ライフサイエンスコーパス: abuse

1 e signaling has long been implicated in drug abuse.

2 to novel treatment strategies for marijuana abuse.

3 for cod fish mince subjected to freeze-thaw abuse.

4 hysical abuse, and 0.9% (0.6-1.4) for sexual abuse.

5 mbined intervention to reduce disrespect and abuse.

6 mes narrowly focused on a particular drug of abuse.

7 ivated learning and the response to drugs of abuse.

8 an intrinsic motivator for cessation of drug abuse.

9 behavioural plasticity triggered by drugs of abuse.

10 useful tool to sustain abstinence from drug abuse.

11 pants with previous and current non-AAS drug abuse.

12 ting behavioural reinforcement and substance abuse.

13 e cardiac diseases in the setting of alcohol abuse.

14 ent of new therapeutic approaches to alcohol abuse.

15 727,591 patients, 268,084 (1.8%) had alcohol abuse.

16 development for therapeutics to reduce AMPH abuse.

17 blematic impulsive behaviour, including drug abuse.

18 atal neuron activity in response to drugs of abuse.

19 l tools for behavioural intervention in drug abuse.

20 to 3.03 (2.56-3.54) for childhood emotional abuse.

21 isorders, depression and co-morbid substance abuse.

22 bserved in individuals with history of child abuse.

23 or maladaptive outcomes, including substance abuse.

24 rventions are highly required to combat drug abuse.

25 polymorphism (MAOA-LPR) and risk for alcohol abuse.

26 moderate physical abuse, and severe physical abuse.

27 ntial biomarkers of illicit 5-nitroimidazole abuse.

28 drug seeking for prototypical substances of abuse.

29 l neurological symptom severity or childhood abuse.

30 nsmission and behavioral effects of drugs of abuse.

31 e a result of prolonged exposure to drugs of abuse.

32 rd are two significant risk factors for drug abuse.

33 rapeutic utility in the treatment of cocaine abuse.

34 s, but less likely to abstain from substance abuse.

35 erability of prodromal patients to substance abuse.

36 e development that is vulnerable to drugs of abuse.

37 Greater still is its occurrence in drugs of abuse.

38 mood, conduct disorder, and childhood sexual abuse.

39 is the leading cause of death from physical abuse.

40 s Medicaid to address its epidemic of opioid abuse.

41 rior cingulate cortex as a function of child abuse.

42 Amphetamines (AMPHs) are globally abused.

43 cal research without necessarily restricting abuses.

44 ological abuse, 6.8% (5.0-9.2) for financial abuse, 4.2% (2.1-8.1) for neglect, 2.6% (1.6-4.4) for ph

45 imate was 11.6% (8.1-16.3) for psychological abuse, 6.8% (5.0-9.2) for financial abuse, 4.2% (2.1-8.1

46 ; P = .02), substance use disorders (alcohol abuse, 96.5 [0.67]; P < .001; drug abuse, 97.6 [0.64]; P

47 (alcohol abuse, 96.5 [0.67]; P < .001; drug abuse, 97.6 [0.64]; P = .02), and specific phobia (97.1

48 derstanding the relationship between alcohol abuse, a common and theoretically modifiable condition,

49 th a high addictive potential that is widely abused across the world.

50 Drugs of abuse act on the neural pathways that mediate natural re

51 playing major roles in the actions of these abused agents in a complex and, at times, interwoven man

52 o smoked (7.4% vs 4.8%; P = .04), people who abused alcohol (10.6% vs 5.7%; P = .04), people with typ

53 al control and decision-making in adults who abused alcohol during adolescence.

54 -compulsive disorder, anorexia, or substance abuse), along with their mates.

55 Exposure to drugs of abuse alters the epigenetic landscape of the brain's rew

56 e that HS is a resilience factor for cocaine abuse and a novel therapeutic target for the treatment o

57 Opiate abuse and addiction have become a worldwide epidemic wit

58 etic landscape likely underlies chronic drug abuse and addiction.

