ライフサイエンスコーパス: accessibility

1 sk, had significantly higher RBC cholesterol accessibility.

2 s in gene expression via modifying chromatin accessibility.

3 be composed of many businesses with varying accessibility.

4 sive switch in gene expression and chromatin accessibility.

5 common SNPs on cell-type-specific chromatin accessibility.

6 ce requires dense packing while ensuring DNA accessibility.

7 ional program, enabled by enhanced chromatin accessibility.

8 sis because of their sensitivity and lack of accessibility.

9 to protein conformational change and solvent accessibility.

10 setting and do not have the benefit of easy accessibility.

11 ward in time through regulation of chromatin accessibility.

12 hion with burdensome logistics and decreased accessibility.

13 n research regarding mechanisms of chromatin accessibility.

14 the larger genomic locus, such as chromatin accessibility.

15 ted changes in gene expression and chromatin accessibility.

16 the levels of gene expression and chromatin accessibility.

17 tions, specifically at regions of shared DNA accessibility.

18 otifs associated with variation in chromatin accessibility.

19 enes (KMT2D and KDM6A) involved in chromatin accessibility.

20 sociated with a concurrent gain in chromatin accessibility.

21 eg, during inflammation facilitates claudin accessibility.

22 compartmentalization, measurements of genome accessibility.

23 g enhancer components and enhancer chromatin accessibility.

24 laxation in the epigenetic regulation of DNA accessibility.

25 g through pore characteristics and microbial accessibility.

26 2000 sites, which are subject to high human accessibility.

27 gene enhancers, thereby regulating chromatin accessibility.

28 ic to the RBC contribute to variation in its accessibility.

29 rmining transcription factors, and chromatin accessibility.

30 Chromatin accessibility, a crucial component of genome regulation,

31 rid F1 system, we found that monoallelic DNA accessibility across autosomes was pervasive, developmen

32 al identity by directly regulating chromatin accessibility across the genome.

33 xamine the changes in chromatin assembly and accessibility after FA exposure.

34 atory response displayed decreased chromatin accessibility after VSG.

35 -wide RIsearch2 predictions with target site accessibilities and transcript abundance estimates.

36 related with significant shifts in chromatin accessibility and a network of challenge-associated TFs.

37 al structures which can facilitate the Li(+) accessibility and also enable the fast diffusion of elec

38 Moreover, FA increased chromatin accessibility and altered the expression of hundreds of

39 ic techniques to introduce new insights on P accessibility and availability in soils.

40 In the absence of IRF4, chromatin accessibility and binding of Helios at PD-1 cis-regulato

41 and chemical heterogeneity of P influences P accessibility and bioavailability.

42 and function of ILC1s by promoting chromatin accessibility and deposition of STAT5 at the promoter of

43 loped for simultaneously profiling chromatin accessibility and DNA methylation on single molecules.

44 scNOMe-seq recovered characteristic accessibility and DNA methylation patterns at DNase hype

45 The data point to changes of accessibility and dynamics of structural elements previo

46 technologies has dramatically increased the accessibility and efficiency of genome editing in many o

47 s occupancy correlates with increased genome accessibility and enhanced expression of downstream gene

48 h transcription factors influenced chromatin accessibility and expression of the genes required for T

49 fibroblasts being visible both in chromatin accessibility and gene expression.

50 splaying low DNA methylation, high chromatin accessibility and H3K9ac enrichment, were classified as

51 vival.ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage rep

52 data with newly generated maps for chromatin accessibility and histone 3 lysine 9 acetylation (H3K9ac

53 Changes in sex-specific chromatin accessibility and histone modifications accompanied thes

54 In this article, we present CAME (Chromatin Accessibility and Methylation), a seed-extension based a

55 (PHF6) can cause focal changes in chromatin accessibility and nucleosome positioning that render cel

56 hat high-order epistasis strongly shapes the accessibility and probability of evolutionary trajectori

57 d the positive correlation between chromatin accessibility and processivity of ten-eleven translocati

