of the new isolated chiral alcoho

185 The absolute configuration of the new spiro stereocenter was

186 The absolute configuration of the newly created chiral cente

187 The absolute configuration of the nonacylated enantiomer of

188 n the diastereomeric esters (or amides), the absolute configuration of the original carbinol (or amin

189 acid acylation before peptide assembly, the absolute configuration of the ornibactin side chain, and

190 The absolute configuration of the phosphine (SP)-PMeIs(p-MeO

191 The absolute configuration of the primary amines was unambig

192 the dienophile can control the relative and absolute configuration of the product.

193 itio theoretical investigation explained the absolute configuration of the products and different ste

194 stereochemical model explaining the observed absolute configuration of the products based on DFT calc

195 The absolute configuration of the products has been assigned

196 The absolute configuration of the products makes the sulfena

197 The absolute configuration of the products that are predicte

198 dichroism should in principle establish the absolute configuration of the propeller-shaped molecules

199 The absolute configuration of the resulting olefinated produ

200 It has also enabled the absolute configuration of the side chain hydroxy group o

201 d transition state of the cycloaddition, the absolute configuration of the starting lactone controlle

202 Variation of the absolute configuration of the starting segments 5a and 9

203 tching/mismatching effect depending upon the absolute configuration of the stereocenter in the starti

204 ediction of the CD spectrum to determine the absolute configuration of the stereogenic carbon C-9 as

205 The identical absolute configuration of the stereogenic center of the

206 her and amide functional groups and constant absolute configuration of the stereogenic centers at all

207 epared with equal efficiency by changing the absolute configuration of the sulfinyl chiral auxiliary.

208 d with the same good results by changing the absolute configuration of the sulfur atom of the sulfiny

209 The absolute configuration of the synthetic material was con

210 idation approach and securely determines the absolute configuration of the targeted natural product,

211 The absolute configuration of the THF cores was secured by a

212 The absolute configuration of the tungsten stereocenter in T

213 characterized with the aim to attribute the absolute configuration of the two adjacent stereocenters

214 The absolute configuration of the two key building blocks wa

215 The absolute configuration of these alkaloids was firmly est

216 The absolute configuration of these enantiomers was assigned

217 ine A, rigorously establish the relative and absolute configuration of these structurally unusual Lyc

218 toxins B, and thus allowed assignment of the absolute configuration of this naturally occurring antib

219 h establishes unequivocally the relative and absolute configuration of this oxopolyene macrolide.

220 -teucladiol enabled the determination of the absolute configuration of this terpene natural product.

221 c aminoxylation step ultimately controls the absolute configuration of three adjacent stereogenic cen

222 ponding enantiomerically pure diones 4b, the absolute configuration of which was determined by compar

223 The absolute configurations of 1,n-glycols (n = 2-12, 16) be

224 A microscale protocol for determination of absolute configurations of 2,3-epoxy alcohols is describ

225 The absolute configurations of 2-4 were established for the

226 The absolute configurations of all of the isolated MBCHs wer

227 The absolute configurations of all the HPLC separated enanti

228 Structures and absolute configurations of analogues 3 and 5 were confir

229 The C23 absolute configurations of both 20S,23S/R-dihydroxyvitam

230 ridine) complexes were used to determine the absolute configurations of chiral mono-ols.

231 d us to suggest that the originally assigned absolute configurations of chiral polyacetylenes from At

232 otal synthesis reported herein confirmed the absolute configurations of curvularides A-E and supporte

233 itive nonempirical protocol to determine the absolute configurations of erythro and threo diols, amin

234 s confirmed that the proposed structures and absolute configurations of hyacinthacines B3, B4, and B5

235 een on the market as Lariam for decades, the absolute configurations of its enantiomers have not been

236 The relative and absolute configurations of KmTx2 were determined using J

237 A macrolide was extrapolated to propose the absolute configurations of mandelalides B-D.

238 ave a stable pyramidal conformation, and the absolute configurations of new chiral centers were assig

239 -performance liquid chromatography), and the absolute configurations of obtained enantiomers were mai

240 The absolute configurations of phosphorothioate diesters, H-

241 The absolute configurations of primary amines were assigned

242 In addition, the absolute configurations of the bicyclo[2.2.2]oct-5-en-2-

243 The absolute configurations of the chiral centers are establ

244 ng, for the first time, an assignment of the absolute configurations of the chromophores.