59 Externalizing disorders-drug abuse and alcohol use disorders-demonstrated the third p

60 o investigate the associations among alcohol abuse and atrial fibrillation (AF), myocardial infarctio

61 ic education about the risks between alcohol abuse and certain types of cancer; * Support policy effo

62 reduce the incidence of prescription opioid abuse and dependence among adults with moderate to sever

63 nted side effects and the potential for drug abuse and diversion.

64 mplications for our etiologic models of drug abuse and especially for contingency management programs

65 explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, suc

66 en a worldwide epidemic of prescription drug abuse and its devastating socioeconomic impacts on publi

67 antly influence susceptibility for substance abuse and mood disorders.

68 ty in detecting clinically significant elder abuse and neglect among older adults receiving care at h

69 ol in detecting clinically significant elder abuse and neglect among older adults receiving care at h

70 g clinically significant or reportable elder abuse and neglect can be raised or lowered to be consist

71 Experiences of abuse and neglect during childhood are major predictors

72 BACKGROUND/Universal screening for elder abuse and neglect is a current controversy in geriatrics

73 scale score should indicate reportable elder abuse and neglect per the State statute.

74 e, physical abuse and neglect, and emotional abuse and neglect) in association with non-suicidal self

75 altreatment (overall, sexual abuse, physical abuse and neglect, and emotional abuse and neglect) in a

76 legal definitions of what constitutes elder abuse and neglect, this further complicates instrument d

77 The authors review the scope of the abuse and overdose epidemic, prescription practices, and

78 Opiate abuse and overdose reached epidemic levels in the United

79 el included both well-known (e.g., substance abuse and psychiatric disorders) and less conventional (

80 ion compliance, drug substitution, or misuse/abuse and require follow-up confirmatory testing by more

81 forms of violence against women are domestic abuse and sexual violence, and victimisation is associat

82 range of research lines, including substance abuse and stress, both research domains in which subject

83 EM mediates impulsivity related to substance abuse and suggest that CREM and its regulated network ma

84 of NOP receptors confers resilience to drug abuse and support a role for NOP receptor antagonism as

85 Learned associations between drugs of abuse and the drug administration environment have an im

86 issues (additional tasks and distractions), abuse and violence, inadequate team (peer) support, prob

87 ed a moderate or severe history of childhood abuse and who were also GG homozygotes for rs110402 show

88 icle disorder, and had a history of nicotine abuse and/or obesity, which are known trigger factors fo

89 .1) for neglect, 2.6% (1.6-4.4) for physical abuse, and 0.9% (0.6-1.4) for sexual abuse.

90 e, with or without a history of severe child abuse, and of psychiatrically healthy control subjects.

91 ed comorbidities, such as dyslipidemia, drug abuse, and opportunistic infections; and lifestyle are r

92 childhood emotional abuse, moderate physical abuse, and severe physical abuse.

93 suicide completers with no history of child abuse, and they were strongly correlated with myelin gen

94 Sleep disorders and substance abuse are highly comorbid and we have previously shown t

95 entanyl in the brain when taken as a drug of abuse are largely unknown.

96 isms that mediate the transition from use to abuse are not fully understood.

97 As synaptic modifications by drugs of abuse are often tied to addiction, these data suggest a

98 een socioeconomic status (SES) and substance abuse are sometimes positive, the poor are sometimes eag

99 or without (N=25) a history of severe child abuse, as well as from psychiatrically healthy control s

100 n ERK/MAPK activity are associated with drug abuse, as well as neuropsychiatric and movement disorder

101 m was psychological treatments for substance abuse, associated with an HR of 0.75 (95% CI, 0.63-0.89)

102 hips were also appreciated between childhood abuse burden and left anterior insular volume.

