ライフサイエンスコーパス: abuser

1 , manganese intoxication in intravenous drug abusers).

2 rs1137070 was significantly higher in heroin abusers.

3 ug craving observed in human psychostimulant abusers.

4 ted in 39 comparison subjects and 39 cocaine abusers.

5 control, attention and vigilance in cocaine abusers.

6 Two thirds were homeless and/or substance abusers.

7 so increased, particularly among amphetamine abusers.

8 cific guidelines for assessment of substance abusers.

9 regions (e.g., prefrontal cortices) in drug abusers.

10 and anhedonia in detoxified methamphetamine abusers.

11 stimulant drug methylphenidate in 25 cocaine abusers.

12 rget and provide care to the youngest heroin abusers.

13 ain dopamine (DA) neurons of chronic cocaine abusers.

14 relative strengths on a vigilance task among abusers.

15 within the dopamine neurons of human cocaine abusers.

16 tudy extends this finding to methamphetamine abusers.

17 in cocaine abusers, alcoholics, and heroine abusers.

18 imilar association occurs in methamphetamine abusers.

19 ession to HAD are accelerated in opiate drug abusers.

20 the thalamus and striatum of methamphetamine abusers.

21 s been detected in lymphocyte DNA of alcohol abusers.

22 e, on brain glucose metabolism in 20 cocaine abusers.

23 d behavior characteristic of chronic cocaine abusers.

24 al blood donors, and 17% of intravenous drug abusers.

25 ing and relapse in abstinent human substance abusers.

26 to excess during follow-up than did the past abusers.

27 s and the 89 patients who were not substance abusers.

28 iously described in ICU patients and alcohol abusers.

29 rican females and African American substance abusers.

30 tamen of 11 self-identified intravenous drug abusers.

31 ned cocaine abstinence in injecting polydrug abusers.

32 d to facilitate drug abstinence in substance abusers.

33 ated disease observed in HIV-1-infected drug abusers.

34 de to D2/D3 receptors) in detoxified cocaine abusers.

35 opride) to MP between controls and marijuana abusers.

36 underlie decision-making impairments in drug abusers.

37 matergic and dopaminergic pathways in opiate abusers.

38 maladaptive decision making seen in cocaine abusers.

39 AIDS dementia is accelerated in opiate drug abusers.

40 t peripheral visual field changes in cocaine abusers.

41 increased the risk for cirrhosis in alcohol abusers.

42 MAT2 availability in the striatum of cocaine abusers.

43 to relapse and outcome in abstinent cocaine abusers.

44 ation responses between controls and cocaine abusers.

45 e been attributed to buprenorphine in opioid abusers.

46 underlying impaired host defense in alcohol abusers.

47 t of reproductive competence in male steroid abusers.

48 croglial activation in human methamphetamine abusers.

49 de (65 mg/d) in 180 opioid-dependent cocaine abusers (124 men, 56 women).

50 arison subjects (1.4 versus 3.7) and cocaine abusers (2.8 versus 4.8).

51 Seventeen abstaining (4-7 days) MA abusers (6 women) were compared with 18 control subjects

52 n with hepatitis C virus (HCV) than non-drug abusers (90% vs 30%).

53 iosis in the brains of human methamphetamine abusers, a level of activation that appears to subside o

54 At day 45 (visit 4), cocaine abusers again showed improvement on the Pursuit Rotor Ta

55 ity have been previously reported in cocaine abusers, alcoholics, and heroine abusers.

56 jor public health problems, and most cocaine abusers also smoke cigarettes.

57 jor public health problems, and most cocaine abusers also smoke cigarettes.

58 tudy reports on 12 abstinent methamphetamine abusers and 12 age-, gender-, and education-matched cont

59 Sixteen cocaine abusers and 13 matched healthy comparison subjects perfo

60 in a group of 15 recently abstinent cocaine abusers and 17 matched healthy controls.

61 the brains of 15 detoxified methamphetamine abusers and 18 comparison subjects.

62 d 62 participants (43 non-detoxified cocaine abusers and 19 controls) using positron emission tomogra

63 ic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigated the

64 Fifteen methamphetamine abusers and 20 non-drug-abusing comparison subjects were

65 Fifteen detoxified methamphetamine abusers and 21 comparison subjects underwent positron em

66 Thirty-seven cocaine abusers and 27 control subjects were administered the fo

67 Fifty-nine cocaine abusers and 32 healthy controls provided data for the fo

68 gray matter volume (GMV) based on 78 heroin abusers and 79 healthy controls.

