ライフサイエンスコーパス: absolutely

1 e embryonic stem cells, we show that CTCF is absolutely and dose-dependently required for looping bet

2 e been described for a century as exhibiting absolutely and relatively long clavicles.

3 ed against most recent islet transplant were absolutely associated with loss of graft function despit

4 that gE(-), gI(-), or US9(-) mutants are not absolutely blocked in axonal transport.

5 llular content of Rubisco decreased not only absolutely, but also relative to the content of PSII.

6 IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because dru

7 a four-point scale (1 = low confidence, 4 = absolutely certain) on MR angiographic and UTE images.

8 he advantage of the DropArray technology was absolutely clear when semiadherent or suspension cells w

9 f the transmembrane domain, and contains the absolutely conserved (679)LWYIK/R(683) sequence, propose

10 Of these residues, only Ile274(7.39) is absolutely conserved across the human adenosine receptor

11 a methionine residue at position 16 of GolS, absolutely conserved among GolS-like proteins but absent

12 Each Qrr contains a 21 nucleotide region absolutely conserved among pathogenic Vibrios, and predi

13 Replacement of an absolutely conserved Asp by charge reversal (D478E), neu

14 salient features of this core structure are absolutely conserved between alphabeta and gammadelta TC

15 e their importance, these components are not absolutely conserved between parts of the tree of life,

16 active site, lined with the residues from an absolutely conserved CDP-AP signature motif (D(1)xxD(2)G

17 ntains an anti-parallel coiled-coil with two absolutely conserved cysteine residues at its apex.

18 -manno-heptose 7-phosphate kinase (HldA), an absolutely conserved enzyme in this pathway, from Burkho

19 lants, whereas the other key amino acids are absolutely conserved from bacteria to plants.

20 An absolutely conserved Gly in the middle of the alpha1-hel

21 e selectivity filter, which is lined by four absolutely conserved histidines.

22 Ten amino acids were absolutely conserved in all the alpha-herpesvirus U(S)1

23 otein of previously unknown function that is absolutely conserved in beta-carboxysomal gene clusters.

24 tion between Phe(364) and Pro(357), which is absolutely conserved in enteroviral polymerases, was fou

25 This tryptophan is absolutely conserved in mammalian Kir channels.

26 Tyr54, absolutely conserved in NK2 family proteins, mediates se

27 tween the PP(i) mimic and two basic residues absolutely conserved in the fingers domain of family B p

28 on, and for Gly in the P1 position, which is absolutely conserved in the natural Atg8 substrates.

29 An absolutely conserved interaction between Phe(727) and a

30 vertebrate Piezo channel subunits define an absolutely conserved motif that may be involved in chann

31 nd that the first of these, TM5, includes an absolutely conserved PhiPPhiXXG motif that is required f

32 P101) are trans in the S state but that two absolutely conserved residues (P14 and P101) become cis

33 Transfer RNAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends

34 PilA1-A6) that, although diverse, contain an absolutely conserved signal peptide hydrophobic (H) doma

35 ition of the hydroxymethyl side chain of the absolutely conserved Thr(772) of the alpha-subunit.

36 boring PHA-1-causing substitutions within an absolutely conserved, cytosolic Gly residue (e.g., betaG

37 The binding site sequences are not absolutely conserved.

38 Pregnancy, although not absolutely contraindicated in this population, carries r

39 investigation, the highly conserved Glu93 is absolutely critical and Tyr13 is also important likely c

40 ent domain protein-caspase-1 inflammasome is absolutely critical for IL-1beta production in response

41 tivator positive coactivator 4 (PC4/Sub1) is absolutely critical for life, because its absence leads

42 nisms underlying these diverse phenomena are absolutely critical for the development of optimized or

43 Reconstitution of T cell immunity is absolutely critical for the effective control of virus-a

44 further show that the presence of PARP-1 is absolutely crucial for reactivation of transcription aft

45 mological risk and to control the vector are absolutely crucial to demolishing the rise of CHIKV.

46 CLP is not absolutely crucial, however; some 5LO activity remained

47 Here we investigate annually resolved, absolutely dated and spatially explicit paleoclimatic ev

48 ocarbon reservoir age offset derived from an absolutely dated annually resolved shell chronology span

49 f a millennial-length, annually resolved and absolutely dated marine delta(18)O archive.

