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1 ons, including the ventral striatum (nucleus accumbens).
2 t with structural differences in the Nucleus Accumbens).
3 us), and limbic system (amygdala and nucleus accumbens).
4 orks and their connectivity with the nucleus accumbens.
5 at prefrontal cortex synapses in the nucleus accumbens.
6 tive change of the RPE signal in the nucleus accumbens.
7 1 dopamine receptor (D1-MSNs) in the nucleus accumbens.
8 A-dependent AMPA transmission in the nucleus accumbens.
9 ion of DA clearance in slices of the nucleus accumbens.
10 gions, particularly the striatum and nucleus accumbens.
11 the CNS such as the hippocampus and nucleus accumbens.
12 ing phasic dopamine signaling in rat nucleus accumbens.
13 ays and in vivo microdialysis in rat nucleus accumbens.
14 in the medial prefrontal cortex and nucleus accumbens.
15 e-induced release of dopamine in the nucleus accumbens.
16 icture evaluation in the caudate and nucleus accumbens.
17 n direct-pathway MSNs (dMSNs) in the nucleus accumbens.
18 ility of medium spiny neurons of the nucleus accumbens.
19 nse to anticipation of reward in the nucleus accumbens.
20 ocin were mediated by actions in the nucleus accumbens.
21 was modulated by D1 availability in nucleus accumbens.
22 nd higher D1-receptor density in the nucleus accumbens.
23 brain's reward regions, such as the nucleus accumbens.
24 ine-enhanced extracellular DA in the nucleus accumbens.
25 depend on oxytocin signaling in the nucleus accumbens.
26 n at the Auts-Caln1 loop base in the nucleus accumbens.
27 tal projection neurons (SPNs) of the nucleus accumbens.
28 or of gene expression, acting in the nucleus accumbens, a brain reward region, is capable of increasi
31 We examined dopamine release in the nucleus accumbens across multiple time scales, using complementa
33 ved in striatum, olfactory tubercle, nucleus accumbens, amygdala, and neocortex, whereas in spinal co
34 ilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, put
35 mes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, put
36 conditions (i.e. prefrontal cortex, nucleus accumbens, amygdala, ventral tegmental area) is not well
37 es on the mesolimbic reward pathway (nucleus accumbens; amygdala) that receive OT projections and con
38 hermore, medium spiny neurons in the nucleus accumbens, an area implicated in development of OCD, dis
39 D2-type medium spiny neurons in the nucleus accumbens, an effect seen in male but not female mice.
41 omoter regions, was evaluated in the nucleus accumbens and dorsal striatum of rats using western blot
42 , the main projection neurons in the nucleus accumbens and dorsal striatum, and their function in rel
44 ility, we focused on the core of the nucleus accumbens and examined expression and epigenetic regulat
45 itability of medium spiny neurons in nucleus accumbens and gating the compositional plasticity of alp
46 hanistic studies of gene networks in nucleus accumbens and gene regulatory mechanisms across a variet
47 e was preferentially associated with nucleus accumbens and medial orbitofrontal cortex activity, wher
49 ities between the ventral striatum's nucleus accumbens and olfactory tubercle (OT) suggests the distr
50 is crucial for processing of affect; nucleus accumbens and orbitofrontal cortex of the reward circuit
52 ite effects on TrkB signaling in the nucleus accumbens and prefrontal cortex, tat-cyclotraxin-B admin
54 h decreased connectivity between the nucleus accumbens and the default mode network and increased con
56 functional connectivity between the nucleus accumbens and the midcingulate cortex in response to mon
58 y neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, whereas act
59 within the caudate, ventral caudate/nucleus accumbens, and anterior and posterior insula, 2) to unex
60 regions, including the hippocampus, nucleus accumbens, and anterior cingulate cortex, in individuals
62 s were increased in the amygdala and nucleus accumbens, and decreased in the hippocampus, but not cau
65 ns studied, orbitofrontal cortex and nucleus accumbens, are not sequentially dependent during context
66 al and epigenetic alterations in the nucleus accumbens, are thought to contribute to this life-long d
67 s identify a functional role for the nucleus accumbens as a critical brain region whereby CBD can pro
68 o induce long-term depression in the nucleus accumbens, as well as increased potentiation at these sy
69 .892C>T (p.Arg298Trp) variant in the nucleus accumbens associated 1 (NACC1) gene in seven affected in