58 Future work should focus on promoting the accessibility and quality of cataract surgery in develop

59 Cys accessibility and quantitative intact mass spectrometry

60 of Arid1a within tumors decreased chromatin accessibility and reduced transcription of genes associa

61 Using single-cell chromatin accessibility and RNA-seq data in K562 leukemic cells, w

62 f makerspaces ameliorates the otherwise poor accessibility and scalability of microfluidic prototypin

63 perfusion with PET are limited by restricted accessibility and short half-lives of perfusion radiotra

64 , which include secondary structure, solvent accessibility and sidechain hydrogen bonds, XSuLT annota

65 rylation causes increases in radius, protein accessibility and stiffness, without disrupting local st

66 ctivity of His is determined by both solvent accessibility and structural flexibility.

67 lable for sequence-based prediction of lipid accessibility and structure-based identification of solv

68 d secondary structure, the predicted solvent accessibility and the contact prediction scores for the

69 immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purifie

70 pecific considerations as these may increase accessibility and thereby exposure and mobility of PAHs.

71 ncy of a PTM-binding protein to regulate DNA accessibility and underscores the role of the novel mech

72 modelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recov

73 gene expression through changes in chromatin accessibility and/or aberrant targeting of epigenetic co

74 an essential indicator of its availability, accessibility, and acceptability.

75 measuring gene expression levels, chromatin accessibility, and DNA methylation.

76 approach for combining gene expression, DNA accessibility, and protein-DNA binding data to quantify

77 the break, protecting DNA ends from nuclease accessibility, and recruits additional NHEJ factors, inc

78 Transcriptome profiling, chromatin accessibility, and RNA polymerase II occupancy demonstra

79 ) that influenced gene expression, chromatin accessibility, and RNA splicing.

80 mbination of X-ray crystallography, cysteine accessibility, and solution spectroscopy.

81 tions supported by CTCF binding sites, DNase accessibility, and/or active histone marks.

82 the molecular mechanisms driving epigenetic accessibility are still unknown.

83 which was associated with loss of chromatin accessibility around cell cycle genes during postnatal m

84 Furthermore, chromatin accessibility, as determined by ATAC-seq (assay for tran

85 rget complementarity, nor miRNA binding site accessibility, as determined by flanking region AU conte

86 Chromosomal accessibility assays can connect accessible chromatin in

87 on, DNase I hypersensitivity and transposase-accessibility assays combined with high-throughput seque

88 vailable computational methods for chromatin accessibility assays.

89 ymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters.

90 f DPF3 in brown adipocytes reduced chromatin accessibility at EBF2-bound enhancers and led to a decre

91 has a dominant role in maintaining chromatin accessibility at enhancers, while the contribution of AR

92 reased transcription and increased chromatin accessibility at ERV regions and their neighboring genes

93 poral changes in transcriptome and chromatin accessibility at genome-wide levels during cardiomyocyte

94 rete loci, accompanied by enhanced chromatin accessibility at hyperacetylated regions in the gene bod

95 We detect significantly increased chromatin accessibility at key genes upregulated as TSCs exit from

96 Instead, EpSCs maintain chromosomal accessibility at key stress response genes that are acti

97 Chromatin accessibility at OCT4-bound sites requires the chromatin

98 domain 2 (HMGN2) specifically promotes STAT5 accessibility at promoter DNA by facilitating the dissoc

99 c regulation, including sex-biased chromatin accessibility at promoters, rather than piggybacking of

100 loss was associated with increased chromatin accessibility at putative enhancers of key leukemogenic

101 - and cancer-associated changes in chromatin accessibility at repetitive sequences, we suggest that r

102 ompanied by genome-wide changes in chromatin accessibility at temporal-specific enhancers.

103 ivation of LINE-1 regulates global chromatin accessibility at the beginning of development and indica

104 lation of global transcription and chromatin accessibility at the initial stage of reprogramming.

105 a limited effect on the average cholesterol accessibility at the surface of the membrane.

106 ill need to address attitudinal, social, and accessibility barriers to health care.