50 Owing to the lack of absolutely dated oceanographic information before the mo

51 etic record shows strong similarity with the absolutely dated speleothem record from China, allowing

52 Here, we present four absolutely dated, overlapping stalagmite oxygen isotopic

53 In mice, both Tfh and Tfr are absolutely dependent on B cells for their formation and

54 This emergent function is enabled by and absolutely dependent on both the supramolecular assembly

55 s demonstrate that histone H4 acetylation is absolutely dependent on CA-induced AhR and MTA2 recruitm

56 While cilia assembly is absolutely dependent on centrioles, it is not known to w

57 s as one of a very limited number of cargoes absolutely dependent on CLIP-170-mediated capture to ini

58 Unlike all known IRESs, the AV IRES is absolutely dependent on DHX29, a requirement imposed by

59 signaling is suppressed in a manner that is absolutely dependent on DUSP5.

60 has been exhaustively characterized as being absolutely dependent on free double stranded DNA ends (t

61 m endogenously synthesized viral proteins is absolutely dependent on its protein half-life.

62 the human mtRNA polymerase (POLRMT) that was absolutely dependent on mitochondrial transcription fact

63 The recruitment is absolutely dependent on nuclear proteins EBNA3A and EBNA

64 pt to low-glutamine conditions rendered them absolutely dependent on PC for growth.

65 an malaria parasite Plasmodium falciparum is absolutely dependent on the acquisition of host pantothe

66 G preparations, the response was found to be absolutely dependent on the presence of small numbers of

67 d compared with wild type; this increase was absolutely dependent on the presence within the flagellu

68 eceptors, RA signaling during development is absolutely dependent on the rate of RA synthesis and deg

69 nt of strategies to target pre-LSCs that are absolutely dependent on their microenvironment.

70 t synthesize the purine ring de novo and are absolutely dependent upon them to meet their purine requ

71 Fragmentation absolutely depends on both RecA-catalyzed homologous str

72 This checkpoint absolutely depends on the Gcn2 kinase.

73 s with significant refractive errors and 130 absolutely emmetropic participants, were enrolled from s

74 her hand, the cleavage of linker peptide was absolutely essential and the release of cytosolic 24 kDa

75 Importantly, although VEGF was thought to be absolutely essential for arterial fates, we find that no

76 s reduced, this amino acid side chain is not absolutely essential for catalysis.

77 is of these residues confirmed that they are absolutely essential for catalytic activity.

78 Separase is absolutely essential for cohesion dissolution in organis

79 While these additional clusters are absolutely essential for enzyme activity, their exact ro

80 yme assays confirmed that these residues are absolutely essential for full catalytic activity.

81 the only muscle-specific protein known to be absolutely essential for fusion of embryonic and adult m

82 mal interaction of CA with CPSF6, though not absolutely essential for HIV-1 replication in physiologi

83 t that optimal binding of CA to CPSF6 is not absolutely essential for HIV-1 replication in vivo but p

84 mportantly, this platelet activation appears absolutely essential for host survival during infection

85 sex as a biological variable in research is absolutely essential for improving our understanding of

86 Therefore, while revA is not absolutely essential for infection, deletion of revA had

87 reveals that tyrosine residues 1007/1008 are absolutely essential for kinase function and signal tran

88 KO embryos, demonstrating that Myo10 is not absolutely essential for mitosis, meiosis, adult surviva

89 Notch1 signaling is absolutely essential for steady-state thymic lymphopoies

90 ults indicate that neither LMP1 nor LMP2A is absolutely essential for the ability of EBV to induce B

91 ther hand, the catalytic activity of PstP is absolutely essential for the in vitro growth.

92 s in a biphasic manner, with late IL-6 being absolutely essential for viral control.

93 um-based motility is involved in, but is not absolutely essential for, B. subtilis pellicle formation

94 As a collection, they are absolutely essential genomic features, but individually

95 mixtures is a redoubtable challenge that is absolutely essential to allow determination of the biolo

96 t highlight potential supporting (albeit not absolutely essential) players.

97 item were scored as 1 (not essential) to 9 (absolutely essential).

98 phomas in this model, but neither protein is absolutely essential.