71 l core or caudal medial shell of the nucleus accumbens attenuated cocaine priming-induced reinstateme
72 A RP1-269M15.3 in frontal cortex and nucleus accumbens basal ganglia, respectively, were significantl
75 tion in brain reward regions such as nucleus accumbens, but could not address gene expression in the
76 ted a more excitable ensemble in the nucleus accumbens, but not orbitofrontal cortex, compared with t
79 the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, r
82 <15 years) versus adults (>21 years): in the accumbens (Cohen's d=-0.19 vs -0.10), amygdala (d=-0.18
85 n medium spiny neurons (MSNs) in the nucleus accumbens core (NAcore) and requires spillover of glutam
86 cortical terminals synapsing in the nucleus accumbens core (NAcore) to stimulate metabotropic glutam
87 nse factor 1 immunoreactivity in the nucleus accumbens core and anteromedial BNST in female mice but
88 for use-dependent inhibition in the nucleus accumbens core and dorsal striatum, is also minimal in t
89 gy to knock down GLT-1 or xCT in the nucleus accumbens core and examined the behavioral and molecular
90 ability of neuronal ensembles in the nucleus accumbens core and shell (NAc(core) and NAc(shell)), and
92 ed mode of dopamine signaling in the nucleus accumbens core and that such signaling relates to elemen
94 to the anteromedial BNST but not the nucleus accumbens core increased social approach and decreased s
95 dorsomedial prefrontal cortex to the nucleus accumbens core makes it difficult to selectively enhance
96 f cortical glutamatergic synapses on nucleus accumbens core medium spiny neurons, but it is unknown h
97 opamine concentration changes in the nucleus accumbens core of rats throughout acquisition and perfor
98 zation stress, and 3 weeks later the nucleus accumbens core was examined for changes in glutamate tra
99 tly, by restoring glutamate transport in the accumbens core with ceftriaxone the capacity of acute st
100 l administration of OSU6162 into the nucleus accumbens core, but not dorsolateral striatum, selective
101 ggest that low D2 mRNA levels in the nucleus accumbens core, likely mediated via epigenetic modificat
104 46), amygdala (d=-0.31), thalamus (d=-0.31), accumbens (d=-0.25) and intracranial volumes (d=-0.12),
105 ng-lasting increase in extracellular nucleus accumbens DA, locomotion, and brain-stimulation reward.
106 coeruleus) and preference/aversion (nucleus accumbens) demonstrate the unique capabilities of these
110 ctivation of glutamatergic inputs to nucleus accumbens during cued reinstatement of cocaine seeking v
111 e-wide RNA expression in post-mortem nucleus accumbens from donors (N=26) with known loneliness measu
114 tum (Hedge's g=0.57, P<0.05) and the nucleus accumbens (Hedge's g=1.30, P<0.05) compared to control c
116 the caudate, putamen, pallidum, and nucleus accumbens in 53 depressed patients (mean age: 44.1 years
117 of dopaminergic neurons in the mouse nucleus accumbens in a sensitized locomotor response to cocaine.
118 m and potentially its projections to nucleus accumbens in context-induced relapse after punishment-im
120 cross the rostral-caudal axis of the nucleus accumbens in the control of drug-induced negative affect
121 plored the role of astrocytes in the nucleus accumbens in the neural mechanisms underlying cocaine se
122 ults emphasize the centrality of the nucleus accumbens in the pathophysiology of reward deficits and
124 medial prefrontal cortex (mPFC) and nucleus accumbens, increased anxiety-like behavior, and decrease
126 odel that synaptic plasticity in the nucleus accumbens is central to age-related changes in voluntary
127 from the medial prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females' a
129 motivate continued drug use, and the nucleus accumbens is important for orchestrating both processes.
130 PS1 includes patterns of activity in nucleus accumbens, lateral prefrontal and parahippocampal cortic
131 thalamus as a prominent input to the nucleus accumbens mediating the expression of opiate-withdrawal-
132 rent understanding about the role of nucleus accumbens MSN subtypes in stress-related depression beha
133 assess molecular differences in the nucleus accumbens (NAc) (a specific brain nucleus postulated to
134 pus (male/female) and upregulated in nucleus accumbens (NAc) (male) in depressed human subjects and i
135 e histone dimethyltransferase G9a in nucleus accumbens (NAc) after chronic cocaine administration.
