ライフサイエンスコーパス: accumbal

1 sis either excited or inhibited striatal and accumbal activity but excitatory effects predominated in

2 Using microdialysis, direct accumbal administration of 1 muM 6c reduced dopamine ove

3 nvestigate the effects of systemic and intra-accumbal administration of the CB1 antagonist SR141716A

4 the dopamine precursor DOPA following intra-accumbal administration of the DOPA decarboxylase inhibi

5 cortex via antidromic stimulation of cortico-accumbal afferents.

6 nfrontation, points to a significant role of accumbal and cortical DA and 5-hydroxytryptamine in the

7 Accumbal and pallidal levels of DeltaFosB were increased

8 nsmission in these cells, demonstrating that accumbal cholinergic neuronal activity regulates depress

9 epression-like behaviors and suggesting that accumbal CIN activity is crucial for the regulation of m

10 ), we identified anomalies within the fronto-accumbal circuit in childhood ADHD, which were associate

11 tistical modeling, indicates that the fronto-accumbal circuit is an important substrate of aggression

12 that strategies aimed at probing the fronto-accumbal circuit may be beneficial for the treatment of

13 e documented the relationship between fronto-accumbal circuitry-a critical cortical pathway to subcor

14 These findings suggest that disruption of accumbal core NMDA receptor-dependent plasticity may rep

15 Excitation of accumbal D2 cells governs vital actions, including avoid

16 The increase in accumbal DA in aggressive animals supports the hypothesi

17 agents or vehicle, no significant changes in accumbal DA were observed.

18 t not the agonist, significant elevations of accumbal DA were observed.

19 Accumbal deep brain stimulation (DBS) is a promising the

20 ment in rats depends on interactions between accumbal dopamine and glutamate systems that are mediate

21 Our data reveal that accumbal dopamine concentrations decrease proportionally

22 adox that cocaine more effectively increases accumbal dopamine despite identical effects on the dopam

23 is effect may represent different aspects of accumbal dopamine function.

24 These data support previous studies in which accumbal dopamine is required for producing a normal loc

25 ey have been implicated in the regulation of accumbal dopamine levels.

26 rs (GlyRs) are involved in the regulation of accumbal dopamine levels.

27 lity of D1 activity in the mPFC to influence accumbal dopamine levels.

28 re, we investigated the presence of GlyRs in accumbal dopamine receptor medium spiny neurons (MSNs) o

29 n inhibitory control by prefrontal cortex on accumbal dopamine release during amygdala activation.

30 An increase in accumbal dopamine release was observed during the stimul

31 tion via a concomitant active suppression of accumbal dopamine release.

32 r no change in basal levels of extracellular accumbal dopamine resulting from repeated psychostimulan

33 try, we determined that the concentration of accumbal dopamine time-locked to cue presentation decrea

34 This inhibitory modulation of accumbal dopamine was receptor-specific, as the decrease

35 In contrast, accumbal glutamate release was determined using individu

36 term potentiation (LTP) of the frontocortico-accumbal glutamatergic synapses correlates with PSD-95 r

37 the form of long-term depression at cortico-accumbal glutamatergic synapses.

38 In addition, accumbal GRIP deletion was associated with blunted long-

39 is the first study to demonstrate a role for accumbal GRIP in behavior.

40 hese data argue against a protective role of accumbal indirect pathway D2Rs in alcohol consumption bu

41 Intra-accumbal infusion of PFI3 attenuated, whereas viral over

42 Systemic and intra-accumbal inhibition of BRD4 with the BET inhibitor, JQ1,

43 B) in the nucleus accumbens (NAc), and intra-accumbal injection of cocaine- and amphetamine-regulated

44 in nicotine-conditioned reward as the intra-accumbal injection of the selective alpha6beta2* alpha-c

45 cocaine-seeking behaviors after either intra-accumbal injections of the BRG1 inhibitor PFI3 or viral-

46 Subsequent experiments showed that intra-accumbal microinjection of AP-5 alone dose-dependently r

47 These findings suggest that deficits in accumbal monoamine release may contribute to the negativ

48 These data rule out the involvement of accumbal NET or SERT in the cocaine-induced increase in

49 Thus, although ACh can modulate striatal and accumbal neuronal activity, DA does not regulate this ef

50 conditioned approach behavior as well as on accumbal neuronal responses time locked to the CS+, the

51 imulus (CS) effects by selectively enhancing accumbal neuronal responses to stimuli.

52 In accumbal neurons in vivo, CaMKIIalpha is recruited to D3

53 for the complex response of neostriatal and accumbal neurons to systemic AMPH administration.

54 applied iontophoretically to neostriatal and accumbal neurons under naturally occurring behavioral co

55 er, ethanol-sensitized mice also had reduced accumbal NMDA receptor function and expression, as well

56 examine the functional relationship between accumbal oxytocin receptor density and social behavior i

57 n nonmonogamous rodent species, and blocking accumbal oxytocin receptors prevents mating-induced part

58 ucrose by activating the mesolimbic dopamine-accumbal pathway, solely based on calorie load.

59 Intra-accumbal PTX produced a dose-dependent increase in locom

60 Intra-accumbal PTX sensitized rats to the locomotor-activating

61 ith a selective increase in the magnitude of accumbal responses during the CS+.

62 fect the conditioned behavior, but increased accumbal responses to the CS+.

63 pavlovian conditioned stimuli by amplifying accumbal responses to those stimuli.

64 No concurrent changes in accumbal serotonin levels were seen during or after the

65 neostriatum, an abrupt increase occurred in accumbal shell, a limbic-related area implicated in goal

66 routing, to the synaptic connectivity of the accumbal shell.

67 The age-dependent alteration of accumbal structure was associated with qualitatively dif

68 eptor binding was determined in striatal and accumbal tissue samples.

69 neous GABA ion channel opening and increased accumbal tonic current.

70 ect mediated by the relationship between the accumbal volume and impulsivity.

71 The magnitude of the accumbal volume reductions within the ADHD group was sig

72 lly, children with ADHD showed reduced right accumbal volumes and frontal-accumbal white matter conne

73 explained by multivariate measures of fronto-accumbal white matter connectivity and cortical thicknes

74 d reduced right accumbal volumes and frontal-accumbal white matter connectivity compared with HC.