99 etic diversity of the hepacivirus genera has absolutely exploded.

100 e of great interest, and the availability of absolutely homogeneous and characterized samples is thus

101 esent in the same nucleus and which can have absolutely identical sequences.

102 in the same nucleus and that can indeed have absolutely identical sequences.

103 gned and synthesized for detection of OCl(-) absolutely in aqueous medium at nanomolar level.

104 Our results are absolutely inconsistent with the model.

105 maintain blood glucose below that level and absolutely <180 mg/dL.

106 butes only modestly to PB potency and is not absolutely necessary for activity.

107 CaM is shown to be absolutely necessary for efficient activity of eEF-2K, a

108 irmed that the ComDE two-component system is absolutely necessary for mutacin production in S. mutans

109 ade via eco-efficient processes, is becoming absolutely necessary for reasons of sustainable producti

110 ent compliance to periodontal maintenance is absolutely necessary for successful long-term therapy.

111 s present in many pathogenic bacteria and is absolutely necessary for the efficient evasion of the Br

112 data suggest that the CD8 coreceptor is not absolutely necessary for the generation of Ag-specific C

113 The NoLS motif in the SBV NSs is absolutely necessary for virus-induced inhibition of cel

114 antisense transcript of HAS2 (HAS2-AS1) was absolutely necessary to induce the transcription of the

115 ine for vesicle refilling, a process that is absolutely necessary to preserve quantal glycine content

116 Reliable estimates of correlations are absolutely necessary to protect a portfolio.

117 ability of the microcompartment shell is not absolutely necessary, but is often beneficial in establi

118 hniques and optical imaging these agents are absolutely necessary.

119 etailed analysis of NREM sleep and dreams is absolutely necessary.

120 hould be to impose no more selection than is absolutely necessary.

121 ility, whereas the dephosphomimetic provides absolutely no rescue.

122 l colonies directly from the Petri dish with absolutely no sample preparation needed.

123 with universal prescriptions-the belief that absolutely nobody or everybody should engage in an actio

124 These functions depend absolutely on the catalytic site within the second dupli

125 a New World arenavirus to use human TfR1 is absolutely predictive of its ability to cause hemorrhagi

126 of on-off-keyed 10 Gbit s(-1) systems and is absolutely prohibitive for today's (>)100 Gbit s(-1) coh

127 h leave-one-patient-out cross-validation and absolutely quantified by selected reaction monitoring as

128 c network between 4 and 37 degrees C through absolutely quantified exo- and endometabolomics data.

129 a selective reaction monitoring technique to absolutely quantify the four organosulfur compounds.

130 We demonstrate that people consistently and absolutely (rather than relatively) match specific audit

131 strength, vinculin-dependent traction forces absolutely require a full-length and activated molecule;

132 maintained epithelium integrity but did not absolutely require Caspase-1 or Gasdermin D.

133 study, we report that Treg division does not absolutely require cell-autonomous TCR signaling in vivo

134 Moreover, cortex glia absolutely require FGF signalling, such that inhibition

135 ell edge protrusions in fibroblasts does not absolutely require kinase activity, raising the question

136 separation and amphiaster formation does not absolutely require the centrosome, but, in its absence,

137 topoisomerase reaction; however, it does not absolutely require the non-conserved carboxyl-terminal d

138 of processing of an ICL, its bypass may not absolutely require TLS polymerases.

139 g, while Th17 and gammadelta T cells are not absolutely required and may compensate for each other.

140 erited at centromeres, and new deposition is absolutely required at each cell cycle for kinetochore f

141 te differentiation, and that while Notch1 is absolutely required early in the lymphopoietic process,

142 However, we show here that Mef2 is absolutely required for a diverse range of Drosophila ad

143 C2 receptor accessory protein (MRAP) that is absolutely required for ACTH binding and signaling.

144 CtIP is absolutely required for activating the nuclease-dependen

145 get genes demonstrated that unbound hp53 was absolutely required for activation of the DNA-damage res

146 maternal zinc-finger protein Zelda (Zld) is absolutely required for activation, and present evidence

147 s have shown that the scaffold module is not absolutely required for activity, but dramatically decre

148 We found that Pyk2 is not absolutely required for adhesion of CTL to ICAM-1, but r

149 olar initiation, but that neither pathway is absolutely required for alveolar fate specification; rat

150 sms raises the question as to whether SOD is absolutely required for animal life and whether the loss

151 he source of the "mother filaments" that are absolutely required for Arp2/3 complex to nucleate actin

152 of normal size, indicating that AtpI is not absolutely required for ATP synthase function.

