ライフサイエンスコーパス: abstinence

1 uses alternative non-drug reward to maintain abstinence.

2 sponses that might be ameliorated by alcohol abstinence.

3 apse compared with patients with 6 months of abstinence.

4 istent nicotine seeking even after prolonged abstinence.

5 aling in D2-MSNs following 10-14 d of forced abstinence.

6 amic regulation of D1 and DAT during 3 wk of abstinence.

7 of relapse despite prolonged periods of drug abstinence.

8 nicotine abuse or whether they persist with abstinence.

9 -day cocaine exposure followed by 2 weeks of abstinence.

10 ver heroin during the choice-based voluntary abstinence.

11 nishment in LgA rats only, thereby promoting abstinence.

12 ffect dependent on a period of sexual reward abstinence.

13 ndent smokers that appears to normalize with abstinence.

14 of alcohol-dependent rats during protracted abstinence.

15 l marijuana for transplant after a period of abstinence.

16 ts, this occurred after 14-18 days of forced abstinence.

17 binoids and on persistence or recovery after abstinence.

18 and ten chronic cannabis users during early abstinence.

19 tion of smokers before and after 3 months of abstinence.

20 ms that persists during periods of sustained abstinence.

21 dependent rats at several time points during abstinence.

22 ext-induced relapse after punishment-imposed abstinence.

23 cle (controls), followed by 30 d of enforced abstinence.

24 ation during acute withdrawal and protracted abstinence.

25 ether these effects were sustained following abstinence.

26 t ventral and dorsal caudate after prolonged abstinence.

27 rug taking behavior under conditions of drug abstinence.

28 ne but not amphetamine injection during drug abstinence.

29 d increased consumption of HF food following abstinence.

30 take can trigger relapse even after years of abstinence.

31 ry outcome was prolonged, validated, 6-month abstinence.

32 fusion study that followed overnight smoking abstinence.

33 g satiety and once after 24 hours of smoking abstinence.

34 ext-induced relapse after punishment-imposed abstinence.

35 may represent biomarkers associated with CD abstinence.

36 ificant cocaine seeking after 15 d of forced abstinence.

37 sment during acute withdrawal and protracted abstinence.

38 individuals, even after periods of prolonged abstinence.

39 itions that promote voluntary (self-imposed) abstinence.

40 of ketamine SA followed by 2 and 4 weeks of abstinence.

41 day 21 but not day 1 of forced or voluntary abstinence.

42 mphetamine craving after forced or voluntary abstinence.

43 s systems are dysregulated during protracted abstinence.

44 e alcohol drinking during protracted alcohol abstinence.

45 seeking alcohol-dependent patients in early abstinence.

46 aintain addiction and provoke relapse during abstinence.

47 etamine craving after choice-based voluntary abstinence.

48 r 5-7 days prior to the scans to standardize abstinence.

49 ble food; 20 trials/day) or home-cage forced abstinence.

50 tential therapeutic tool by which to prolong abstinence.

51 its in short-term memory that recovered with abstinence.

52 to aggress and relapse vulnerability during abstinence.

53 eroin craving after forced but not voluntary abstinence.

54 d by chronic relapse despite long periods of abstinence.

55 provoking drug craving even after prolonged abstinence.

56 mphetamine during the choice-based voluntary abstinence.

57 5% CI, 0.12-1.03; F1,67 = 5.65; P = .02) and abstinence (10.0 more abstinent days; Cohen d = 0.57; 95

58 A-PET brain imaging after overnight nicotine abstinence (18 h before scanning), using a validated bol

59 n tests, the rats underwent either voluntary abstinence (achieved via a discrete choice procedure bet

60 Even after prolonged periods of abstinence, addicts are at risk of relapse, particularly

61 Complete abstinence after an episode of AH positively impacts lon

62 gh (65%) and low (26%-29%) rates of complete abstinence after an episode of AH.

63 mission might be useful to predict long-term abstinence after an episode of AH.

64 ity criteria, with 50% requiring a period of abstinence and 64% requiring urine drug screening.

65 ined attention were measured after overnight abstinence and again after smoking.

