ライフサイエンスコーパス: account for @1 of

1 Reduced-dose CT examinations accounted for 8040 of 105 334 (7.6%) CT examinations, a

2 data were obtained using a dual-input model, accounting for uptake of (11)C-laniquidar and its labele

3 Nonunique variants accounted for 122 of 185 (66%) families.

4 y chain 7) were each identified >3 times and accounted for 78 of 185 (42%) hypertrophic cardiomyopath

5 We demonstrate that the latter accounted for inhibition of 5-Aza-dC incorporation into

6 a and feminization of the urethra, which may account for development of a single urogenital sinus in

7 Germline GATA2 mutations accounted for 15% of advanced and 7% of all primary MDS

8 expected cases in ExAC, these variants would account for 13% of all cases in the studied diseases if

9 t commonly affect the inferior vena cava and account for 5% of all leiomyosarcomas.

10 For Flt1, just three mRNA isoforms account for > 94% of all transcripts, with increased tra

11 occurred in 2.2% of all patients tested and accounted for 22% of all BRAF mutations identified.

12 Rare cancers accounted for 24% of all cancers diagnosed in the EU dur

13 E (SD or DP) was present in 86% of cases and accounted for 35% of all patients with SD or DP (P < .00

14 Cardiac deaths accounted for 46% of all deaths, whereas nonhemorrhagic

15 complaints, whereas 10% of ophthalmologists accounted for 61% of all complaints.

16 habitat and the five most widespread clones accounted for 68% of all individuals sampled.

17 In the first 30 days after CABG, SCD (n=5) accounted for 7% of all deaths.

18 ed multiple readmissions within 180 days and accounted for 77% of all readmissions.

19 a 5.20% rise in surgery consultations, which accounted for 90% of all consultations.

20 anti-VEGF agents ranibizumab and aflibercept accounted for 95% of all drug reimbursement.

21 PTE-associated cases accounted for >50% of all S. uberis clinical mastitis ca

22 the most common alternative splicing events, accounting for 33% of all splicing events, and 43% of th

23 life history parameters of a few model taxa, accounting for 67% of all studies reviewed.

24 % incurred only one during the study period (accounting for 68% of all paid claims), 16% had at least

25 ire niche" in the coterminous United States, accounting for 84% of all wildfires and 44% of total are

26 oinsufficiency in the progranulin (GRN) gene accounts for 10% of all cases of familial FTD.

27 quent development of posttraumatic OA, which accounts for 12% of all OA.

28 HCV genotype 4 accounts for 20% of all infections, but clinical trial d

29 Ductal carcinoma in situ (DCIS) accounts for 20% of all newly diagnosed breast cancers.

30 hernia (CDH) is a serious birth defect that accounts for 8% of all major birth anomalies.

31 Glioma accounts for 80% of all primary malignant tumors in the

32 High-grade serous (HGS) ovarian cancer accounts for 90% of all ovarian cancer-related deaths.

33 F hydrophobic activation segment (AS) pocket accounts for >95% of all kinase mutations.

34 Rates remained similar after accounting for use of alternate oral, injectable, or inf

35 a negative-feedback regulatory loop that may account for suppression of antitumor immune responses in

36 rred to as KCNJ5MUT) in adrenocortical cells account for half of APAs worldwide.

37 The EBF1-PDGFRB gene fusion accounts for <1% of B-cell precursor acute lymphoblastic

38 ic bypass (RYGB) and sleeve gastrectomy (SG) account for >95% of bariatric procedures in United State

39 phosphorylates a downstream site (S719) that accounts for 40% of basal NHE3 activity.

40 rmed in additional sensitivity analyses that accounted for use of belatacept in combination with tacr

41 sible soil Pb concentration as the predictor accounted for 26% of BLL variability.

42 By 52 weeks of age, liver accounted for 25% of body weight and showed continued ba

43 neous epithelia, and the high-risk HPV types account for 5% of cancer cases worldwide.

44 Lung cancer accounts for 17% of cancer-related deaths worldwide, and

45 ptor (PPAR)alpha and under normal conditions accounts for 70% of cardiac ATP content.

46 d almost exclusively to the Amish community (accounting for 99% of case patients) and affected only a

47 s of the genes PRF1 (FHL2) and UNC13D (FHL3) accounted for 70% of cases of FHL.