103 tervention designed to tackle disrespect and abuse by changing the norms and standards of care is a p

104 e in the development and maintenance of drug abuse by influencing neuronal and synaptic functions in

105 Drugs of abuse can activate microglia and astrocytes through sign

106 havioral state; however, stress and drugs of abuse can differentially affect the opposing circuitry w

107 perturbations including exposure to drugs of abuse can produce profound effects on the physiology and

108 s studies using rodents reveal that drugs of abuse cause dendritic spine plasticity in prelimbic medi

109 Drugs of abuse cause persistent alterations in synaptic plasticit

110 Alcohol abuse causes half of all deaths from cirrhosis in the We

111 ABSTRACT: Alcohol abuse causes major social, economic and health-related p

112 indeed a strong intrinsic motivator for drug abuse cessation.

113 categories assessed, psychoactive substance abuse conferred the highest risk for all-cause mortality

114 (including duration and severity of alcohol abuse, craving, and anxiety or depressive symptoms) were

115 al cannabidiol to address the current opioid abuse crisis.

116 valence and severity of methamphetamine (MA) abuse demands greater neurobiological understanding of i

117 We determined the risk of an alcohol abuse diagnosis on incident AF, MI, and CHF.

118 5; 95% CI, 1.21-1.49), alcohol and substance abuse disorders (aOR, 1.34; 95% CI, 1.05-1.72), mood dis

119 Alcohol abuse disorders are associated with dysfunction of front

120 th no comorbid psychiatric, medical, or drug abuse disorders were scanned following 2 weeks of outpat

121 ddiction and a DSM-V criterion for substance abuse disorders, the molecular adaptations producing tol

122 for advancing our understanding of substance abuse disorders.

123 europsychiatric disease, including substance abuse disorders.

124 Tolerance is a DSM-V criterion for substance abuse disorders.

125 ould be developed as medications for alcohol abuse disorders.

126 th multiple phenotypes such as the substance abuse disorders.

127 deficit hyperactivity disorder and substance abuse disorders.

128 ddiction and a DSM-V criterion for substance abuse disorders.

129 Cocaine abuse disrupts dopamine system function, and reduces coc

130 Primary screening of drugs of abuse (DoA) currently relies on immunoassays that are pr

131 inhibit glutamatergic responses to drugs of abuse, drug-associated cues, and stressors.

132 king observed in individuals who chronically abuse drugs reflects a decrease in goal-directed behavio

133 that are elicited by and shared between all abused drugs from the perspective of tetrapartite synaps

134 es constitute a growing and dynamic class of abused drugs in the United States.

135 mat used for small molecule analysis such as abused drugs restricts the quantitation ability of LFA s

136 self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicoti

137 e observed following withdrawal from several abused drugs, including cocaine.

138 Ethanol is one of the most commonly abused drugs.

139 odds of a woman experiencing disrespect and abuse during childbirth (odds ratio [OR]: 0.34, 95% CI:

140 n to reduce the prevalence of disrespect and abuse during childbirth in Tanzania.

141 self-reported experiences of disrespect and abuse during childbirth.

142 s assessed as exposure to sexual or physical abuse during childhood.

143 ers had a greater reduction in risk for drug abuse during pregnancy (odds ratio=0.40, 95% CI=0.34, 0.

144 hin-person analyses of registration for drug abuse during pregnancy among Swedish women born between

145 in habit formation and affected by drugs of abuse, during performance of a complex reward-guided dec

146 with therapeutic potential, and in drugs of abuse (e.g., hallucinogens, central stimulants, empathog

147 pean Monitoring Center of Drugs and Drugs of Abuse (EMCDDA).

148 The present opioid abuse epidemic should prompt physicians to consider revi

149 CE STATEMENT The current prescription opioid abuse epidemic underscores the urgency to develop altern

150 cidate their role in the prescription opioid abuse epidemic.

151 tion and without a cohabiting, actively drug-abusing father.