66 reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine rep

67 t on context-induced relapse after 1 week of abstinence and cue-induced reinstatement after extinctio

68 ext-induced relapse after punishment-imposed abstinence and further suggest a role of the vSub-->NAc

69 tic efficacy, defined as extended periods of abstinence and longer time to relapse, compared with mal

70 microV) and 6 (1.17 [1.19] microV) months of abstinence and lower at 2 days (0.17 [1.09] microV), 1 w

71 icating its therapeutic potential to promote abstinence and prevent relapse in individuals addicted t

72 vioral therapy and topiramate also increased abstinence and reduced binge-eating frequency and relate

73 ne had significantly higher rates of smoking abstinence and reduction than patients randomized to pla

74 Relapsing to drug abuse despite periods of abstinence and sincere attempts to quit is one of the mo

75 t to determine possible interactions between abstinence and subsequent drug re-exposure.

76 n of methamphetamine craving after voluntary abstinence and that DMS neuronal ensembles mediate this

77 es in FAAH binding during prolonged cannabis abstinence and whether lower FAAH binding predates drug

78 sure assessment, biochemical verification of abstinence, and definition of e-cigarette use) were also

79 aining behavior change following a period of abstinence, and may play a significant role in drug rela

80 percentage of negative opioid urine results, abstinence, and time to first illicit opioid use.

81 Cognitive deficits in early abstinence are associated with increased relapse risk.

82 es adopted for patients who initially reject abstinence as a goal.

83 imary end point was point-prevalence smoking abstinence assessed at 24 weeks by 7-day recall and bioc

84 650, were offered for biochemically verified abstinence at 1, 2, and 3 weeks, and 1, 3, and 6 months.

85 fit was seen with the combination of smoking abstinence at 15 years and LDCT screening, which resulte

86 t 26 or 52 weeks, including point-prevalence abstinence at 26 weeks (nicotine patch, 22.8% [55/241];

87 self-reported initial abstinence, prolonged abstinence at 26 weeks, and point-prevalence abstinence

88 nfirmed self-reported 7-day point-prevalence abstinence at 26 weeks.

89 in biochemically confirmed rates of smoking abstinence at 26 weeks.

90 e also assessed biochemically verified 7-day abstinence at 3, 6, and 18 months.

91 Outcomes of interest were smoking abstinence at 6 and 12 months, defined using the most ri

92 sation drugs increased the odds of continued abstinence at 6 months (odds ratio range, 1.82 [95% CI,

93 ted for differential acceptance, the rate of abstinence at 6 months was 13.2 percentage points (95% c

94 being sexually active at enrolment reported abstinence at their follow-up visit (p<0.0001).

95 abstinence at 26 weeks, and point-prevalence abstinence at weeks 4, 12, and 52.

96 ng all marijuana-using patients or mandating abstinence before transplant listing.

97 The primary outcome was continuous abstinence between 6 months (end of incentives) and 18 m

98 Rates of continuous abstinence between months 6 and 18 were 9.5% in the ince

99 urogenesis in the adult rodent brain) during abstinence blocked compulsive-like context-driven metham

100 l other groups, demonstrating that following abstinence, both cocaine's ability to increase DA releas

101 cutive functions may persist after prolonged abstinence, but persistence or recovery across all cogni

102 Although alcohol abstinence can cause regression of ALD, and weight loss

103 ining nearly 1.5 weeks of additional alcohol abstinence compared with controls.

104 levels were decreased within the BLA during abstinence compared with during drinking.

105 n=43) transdermal patch following overnight abstinence completed three sessions occurring during hor

106 ine treatment, during self-administration or abstinence, completely reversed cocaine tolerance.

107 We examined the effects of abstinence condition and smoking outcome (lapse vs non-l

108 Under both training and abstinence conditions, cue-induced methamphetamine seeki

109 Abstinence (confirmed by CO <5 p.p.m.) and smoking reduc

110 ed following 2 weeks of outpatient monitored abstinence (confirmed with three times per week urine al

111 relapse test-activated Fos neurons in DMS on abstinence day 18 decreased incubated methamphetamine se

112 in the extinction tests was higher after 21 abstinence days than after 1 day (incubation of methamph

113 y decreased methamphetamine seeking after 21 abstinence days.

