ライフサイエンスコーパス: access of @1 to

1 sistent with the hypothesis that MSP hinders access of Mn2+ to a site of photoligation.

2 ith GCAP-2 and found that GCAP-2 reduces the access of trypsin to a site in the kinase homology domai

3 tive effects by competitively inhibiting the access of FPRL1 to Abeta(42).

4 Histone binding and blocking access of coactivators to acetylation sites on histones

5 ternative NHEJ or participates in regulating access of DSBs to alternative repair pathways.

6 mechanism by which reticulon proteins block access of BACE1 to amyloid precursor protein and reduce

7 e the lumenal surface glycocalyx limited the access of AdV to apical GPI-CAR.

8 expanded to meet increased demand, including access of up to approximately 33 x 10(9) gal/year (125 x

9 on from microtubule attachment may influence access of MCAK to Aurora B kinase and its opposing phosp

10 e vesicles or proteoliposomes, thus allowing access of ATP to both sides of the bilayer.

11 ase of proteins from the organelle lumen and access of proteases to both lumenal and integral membran

12 e N-terminal domain of CaM in regulating the access of ATP to CaMKI.

13 ar location of p15 and p27 ensures the prior access of p15 to cdk4.

14 ymers in hemicellulose and also increase the access of enzymes to cellulose fibers.

15 erefore is maintained in part by restricting access of telomerase to chromosome termini, but this lim

16 ly increased, implying that CopZ reduces the access of CsoR to copper.

17 The bound carbonate blocks direct access of substrates to Cu(I), suggesting that an adjunc

18 action sequence is not caused by the limited access of phenol to cyclohexanol, but is due to the abse

19 pH and opens at acidic pH to allow the rapid access of urea to cytoplasmic urease.

20 the cell surface, we demonstrate that direct access of gp96 to DCs induces their maturation, resultin

21 In this manner, MAP1B restricts the access of AMPARs to dendritic spines and the postsynapti

22 f Drosophila melanogaster mutants that block access of cargo to different endocytic compartments.

23 cription by blocking polymerase movement and access of factors to DNA.

24 re" processes potentially provide the needed access of proteins to DNA in chromatin.

25 ile others facilitate activation by allowing access of regulators to DNA.

26 the presence of polymorphic genes affecting access of sperm to eggs.

27 We suggest that access of IgG to epitopes in the central nervous system

28 iate with H3 in 14-3-3sigma, which prevented access of Suv39h1 to H3, thereby preventing hypermethyla

29 loroquine-resistance mechanism regulates the access of chloroquine to hematin.

30 loading vesicles and for blocking premature access of peptides to HLA class II molecules during matu

31 ariable loop conformations that restrict the access of antibodies to immunogenic neutralization epito

32 ed at culling infected cows and limiting the access of cattle to infective oocysts.

33 surface of the microtubule could facilitate access of alphaTAT1 to its luminal site of action if mic

34 role of receptor phosphorylation is to allow access of arrestin to its receptor binding domain rather

35 y modulate BACE1 activity through preventing access of BACE1 to its cellular APP substrate.

36 support of the view that methylation limits access of FOXP3 to its DNA targets, we showed that incre

37 and Msn2 such that nucleosomes can restrict access of Msn2 to its canonical binding sites while Msn2

38 regulate cell envelope structure to decrease access of nisin to its lipid II target.

39 the M2 helix of SERCA, possibly controlling access of PLB to its binding site on SERCA.

40 igh tubulin concentrations might prevent the access of PLCbeta1 to its substrate.

41 ld inhibits telomere maintenance by blocking access of telomerase to its cognate binding site at telo

42 histidines at the subunit interface controls access of zinc to its binding site.

43 We demonstrated that limiting the access of GC to LHr decreases the ability of the host ce

44 ous calpain activity, likely via the spatial access of calpain to MAP2.

45 the protein arrestin-1, which blocks further access of Gt to Meta II.