152 ng salt extractable protein from freeze-thaw abused fish mince, providing similar or better cryoprote

153 HIV-1 infection and methamphetamine (METH) abuse frequently occur simultaneously and may have syner

154 disorder (P < .001), and those with alcohol abuse had a mean (SE) of 5.6 (1.2) points lower IQ than

155 Child abuse has devastating and long-lasting consequences, con

156 ABSTRACT: Ethanol, like other drugs of abuse, has both rewarding and aversive properties.

157 on epigenetic mechanisms involved in alcohol abuse have focus on hepatic and neuronal regions, leavin

158 Donor age, obesity, alcohol abuse, hepatitis serology, liver only donor, imaging res

159 Substance abuse history was the strongest predictor of OD (odds ra

160 is known to be disrupted after chronic drug abuse; however, it remains unclear what neural signals i

161 Although marijuana is the most commonly abused illicit drug, the implications of legalized, wide

162 e (AMPH) and methamphetamine (MA) are widely abused illicit drugs.

163 Alcohol abuse impairs immune defense.

164 Cannabis abuse in adolescence is associated with increased risk o

165 gs extend our understanding of risk for drug abuse in individuals with poor inhibitory control and su

166 ssociated with childhood physical and sexual abuse in interaction with an FKBP5 risk allele previousl

167 r relevance to this study, is the antibiotic abuse in pig breeding.

168 The estimated odds ratio for drug abuse in pregnancy-discordant monozygotic twins was even

169 t is the most common strategy to manage drug abuse in pregnant women.

170 One approach to decrease drug abuse in sports would be to accept that there is a delay

171 gs has led to the current epidemic of opioid abuse in the US.

172 Risk for drug abuse in women is substantially reduced during pregnancy

173 The results suggest that child abuse, in part through epigenetic reprogramming of oligo

174 related behaviour caused by several drugs of abuse, including alcohol.

175 attenuate the behavioral effects of drugs of abuse, including cocaine.

176 Alcohol abuse increased the risk of AF, MI, and CHF to a similar

177 Alcohol, like other drugs of abuse, increases levels of dopamine in the nucleus accum

178 ress disorder, substance dependence, current abuse, intellectual disability, or unstable serious phys

179 ty, mental health, abstaining from substance abuse, interpersonal functioning, and parenting responsi

180 Prescription opioid abuse is a growing concern that has garnered widespread

181 Nonetheless, elder abuse is a neglected global public health priority, espe

182 Substance abuse is a pressing problem with few therapeutic options

183 Methamphetamine (METH) abuse is a serious social and health problem worldwide.

184 nfection in individuals who utilize drugs of abuse is a significant problem, because these drugs have

185 ividual analyses indicate that risk for drug abuse is also substantially reduced in the postpartum pe

186 Finally, results showed that child abuse is associated in the Kappa intron with a selective

187 Elder abuse is recognised worldwide as a serious problem, yet

188 s (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechan

189 d increased attention to childhood emotional abuse is warranted.

190 An efficient control of abuses is guaranteed not only by highly performing analy

191 een studied in the context of other drugs of abuse, it is not known whether toluene exposure differen

192 Intravenous drug abuse (IVDA) is a known risk factor for endogenous funga

193 Most drugs of abuse lead to a general blunting of dopamine release in

194 hat are more effective, safer, and devoid of abuse liabilities are desperately needed.

195 trate activity at DAT and NET, and decreases abuse liability of the compounds.

196 mmune mechanisms that may contribute to drug-abuse liability, exploring evidence from opioids, alcoho

197 mparisons of their therapeutic potential and abuse liability, two specific areas that are of signific

198 rategy that lacks tolerance, dependence, and abuse liability.

199 rstand how the chemical modifications affect abuse liability.

200 ive impairments in offspring of mothers that abuse marijuana during pregnancy.

201 be at risk for perpetrating intimate partner abuse may save lives.

202 ance of understanding how genes and drugs of abuse mechanistically impact each other.

203 al lead for development as a psychostimulant abuse medication.