114 g under extinction conditions after 1 and 21 abstinence days.

115 ne seeking in extinction tests after 1 or 21 abstinence days.

116 g under extinction conditions after 1 and 21 abstinence days.

117 For dorsal striatum seeds, 24-h abstinence decreased connectivity across both groups wit

118 ocaine-dependent persons (7-month to 25-year abstinence, DFFCD) (n=7) were studied, with measurements

119 Predictors of sustained smoking abstinence differed among participants assigned to rewar

120 ike excessive alcohol intake during the post-abstinence drinking days, an effect that persisted durin

121 ng in smokers and recent ex-smokers (average abstinence duration of 25 weeks).

122 c factors at admission capable of predicting abstinence during long-term follow-up in patients with A

123 ed midbrain activity correlated with cocaine abstinence during the 1-year follow-up.

124 was carbon monoxide-confirmed self-reported abstinence during weeks 15 through 24.

125 The 118 participants (57%) who maintained abstinence during weeks 5-6 were continued on buprenorph

126 cues associated with drug use often thwarts abstinence efforts by triggering drug using memories tha

127 ministered infusion of cocaine at the end of abstinence, even after 60 d, fully reinstated tolerance

128 These results suggest that with abstinence ex-smokers may recover from low striatal D2R

129 ced drug-seeking during the initial phase of abstinence, followed by a decline over time.

130 cohol-related behaviors in rats 3 weeks into abstinence following alcohol dependence.

131 13) and percentage of participants achieving abstinence for the last 3 weeks.

132 were carbon monoxide-confirmed self-reported abstinence for weeks 21 through 24 and weeks 21 through

133 point was biochemically confirmed continuous abstinence for weeks 9-12.

134 Abstinence from alcohol is associated with the recruitme

135 ent of a neuronal ensemble in the CeA during abstinence from alcohol is causally related to excessive

136 were to (1) determine the impact of complete abstinence from alcohol on long-term survival and (2) id

137 rgic system might help to maintain long-term abstinence from alcohol.

138 novel treatments for addiction that promote abstinence from and relapse to drug use.

139 As abstinence from breastfeeding is not recommended, altern

140 tained similar levels of COC-SA, (ii) forced abstinence from COC-SA enhanced mPFC PN excitability in

141 and chromatin immunoprecipitation following abstinence from cocaine self-administration.

142 ed about food-paired stimuli after prolonged abstinence from cocaine self-administration.

143 Sustained abstinence from cocaine use is frequently compromised by

144 e episodes, which occur even after sustained abstinence from cocaine, and suggest that treatments aim

145 nd escalated cocaine intake despite extended abstinence from cocaine.

146 moting Drp1 enhances seeking after long-term abstinence from cocaine.

147 may be a potentially useful tool to sustain abstinence from drug abuse.

148 ic potassium channels in the NAc may promote abstinence from drug-taking behaviors.

149 enorphine-naloxone in maintaining short-term abstinence from heroin and other illicit substances and

150 e with naloxone hydrochloride in maintaining abstinence from heroin and other illicit substances in n

151 Forced abstinence from higher preferred levels of drug taking e

152 residential facility, where they maintained abstinence from illicit drugs of abuse and received beha

153 reinforces the need for early detection and abstinence from intense exercise.

154 palatable food maintains prolonged voluntary abstinence from intravenous methamphetamine self-adminis

155 ncreased motor impulsivity during protracted abstinence from long-term alcohol exposure.

156 igible for transplantation after a period of abstinence from marijuana (n=241, 68.3%).

157 Following overnight abstinence from nicotine, participants completed a proto

158 he longest duration (in consecutive days) of abstinence from opioids during the intervention phase (3

159 ith sexual behavior, followed by a period of abstinence from sexual behavior, causes increased reward

160 mary outcome measure was prolonged validated abstinence from smoking 4 weeks after quit day.

