ライフサイエンスコーパス: accrual

1 C (STARS and ROSEL) closed early due to slow accrual.

2 , which is a period of substantial bone mass accrual.

3 tracellular enzymatic activities, or biomass accrual.

4 closed early because of lower than projected accrual.

5 was unlikely to change with further patient accrual.

6 100% of cases, which can limit hospital case accrual.

7 er 94 patients were enrolled because of slow accrual.

8 uld require 6.7 years on average to complete accrual.

9 se were documented as challenges for patient accrual.

10 hibited this response at the level of RNF168 accrual.

11 e toxicity was not identified during patient accrual.

12 lled an average of 15% of their total target accrual.

13 orders, may have deleterious effects on bone accrual.

14 closed with 337 patients as a result of slow accrual.

15 hetic tone, thus potently favoring bone mass accrual.

16 osteoblast-secreted Wnt ligands in bone-mass accrual.

17 d as the most important predictors of damage accrual.

18 the trial was halted prematurely due to slow accrual.

19 the brain, is a major regulator of bone mass accrual.

20 a episodes before study termination for poor accrual.

21 egnancy are important for fetal bone mineral accrual.

22 ssessable for toxic effects after completing accrual.

23 A was prematurely terminated because of slow accrual.

24 the sympathetic tone and increase bone mass accrual.

25 United States with potential impact on trial accrual.

26 are still accruing, this also means stopping accrual.

27 by the patient at the time of clinical trial accrual.

28 efects in replication capacity and bone mass accrual.

29 n accrual and asking how mating affects that accrual.

30 t linear growth but compromised overall bone accrual.

31 rmation is not closely linked with WM lesion accrual.

32 This trial is currently closed to accrual.

33 tive effects of pregnancy against disability accrual.

34 gnaling pathway, thereby facilitating T cell accrual.

35 one arm was discontinued as a result of poor accrual.

36 ion complex, therefore allowing beta-catenin accrual.

37 vents the replication of damaged DNA and DSB accrual.

38 An analysis was performed for slow accrual: 136 patients were enrolled from 2010 through 20

39 ventually accrued on the 191 trials (current accrual, 154,579) and that 2,991 of these patients will

40 Median RTOG accrual (1997 to 2002) at HLACs was four versus 65 patie

41 The study was closed early because of slow accrual; 340 of the 356 patients were eligible.

42 cruitment was closed prematurely due to poor accrual after 89 of 200 planned patients were randomly a

43 embryonic development, as well as bone mass accrual after birth, through two complementary cellular

44 study was discontinued early because of slow accrual after the enrollment of 70 patients.

45 rapy are likely key factors that impair bone accrual, along with downstream effects including malnutr

46 contribute to lifelong growth and bone mass accrual, although the specific role of maternal deficien

47 Following complete accrual, an unplanned early analysis for efficacy was pe

48 safety monitoring board on the basis of slow accrual and a low likelihood of detecting a difference i

49 pose Broadening trial eligibility to improve accrual and access and to better reflect intended-to-tre

50 The study completed accrual and all analyses are final.

51 The reported study has completed accrual and all analyses are final.

52 ggesting a causal link between pretangle tau accrual and altered locus coeruleus fibre morphology.

53 The protocol is closed to accrual and analysis was performed per protocol.

54 habditis elegans germline stem cell mutation accrual and asking how mating affects that accrual.

55 g oxidative stress-mediated arterial calcium accrual and bone loss.

56 Further accrual and follow-up are required to assess longer-term

57 n hypothalamic neurons to regulate bone mass accrual and identify CREB as a critical determinant of t

58 n fibrillar and soluble amyloid-beta and tau accrual and in the glial response that discriminated dem

59 ort A was closed prematurely because of poor accrual and is not reported.

60 ings highlight the importance of CD36 in the accrual and nucleation of NLRP3 ligands from within the

61 Lrp6 are essential for normal postnatal bone accrual and osteoblast function.

62 TSP-1 prevented PGE-stimulated cAMP accrual and phosphorylation of PKA substrates, through a

63 Ecosystem carbon (C) accrual and storage can be enhanced by removing large he

64 d scheduled interim analysis because of slow accrual and the end of funding, which left the study und

65 This trial is closed to accrual and the final analysis is presented in this repo

66 ble patient characteristics over the time of accrual and the quality of follow-up management.

67 utional review board approval before patient accrual and was compliant with HIPAA.

68 with implications for patient safety, trial accrual, and access to care.