107 Importantly, this accessibility-based electrocatalytic sensing strategy is

108 regions exhibit dynamic changes in chromatin accessibility between developmental stages and could the

109 od not only can precisely identify chromatin accessibility but also outperforms other methods.

110 romatin-remodeling enzymes that control gene accessibility by altering chromatin compaction or nucleo

111 was conducted and correlated with chromatin accessibility by ATAC-seq and gene expression by RNA-seq

112 e classes in vitro and genome-wide chromatin accessibility by ATAC-seq, we found that the occupancy o

113 aride monooxygenase that increases substrate accessibility by oxidative cleavage of the chitin chains

114 t surrounding the reactive AO group, and its accessibility by the probe.

115 cal processes, from information spreading to accessibility, by disrupting network paths.

116 Whether chromatin accessibility can be assessed in complex, dynamic system

117 Single-cell chromatin accessibility can guide prospective characterization of

118 7.6 Gb RNA-seq data to investigate chromatin accessibility changes and global gene expression under e

119 are reprogrammed, global gene expression and accessibility changes are still incomplete when compared

120 Chromatin accessibility changes between developmental stages are h

121 study, we use ATAC-seq to identify chromatin accessibility changes in a whole animal, the model organ

122 ace marker CD24 as co-varying with chromatin accessibility changes linked to GATA transcription facto

123 base, a collection of ChIP-seq and chromatin accessibility data (DNase-seq and ATAC-seq) published be

124 ype-specific features derived from chromatin accessibility data.

125 It is found that protein accessibility decreases as the nucleotide is located clo

126 e exploited a new method, differential viral accessibility (DIVA), to show that loss of MORC2 results

127 *)-124) trigger reconfiguration of chromatin accessibility, DNA methylation, and mRNA expression to i

128 To characterize transcriptome and chromatin accessibility during early cardiomyocyte differentiation

129 us pectin encapsulation increased intestinal accessibility during passage through the small intestine

130 mic changes in gene expression and chromatin accessibility during TSC differentiation.

131 lyses revealed transcriptional and chromatin accessibility dynamics and lineage relationships during

132 hts by mapping in exquisite detail chromatin accessibility dynamics as mouse embryonic fibroblasts ar

133 of molecular modeling, substituted cysteine accessibility, electrophysiology and glutamate uptake as

134 term memory, enhanced attitude extremity and accessibility, enhanced attitude impact on the regulatio

135 these GA repeat motifs, increases chromatin accessibility, enhances histone gene transcription, and

136 high simplicity, providing affordability and accessibility even to poor, resource-limited settings.

137 d via large-scale in vitro assays, chromatin accessibility, evolutionary conservation, and pCRE combi

138 Chromatin accessibility experiments such as DNaseI sequencing (DNa

139 filter for drug like features, and synthetic accessibility for chemical synthesis, out of 593 hits, 3

140 ems make the appropriate changes to increase accessibility for eligible patients.

141 (FCXM) results, thus enabling improved organ accessibility for the waiting list patients and a better

142 seq) data, and characterization of chromatin accessibility from ATAC-seq datasets.

143 ate (M state): its stability and its kinetic accessibility from its unfolded state (U state).

144 computational methods to identify chromatin accessibility from MAPit-BGS and NOMe-seq.

145 ion based approach that identifies chromatin accessibility from NOMe-seq.

146 in and beta-carotene liberation and in vitro accessibility from spinach were investigated.

147 fail to reliably determine regulatory region accessibility from the analysis of these experimental da

148 We present a novel tool to classify lipid accessibility from the protein structure, which is appli

149 Mapping chromatin accessibility has been widely used to identify the locat

150 and epigenomic approach to analyze chromatin accessibility, histone modifications, transcription-fact

151 results reveal dynamic changes of chromatin accessibility in adult mammalian brains and suggest an e

152 lation between gene expression and chromatin accessibility in CD8(+) tumor-infiltrating lymphocytes (

153 tative enhancers display increased chromatin accessibility in DE that is associated with Smad2/3 bind

154 te sequencing) to study changes of chromatin accessibility in euchromatic and heterochromatic regions

155 Analysis of chromatin accessibility in F3 and F4 sperm reveals significant dif

156 n is not simply due to the loss of chromatin accessibility in proximal regions.