136 e mitochondrial fission mediator, in nucleus accumbens (NAc) after repeated cocaine exposure and in c
137 r the second extinction test and the nucleus accumbens (NAc) and dorsal striatum were collected to me
138 addiction cycle: the dopamine-dense nucleus accumbens (NAc) and norepinephrine-rich ventral bed nucl
139 tional and structural changes in the nucleus accumbens (NAc) and prefrontal cortex (PFC) associated w
140 sends excitatory projections to the nucleus accumbens (NAc) and regulates motivated behaviors partia
141 amine receptor (DRD)-1 and -2 in the nucleus accumbens (NAc) and with down-regulated Lepr in the vent
142 medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) are both integral components of the cort
143 vation of cholinergic neurons in the nucleus accumbens (NAc) are inhibited by CB1 agonists and eCBs.
144 global DNA hydroxymethylation in the nucleus accumbens (NAc) because neuroplastic changes in the NAc
145 ium spiny neurons (MSNs) of the core nucleus accumbens (NAc) by combining patch-clamp recordings with
147 ed real-time dopamine release in the nucleus accumbens (NAc) core or shell while rats received unsign
148 craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of C
151 n medium spiny neurons (MSNs) of the nucleus accumbens (NAc) drives behavioral adaptations in addicti
152 ventral tegmental area (VTA) to the nucleus accumbens (NAc) fire in response to unpredicted rewards
153 Transcriptional profiling of the nucleus accumbens (NAc) from handled rats following repeated exp
155 57BL/6J mice to confirm the role for nucleus accumbens (NAC) glutamate/Homer2 expression in MA prefer
156 e medial prefrontal cortex (mPFC)-to-nucleus accumbens (NAc) glutamatergic transmission is selectivel
158 a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility.
160 essing GABAergic interneurons of the nucleus accumbens (NAc) in the behavioral adaptations induced by
162 owing evidence of Cdk5 expression in nucleus accumbens (NAc) influencing reward-related behaviors.
164 itatory synaptic transmission in the nucleus accumbens (NAc) is a key biological substrate underlying
165 viously showed that DeltaFosB in the nucleus accumbens (NAc) is a key mediator of this cross-sensitiz
169 term potentiation (theta-LTP) in the nucleus accumbens (NAc) is significantly impaired in slices take
171 a dynamic role in cocaine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, thos
173 olecular and cellular adaptations in nucleus accumbens (NAc) medium spiny neurons (MSNs) underlie str
175 al mPFC projections to a subfield of nucleus accumbens (NAc) neurons naturally encodes the decision t
178 tein expression are increased in the nucleus accumbens (NAc) of mice excessively consuming alcohol.
179 we measured phasic DA release in the nucleus accumbens (NAc) of rats during presentation of cues that
181 abnormal blood vessel morphology in nucleus accumbens (NAc) of stress-susceptible but not resilient
183 in the basolateral amygdala (BLA) to nucleus accumbens (NAc) projection, and maturation of these sile
185 histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associati
188 d increased beta-gal staining in the nucleus accumbens (NAC) shell and dorsal raphe nucleus, and foun
189 ressing neurons (D1+ neurons) in the nucleus accumbens (NAc) shell but not the core in mice, which re
190 ssive-like behavior through a common nucleus accumbens (NAc) shell calcium-permeable alpha-amino-3-hy
191 vated orbitofrontal cortex (OFC) and nucleus accumbens (NAc) shell ensembles using wild-type and Fos-
192 e studied the role of projections to nucleus accumbens (NAc) shell from ventral subiculum (vSub), bas
193 of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient ro
196 ist Ro25 was infused into IL-mPFC or nucleus accumbens (NAc) shell, another structure implicated in e
197 ulates the expression of Fosb in the nucleus accumbens (NAc) to promote the cell-type-specific accumu
198 creases dopamine (DA) release in the nucleus accumbens (NAc) via inhibition of local VTA GABAergic ne
199 ses in dopamine concentration in the nucleus accumbens (NAc) while discrete aversive stimuli elicit p
200 s of AMPA glutamate receptors in the nucleus accumbens (NAc), a brain region critical for modulating
201 her impaired dopamine release in the nucleus accumbens (NAc), a brain region critical to goal-directe
203 n medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a critical brain region for cocaine cra
208 is also highly expressed within the nucleus accumbens (NAc), a pivotal brain region underlying rewar
209 ited preferential D2R changes in the nucleus accumbens (NAc), a striatal region that critically regul
210 n implicated in social behavior: the nucleus accumbens (NAc), amygdala, and ventral tegmental area.