69 ed on Dec 20, 2013, after achieving complete accrual, and follow-up remains ongoing for the primary o

70 A) damage-repair proteins subsequent to RNF8 accrual, and for proficient double-strand break repair.

71 cal power calculations, insufficient patient accrual, and incorrect predictions of baseline event rat

72 uences for MSC lineage commitment, fetal fat accrual, and offspring obesity risk.

73 directly control osteoclastogenesis and bone accrual around endosseous implants.

74 fy variables associated with rates of damage accrual as measured by the SDI.

75 ly, Paip2 accumulation was dependent on PABP accrual, as preventing PABP1 accumulation suppressed vir

76 al carnitine content, and prevents body mass accrual associated with carbohydrate feeding alone.

77 rt with carcinoid tumours, and we terminated accrual at 20 patients.

78 thway was required for optimal cortical bone accrual at the periosteum in mice.

79 y, plays antagonistic functions on bone mass accrual at these two sites.

80 olled on trials that ended with insufficient accrual because of an inadequate accrual rate.

81 e patients will be on trials that have < 90% accrual because of inadequate accrual rates (1.7%).

82 We focus on trials that ended with < 90% accrual because of inadequate accrual rates rather than

83 t that 22.0% of these trials will have < 90% accrual because of inadequate accrual rates.

84 ation on or after Jan 1, 1970, and completed accrual before Dec 31, 2010; had to have been randomised

85 efined as old versus newer era using initial accrual before or after 1995.

86 Accrual began December 2005 and was completed in 13 mont

87 Patient accrual began in March 2010 and ended in August 2011.

88 Accrual began on September 5, 2012, and ended on June 28

89 This trial is closed to accrual but follow-up is ongoing.

90 a positive and dominant effect on bone mass accrual by enhancing bone formation and limiting bone re

91 clearance, indicating endogenous free water accrual by urine concentration.

92 all--hormonal changes, and deficits in bone accrual can persist.

93 A (VEGFA) in the mouse did not diminish bone accrual caused by HIF1alpha stabilization.

94 Results Planned enrollment was 356 patients; accrual ceased at 272 because of high relapse incidence

95 Purpose Despite increasing awareness of accrual challenges, it is unknown if accrual of older pa

96 anisms involved in adipose tissue macrophage accrual continue to be elusive.

97 Accrual continued on PC.

98 Data accrual continued until theoretical saturation was achie

99 Accrual continues seamlessly to the other research arms

100 included study protocols, trial budgets, and accrual data.

101 rty to young adulthood, when bone growth and accrual decelerate.

102 ren and adolescents did not affect bone mass accrual despite significant increases in serum 25(OH)D c

103 Serotonin is a bioamine regulating bone mass accrual differently depending on its site of synthesis.

104 were assessed based on the timing of damage accrual during cohort participation.

105 ling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis.

106 gain, DeltaBMIZ is the best indicator of fat accrual during the first 5 postnatal months.

107 Bone accrual during youth is critical to establish sufficient

108 (Cel)-containing comparisons, which stopped accrual early at interim analysis on the basis of failur

109 sly promotes low fat mass and high bone mass accrual early in life.

110 Accrual exceeded 1,200 patients per year.

111 Here we establish that ecosystem nitrate accrual exhibits consistent and negative nonlinear corre

112 We examine in detail the accrual experience of the Cooperative Group phase III tr

113 ed from 2000 to 2007 were examined for their accrual experience.

114 up trials has a positive peak during patient accrual followed by a negative trough during follow-up.

115 tem-derived serotonin (BDS) favors bone mass accrual following its binding to Htr2c receptors on vent

116 how brain-derived serotonin favors bone mass accrual following its binding to the Htr2c receptor on n

117 ssion models uncovered different patterns of accrual for female patients and male patients on county-

118 nts, optimization of bone growth and mineral accrual for life, pediatric bone mineral density and fra

119 accrual to adjuvant trials but worsening of accrual for neoadjuvant/metastatic trials.

120 Accrual for nonsquamous patients halted in 2013.

121 lected following the opening of the study to accrual from October 10, 2006, through December 31, 2014

122 tive propensity-matched cohort analysis with accrual from September 1, 2012, to September 30, 2015.

123 m tertiary academic centers, but prospective accrual from the community over the last 12 years has re

124 The trial reached its accrual goal of 42 median age, 63 years (range, 45-83 ye

125 als that stopped accrual with < 90% of their accrual goal, the reasons for having < 90% accrual were

126 the study did not reach its original target accrual goal.