157 fect DNA methylation, but modifies chromatin accessibility in the conserved noncoding sequence 3 (CNS

158 ys327, out of three, has an enhanced solvent accessibility in the inward-facing (relative to the outw

159 g, as well as direct assessment of chromatin accessibility in the striatum, a brain region central to

160 that urease activation is limited by nickel accessibility in vivo Our data uncover the crucial role

161 nonencapsulated strains: increased cell wall accessibility, increased nonspecific opsonophagocytic ki

162 ers, but no significant changes in chromatin accessibility, indicating that HFD-regulated gene transc

163 Integrating chromatin accessibility information with sequence information impr

164 Increased chromatin accessibility is a feature of cell-type-specific cis-reg

165 For membrane proteins, lipid accessibility is an essential property.

166 t for all vectors, indicating that chromatin accessibility is not the sole determinant.

167 occurs via distal enhancers, whose chromatin accessibility is typically cell type-specific, whereas u

168 Here we compared chromatin accessibility landscapes of adult mouse dentate granule

169 Here, we define chromatin accessibility landscapes of major, layer-specific excita

170 ncing reads are sampled independently of the accessibility measurement.

171 Using the substituted cysteine accessibility method (SCAM), we evaluated the role of po

172 CNT3 protein hCNT3(C-), substituted cysteine accessibility method analysis with the membrane-impermea

173 ed Mocap, a method that integrates chromatin accessibility, motif scores, TF footprints, CpG/GC conte

174 tochrome c oxidase is attained by tuning the accessibility of a low lying alternative electronic grou

175 Our results demonstrate the accessibility of a regime where elastic collisions also

176 utually exclusive conformations that dictate accessibility of a rut site to Rho.

177 zes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs.

178 s, and (c) it facilitates situation-specific accessibility of alternate cognitive procedures.

179 ges in protein structure via altered solvent accessibility of amino acid side chains.

180 ylation at the promoter region and chromatin accessibility of an upstream genomic region with enhance

181 nfluences the bioavailability and intestinal accessibility of anthocyanins in humans.

182 ted prior to publication by inventor-defined accessibility of any given model.

183 to facilitate and boost the development and accessibility of AR and VR contents for bioinformatics a

184 This review summarizes the availability and accessibility of brain epigenetic and functional genomic

185 tein domain, binds CFH tightly and increases accessibility of CCPs 19 and 20.

186 erform critical functions in determining the accessibility of chromatin DNA to trans-acting factors.

187 hances CREB1 binding intensity and increases accessibility of CREB1 binding sites.

188 l temporal gene expression by regulating the accessibility of DNA regulatory elements.

189 genetic modifications such as H3K4me1 or the accessibility of DNA when measured both in enhancer assa

190 lity of late-acting enhancers and decreasing accessibility of early-acting enhancers.

191 y and its great importance in regulating the accessibility of enzymes to their substrates.

192 e, broad structural stability, and synthetic accessibility of eta-helices could facilitate their util

193 Given the accessibility of exome sequencing, this problem has thus

194 and automation to increase the accuracy and accessibility of GBS data analysis.

195 One of the dangers of ready accessibility of health care data and computational tool

196 fraction to 49 +/- 2%, whereby primarily the accessibility of higher molecular weight PAHs (log Kow >

197 electrostatic surface charges and increased accessibility of hydrophobic residues (including the nuc

198 represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory genes.

199 ontrolled molecular switch by modulating the accessibility of its farnesyl moiety, which does not req

200 Here, we show that m6A increases the accessibility of its surrounding RNA sequence to bind he

201 th tumorigenesis and EMT that correlate with accessibility of key epithelial and EMT transcription fa

202 nd broaden the application opportunities and accessibility of kinetic modeling across the field.

203 licity of the underlying Stokes flow and the accessibility of lab-on-chip technology.