153 The AR1b elements are absolutely required for auto-induction of UPC2 gene expr

154 -FNIP complex deregulated in BHD syndrome is absolutely required for B-cell differentiation, and that

155 omains within the C terminus of LapA are not absolutely required for biofilm formation, export, or lo

156 This protein, together with TonB2, is absolutely required for both the uptake of endogenously

157 n EMRE was identified as a uniporter subunit absolutely required for Ca(2+) permeation.

158 MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas

159 ate alpha-COO(-) group to the carboxamide is absolutely required for catalysis.

160 ily, including a conserved histidine that is absolutely required for catalytic activity.

161 ualitatively different CDK complexes are not absolutely required for cell cycle progression either du

162 mines are small organic polycations that are absolutely required for cell growth and proliferation; y

163 Glycine 4864 is not absolutely required for channel gating, but some flexibi

164 Although DNA-PKcs is absolutely required for CJs, SJs are formed to variable

165 ins from urease expression is modest and not absolutely required for colonization, urease can contrib

166 Moreover, two TPN classes are absolutely required for conditioned taste aversion, a le

167 ssary for antigen receptor signaling, it was absolutely required for costimulation through the TNF re

168 These data suggest that 3'RR is not absolutely required for CSR and, thus, is not essential

169 ronic long-range tertiary pseudoknot that is absolutely required for deamination of one particular ad

170 n factor expressed in dentate stem cells and absolutely required for dentate granule cell production.

171 rf2x have been shown to be the only proteins absolutely required for detectable excision.

172 indicating that GI tract inducible CYP1A1 is absolutely required for detoxication of oral BaP.

173 that proliferation at this step was not only absolutely required for differentiation but also that it

174 Residue S186 of ZEBRA, Z(S186), which is absolutely required for disruption of latency, participa

175 ween them, and the interacting residues were absolutely required for DksA function.

176 how that among the comG genes, only comGA is absolutely required for DNA binding to the cell surface.

177 data demonstrated that Bax translocation is absolutely required for DR6-induced apoptosis.

178 onstration that transient ING4 expression is absolutely required for epithelial differentiation, its

179 We conclude that FMRP is absolutely required for experience-dependent changes in

180 postsynaptic density protein-95 (PSD-95) was absolutely required for experience-dependent maturation

181 Asp1 to Asp3 are absolutely required for export of the substrate GspB, bu

182 ng factor AREB2/ABF4, which binds to a G-box absolutely required for expression of the COX5b-1 gene.

183 We also found that no auxiliary factor is absolutely required for flavinylation, indicating that t

184 ning the integrity of the complex but is not absolutely required for formation of the daughter filame

185 hrough the Rev1-interacting region (RIR), is absolutely required for function.

186 RalA function is absolutely required for furrow formation and initiation.

187 region of the C-terminal cytoplasmic tail is absolutely required for fusion activity.

188 indicating that a fully formed ABE I is not absolutely required for FXI activation.

189 ngle immunoglobulin (Ig)-like domain that is absolutely required for gamete fusion [3, 4].

190 K79 trimethylation contributes to but is not absolutely required for GGR, and lower levels of H3K79 m

191 The polyamine spermidine is absolutely required for growth and cell proliferation in

192 PI4KA kinase activity was found to be absolutely required for HCV replication using a small in

193 However, T cells were not absolutely required for IL-22 production because imiquim

194 Expression of the CTLA-4 gene is absolutely required for immune homeostasis, but aspects

195 lysis demonstrated that aa 60-90 of HRS were absolutely required for in vitro as well as in vivo sign

196 The Scar/WAVE complex is absolutely required for lamellipodia and is a key effect

197 ylinositol (GPI) membrane anchor is also not absolutely required for LON-2 activity.