48 De novo mutations (DNMs) accounted for 8% of cases, including approximately 3% of

49 se Americans, Native Hawaiians, and Latinos, accounting for 32% of cases.

50 ertoire was noted, with only four IGHV genes accounting for 46% of cases and approximately 70% of cas

51 HDS-induced liver injury now accounts for 20% of cases of hepatotoxicity in the Unite

52 Accounting for probability of causation, in the European

53 ate rearrangement via beta-silyl elimination accounts for formation of chain-end -Si(OR)3 groups and

54 aracterized by histologic heterogeneity, and accounts for 15% of childhood deaths from cancer.

55 The mathematical model applied here accounts for transport of chlorinated ethenes in flowing

56 iffusion dominated open-water GHG transport, accounting for >99% of CO2 and N2 O emissions, and 71%

57 een job strain and the whole cortisol curve, accounting for sources of cortisol variability.

58 Demographic composition accounted for 36% of county CVD mortality variation, and

59 Type I accounts for 95% of CRISPR systems, and has been used to

60 orted, and a random effects model was run to account for clustering of CT examinations at facilities.

61 Production of Hg accounts for 27% of cumulative Hg releases to the enviro

62 underscores the methodological importance of accounting for time of day in fMRI protocols.SIGNIFICANC

63 terval 2%-18%) higher risk of delisting when accounting for rates of death and transplantation and ad

64 We accounted for misreporting of dengue due to the introduc

65 n overall racial/ethnic survival disparities accounting for 24% of disparities in breast cancer, 24%

66 neral models to be developed and modified to account for patterns of diversity, diversification, line

67 asses of unmyelinated sensory neurons, which account for >40% of dorsal root ganglia neurons, display

68 s also an important route of HBCD excretion, accounting for 13% of dose for alpha-HBCD, 30% for ss-HB

69 e the major route of excretion; cumulatively accounting for 42% of dose for alpha-HBCD, 59% for ss-HB

70 of viral-load-informed differentiated care, accounting for limitations of dried blood sample testing

71 Parent drug accounted for 25% of drug-related material, whereas that

72 20% of pregnancies and maternal infections account for 15% of early miscarriages.

73 Febrile children account for 15% of emergency department visits and outco

74 Omission of individual twigs accounted for 96% of errors.

75 Africa accounted for 54% of estimated cases and 65% of all feta

76 tose-, glucose-, or HFCS-sweetened beverages accounting for 25% of estimated calorie requirements whi

77 orbidity and mortality in the United States, accounting for 1 of every 3 deaths among adults.

78 Digestive cancer, most frequently bowel, accounted for 41% of excess cancers beyond 30 years.

79 7 letters), analyzed by treatment assignment accounting for nonindependence of eyes when patients had

80 the associated SMOC2 haplotype are profound, accounting for 36% of facial length variation in the dog

81 ltransferase (SHMT), was enriched in nuclei, accounting for 35% of folate cofactors, explaining previ

82 DOC is estimated to account for 20% of global export production, but the de

83 ron, glass, and cement are carbon-intensive, accounting for 23% of global CO2 emissions.

84 in genes encoding sarcomeric proteins, which account for most of HCM cases.

85 on after neddylation inhibition could partly account for reduction of hepatic stellate cell (HSC) act

86 Altitude predicted AMS and accounted for 28% of heterogeneity between studies.

87 with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF cases, and its prevalence relativ

88 In Africa, HPV 16 accounted for 13% of HPV-positive WHIV with normal cytol

89 is of a distribution, independently shown to account for patterns of human inference.

90 (Myosin-binding protein C) founder mutations account for 35% of hypertrophic cardiomyopathy (HCM) cas

91 Bacterial serotypes I-V account for 98% of identified colonizing GBS isolates wo

92 On average, solute transporters accounted for 23% of identified protein sequences in the

93 We estimate that CSF1R mutations account for 10% of idiopathic adult onset leukodystrophi

94 r becomes water vapor and energetically this accounts for much of incoming solar radiation.

95 s facility-months as the unit of analysis to account for lack of independence by site, we found that

96 family history, and normal electrocardiogram accounted for 75% of indications rated R.