245 he basis of these simplified approaches, the absolute configurations of the compounds have been unamb

246 The absolute configurations of the diastereomers were determ

247 Structures and absolute configurations of the diols 21a, 21b, and 22a a

248 ta)-CHX-P(gamma) carbons on the basis of the absolute configurations of the individual diastereomers

249 mic compounds via chiral HPLC and assign the absolute configurations of the isolated enantiomers by X

250 as well as the difficulty in determining the absolute configurations of the isolated MBCHs.

251 f the halogen substituents, and relative and absolute configurations of the known natural products.

252 The relative and absolute configurations of the meroterpenoids were deter

253 eoselective fashion by proper control of the absolute configurations of the methoxy groups in the bis

254 The absolute configurations of the natural products were una

255 The absolute configurations of the novel atropisomers has be

256 The absolute configurations of the resolved prolines and pro

257 ography on chiral stationary phases, and the absolute configurations of the separated enantiomers wer

258 cally observed structural changes (e.g., the absolute configurations of the three PP binding sites sw

259 Of particular note, all absolute configurations of verticillane diterpenes in th

260 mpounds to be resolved into enantiomers, the absolute configurations of which are denoted Lambda (lef

261 al benzene compounds is often used to assign absolute configurations on the basis of sector rules.

262 wed the determination of the product aldols' absolute configuration (S).

263 ng to unambiguously assign the atropisomers' absolute configuration, something, to the best of our kn

264 odel reaction and systematic analysis of the absolute configuration support the suggested mechanism.

265 faster and more reliable VCD assignments of absolute configuration, the ability to rapidly explore c

266 become invaluable for the assignment of the absolute configuration, the study of conformational isom

267 ic stereoisomers led to determination of its absolute configuration, thus correcting the original ass

268 tiviral activity well correlating with the R absolute configuration to the stereogenic center of the

269 Preparation and assignment of absolute configurations to both enantiomers of the sex p

270 omalous X-ray diffraction, we determined the absolute configuration using a combination of NMR, optic

271 atic methods that speed-up the assignment of absolute configuration using vibrational circular dichro

272 Its absolute configuration was again assigned by ECD investi

273 Its absolute configuration was assigned by the known configu

274 The absolute configuration was assigned for mandelalide A af

275 Sinister absolute configuration was assigned to (+)-subincanadine

276 microsyringe as the reaction vessel, and the absolute configuration was assigned via qualitative dete

277 The relative and absolute configuration was determined by a combination o

278 The absolute configuration was determined by chemical reacti

279 ed by means of enantioselective HPLC and the absolute configuration was determined by TD-DFT simulati

280 its two enantiomers by chiral HPLC, and the absolute configuration was established by circular dichr

281 The absolute configuration was established by comparison of

282 oorganisms and DNA gyrase a preference for S-absolute configuration was found whereas R-absolute ster

283 The assigned absolute configuration was further supported by the resu

284 The (+)-PP absolute configuration was thus established for the anti

285 intermediates whose relative (and ultimately absolute) configuration was assigned on the basis of (1)

286 l 3-spirotetramic acid of hitherto uncertain absolute configuration, was synthesized for the first ti

287 tereomers were isolated by HPLC (4, 5) whose absolute configurations were assigned according to the h

288 isolated by enantioselective HPLC and their absolute configurations were assigned by TD-DFT simulati

289 Absolute configurations were assigned by X-ray crystallo

290 tions (DFT-D3, TD DFT, and sTD DFT), and the absolute configurations were assigned for all chiral rep

291 The absolute configurations were assigned using LC-MS, chira

292 The absolute configurations were determined by comparison of

293 were resolved into their enantiomers, whose absolute configurations were determined by comparison of

294 e readily resolved by chiral HPLC, and their absolute configurations were determined by X-ray crystal

295 Their absolute configurations were unequivocally determined, a

296 ish molecular conformation and correlate the absolute configuration with the observed NMR shift.

297 both gave the trans-aziridines with the same absolute configuration with the same catalyst; however,

298 isolated from the natural source enabled the absolute configurations within these alkaloids to be con

299 he determination of the correct relative and absolute configuration without additional information fr

300 both the E and Z isomers to provide the same absolute configuration without showing E-Z isomerization