161 Brief abstinence from smoking impairs cognition, particularly

162 To evaluate if abstinence from smoking on the day of surgery is associa

163 The duration of abstinence from smoking required to reduce this risk is

164 ention-to-treat analyses, rates of sustained abstinence from smoking through 6 months were higher wit

165 ed to an $800 reward contingent on sustained abstinence from smoking, a refundable $150 deposit plus

166 dence on nicotine, as well as craving during abstinence from smoking, without significantly increasin

167 nsulin to evaluate its efficacy during acute abstinence from smoking.

168 fter prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine

169 n of methamphetamine craving after voluntary abstinence generalizes to female rats.

170 oup 1), alcoholic cirrhosis with >/=6 months abstinence (Group 2).

171 vestigating a group of long-term ex-smokers (abstinence >1.5 years), and to explore associations betw

172 g sublingual buprenorphine maintained opioid abstinence (hazard ratio, 13.8; 95% CI, 0.018-0.258; P =

173 monstrate increased motor impulsivity during abstinence; however, the neuronal mechanisms underlying

174 f WIN seeking that increased with 21 days of abstinence (ie, 'incubation of craving').

175 ddicted to cocaine with varying durations of abstinence (ie, 2 days, 1 week, 1 month, 6 months, and 1

176 dy was designed to investigate the effect of abstinence in combination with environmental enrichment

177 the importance of adult neurogenesis during abstinence in compulsive-like drug reinstatement.

178 the trajectory of cue-induced craving during abstinence in humans is of importance for addiction medi

179 etamine craving after choice-based voluntary abstinence in male rats.

180 ohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious ment

181 ptoms during acute withdrawal and protracted abstinence in rats previously exposed to chronic intermi

182 ted the re-escalation of heroin intake after abstinence in rats with extended access to heroin, an an

183 ated depression-like behavior following EtOH abstinence in singly housed female C57BL/6J mice.

184 ocaine: escalation, motivation, self-imposed abstinence in the face of punishment, or propensity to r

185 PR] 1.71 [95% CI 1.32, 2.22]; p < 0.001) and abstinence in the past 14 days (45.1% versus 26.4%; adju

186 Strategies aimed at promoting alcohol abstinence in these patients are necessary.

187 The morning following their second night of abstinence, in random order, study participants received

188 Abstinence indicators (negative urines, days abstinent f

189 These preliminary findings suggest that abstinence-induced changes in catecholamine transmission

190 ex during sustained inhibition, with greater abstinence-induced decreases in activation observed amon

191 The combination of abstinence-induced decreases in left DLPFC activation an

192 Robust abstinence-induced increases in connectivity with bilate

193 with slow) metabolizers exhibited heightened abstinence-induced neural responses to smoking cues in t

194 te and left frontal pole was associated with abstinence-induced subjective cravings to smoke.

195 BOLD signal revealed a significant group-by-abstinence interaction in occipital/parietal cortex duri

196 ts indicate that drug seeking during initial abstinence involves 5-HT and beta-adrenergic signaling i

197 High rates of relapse to drug use during abstinence is a defining feature of human drug addiction

198 to a hypo- or hyperdopaminergic state during abstinence is a long-standing, unresolved debate among a

199 r results demonstrate that 7 days of cocaine abstinence is associated with decreased GluA2 Q/R site e

200 a hyperdopaminergic state during protracted abstinence is associated with vulnerability for relapse.

201 Abstinence is essential for long-term survival.

202 As such, relapse to drug use during abstinence is frequently triggered by an encounter with

203 these changes to compulsive drug taking and abstinence is not clear.

204 SIGNIFICANCE STATEMENT: In human addicts, abstinence is often self-imposed and relapse can be trig

205 Although abstinence is often the aim of treatment, many drinkers

206 ent of a neuronal ensemble in the CeA during abstinence is required for excessive alcohol drinking in

207 onsible for AF and determine whether alcohol abstinence is required for patients with AF.