204 ee different modalities, including promoting accessibility of late-acting enhancers and decreasing ac

205 ) mass spectrometry to determine the solvent accessibility of mVP40 residues in the absence and prese

206 However, accessibility of NGS data remains a problem, and few use

207 The latter was restricted by accessibility of non-junctional claudin molecules such a

208 of chromatin by complexes that increase the accessibility of nucleosomal DNA.

209 clease digestion revealed a strongly reduced accessibility of nucleosome linkers in the compact AT-IN

210 Instead, there was an increase in the accessibility of nucleosomes, as measured by micrococcal

211 all reaction selectivity, reaction rate, and accessibility of off-cycle iron(I)-SciOPP species.

212 several specific glycans could increase the accessibility of other glycans or regions of the protein

213 The bio-accessibility of phenolics, flavonoids, rutin, beta-caro

214 The solvent accessibility of R696 is likely mediated by the hydrophi

215 Variation in accessibility of RBC cholesterol was unrelated to the ch

216 cleotides resulted in changes in the solvent accessibility of regions of each protein that led to pre

217 subfossil wood and are likely to improve the accessibility of relict wood for genome-scale ancient DN

218 as they impact both the reproducibility and accessibility of research findings.

219 defined membrane thickness to classify lipid accessibility of residues.

220 hrough histone acetylation that promotes the accessibility of RNA polymerases to the gene promoters.

221 Our results provide novel insight into the accessibility of sedimentary organic matter and demonstr

222 The scope and accessibility of sequence-controlled multiblock copolyme

223 Here, we studied the accessibility of single cysteines substituted along the

224 of selection on the influenza genome and the accessibility of specific mutational trajectories are si

225 Synthetic accessibility of such molecules, however, has been chall

226 particles, higher surface area and increased accessibility of surface sites.

227 ir largest effect is in altering the solvent accessibility of the active site by expanding the active

228 f the NBDs with the subsequent return of the accessibility of the binding site to the cytoplasmic sid

229 rcially available reagents, highlighting the accessibility of the BONCAT method to researchers intere

230 hat secretory Munc18s in general control the accessibility of the bound syntaxin, probably preparing

231 otes NBD dimerization, resulting in external accessibility of the drug-binding site (outward-facing,

232 re-dependent polyester chain flexibility and accessibility of the enzyme active site.

233 at governs enzymatic activity is the limited accessibility of the enzyme to its substrates that may b

234 distribution of novel technologies and open accessibility of the generated data will multiply their

235 ymmetric unit are correlated with changes in accessibility of the kinase active site, which are consi

236 ramolecular carbonyl-ene reaction (ICE), the accessibility of the naphthoates culminates in a new syn

237 rein, we quantitatively explore the nuclease accessibility of the nucleic acid as a function of "dept

238 ant STAT1 molecules showed variations in the accessibility of the phosphorylation site Y701, which co

239 outs (i) the covalent maleimide fluorescence accessibility of the surface-bound P2X7R and (ii) covale

240 lose in the plant cell wall, thus increasing accessibility of the target substrate for the host cell.

241 etermined the membrane partition and solvent accessibility of the TMD in bicelles that mimic a lipid

242 in regulating chromatin dynamics and in the accessibility of the underlying DNA.

243 rimer, and how the glycan shield impacts the accessibility of the underlying protein surface, we perf

244 The accessibility of these interfaces is determined by the s

245 checklist increases the clinical utility and accessibility of these recommendations, by offering a sy

246 nsion of the cPALM technique will expand the accessibility of this approach to a range of laboratorie

247 ents by which PBX-MEIS facilitates chromatin accessibility of transcriptionally inactive genes: In un

248 The accessibility of tumor cells obtained from peripheral bl

249 gh accessibility, whereas Tg retains limited accessibility, of telomeric G-quadruplex DNA to compleme

250 methylation patterns correlate with distinct accessibility patterns, where DNA methylation associates

251 Chromatin accessibility plays a key role in epigenetic regulation

252 s gap by addressing the problem of chromatin accessibility prediction with a convolutional Long Short