198 the 3' terminal nucleotides in miR-122 were absolutely required for maintaining HCV RNA abundance bu

199 and in vivo data demonstrated that B7-H1 was absolutely required for MDSC to exert immune regulatory

200 These factors are not absolutely required for meiotic maturation or its negati

201 t, are mediated exclusively by Orai1 and are absolutely required for milk ejection and pup survival,

202 We conclude that Geminin is absolutely required for mitotic proliferation of spermat

203 shown to be highly conserved in amniotes and absolutely required for myeloid-restricted expression of

204 vior, suggesting that none of these cues are absolutely required for navigation back to the food.

205 WT activity, but this disulfide bond is not absolutely required for normal activity.

206 of TGFbeta superfamily signaling, SMAD4, is absolutely required for normal FSH synthesis in both mal

207 is a physiologically relevant event that is absolutely required for nuclear GRK5 localization downst

208 ividual or specific combination of NoLSs was absolutely required for nucleolar localization, we sugge

209 less, neither cilia nor ciliary motility are absolutely required for otolith tethering: a mutant that

210 te for the first time that these enzymes are absolutely required for phage reproduction.

211 onstitutive TGFbetaRI binding protein and is absolutely required for phosphorylation of STATs in a SM

212 the two-component proteins PhoR and PhoB, is absolutely required for Pi signaling in Escherichia coli

213 vo, while the Csy1 and Csy3 proteins are not absolutely required for production of these small RNAs.

214 ifically expressed in the vasculature and is absolutely required for proper angiogenic sprouting into

215 Whereas MEF2A is absolutely required for proper myoblast differentiation,

216 Although Hsp104 is absolutely required for proteasomal degradation of Sdj1-

217 cteria to humans, only the serine residue is absolutely required for Psd1p autocatalysis and function

218 NA repair activity may facilitate but not be absolutely required for rapid evolutionary change.

219 l inhibition by MB suggests that dynactin is absolutely required for retrograde DCV transport but doe

220 Thus WD60/FAP163 is a dynein IC that is absolutely required for retrograde IFT and ciliary assem

221 lly, but not paternally, derived AtLETM2 was absolutely required for seed development.

222 orphology of their projections, and PGCs are absolutely required for SGP wrapping behaviors.

223 t binding site, but, surprisingly, it is not absolutely required for signaling.

224 We also demonstrate that type I IFNs are absolutely required for survival following intracranial

225 l line-derived neurotrophic factor (GDNF) is absolutely required for survival of dopaminergic (DA) ni

226 at the compositional characteristics are not absolutely required for T3SS targeting and that other re

227 of the ICP0 sequence (SLS4) was found to be absolutely required for targeting cellular sumoylated sp

228 myces cerevisiae, Rad26 is important but not absolutely required for TCR.

229 acute Friend Virus (FV) infection, they were absolutely required for the control of chronic infection

230 athway, genetic analysis reveals that YAP is absolutely required for the development of APC-deficient

231 Thus, IFN-gamma is absolutely required for the development of autoimmune pe

232 Caspase-1 activation and IL-1 signaling are absolutely required for the efficient control of Helicob

233 SrtA was absolutely required for the formation of the SpaBC heter

234 sidase and that CD1e is an accessory protein absolutely required for the generation of the lipid immu

235 However, proper phosphorylation of CBL1 is absolutely required for the in vivo activation of the AK

236 demonstrated that Lang+ dDC, but not LC, are absolutely required for the induction of a rapid and rob

237 genetic strategy, we show here that Stat5 is absolutely required for the pathogenesis of PV induced b

238 ice that mTOR complex 1 (mTORC1) activity is absolutely required for the proliferation of Apc-deficie

239 , T(34), A(36), T(37), A(44), and T(45)) are absolutely required for the promoter activity.

240 Host type I IFN signaling was absolutely required for the reduced tumor growth, prolon

241 Zn(2+) is absolutely required for the S18-1/S6 interaction while i

242 that is installed posttranslationally and is absolutely required for their antibiotic activity.

243 he upstream region of 21U-RNAs, CTGTTTCA, is absolutely required for their individual expression.

244 ice, demonstrating that IFN signaling is not absolutely required for these neuroinflammatory response

245 of Vpx, implying that neither properties is absolutely required for this function and indicating tha

246 but because of functional redundancy, it is absolutely required for this process in cells deficient

247 nstrating that adaptive immune cells are not absolutely required for this process.