204 Thus, efforts to mitigate alcohol abuse might result in meaningful reductions of cardiovas

205 ine about self-report of childhood emotional abuse, moderate physical abuse, and severe physical abus

206 Both endogenous opioids and opiate drugs of abuse modulate learning of habitual and goal-directed ac

207 s with pancreas divisum (n = 3), and alcohol abuse (n = 2).

208 maltreatment (physical, sexual, or emotional abuse, neglect, or family conflict) before age 18 years

209 Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse e

210 Early life stress (ELS) in the form of child abuse/neglect is associated with an increased risk of de

211 The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of

212 , surgery, drug therapy, smoking, or alcohol abuse, nor was there any relevant family history.

213 She denied abuse of alcohol or recreational drugs and reported she

214 hrombotic microangiopathy (TMA) following IV abuse of extended-release oxymorphone hydrochloride (Opa

215 e is no complete solution for the problem of abuse of statistics, but methodological training needs t

216 As such this article represents a severe abuse of the scientific publishing system.

217 toms (e.g., cognitive deficits and substance abuse) often precede the clinical diagnosis of schizophr

218 addiction and the damaging effects of heroin abuse on cognition and the salience network.

219 The population-attributable risk of alcohol abuse on each outcome was of similar magnitude to other

220 monstrate the functional impact of a drug of abuse on synaptic mechanisms of identified afferents to

221 disorder, depression, anxiety, and substance abuse) on this association.

222 Heroin is a highly abused opioid and incurs a significant detriment to soci

223 induced antibodies bound to heroin and other abused opioids, including hydrocodone, oxycodone, hydrom

224 hronic kidney disease (CKD), alcohol or drug abuse or dependence diagnosis, and anemia.

225 rgic abnormalities are due to acute nicotine abuse or whether they persist with abstinence.

226 clinical models of anxiety, cough, substance abuse, pain (spinal and peripheral), and urinary inconti

227 Women reported much more emotional/economic abuse (past-year ranges 1.4%-5.7% for men and 4.1%-27.7%

228 may contribute to sex differences in opioid abuse patterns and may guide sex-specific therapies.

229 s of childhood maltreatment (overall, sexual abuse, physical abuse and neglect, and emotional abuse a

230 main measure additionally included emotional abuse, physical neglect, and emotional neglect.

231 tors such as smoking, obesity, and substance abuse play a part but do not fully explain the steeper g

232 nique DAT inhibitor that has no cocaine-like abuse potential by itself.

233 ement because deltaR agonists show decreased abuse potential compared with current opioid analgesics

234 Clinical studies have indicated a lower abuse potential for TRIs than psychostimulants.

235 nt devoid of the psychotomimetic effects and abuse potential of ketamine.

236 The effects of ibudilast on the abuse potential of opioids in humans are largely unknown

237 rapeutics include controlled substances with abuse potential or drugs with undesirable side effects.

238 d and nonopioid mechanisms of action and low abuse potential, is effective for use in supervised with

239 vely inhibited by psychostimulants with high abuse potential.

240 tropic and sedative side effects, as well as abuse potential.

241 gy in developing future analgesics that lack abuse potential.

242 elessness, intravenous drug use, and alcohol abuse predisposed patients to emm32.2 iGAS disease; howe

243 Studies reporting estimates of past-year abuse prevalence in adults aged 60 years or older were i

244 prehensive search strategy to identify elder abuse prevalence studies in the community published from

245 nsure patient safety and secondly to prevent abuses/procedural biases.

246 Patients had no history of drug abuse, psychosis, dementia/neurodegenerative diseases or

247 platform for identifying adverse effects of abused psychostimulants and pharmaceutical agents, and c

248 carotid stenosis intervention, and substance abuse referral for alcohol.

249 amine that is shared by sucrose and drugs of abuse, reinstated sucrose seeking does not induce glutam

250 c administration of TAAR1 agonists decreased abuse-related behaviors of cocaine.

251 that elongating the N-alkyl chain decreased abuse-related effects in vivo that appeared to parallel

252 ong bath salt constituents contribute to the abuse-related effects of bath salts preparations.