208 In many human alcoholics, abstinence is self-imposed because of the negative conse

209 In many human alcoholics, abstinence is self-imposed because of the negative conse

210 Sustained abstinence is the optimum outcome for severe disorder.

211 Six months of alcohol abstinence is typically required before liver transplant

212 Moderate drinking (vs abstinence) is associated with lower risk of CVD in the

213 After 6 months of forced drug abstinence, LgA rats returned to pre-escalation baseline

214 s diagnosed with cocaine dependence in early abstinence (<2 months, EACD) (n=23), and drug-free forme

215 n treatment depends on maintaining long-term abstinence, making relapse prevention an essential thera

216 inst heavy alcohol consumption, but complete abstinence may not be required to prevent accelerated li

217 king abstinence+placebo and (c) 24 h smoking abstinence+MPH.

218 e re-examined by FDOPA-PET after 3 months of abstinence (n = 15).

219 Treatment response was defined as complete abstinence (no alcohol consumption during 3 months of ac

220 -pressing behavior of morphine seeking after abstinence of morphine at 0.2 mg/kg, whereas this behavi

221 Addiction is characterized by cycles of abstinence, often for many months, followed by relapse,

222 e investigated the effects of forced cocaine abstinence on GluA2 Q/R site editing and ADAR2 expressio

223 ith non-reinforced drug seeking during early abstinence (on extinction day 1 (ED1)) may contribute to

224 The intervention did not affect short-term abstinence or depression outcomes.

225 r relapse to aggression seeking after forced abstinence or punishment-induced suppression of aggressi

226 Treatments did not differ on any abstinence outcome measure at 26 or 52 weeks, including

227 essation, as measured by self-reported 7-day abstinence over 22 to 26 weeks (2 randomized, controlled

228 d by lay counsellors, enhanced remission and abstinence over 3 months among male primary care attende

229 were independently associated with complete abstinence (P < 0.001 and P = 0.02, respectively) during

230 ed a linear decline from 2 days to 1 year of abstinence (P </= .001, partial eta2 > 0.26).

231 microV), and 1 year (-0.27 [1.74] microV) of abstinence (P = .02, partial eta2 = 0.16).

232 Following 24-h abstinence, participants underwent fMRI scanning while v

233 After a brief smoking abstinence, participants were exposed to the cigarettes

234 (DA) system functions after periods of drug abstinence, particularly its role in behavior in nondrug

235 These data cannot distinguish whether abstinence per se reduces risk or whether it is associat

236 strated equivalent levels of craving over an abstinence period of 30 days.

237 Following an abstinence period of 7 d, males were tested for amphetam

238 protracted (2 weeks), but not acute (24 h), abstinence period.

239 which was normalized following a 14 or 60 d abstinence period; however, although these rats appeared

240 fter recovery of DAT function over prolonged abstinence periods.

241 n show enhanced effects following withdrawal/abstinence periods.

242 ) smoking as usual+placebo; (b) 24 h smoking abstinence+placebo and (c) 24 h smoking abstinence+MPH.

243 Unexpectedly, prolonged voluntary abstinence prevented the emergence of incubation of hero

244 In addition, IntA plus abstinence produced greater evoked DA release in the pre

245 bon monoxide-confirmed self-reported initial abstinence, prolonged abstinence at 26 weeks, and point-

246 eural responses to smoking cues during early abstinence, providing a plausible mechanism to explain d

247 n = 760) had significantly higher continuous abstinence rates during weeks 15 through 24 vs the place

248 The results showed that the abstinence rates of the fathers at 6 months (adjusted OR

249 nicline-treated participants achieved higher abstinence rates than those on placebo (odds ratio [OR]

250 bupropion and nicotine patch achieved higher abstinence rates than those on placebo (OR 2.07 [1.75 to

251 Continuous abstinence rates were 35.8% and 25.8%, respectively (P=0

252 Point-prevalence abstinence rates were 47.3% in the varenicline group and

253 Although 6-month abstinence rates were high for both conditions (>/=70.0%

254 reater reductions in the number of OBE days, abstinence rates, and eating disorder psychopathologic f

255 stive behavior was measured after 30 days of abstinence, rats significantly increased their consumpti