97 -NSD1, EZH2, DNMT3A, CHD8, HIST1H1E, and EED-accounted for 44% of individuals (311/710).

98 s from May to July 2015 for 24 brands, which accounted for >95% of infant-toddler food sales.

99 Eventually, persisters resume growth, accounting for relapses of infection.

100 The five most common emm types accounted for 41% of isolates.

101 In a 30-valent M-protein vaccine, emm types accounted for 91% of isolates.

102 g and maintaining a nest should additionally account for aspects of its architecture.

103 cuit is at the core of PTSD pathophysiology, accounting for much of its phenomenology and most of its

104 ransitions from C*G to T*A base pairs, which account for half of known pathogenic point mutations in

105 ing PrEP to 30% of MSM to the age group that account for 90% of local HIV incident cases (21-52 years

106 ta were available (2014 or 2015), glyphosate accounted for 26% of maize, 43% of soybean and 45% of co

107 Non-small-cell lung carcinoma (NSCLC) accounts for 85% of malignant lung tumors and is the lea

108 sm in a common mouse model of breast cancer, accounting for >90% of metastases.

109 In a community, it is unknown what factors account for transmission of methicillin-resistant Staphy

110 crobial species whose abundance collectively accounted for 53% of microbial composition.

111 umvent toxicity, despite the exogenous shRNA accounting for 70% of microRNAs.

112 osoma cruzi transmission is now estimated to account for 22% of new infections, representing a signif

113 etes is the leading cause of kidney failure, accounting for >45% of new cases of dialysis.

114 facilitation, have been suggested but cannot account for encoding of novel associations.

115 series of simulations and normalizations to account for contributions of NP nonsphericity and off-ce

116 ing has suggested that mutations in MSX1 may account for ~2% of NSCLP.

117 and organic carbon (OC, r = 0.95 p < 0.01), accounting for >90% of OC on average.

118 tify novel risk loci for asthma and AR while accounting for parent-of-origin effect.

119 Toxin type A accounted for half of outbreaks, and these outbreaks had

120 Our results show that agriculture accounts for 77% of overall water consumption and it rel

121 Approximately 1% of all physicians accounted for 32% of paid claims.

122 . major undergo autophagy, which effectively accounted for restriction of parasite replication.

123 production of reactive oxygen species (ROS) accounts for restriction of parasite replication, Leishm

124 s collective action, or decision making that accounts for memories of past experience, can emerge and

125 We used random intercepts to account for clustering of patients within facilities and

126 g rates varied by physician characteristics, accounting for clustering of patients among physicians a

127 th adjustment for baseline health status and accounting for clustering of patients within sites.

128 netic loci influencing blood cell production account for <10% of platelet and red blood cell variabil

129 ent of PM2.5 in this case was organic carbon accounting for 65% of PM2.5 mass.

130 ypical hybrid PRC2 subcomplexes, potentially accounting for enhancement of Polycomb activity, and sug

131 In addition, several advanced models that account for uptake of radiolabeled metabolites were eval

132 DNA transposon mechanism that can plausibly account for episodes of rapid, extensive intron gain dur

133 Local events accounted for 15% of recurrences.

134 Mutations in CNGB3 alone account for 50% of reported cases of achromatopsia.

135 son and Cox proportional hazards regression, accounting for clustering of residents within homes, on

136 Cardiopulmonary costs accounted for 23% of resting EE, but less than 5% of net

137 n the surface of large rubber particles that account for 93% of rubber in the latex (despite constitu

138 Sports-related SCAs accounted for 39% of SCAs in patients aged </=18, 13% of

139 ound that (i) avoidable food waste in Norway accounts for 17% of sold food; (ii) 10% of the avoidable

140 c plasticity in the hippocampus, which could account for deficits of spatial memory.

141 alen presented the Red Queen's hypothesis to account for evolution of species within a multispecies e

142 estrated at cis-regulatory modules (CRMs) to account for coregulation of specific biological pathways

143 irst, we generalized the likelihood model to account for correlations of statistics to achieve optima

144 PAS accounted for 18% of strokes in women younger than 35 ye

145 Untreated VF despite recommended programming accounted for 56% of sudden deaths and 11% of all deaths

146 SteD also accounted for suppression of T cell activation during Sa

147 ived secondary organic carbon together often accounted for >75% of TC.