69 Depressive disorders are common among opiate abusers and are associated with detrimental behavioral e

70 nous European Caucasian population of heroin abusers and control subjects and in an animal model of h

71 robust allele frequency differences between abusers and controls in both European- and African-Ameri

72 Both METH abusers and controls showed decreased striatal D2R avail

73 these systems in three populations of opiate abusers and controls, totaling 489 individuals from Euro

74 The orphans were similar to the alcohol abusers and dissimilar to the other drinkers in alcohol

75 evelop immune thrombocytopenia than non-drug abusers and have a higher coinfection with hepatitis C v

76 Drug abusers and HIV patients with HAND had increased levels

77 etabolic rate in the orbitofrontal cortex in abusers and in comparison subjects.

78 opportunistic infections in intravenous drug abusers and in opioid-medicated postsurgical patients.

79 e periamygdaloid cortex (PAC) in both heroin abusers and MDD subjects.

80 nd viral infections such as HIV in both drug abusers and patients receiving morphine.

81 ed FHC expression and CXCR4 status in opiate abusers and patients with HIV-associated neurocognitive

82 p of depression to alcohol use among cocaine abusers and suggest a need for further studies of the as

83 ared with those of the 109 current substance abusers and the 89 patients who were not substance abuse

84 y rewards of different magnitudes in cocaine abusers and to study its association with motivation and

85 ncy differences between heavy poly-substance abusers and well characterized control individuals.

86 midbrain gene expression in chronic cocaine abusers and well-matched drug-free control subjects usin

87 ls from the music industry, intravenous drug abusers, and prisoners.

88 in the brains of both animals and human drug abusers, and the cellular mechanisms underlying this inj

89 routes by which HIV is spread, noninjection abusers are also at high risk.

90 ~20% of downregulated genes in human heroin abusers are ELK1 targets.

91 n, but DCS effects on CET in substance users/abusers are less robust.

92 Almost all AAS abusers are male and lift weights, but the risk factors

93 HIV-1-seropositive drug abusers are more prone to develop immune thrombocytopeni

94 ic, opioid, and serotonergic systems in drug abusers are seen in positron emission tomography scans.

95 ansporters observed in studies of human drug abusers are the result of the neurobiological effects of

96 dala; the correlation was inversed in opiate abusers as compared with controls.

97 Striatal ELK1 in heroin abusers associated with the polymorphism rs2075572 in OP

98 ulate, limbic, and paralimbic cortices of MA abusers (averaging 11.3% below control; p < 0.05).

99 tomography and [(11)C]raclopride in 16 METH abusers, both after placebo and after challenge with 60

100 should be broadened to include not only the abuser but also those who may be at risk because of thei

101 ave improved treatment outcomes of substance abusers, but have not been widely implemented in communi

102 ficacious in improving outcomes in substance abusers, but these treatments have rarely been implement

103 same images, and the other to group cocaine abusers by insight.

104 Here, we test whether cannabis abusers (CA) have impaired frontal function and reactivi

105 ntly drug-abstinent (3 months to 2 years) MA abusers compared with 27 nonsubstance-abusing control su

106 oamine transporter type 2 (VMAT2) in cocaine abusers compared with control subjects.

107 cortical and subcortical regions in cocaine abusers compared with healthy controls.

108 Abusers consistently show reduced subjective effects of

109 ble aspects of addiction, as human substance abusers continue to pursue drugs despite incurring signi

110 es in striatal metabolism in methamphetamine abusers could reflect long-lasting changes in dopamine c

111 In marijuana abusers, DA responses in ventral striatum were also inve

112 The cocaine abusers demonstrated an overall reduced regional brain r

113 In cocaine abusers despite the markedly attenuated dopaminergic eff

114 eepiness induced by lorazepam in some of the abusers, despite their significantly lower plasma concen

115 Drug abusers dually infected with HCV and HIV-1 had a greater

116 the blood cocaine concentration reported in abusers dying of cocaine intoxication.