256 Seven years of smoking abstinence reduced lung cancer-specific mortality at a m

257 n summary, we provide a new dynamic model of abstinence-related changes in the striatal DA system; in

258 Abstinence-related neurobiological changes occur in simi

259 support versus placebo in Pakistan; 6 month abstinence relative risk (RR): 2.3, 95% CI 1.4-3.8); gro

260 ual comparisons of consumption and long-term abstinence revealed significant increases in K in the ri

261 ittle evidence of immune activation; alcohol abstinence reversed most, but not all, of the immunologi

262 rt versus no intervention in Egypt, 12 month abstinence RR 3.3, 95% CI 1.4-8.9).

263 in the right habenula decreased in CD in the abstinence/saline condition vs acute cocaine and HC.

264 post-cocaine and in the left putamen in the abstinence/saline condition.

265 tivation of the CeA neuronal ensemble during abstinence significantly decreased alcohol drinking in b

266 ial fission in the NAc, during early cocaine abstinence, suggesting potential therapeutic treatment o

267 Secondary outcomes included abstinence symptoms (withdrawal and craving) and cogniti

268 analyzed data from infants with the neonatal abstinence syndrome from 2004 through 2013 in 299 neonat

269 ionwide that were attributed to the neonatal abstinence syndrome increased from 0.6% to 4.0% (P<0.001

270 s in utero and who had signs of the neonatal abstinence syndrome to receive either sublingual bupreno

271 From 2004 through 2013, the neonatal abstinence syndrome was responsible for a substantial an

272 rent pharmacologic treatment of the neonatal abstinence syndrome with morphine is associated with a l

273 Among infants with the neonatal abstinence syndrome, treatment with sublingual buprenorp

274 to the fetus, leading to postpartum neonatal abstinence syndrome.

275 during both acute withdrawal and protracted abstinence test sessions, whereas KOR antagonism had no

276 e seeking was higher after 21 d of voluntary abstinence than after 1 d (incubation of methamphetamine

277 after 21 days of either voluntary or forced abstinence than after 1 day (incubation of methamphetami

278 g abruptly is more likely to lead to lasting abstinence than cutting down first, even for smokers who

279 CI, 1.01-2.01) were associated with greater abstinence than placebo.

280 Consequences of Smoking, after >15 years of abstinence, the cardiovascular risk of former smokers be

281 ally, in two separate sessions following 6-h abstinence they viewed either PSEs or PNEs while cue-ind

282 disorders), following an overnight period of abstinence, to identify regions of the left dorsal later

283 Between tests, the rats underwent voluntary abstinence (using a discrete choice procedure between me

284 urbances measured in the NSFT following EtOH abstinence utilizing the N-methyl D-aspartate receptor (

285 nd increased PCC BOLD percent signal change (abstinence vs smoking satiety).

286 rved after adjusting for covariates and that abstinence was associated with decline in the levels of

287 This reduction was greater when abstinence was combined with screening, highlighting the

288 ined with Cox regressions; longest period of abstinence was examined with a t test, and ecological mo

289 rmalized ratio, creatinine scores), complete abstinence was independently associated with survival (P

290 During follow-up, complete abstinence was reported in 39% and was associated with b

291 Changes in behavioral performance during abstinence were associated with changes in activation in

292 Rates of 7-day abstinence were higher in the incentive group than in th

293 At 26 weeks, the risk differences for abstinence were, for patch vs varenicline, -0.76% (95% C

294 were seen in ventral striatum during smoking abstinence when subjects performed the monetary incentiv

295 intervention between 1 month and 6 months of abstinence, when addicted individuals may be most vulner

296 ch, and bupropion in helping smokers achieve abstinence, whereas bupropion and nicotine patch were mo

297 460 abolished cognitive deficits of nicotine abstinence, whereas the inhibitor of 2-AG enzymatic degr

298 increase in alcohol intake after a period of abstinence) while having no impact on context- plus cue-

299 y signals recover or adjust after protracted abstinence will be important in understanding recovery p

300 ng adults with opioid dependence maintaining abstinence with a stable dose of sublingual buprenorphin