148 proportional hazards regression models that accounted for clustering of teeth within individuals and

149 China and India jointly account for 38% of the world population, so understandin

150 occoli by-products from frozen-food industry account for 45% of the initial broccoli heads.

151 Absent in chow-fed animals, PI-BMDCs account for 60% of the ATMs in the type 2 diabetic mice.

152 20 polluting rivers, mostly located in Asia, account for 67% of the global total.

153 he level of milk production, four watersheds account for 78% of the national water stress impact, as

154 C-terminal intrinsically disordered regions account for 80% of the phosphoprotein of the respiratory

155 al diversity, but those currently identified account for <5% of the variance.

156 ns during the cold season (September to May) account for >/= 50% of the annual CH4 flux, with the hig

157 nce susceptibility genes, which individually account for >1% of the familial risk.

158 n models and found that ERK inhibition could account for all of the changes in anti-nociception induc

159 ith earlier ages at onset, but this does not account for all of the difference, and the existence of

160 As these loci do not account for all of the genetic variance of CL/P, we hypo

161 CYP76AK8), the combined activities of which account for all of the oxidation events leading to the b

162 ples of blast biophysics, and further, could account for aspects of the neuropsychiatric clinical seq

163 -based diagnosis of reflux may not routinely account for duration of the reflux episode.

164 Demography is increasingly being invoked to account for features of the archaeological record, such

165 or protein localization in neurites that may account for half of the neurite-localized proteome.

166 the peptide-binding groove of HLA-DPB1 could account for most of the association between the rs927737

167 Interactions with the DNA backbone account for most of the binding affinity.

168 A small number of procedures account for most of the cost variation burden in pediatr

169 ility, and found that scaled mRNA levels can account for most of the mean-level-variability but not n

170 de examples that show how this picture could account for most of the observed data, since energy flow

171 Knowing that functional traits account for most of the phylogenetic pattern should prov

172 age, height, body mass index, and heart rate account for most of the variability in RV volumes and fu

173 Upper-layer neurons (i.e., layers II-IV) account for most of the variation in neuron numbers acro

174 Although the external forcings account for most of the warming trend, the decadal varia

175 the auditory system, sound localization must account for movements of the head and ears, a computatio

176 suggest the pathway demonstrated here could account for much of the (CH3)2Hg found in the ocean.

177 erminal sequence variants (G1 and G2), which account for much of the increased risk for kidney diseas

178 er show that variations in spatial precision account for much of the variation in crowding, including

179 a molecule with these unique properties must account for regulation of the signalling efficiency of m

180 , including homeobox A5 (HOXA5), which could account for some of the clinical overlap in CHARGE and K

181 cts could reconcile past inconsistencies and account for some of the missing heritability of blood pr

182 assium is a risk factor for diabetes and may account for some of the racial disparity in diabetes ris

183 TP13A2 variation is particularly common, may account for some of the variation in penetrance.

184 These loci accounted for 12% of the variance in MMA concentration.

185 Cochrane SRs, which accounted for 15% of the sample, had more complete repor

186 Women with simplified scores >6 accounted for 16% of the population but 56% of HIV acqui

187 Sodium gradients accounted for 18% of the variation in delta(15) N, 45% i

188 Total soil Pb concentration as the predictor accounted for 23% of the variability in child BLL; bioac

189 Seizures and overdoses accounted for 25 of the 29 related SAEs.

190 Overall, ITV accounted for 25% of the total trait variation within co

191 sture frequency in the crop rotation system) accounted for 27% of the relative influence on rC , foll

192 ht, and body mass index, and these variables accounted for 28% of the variability in ADAU (P<0.007 fo

193 death (HRR = 0.73, 95% CI:0.58 to 0.91) and accounted for 30% of the between-province heterogeneity

194 metabolism, and monochloramine cometabolism accounted for 30% of the observed monochloramine loss.

195 phenology change, methodological approaches accounted for 4% of the variation in measurements, where

196 Angina readmission accounted for 45% of the composite outcome and was the m

197 H concentrations in personal air and on skin accounted for 54% of the variation in fold changes of ur

198 regions (1%) but enriched in UTRs where they accounted for 57% of the events.