117 Pain management in opioid abusers engenders ethical and practical difficulties for

118 rain DA transporters in five methamphetamine abusers evaluated during short abstinence (<6 months) an

119 Ketamine abusers exhibit urinary frequency, urgency, and at times

120 for whole brain metabolism, methamphetamine abusers exhibited significantly lower metabolism in the

121 underscore the value of screening substance abusers for PTSD, because it can identify a small but su

122 nical significance of lower VMAT2 in cocaine abusers, for example, its relationship to relapse and vu

123 somal markers whose alleles distinguish drug abusers from control individuals in each of two samples,

124 Within the abuser group, higher levels of stimulant use were largel

125 On average, MA abusers had 7.8% smaller hippocampal volumes than contro

126 Methamphetamine abusers had a significantly lower level of D2 receptor a

127 60 years of age, 18% of the college alcohol abusers had died, 11% were abstinent, 11% were controlle

128 0 years of age, 28% of the core city alcohol abusers had died, 30% were abstinent, 11% were controlle

129 METH abusers had lower D2R availability in caudate than in co

130 Victim-abusers had more frequently witnessed serious intrafamil

131 cifically, compared with controls, marijuana abusers had significantly attenuated behavioral ("self-r

132 The number of ketamine abusers has increased significantly recently.

133 Studies in methamphetamine abusers have also documented significant loss of DA tran

134 Substance abusers have difficulty ignoring drug-related cues, whic

135 Many HIV-infected opiate abusers have increased neuroinflammation that may augmen

136 ubjects, recently detoxified methamphetamine abusers have lower metabolism in the striatum and thalam

137 tomography (PET) imaging studies in cocaine abusers have shown that low dopamine release in the stri

138 be effective in groups of indigent substance abusers, health services must be integrated into the wel

139 On the Pursuit Rotor Task, cocaine abusers improved their performance at a faster rate than

140 m 52 consecutively admitted injecting heroin abusers in a methadone maintenance treatment program.

141 acteristics of male child victims who became abusers in later life.

142 d with an increased risk of victims becoming abusers in later life.

143 Among indigent alcohol and drug abusers in New York City, the rates of tuberculosis, AID

144 nce of functional changes in methamphetamine abusers in regions other than those innervated by dopami

145 tients, 70 were classified as past substance abusers in remission at baseline.

146 nd clinical role of depression among cocaine abusers in treatment.

147 ntly differed significantly from the current abusers in variables involving frequency of drug and alc

148 bsequently committed sexual offences (victim-abusers), in almost all cases with children, mainly outs

149 doses within the range administered by drug abusers induces cerebral microischemia and that these ef

150 ccelerated disease progression among alcohol abusers infected with HCV is clinically well recognized,

151 a synergistic manner, and suggest that METH abusers infected with HIV may be at increased risk for b

152 ed susceptibility to infection among alcohol abusers is a significant but not well-understood problem

153 idence that low striatal DA function in METH abusers is associated with a greater likelihood of relap

154 ssessed whether striatal DA activity in METH abusers is associated with clinical outcomes.

155 m seen in this region in the methamphetamine abusers is the result of methamphetamine effects in circ

156 re severe forms of HAND in HIV-infected drug abusers is unclear.

157 ion in humans that the doses used by cocaine abusers lead to significant blockade of DAT, and that th

158 Mood disturbances in methamphetamine (MA) abusers likely influence drug use, but the neurobiologic

159 In cocaine abusers, low levels of D2 receptors are associated with

160 erdose of acetaminophen in a chronic alcohol abuser may result in more severe hepatotoxicity than in

161 Cocaine abusers may experience drug craving upon exposure to env

162 own to be sites of neurotoxicity in adult MA abusers, may be more vulnerable to prenatal MA exposure

163 In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppre

164 (effect size 0.89; P<0.001), but in cocaine abusers methylphenidate's effects did not differ from pl

165 hophysiological changes occurring in cocaine abusers' midbrains should contribute to the development

166 n to a verbal working memory task in cocaine abusers (n=16) and healthy controls (n=16).

167 that almost 20 million Americans are current abusers of illicit substances.

168 Abusers of MA have abnormalities in brain regions implic

169 Abusers of MA provided higher self-ratings of depression

170 ethamphetamine at dose levels taken by human abusers of the drug leads to dopamine transporter reduct

171 nagement of chronic pain, and chronic heroin abusers, often present with complications such as increa

172 Six (29%) of 21 victim-abusers on whom we had relevant data had been cruel to a

173 commercial blood donors and intravenous drug abusers, only 1%-3% of the TTV-positive individuals were

174 rain endothelium seen in HIV(+)/cocaine drug abusers paralleled increased CD68 immunostaining compare

175 In contrast, abusers performed significantly better on one test of at

176 hese functions, univariate tests showed that abusers performed significantly worse on certain tests o

177 Multivariate tests showed that abusers performed significantly worse than nonabusers on

178 nical manifestations seen in opioid user and abuser populations.