46 sult further validates our proposal that the access of solvent to methionine sites, as measured by th

47 or p130, interacts with Sin1 and blocks the access of Akt to mTORC2, leading to attenuated Akt activ

48 hat form the anionic semiquinone and promote access of oxygen to N5.

49 These features are proposed to limit the access of therapies to neoplastic cells and blunt treatm

50 rans-synaptic bridges by sterically blocking access of neurexins to neuroligins.

51 embody a "gate," which provides alternating access of protons to one or the other side of the membra

52 noncoding RNAs, called Y RNAs, that inhibit access of Ro to other RNAs.

53 of glucocorticoids, thus ensuring selective access of aldosterone to otherwise non-selective mineral

54 and conditions that deplete PIP2 or restrict access of TRPV4 to PIP2--in the case of PACSIN3--change

55 s for the selection of viral tropism and the access of drugs to protease for specific tropic types.

56 to grana margin, which leads to a controlled access of proteases to PS II.

57 odel whereby BRCA1 impacts on 53BP1 to allow access of POH1 to RAP80.

58 on of the subset repressor IRF8, and impedes access of JunD to regulatory regions of alternative effe

59 TRAP150 interacts with dimeric PSF to block access of RNA to RRM2, thereby regulating the activity o

60 However, changes in access of insulin to sensitive tissues such as skeletal

61 Access of cAMP to Site A is mediated by Site B.

62 p-dependent synthesis by also inhibiting the access of Mal63p to site 1 in the UASMAL.

63 ame or overlapping regions on RYR1 and block access of trypsin to sites at amino acids 3630 and 3637.

64 1(490-530), with distinct roles in mediating access of SARAF to SOAR.

65 Upon induction, GR modulates access of ER to specific sites in the genome by reorgani

66 bsence of FANCD2, MRE11 exonuclease-promoted access of FAN1 to stalled forks results in severe FAN1-m

67 In contrast, Plin directly regulates the access of HSL to substrate via close, if not direct, int

68 as yttrium 90, and on strategies to optimize access of antibody to target antigens.

69 de with an exploration of the vital issue of access of antibodies to targets within the central nervo

70 naling pathways may be modulated by altering access of CD45 to TCR-associated substrates involved in

71 osylation and ubiquitination) for regulating access of telomerase to telomeres.

72 his interaction may function to regulate the access of telomerase to telomeric DNA ends.

73 The access of AID to the nucleus is limited by CRM1-mediated

74 ubule-associated protein MAP1B in modulating access of AMPARs to the postsynaptic membrane.

75 olved a similar strategy for controlling the access of anions to the active site.

76 of protons for catalysis, and to control the access of anions to the active site.

77 Both constructs allow full access of antibodies to the foreign epitope, DPAFR from

78 In addition, fixation apparently limited the access of antibodies to the V3 loop and gp41-interactive

79 often produces angle closure by blocking the access of aqueous to the anterior chamber, sometimes par

80 ib all had the potential to compete with the access of aspirin to the substrate binding channel of CO

81 eactive bond controls BiP-ATF6 stability and access of ATF6 to the COPII budding machinery.

82 ndicated that unique P2X7R features regulate access of AZ10606120 to the allosteric site.

83 maintains the protective barrier and limits access of bacteria to the lamina propria; 2) production

84 nuclear pool of Far1 may temporally regulate access of Cdc24 to the cell cortex.