199 Serotype IV accounted for 6% of the colonizing isolates, a rate cons

200 e 535 (27%) contacts classified as high risk accounted for 60% of the tuberculosis identified during

201 stimated that pneumococcal genomic variation accounted for 63% of the phenotype variation, whereas th

202 by LC-MS/MS analysis (q-value </= 0.01) that accounted for 64% of the theoretical proteome.

203 Changes in modifiable coronary risk factors accounted for 66% of the decline in coronary heart disea

204 Sub-Saharan Africa accounted for 73% of the estimated cryptococcal meningit

205 Together, antibiotic use and importation accounted for 75% of the regional variation in C diffici

206 nteract to affect breeding propensity (which accounted for 83% of the variation in owl reproductive s

207 ts (energy, water, land, materials) together accounted for 84% of the variance in product rankings.

208 erage anti-Der p 1 and anti-Der p 2 together accounted for 85% of the specific IgE.

209 Enterococcus hirae accounted for 92% of the fecal isolates, whereas seconda

210 Ranibizumab and aflibercept alone accounted for 95% of the entire $1.9 billion in drug rei

211 40% were "upward consumers." "Low consumers" accounted for >40% of the sample.

212 These accounted for >60% of the hybrid regions found in the ge

213 , the lipidomic profiles (over 1,700 lipids) accounted for >60% of the inter-individual variation of

214 le, after 120 h, the metabolites of naproxen accounted for >90% of the extractable chemical mass, whi

215 The resource footprints accounted for >90% of the variation in the damage footpr

216 Two gene ontology categories accounted for half of the loci identified in the screeni

217 Two parental pairs accounted for half of the significant pairwise interacti

218 tudied, and the basic biology research theme accounted for half of the total research activities.

219 A total of 106 epitopes accounted for half of the total T cell response, underli

220 In a secondary analysis, rs116907128 accounted for most of the admixture mapping signal obser

221 aemia, fever during labour, and hypertension accounted for most of the complications.

222 Sudden deaths that occurred out of hospital accounted for most of the deaths, followed by deaths due

223 als, lifetime stress and depressive symptoms accounted for most of the effect (WQS weights: 0.27 and

224 gher lifetime stress and depressive symptoms accounted for most of the effect on mtDNAcn (WQS weights

225 Older children accounted for most of the increase after 2009 (0.035 [95

226 stion of MC-producing algae of cyanobacteria accounted for most of the MC that accumulated in T. chin

227 Only 20 peptide scaffolds accounted for most of the natural DRP structural diversi

228 d unanticipated proximity-induced reactivity accounted for most of the problems in the execution of t

229 als from investigator-led research consortia accounted for nine of the 16 studies cited more than 100

230 ims), and 4% had at least three paid claims (accounting for 12% of the claims).

231 l achievement over time, up to 9% at age 16, accounting for 15% of the heritable variance.

232 d claims), 16% had at least two paid claims (accounting for 32% of the claims), and 4% had at least t

233 icted GABA levels in the schizophrenia group accounting for 42% of the variance, but the effect of ag

234 SP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a k

235 presented independent risk factors, together accounting for 60% of the variance for pain persistence.

236 ffect of hereditary CAA on cortical atrophy, accounting for 63% of the total effect.

237 onsible for removing S. ilicifolium biomass, accounting for 83% of the mass-standardized bites.

238 n depth for the 122 countries in our sample, accounting for 90% of the world's population.

239 d jet through the valve is most significant (accounting for 99% of the total drop in stenotic subject

240 ood monocytosis >/=1 x 10(9)/L and monocytes accounting for >/=10% of the white blood cells, this agi

241 roperly understand the impacts of water use, accounting for each of the main feeds for milk productio

242 But current definition of robustness is only accounting for half of the story: the connectivity of th

243 ed an emerging importance of Hg(0) emissions accounting for half of the total global emissions estima

244 ced tunnelling, an extrinsic transport model accounting for most of the aligned fiber's room temperat

245 the dominant pathway by which N is acquired, accounting for ~66% of the N uptake by plants.

246 spp.) is the most important sugar crop that accounts for 75% of the world's sugar production.

247 est contiguous forest belt in the world that accounts for 17% of the global forest cover; however, de

248 so known as hypernephroma or grawitz tumor - accounts for 3% of the adulthood malignancies.