127 he number of trials that fail to reach their accrual goals and to minimize the number of patients acc

128 istration phase III study failed to meet its accrual goals, it did appear to show some benefit, espec

129 oup phase III trials failed to achieve their accrual goals.

130 After patient accrual had begun, the trial design was amended in 2003

131 disease (CHD) poses multiple threats to bone accrual; however, the associated fracture risk is not we

132 ry clinical milestone has been completion of accrual in a phase 3 trial of intratumoral herpes simple

133 th LDL containing ceramide promoted ceramide accrual in cells and was accompanied by reduced insulin-

134 elective antibody, to attenuate amyloid-beta accrual in cerebral vessels and to acutely restore vascu

135 allosteric inhibitor impaired human platelet accrual in damaged arterioles.

136 limiting aortic type I collagen and calcium accrual in diabetic LDLR-deficient mice.

137 sr39tk expression and the quantity of tracer accrual in DU-145, with the minimal value for PET detect

138 n D and calcium supplementation on bone mass accrual in HIV-infected youth.

139 entrations), production (based on ergosterol accrual in ingrowth cores), and turnover rate (the quoti

140 a suppressor of bone formation and bone mass accrual in mice.

141 degeneration that contributes to disability accrual in multiple sclerosis.

142 ive strategy for rapid and efficient patient accrual in pediatric SCA studies.

143 h the total volume of sedentary time and its accrual in prolonged, uninterrupted bouts are associated

144 red sedentary behavior (its total volume and accrual in prolonged, uninterrupted bouts) and all-cause

145 genome-wide measurements of in vivo mutation accrual in stem cells and will enable further characteri

146 fferentiation before birth, and control bone accrual in the adult.

147 Spaceflight resulted in lower cortical bone accrual in the femur but had no effect on cortical bone

148 phenotypes that includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus

149 was detected in the locus coeruleus prior to accrual in the medial entorhinal cortex or hippocampus,

150 ase II trials (70 trial arms) that completed accrual in the years 1975 through 2005 and conducted by

151 anized lifestyles in later life on bone mass accrual in young adults from a rural community in India

152 foods may lead to healthy fat and bone mass accrual in young children.

153 erol concentrations may improve bone mineral accrual in young runners with EBT.

154 Final accrual included 1,738 patients; 865 patients received e

155 Challenges to trial accrual included patient preference of noninvestigationa

156 Accrual information was obtained from trial sponsors.

157 Bone mass accrual is a major determinant of skeletal mass, governe

158 mice expressed low levels of CD25, and their accrual is associated with declining levels of IL-2 in a

159 Accrual is complete and follow-up is still on-going.

160 Because bone mass accrual is completed by young adulthood, assessing stimu

161 Bone mass accrual is inhibited by sympathetic signaling centrally

162 Accrual is ongoing in some disease cohorts.

163 when trials are forced to close for lack of accrual, it is imperative to build multidisciplinary con

164 trictive eligibility criteria can slow trial accrual, jeopardize the generalizability of results, and

165 that were stopped early due to insufficient accrual/logistical issues.

166 ions in the aortic media, attenuated calcium accrual more than 2-fold, and doubled longevity as compa

167 Accrual occurred from November 2006 through July 2012, w

168 year (mean, 1.3 years) postvaccination until accrual of >/=96 confirmed HZ cases (as determined by te

169 Accrual of 1,113 evaluable patients per treatment arm wa

170 sis of the first cohort, which had a planned accrual of 17 participants.

171 The combination arm completed the full accrual of 28 patients, of whom 22 patients (78.5%) had

172 added 14% more events and shortened time to accrual of a fixed number of events.

173 displayed disrupted fluid flux and increased accrual of autofluorescent material after long-term POS

174 AS-1 mimics DHT while TFM-4AS-1 promotes the accrual of bone and muscle mass while having reduced eff

175 ith children who were healthy weight for the accrual of bone mass in response to an extra 3 servings

176 enting disease relapse, and limiting overall accrual of both disease-related damage and treatment-rel

177 ys over the same period, reducing the annual accrual of C in woody biomass by 41%.

178 detrimental in the failing heart because of accrual of cardiomyocyte death.