253 D8 T cells display a preprogrammed chromatin accessibility profile and maintain a molecular history o

254 The Omni-ATAC protocol generates chromatin accessibility profiles from archival frozen tissue sampl

255 ancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, wit

256 ve analyses of gene expression and chromatin accessibility profiles of transdifferentiated cells comp

257 The chromatin accessibility profiles provide useful information in pre

258 Integration of chromatin accessibility profiles with gene expression data identif

259 an improved ATAC-seq protocol for chromatin accessibility profiling that works across multiple appli

260 High-resolution chromatin accessibility profiling using assay for transposase-acce

261 Recently, Methyltransferase Accessibility Protocol for individual templates-Bisulfit

262 the understanding of the role of PANS in DNA accessibility regulation.

263 se His residues were correlated with solvent accessibility-related parameters both by crystal structu

264 ecially those related to persistence and web-accessibility/resolvability.

265 ormation arising from local relative solvent accessibility (RSA) between two residues into the Kirchh

266 ore that quantifies tissue-specific nuclease accessibility significantly improves prediction performa

267 +) T cells, we define a pattern of chromatin accessibility specific for T-cell exhaustion, characteri

268 Memory CD8 T cells displayed a chromatin accessibility structure that was absent from other acute

269 ature MG is accompanied by reduced chromatin accessibility, suggesting that epigenetic factors limit

270 h distinct motifs, and they had less surface accessibility than other lysine residues in the protein.

271 Additionally, 44% of respondents considered accessibility to AIT and 36% stating patient costs were

272 ows high-resolution measurement of chromatin accessibility to DNase I cleavage, permitting identifica

273 ted to food security, economic activity, and accessibility to facilities) and call data records (capt

274 osome structure for the understanding of how accessibility to genomic DNA is regulated in cells.

275 the power of using whole organism chromatin accessibility to identify novel regulatory regions in co

276 onfirming the hypothesis of a reduced pepsin accessibility to its substrate.

277 and define its role in regulating chromatin accessibility to lineage-specific transcription factors.

278 boratory testing, with the goal of improving accessibility to medical diagnostics in developing count

279 Analysing protein mobility, cluster size and accessibility to myc-epitopes we show that forces acting

280 sticated setups are required, decreasing its accessibility to research laboratories.

281 olNet, which enhances compatibility and user accessibility to the new package.

282 described, but commonly suffer from limited accessibility to the resulting predictions and reduced b

283 Accessibility to the specialized sensory organelles and

284 graphy also show promise for gout diagnosis, accessibility to these methods may be limited.

285 pioneer factor OCT4 binds chromatin to shape accessibility, transcription factor co-binding, and regu

286 rmative power of a technology depends on its accessibility, two main challenges are an automated desi

287 on IL-23 with reduced backbone amide solvent accessibility upon antibody binding were identified by H

288 at UTX-mediated regulation of super-enhancer accessibility was a key mechanism for commitment to the

289 Genetically determined accessibility was enriched at distal enhancers, but rand

290 were similar, whereas that of beta-carotene accessibility was only about two-fold.

291 e standardization of annotation, and improve accessibility, we created denovo-db, a database for huma

292 trated that changes in genome-wide chromatin accessibility were similar across hiPSC and hESC cell li

293 Lutein liberation and in vitro accessibility were three-fold higher from spinach puree

294 ncing of LINE-1 elements decreases chromatin accessibility, whereas prolonged activation prevents the

295 As a result, 8oxoG induces high accessibility, whereas Tg retains limited accessibility,

296 t transplantation, due to its large area and accessibility, which allows minimally invasive procedure

297 gkappa V alleles have differential chromatin accessibility, which may serve as the underlying basis o

298 s microvascular perfusion and small molecule accessibility, with improvement in overall renal functio

299 le studies, we find that the increase of DNA accessibility within the H3K36me3-containing nucleosome,

300 of Arabidopsis thaliana that increase enzyme accessibility without negative impacts on plant growth o