179 route of administration for human substance abusers, preclinical models that incorporate inhaled exp

180 For cocaine abusers, prefrontal cortex sensitivity to money was inst

181 Cessation of drug use in chronic opiate abusers produces a severe withdrawal syndrome that is hi

182 s in a context in which many live with their abuser, protecting confidentiality when breaches could p

183 erminals) in the striatum of methamphetamine abusers recover with protracted abstinence and that rela

184 eptors during intoxication in active cocaine abusers regardless of cues exposure, which might contrib

185 ment on a motor learning test in the cocaine abusers relative to controls.

186 e of the vesicular dopamine pool, in cocaine abusers relative to healthy subjects.

187 studies of psychiatric comorbidity in opioid abusers reported rates of comorbidity that far exceeded

188 o, in comparison subjects but not in cocaine abusers, reward-induced improvements in performance were

189 e use comorbidity was assessed in 716 opioid abusers seeking methadone maintenance.

190 In MA abusers, self-reports of depressive symptoms covaried po

191 did not differ between groups, the marijuana abusers showed markedly blunted responses when challenge

192 Methamphetamine abusers showed significant dopamine transporter reductio

193 Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA)

194 Compared to controls, cocaine abusers showed: (1) hypoactivation in the mesencephalon,

195 tes, cocaine at doses typically used by drug abusers significantly increased brain glucose metabolism

196 self-reports of depression and anxiety in MA abusers suggest that these regions are involved in affec

197 dopamine neurons of NURR1-deficient cocaine abusers, suggesting that NURR1 plays a critical role in

198 hich replicates previous findings in cocaine abusers, suggests that D2 receptor-mediated dysregulatio

199 the comparison subjects, the methamphetamine abusers tested after protracted abstinence had lower met

200 ) abstinence interval, eight methamphetamine abusers tested only after protracted abstinence, and 11

201 hich were significantly higher for marijuana abusers than controls.

202 P(ND) was significantly lower in the cocaine abusers than in the comparison subjects in the limbic st

203 11195 binding were higher in methamphetamine abusers than those in control subjects in all brain regi

204 eactivity to the DA stimulation in marijuana abusers that might contribute to their negative emotiona

205 In the cocaine abusers, the predictive ability of the late positive pot

206 system was used to model the weekend opiate abuser: the nondependent, nonaddicted, and nontolerant p

207 l stimuli may be involved in motivating drug abusers to engage in drug seeking after abstinence.

208 DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinson

209 transporters in striatum, in methamphetamine abusers using positron emission tomography and [(11)C]d-

210 hole brain metabolism in the methamphetamine abusers was 14% higher than that of comparison subjects;

211 A characteristic feature of heroin abusers was decreased expression of MOR and extracellula

212 ous methylphenidate and in 24 of the cocaine abusers, we also compared dopamine increases when methyl

213 of inhibitory control deficits in substance abusers, we examined neural processing characteristics i

214 ecreases in dopamine D2 receptors in cocaine abusers were associated with decreased metabolism in the

215 The past abusers were significantly more likely to be women, and

216 For this purpose, METH abusers were tested within 6 months of last METH use and

217 , the majority of whom were intravenous drug abusers, were analyzed by using PCR with restriction fra

218 prefrontal and parietal cortices in cocaine abusers when compared with controls, which might reflect

219 the orbitofrontal cortex in methamphetamine abusers, which replicates previous findings in cocaine a

220 XCR4 and exacerbate neuropathology in opiate abusers who are affected by neuroinflammatory/infectious

221 The 10 METH abusers who completed detoxification did not differ from

222 subjects; this reduction was evident even in abusers who had been detoxified for at least 11 months.

223 The six METH abusers who relapsed during the follow-up period had low

224 F]fluorodeoxyglucose in five methamphetamine abusers who were evaluated after both a short (<6 months

225 tion and cognitive impairment seen in opioid abusers with HIV-1.

226 er predicted cocaine image choice in cocaine abusers with impaired insight.

227 (and actual cocaine use severity) in cocaine abusers with intact insight.

228 ine at time of study (as compared to cocaine abusers with negative urines) suggesting that the defici

229 widely prescribed for the treatment of drug abusers with opioid dependence, affects human immunodefi

230 bnormalities were accentuated in the cocaine abusers with positive urines for cocaine at time of stud

231 ranulocytopenia frequently occurs in alcohol abusers with severe bacterial infection, which strongly

232 erlying the impaired host defense in alcohol abusers with severe bacterial infections.

233 Heroin abusers with the C allele had lower measures of GMV in t

234 8 participants (24 controls and 24 marijuana abusers) with methylphenidate (MP), a drug that elevates

235 logical deficits commonly afflicting cocaine abusers, yet the underlying mechanisms responsible for t