248 mily effectors BAX and BAK are thought to be absolutely required for this process.

249 In contrast, BIG1-4 are absolutely required for trafficking of both endocytosed

250 The distal CRM is absolutely required for viability, whereas the proximal

251 t is cis acting for viral fitness but is not absolutely required for viral replication in cell cultur

252 Elevated cytoplasmic calcium is absolutely required for virus replication, but the under

253 They also demonstrate that the domain is not absolutely required for virus viability in cell culture

254 doknot but that the pseudoknot per se is not absolutely required for virus viability.

255 lying that WIP-WASp complex formation is not absolutely required for WASp localization.

256 Thus, a protein for the absolutely required import of pyrimidine nucleobases int

257 We demonstrate that TF is not absolutely required in culture, although disrupting TF p

258 lso found that a SECIS element was no longer absolutely required in such a system.

259 nous replication checkpoint but that Ddc1 is absolutely required in the absence of Mrc1.

260 a small group of organic compounds that are absolutely required in the human diet.

261 ucing B cells in the intestine, they are not absolutely required in the setting of rotavirus infectio

262 T cell target recognition absolutely required that mBC-CML cells express MHC molec

263 ding and presentation of mycoketide antigens absolutely required the unusual, mycobacteria-specific l

264 gested that pre-existing disulfide links are absolutely required to allow protein folding and, conver

265 F2-leader 3 5' untranslated region, which is absolutely required to enable IGF2-leader 3 mRNA transla

266 T deficiency targeted the Jalpha18, which is absolutely required to form the TCR with the appropriate

267 However, B cells were absolutely required to provide lymphotoxin (LT) alpha1be

268 SpoIIQ is absolutely required to recruit SpoIIIAH to the sporulati

269 ur findings support a model in which TFAM is absolutely required to recruit the transcription machine

270 and recycling to the plasma membrane but is absolutely required, much like actin, for early-to-late-

271 Some of them are absolutely required, whereas others are needed only for

272 romoted Th17 differentiation, but it was not absolutely required.

273 nsuring that lateral roots only develop when absolutely required.

274 ouse infection, when OspC is transiently but absolutely required.

275 everal pathways in which TRPV3 activation is absolutely required.

276 ger domains appear to contribute but are not absolutely required.

277 ocytes, but neither T nor B lymphocytes were absolutely required.

278 However, inter-rugal growth is not absolutely required: new stripes of Shh expression still

279 monstrate that the N7-demethylation reaction absolutely requires a unique, tightly bound protein comp

280 rmore, it is not known if proton selectivity absolutely requires all four histidines with two of the

281 ndent dendritogenesis in both neuron classes absolutely requires dfmr1 during one developmental windo

282 ions of non-physiological hypoxia the embryo absolutely requires Hif1alpha to continue normal develop

283 However, liver transplant (LT) tolerance absolutely requires interferon (IFN)-gamma, a rejection-

284 adapting early endosomes (EEs) to dynein but absolutely requires p25 in dynactin.

285 Flh function; however, parapineal migration absolutely requires Tbx2b activity.

286 naling upstream of IkappaB kinase activation absolutely requires the influx of extracellular Ca(2+) v

287 c alterations, as lymphocyte differentiation absolutely requires the introduction of indelible geneti

288 ing of the viral genome into an empty capsid absolutely requires the L4-22K protein to bind to packag

289 is instead inhibited by heterochromatin and absolutely requires the nucleosome remodeler DRD1.

290 tiates at the morula-to-blastocyst stage and absolutely requires Xist.

291 More importantly, these leukocytes were absolutely resistant to leukotoxin-induced cytolysis.

292 certainty have their non-classical dynamics absolutely restricted to only the identity operation.

293 also show that expression of Atoh1 does not absolutely result in commitment to a HC fate.

294 The resulting procedure was found absolutely safe.

295 athways can be engineered without developing absolutely specific enzymes.

296 Tamoxifen-dependent recombination was absolutely specific to proximal tubule.

297 specific biomarker, no manometric pattern is absolutely specific.

298 all connected core of 124 reactions that are absolutely superessential (that is, required in all meta

299 sfavored addition to enolate acceptors to an absolutely unexpected extent.

300 e outcome of these high-risk patients is not absolutely uniform, with some patients presenting long s