85 f Pgamma to Met(758) would effectively block access of cGMP to the catalytic cavity, providing a stru

86 teractions and function to sterically hinder access of complement to the mycoplasma cell membrane whi

87 Rather, the MBS1-4 region appears to control access of copper to the functionally important metal-bin

88 Our data indicate that MRN enables access of Ctp1 to the DSB but blocks access of Exo1.

89 protein has been proposed to facilitate the access of cyanide to the catalytic center of the oxidize

90 nstrate that the photodissociated CO impedes access of dioxygen to the heme a(3) site in ba(3), makin

91 inity for 5,6-dimethylbenzimidazole (DMB) or access of DMB to the active site is restricted in these

92 omic DNA from thermal destabilization and on access of DNA to the cellular machinery, demands that ma

93 Access of DNA to the cytosolic compartment is mediated b

94 unclear, however, whether the ligand blocks access of DTT to the receptor, or the ligand stabilizes

95 TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F assembly

96 TC-binding factor (CTCF) and acting to block access of enhancers to the Igf2 promoter.

97 materials for gas separation, adjusting the access of fluids to the porous network.

98 protein-protein associations that impede the access of gadodiamide to the residues of the interaction

99 The access of GPCRs to the cell surface is tightly regulated

100 ntroducing mesoporosity is to allow enhanced access of guests to the microporous hosts.

101 ll-surface proteoglycans, thereby preventing access of HDL to the plasma membrane.

102 This is likely due to restricted access of hPg to the active site of the SakSTARg-hPm com

103 se than for the sc-protease, suggesting that access of inhibitors to the protease catalytic site is f

104 is movement regulates the gates that control access of ions to the permeation pathway.

105 cm.s-1 after 2-min exposure to 4 mM DOC, but access of K+ to the endoneurial compartment was more res

106 This is important because tau regulates the access of katanin to the microtubule.

107 primary role of P as a bridge mediating the access of L to the RNA template, whereby its N-terminal

108 reveals that these arginine residues reduce access of ligands to the binding cleft and change the el

109 ere fasciculin 2 appears to sterically block access of ligands to the gorge, again we observe a two-p

110 ore sensitive sensors, as a result of better access of ligands to the proteins active sites and also

111 regulate the structure of chromatin and the access of macromolecules to the DNA were investigated.

112 firmed the ability of insulin to enhance the access of macromolecules to the peripheral interstitial

113 protein conformational change that inhibits access of metal to the active site in the other beta-pro

114 er, the extent to which side portals control access of molecules to the channel or influence channel

115 same tissue (EC50, 1.6 nM), consistent with access of NO to the slice interior being greatly hindere

116 dence suggested that nares occlusion blocked access of odors to the main olfactory epithelium for the

117 c protease; also named USP7) and blocked the access of p53 to the same region of HAUSP.

118 The mechanisms that license access of Polzeta to the primer terminus and regulate th

119 s as a component of the mechanism to control access of preproteins to the membrane translocation chan

120 ASOs designed to sterically block access of proteins to the RNA modulate mRNA metabolism b

121 chia coli ATP synthase is thought to control access of protons to the ring of c subunits during proto

122 y inserted into the flap motif and regulates access of reactants to the active site.

123 transcript leader which in turn impedes the access of ribosomes to the downstream cistron.

124 lex RNA hairpin structure that would prevent access of ribosomes to the ribosome binding site.

125 and may function as a roadblock to restrict access of RNA to the active site in the body region.

126 ggest that acidic residues normally modulate access of RNAs to the arginine patch.

127 lculations, some of which yield quite facile access of solvent to the active site.

128 located at the top of the barrel may prevent access of solvent to the interior of the barrel.

129 Thus, CUP/AP-2alpha delays access of Sp3 to the Sp regulatory element, preventing p

130 CheB shows that the regulatory domain blocks access of substrate to the active site of the catalytic

131 N/D loop, which is thought to influence the access of substrate to the active site pocket.

132 nd the mechanism of action involves blocking access of substrate to the active site.

133 of protein residues in a manner that blocks access of substrate to the active site.

134 for isoleucine at residue 148 would restrict access of substrate to the catalytic serine at residue 4

135 ational or chemical changes which facilitate access of substrates to the active site and promote corr

136 hat the loop functions as a gate controlling access of substrates to the active site and that these s

137 A flap region that controls access of substrates to the active site in other PP2C ph

138 gest that movement of a helical lid controls access of substrates to the active site of RifR.