179 Accrual of disability during the RCT (R(2)=0.12; p<0.000

180 s is characterised clinically by the gradual accrual of disability independent of relapses and can oc

181 uts of gene copy number amplification during accrual of distant point mutations can potently facilita

182 Assaying in vivo accrual of DNA damage and DNA mutations by stem cells an

183 egulatory mechanism leads to the spontaneous accrual of DNA damage and may contribute to the abnormal

184 is stimulated by autocrine IL-6 and inhibits accrual of Ets-1, Set1 methyltransferase and trimethylat

185 Accrual of further patients was discontinued in any rese

186 roup's biology has also benefited from rapid accrual of genomic resources, particularly with respect

187 In this study, DCs present in seroma, an accrual of human afferent lymph occurring after lymph no

188 tected in seroma fluids, which represents an accrual of human afferent lymph, indicating that they ma

189 The accrual of large genotyped AN case-control samples shoul

190 The factors, however, that regulate the accrual of macrophages in adipose tissue are not well un

191 environmental context and proposes that the accrual of mtDNA variation could contribute to animal sp

192 We show that the accrual of mutations should track cell divisions not onl

193 cling correlates with a dramatic increase in accrual of mutations.

194 rm of multiple sclerosis is characterized by accrual of neurological dysfunction from disease onset w

195 The study is closed to accrual of new patients, but several enrolled patients a

196 evious publications that revealed continuous accrual of newly synthesized channels along plaque edges

197 Novel strategies to increase accrual of older patients are critical to meaningfully c

198 Methods We examined accrual of older patients to Alliance for Clinical Trial

199 ness of accrual challenges, it is unknown if accrual of older patients to breast cancer treatment tri

200 f oncogenic mutations over time, because the accrual of oncogenic events is thought to be the rate-li

201 rly MRs have markedly attenuated age-related accrual of oxidation damage to thiol groups and age-asso

202 The accrual of patients with RET-rearranged lung cancer to t

203 Inadequate accrual of pediatric patients precluded conclusions in t

204 With accrual of pedigree data over multiple decades, we retes

205 n the fibrous cap of the plaques lead to the accrual of plaque-destabilizing mechanical stress.

206 ling via STAT1 has a cell-autonomous role in accrual of PP pDCs in vivo.

207 en lattice sites locally to adjust the phase accrual of propagating electrons.

208 dual stromal cells, as evidenced by promoter accrual of repressive histone marks.

209 e use a model of inflammation resulting from accrual of self DNA (DNase II(-/-) type I IFN receptor [

210 Our findings suggest that the lifetime accrual of sensory experience optimizes functional brain

211 ing that wakefulness can be dissociated from accrual of sleep need.

212 icoid and glucocorticoid release, endogenous accrual of surplus body water, and precise surplus excre

213 INT6 silencing impaired the accrual of the ubiquitin ligase RNF8 at DSBs and the for

214 the mechanisms underlying the age-dependent accrual of Treg remain unclear.

215 In DNase II-deficient mice, the excessive accrual of undegraded DNA leads to both a STING-dependen

216 se II and the type I IFN receptor, excessive accrual of undegraded DNA results in a STING-dependent,

217 ill be necessary to reduce significantly the accrual of vascular calcifications and cardiovascular mo

218 antiviral IFN-I responses and influence the accrual of virus-specific NK or CD8(+) T cells in a viru

219 After additional accrual on an extension phase, total enrollment was 60 p

220 The CHHiP trial completed accrual on June 16, 2011, and the QoL substudy was close

221 required to determine the impact of impaired accrual or actual loss of bone during adolescence on sub

222 no difference according to year of starting accrual or cooperative group.

223 ain serotonin positively regulates bone mass accrual peripheral serotonin is a potent inhibitor of bo

224 Timely accrual poses a challenge to the conduct of a large rand

225 rol the intensity of T cell responses, their accrual probably contributes to age-related immune dysfu

226 ew Madrid region is driven by ongoing strain accrual processes and that, despite low deformation rate

227 Feasibility of large-scale accrual, prospective tumor collection, and molecular str

228 secondary end points as well as a decreasing accrual rate (NCT01233713).

229 The accrual rate of 2.6 patients per month was superior to t

230 Feasibility, defined by the accrual rate, the safety of the preoperative regimen, an

231 nsufficient accrual because of an inadequate accrual rate.

232 hat have < 90% accrual because of inadequate accrual rates (1.7%).

233 We find that insufficient accrual rates are not as high as previously reported and

234 With no differential patient accrual rates because of the trial design, we find no be

235 ded with < 90% accrual because of inadequate accrual rates rather than for other reasons, such as an

236 decrease in final chlorophyll a biomass and accrual rates the most in the downstream reach containin

237 tive treatment and supportive care, although accrual rates to therapeutic clinical trials remain disa

238 If it is thought that the patient accrual rates will be substantially higher because of th

239 recision) and the quality of the image data, accrual rates, and study power is needed.