249 spin entropy rises to a prominent peak that accounts for 30% of the total spin degrees of freedom.

250 This model accounts for 59% of the total variance and presents a go

251 tical bed shear stress for erosion (tau cr ) accounts for 63% of the total observed period on average

252 This model accounts for 69% of the variance in mean microcystin con

253 of the enzyme monoacylglycerol lipase, which accounts for 85% of the 2-AG degradation in the mouse CN

254 of the enzyme monoacylglycerol lipase, which accounts for 85% of the 2-arachidonoylglycerol degradati

255 e in the high-resolution x-ray model and yet accounts for 90 of the toxin's 387 amino acid residues.

256 esized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule typ

257 er) with extrusion of O horizontal line(18)O accounts for exchange of the oxygen atom label.

258 Syrian abandonment of irrigated agriculture accounts for half of the stream flow increase, with the

259 gly H/D isotope-dependent VA potentials then accounts for most of the broadening in the OH stretching

260 repair, suggesting that the classic pathway accounts for most of the effects observed after global I

261 ell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC.

262 Strikingly, geography accounts for most of the phylogenetic signal in host use

263 While predation risk accounts for most of the total effect of the predator on

264 Phylogenetic structuring accounts for most of the variation for all traits except

265 methanogenic reactors showed that this step accounts for much of the reported OMP biotransformation

266 The resulting examination not only accounts for some of the known stress tolerance traits k

267 The transport of NH4(+) ions accounts for ~90% of the total current, thus quantitativ

268 auna assimilate Cs from these polychaetes to account for >90% of their body burden.

269 bing virus capsid structures that is able to account for many of these limitations, including a more

270 esting that changes in patient selection may account for some of these observed discrepancies.

271 ained substantial and significant even after accounting for all of these processes.

272 tions that affect the PI3K p110alpha subunit account for activation of this pathway in 20% to 40% of

273 ed during the study period, with aquaculture accounting for 30% of this total forest change.

274 ties, with information about model structure accounting for 82% of this reduction and uncertainty abo

275 rongly suggesting that increased necroptosis accounts for exacerbation of this injury in conditions o

276 75 km distant) were the most likely sources, accounting for 70% of timbers.

277 ssions from drylands, which are estimated to account for 30% of total gaseous nitrogen emissions on E

278 oned genes underlying Crgn1 and Crgn2, which accounted for 40% of total variance in glomerular inflam

279 % each (n = 83) received at least $93622 and accounted for 44% of total payments.

280 Flavonoids accounted for 80% of total (poly)phenolic compounds, bei

281 The top 5 highest reimbursed services accounted for 85% of total ophthalmic Medicare payments

282 cticed in California for more than 30 years, accounting for 1% of total oil production in 2012 from m

283 statins were used by 18.2% of statin users, accounting for 55% of total costs in 2012-2013.

284 (canolol) is the dominant phenolic compound, accounting for 85% of total phenolics.

285 alpha2-3-linked sialic acid accounts for <20% of total sialic acid and is predominan

286 ion of synaptic proteins, but no single gene accounts for >1% of total ASD cases.

287 cher than previously thought and potentially account for mixtures of traits and species observed in f

288 Propensity matching was used to account for confounders of transfusion and thrombotic ri

289 thyroid-stimulating hormone-secreting tumors accounts for 1% of tumors and is treated with surgery an

290 Our results account for properties of two recently discovered types

291 f physiological processes in 29 wheat models account for >50% of uncertainty in simulated grain yield

292 us assessments that population estimates can account for uncertainties of up to 55% in static normali

293 es for 6,782 vessels in 13 US fisheries that account for 20% of US landings revenue.

294 Broad-spectrum antibiotics accounted for 26% of use in SCHs (range, 8%-36%), simila

295 adjust for potential confounding factors and account for sources of variability that are not of prima

296 PC2 ('transience'), accounting for 27% of variance, described how much indiv

297 er performance degradation with higher load, accounting for 31% of variance, p(corrected) = 0.015.

298 ed between-year changes in outcome, together accounting for 33% of variance in reliable improvement a

299 ed non-target P3s in SZ patients, the latter accounting for 37% of variance in negative symptoms.

300 PC1 ('binge-eating'), accounting for 38% of variation, captured temporal clust