139 TNB-modified KDO 8-P synthase or blockage of access of substrates to the active site.

140 and closing of the vestibule might regulate access of substrates to the carrier domain, which is inv

141 region is eliminated, allowing for improved access of substrates to the catalytic pocket.

142 of the protein and is thought to control the access of substrates to the distal pocket.

143 d, via the process of gating, to control the access of substrates to the embedded catalytic center an

144 prone to unfolding CYC-2.2 allows for better access of substrates to the heme and thus exhibits highe

145 tivators opens a gated channel that controls access of substrates to the protease, but does not pertu

146 ng of the periplasmic cavity not only limits access of sugar to the binding site of LacY but also con

147 rity of the Nbs exhibits varied increases in access of sugar to the binding site with an increase in

148 y with a closed periplasmic side that limits access of sugar to the binding site.

149 nsport cycle, without significantly altering access of sugar to the binding site.

150 ant from surfactant inhibitors, and enhances access of surfactant to the gas-liquid interface.

151 principal TFIID functions by regulating the access of TBP to the TATA element.

152 In one group of animals, access of tears to the bare stroma was allowed-in vivo,

153 ole in chromosome end capping, Pot1 prevents access of telomerase to the 3'-end and protects against

154 required to protect the telomere and mediate access of telomerase to the chromosomal terminus.

155 nding protein complex that presumably limits access of telomerase to the chromosome end.

156 lomeric DNA binding domain greatly increases access of telomerase to the telomere.

157 ation, suggesting that tankyrase 1 regulates access of telomerase to the telomeric complex.

158 he attached N-terminal domain does not block access of thioredoxin to the TrR-derived Cys342-Cys345 c

159 ibodies TM60 and LJ-Ib10, in platelets where access of thrombin to the STDR was blocked by polyclonal

160 stem-loop structure, thereby increasing the access of U1snRNP to the 5' splice site of tau exon 10.

161 , indicating that sialic acid hinders direct access of virus to the protein entry receptor.

162 te acts as a nonselective gate that controls access of VOCs to the underlying surface area of the por

163 HapR binding thus directly blocks access of VpsR to the promoter.

164 We surmise that access of VTF to the signal sequence is prevented when U

165 ve prepared MRI contrast agents in which the access of water to the first coordination sphere of a ch

166 Despite the apparently greater ease of access of water to the interior of hCYB5B than of rCYB5B

167 ormation in MD simulations, thus restricting access of water to the protein interior.

168 he loop between M6 and M7 (L6-7), and reduce access of Ca2+ to their binding sites.

169 ilitate its central function: regulating the access of CD28 to their shared ligands.

170 d wild-type spores might reflect the ease of access of germinants to their receptors in the absence o

171 s lack the covalent link to the protein, the access of ligands to their binding pocket may follow sim

172 no terminus and adjacent TPR arrays, but the access of Brf1 to these sites is limited by autoinhibiti

173 the endoplasmic reticulum (ER) lumen, where access of enzyme to these predominantly cytosolic substr

174 the transport pathway sterically blocks the access of MTSES to these sites, thereby providing direct

175 y of energetically distinct pathways for the access of solvent to these structurally related exchange

176 the {010} faces is stereoselective and that access of water to these faces is essential for the tran

177 hey are fully separated, providing potential access of substrates to this kinase, even in its dimeric

178 ellular functions, such as organizing direct access of chromatin to transcriptional regulators.

179 Transport parameters determine the access of drugs to tumors.

180 inding of SOCS-1 to Tyr(441) also blocks the access of STAT1 to Tyr(419) and that this effect may be

181 Binding at this site presumably blocks access of substrate to Tyr-385, a residue essential for

182 1 and a glycoprotein substrate to facilitate access of STT3B to unmodified acceptor sites.