253 ediating serotonergic attenuation of cocaine abuse-related neurochemical and behavioral effects.

254 Cocaine is the leading cause for drug-abuse-related visits to emergency departments, most of w

255 Effective medications for drug abuse remain a largely unmet goal in biomedical science.

256 Cocaine abuse remains a public health concern for which pharmaco

257 ta-analysis of studies that included overall abuse revealed heterogeneity.

258 y management programs seeking to reduce drug abuse risk.

259 ychiatric disorders, in particular substance abuse, schizophrenia, and the potential antidepressant p

260 NBOMe are not a part of the routine drugs-of-abuse screening procedure for many police forces, and th

261 ow-income and middle-income countries, elder abuse seems to affect one in six older adults worldwide,

262 Although prescription opioid abuse shows geographic variation, all physicians should

263 dopamine tone following exposure to drugs of abuse.SIGNIFICANCE STATEMENT Here we report that mice la

264 A history of child abuse specifically associated in the anterior insula wit

265 used to perform ex vivo analysis of drugs of abuse spiked in urine and OF samples.

266 Alcohol is the most commonly abused substance among adolescents, promoting the develo

267 ction following chronic exposure to drugs of abuse such as cocaine may impair appropriate valuation o

268 ns themselves appear insensitive to drugs of abuse, such as cocaine, when afferents are collectively

269 d and the reinforcing properties of drugs of abuse, such as psychostimulants.

270 have antidepressant effects and is a drug of abuse, suggesting it may have dopaminergic effects.

271 w assays (LFAs) are an ideal choice for drug abuse testing favored by their practicability, portabili

272 ere may be more complex consequences of drug abuse than current theories have explored, especially wh

273 hylamphetamine (4-MA) is an emerging drug of abuse that interacts with transporters, but limited stru

274 and growing concern regarding opioid use and abuse, there has been a push toward greater regulation o

275 Escapees recounted the abuses they had suffered, including forced religious con

276 duce multiple behavioral effects of drugs of abuse through their actions on the mesocorticolimbic sys

277 Our knowledge of ethanol use and abuse thus relies on understanding its effects on the br

278 Research has linked childhood abuse to a variety of adult psychiatric problems, but li

279 imental manipulations, ranging from drugs of abuse to disease-causing mutations.

280 h salts use is associated with high rates of abuse, toxicity, and death.

281 itry and are often one of the first drugs of abuse tried by adolescents.

282 ionships, and (4) partner factors (substance abuse, unemployment, and infidelity).

283 sessment of biomarkers for emerging drugs of abuse using a four-step analytical procedure.

284 M) in mediating impulsivity relevant to drug abuse vulnerability.

285 to examine the glutamate underpinnings of MA abuse vulnerability.

286 The pooled prevalence rate for overall elder abuse was 15.7% (95% CI 12.8-19.3).

287 Drug abuse was assessed from medical, criminal, and pharmacy

288 After multivariable adjustment, alcohol abuse was associated with an increased risk of incident

289 A history of child abuse was associated with cell type-specific changes in

290 Overall, prevalence of smoking and alcohol abuse was higher among patients with AD than the general

291 ative association between pregnancy and drug abuse was moderately stronger in cousins (odds ratio=0.4

292 Using a rodent model of cocaine abuse, we found long-lasting, possibly permanent, cocain

293 rder, hearing difficulty, or history of drug abuse were excluded.

294 In the population, rates of drug abuse were lower during pregnancy (unadjusted odds ratio

295 ians should be highly inquisitive of IV drug abuse when presented with cases of TMA.

296 Within individuals, the odds ratio for drug abuse while pregnant compared with an equivalent prepreg

297 little is known about associations of child abuse with adult mortality.

298 point to both a co-occurrence and a cycle of abuse, with childhood trauma leading to violence against

299 are), intraabdominal conditions, and alcohol abuse/withdrawal.

300 ical symptoms and the magnitude of childhood abuse would be associated with overlapping anterior cing