240 ill have < 90% accrual because of inadequate accrual rates.

241 hat leptin-dependent inhibition of bone mass accrual relies on both transcriptional events taking pla

242 Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic

243 s in mammalian cells, with SUMO1 and SUMO2/3 accrual requiring the E3 ligase enzymes PIAS4 and PIAS1.

244 Patient accrual started on July 16, 2007, and was completed on J

245 Accrual stopped early in 2012 for squamous patients beca

246 ary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to

247 d by the sympathetic regulation of bone mass accrual take place.

248 rpowered because it did not meet the planned accrual target, and OS was higher than predicted in both

249 ssed at a preplanned interim analysis, trial accrual terminated in April, 2011.

250 and HFD produced selective deficits in bone accrual that were associated with alterations in progeni

251 After completion of the planned accrual, the protocol was amended to introduce a third a

252 Given the feasibility of accrual, the statistical plan only permitted detection o

253 The study is ongoing but closed to accrual; these are the results of the final analysis of

254 s) or high-accruing centers (HHACs) based on accrual to 21 RTOG HNC trials (1997 to 2002).

255 Actual accrual to 93.2% of trials was 1,804 patients, an estima

256 ting the threshold ratios underlying nitrate accrual to a constrained stoichiometric window.

257 We observed some improvement in accrual to adjuvant trials but worsening of accrual for

258 Completion of accrual to all other arms was not feasible.

259 in this setting necessitated termination of accrual to B-33, unblinding, and offering of exemestane

260 ta monitoring committee recommended stopping accrual to both celecoxib-containing arms on grounds of

261 Accrual to cohort 2 was stopped after an unplanned inter

262 The CTD uses revenue from accrual to existing trials to cross-subsidize past trial

263 We limited assessment of accrual to studies with US sites.

264 rafted to prevent and treat vascular calcium accrual, to the benefit of our patients afflicted with a

265 To examine accrual trends, we modeled age as a function of time, us

266 ition to profoundly low overall cancer trial accrual, vast underrepresentation by age, cancer stage,

267 each of these sources to liver-triglyceride accrual, VLDL-triglyceride synthesis, and hypertriglycer

268 The effect of accrual volume on OS was estimated by Cox proportional h

269 Target accrual was 130 patients to detect an increase in median

270 was 2-year event-free survival; the planned accrual was 38 patients.

271 The target accrual was 44 patients to have 10% type I and II error

272 Target accrual was 50 patients, with a one-stage design.

273 Target accrual was 680 patients.

274 Increased plant C accrual was accompanied by higher soil microbial activit

275 The planned trial accrual was completed in May, 2012, and follow-up is ong

276 Accrual was from November 1998 to April 2009.

277 Accrual was halted on the basis of the data and safety m

278 Subject accrual was plotted as a function of resuscitation durat

279 Finally, Treg accrual was significantly blunted in aged IL-6-deficient

280 orptiometry scanning revealed that bone-mass accrual was significantly inhibited in homozygotes as ea

281 Among trials with US sites, time to accrual was slower (41 vs 22 months; P = .002) and less

282 Accrual was stopped early because the trial results cros

283 Accrual was stopped early for futility.

284 Accrual was stopped short of 930 patients on the basis o

285 Accrual was terminated at 338 of 2,150 planned patients

286 Patient accrual was terminated in December, 2008, because of slo

287 Accrual was terminated with 908 of 1,820 patients enroll

288 ympathetic tone signals to inhibit bone mass accrual, we performed a systematic, cell-specific analys

289 patient characteristics and rates of damage accrual were assessed based on the damage score at the l

290 e-varying patient characteristics and damage accrual were assessed based on the timing of damage accr

291 r accrual goal, the reasons for having < 90% accrual were documented.

292 l trials open in the United States and their accrual were examined to identify opportunities to accel

293 It decreases accrual when synthesized in the gut, and increases it wh

294 on limitation appears to drive rapid nitrate accrual, which may then be further enhanced by nitrifica

295 a phase II/III trial are whether to suspend accrual while the phase II data mature and the choice of

296 indicate that ZO-1 binding regulates channel accrual, while disengagement from ZO-1 is critical for G

297 It is anticipated that clinical trial accrual will increase substantially, providing further g

298 For trials that stopped accrual with < 90% of their accrual goal, the reasons fo

299 data show a role for IL-6 in promoting eTreg accrual with age likely through maintenance of ICOS expr

300 esian predictive calculation that additional accrual would be unlikely to change the qualitative comp