211 tive knockdown of Tlr4 mRNA in mouse nucleus accumbens (NAc), and (3) injection of the TLR4 antagonis
212 d by the basolateral amygdala (BLA), nucleus accumbens (NAc), and medial prefrontal cortex (mPFC).
213 d-related brain regions, such as the nucleus accumbens (NAc), are linked to the pathophysiology of de
215 n in brain reward regions, including nucleus accumbens (NAc), contribute to persistent functional cha
217 increases levels of dopamine in the nucleus accumbens (nAc), facilitating behavioural reinforcement
218 cific changes in activity within the nucleus accumbens (NAc), which occur during anticipatory periods
219 ine generates silent synapses in the nucleus accumbens (NAc), whose eventual unsilencing/maturation b
233 the ventral tegmental area (VTA) and nucleus accumbens (NAc); however, direct neuroanatomical evidenc
236 varenicline (0.3 mul/side) into the nucleus accumbens (NAc; 0 or 3.5 mug), but not the ventral tegme
237 subcortical reward-related regions (nucleus accumbens, NAC) mediates the selection of appropriate be
238 mined functional connectivity of the nucleus accumbens (NAcc) - a hub of the reward network - focusin
239 neuroimaging research indicates that nucleus accumbens (NAcc) and anterior insula (AIns) activity inv
241 ve value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice and with w
242 rmal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive
243 e kappa-opioid receptor (KOR) in the nucleus accumbens (NAcc) powerfully mediates negative affective
245 d in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPFC), insu
246 nts and the connectivity between the nucleus accumbens (NAcc), the amygdala, and the medial prefronta
248 log Kmt2b, in adult ventral striatum/nucleus accumbens neurons markedly increased anxiety scores in m
250 nd an alternate neurofeedback group (nucleus accumbens), none sustained activation in target regions
254 opamine signaling in the core of the nucleus accumbens of rats to determine the relationship between
256 sula activity, but no differences in nucleus accumbens or orbitofrontal activation, compared with ine
258 ce-induced neural adaptations in the nucleus accumbens, prefrontal cortex, and ventral tegmental area
259 reveal that spontaneous activity of nucleus accumbens-projecting VTA (VTA-NAc) neurons is selectivel
261 1b in human brain and blood, greater nucleus accumbens reactivity to positive emotional stimuli and e
264 romatin remodeling complexes, in the nucleus accumbens regulates reward-related behaviors in response
267 tion with SMAD3 are increased in the nucleus accumbens, resulting in increased binding of BRG1 to the
268 nent of this network is the anterior nucleus accumbens shell (aNAcSh), which sends GABAergic projecti
269 ptogenetic stimulation of infralimbic cortex-accumbens shell (ILC-NAc shell) inputs or treatment with
270 evated mRNA expression in the medial nucleus accumbens shell (NAcSh) and caudate nucleus in postmorte
271 h prominent morphological changes in nucleus accumbens shell (NACsh) neurons, including increases in
272 U) is a neuropeptide enriched in the nucleus accumbens shell (NAcSh), a brain region associated with
273 mPFC and/or vmPFC projections to the nucleus accumbens shell allows the chemogenetic exploitation of
275 tal cortex (vmPFC) projection to the nucleus accumbens shell is important for extinction of cocaine s
276 a nigra, entopeduncular nucleus, and nucleus accumbens shell measured using brain mapping analyses of
277 ckade of PKA binding to AKAPs in the nucleus accumbens shell of Sprague-Dawley rats attenuates reinst
278 ke dopamine receptors (D1DRs) in the nucleus accumbens shell promoted cocaine seeking through a proce
279 ed only in neuronal ensembles of the nucleus accumbens shell that are related to associative learning
280 ne to induce dopamine release in the nucleus accumbens shell, a brain area believed to underlie nicot
281 undantly to cingulate cortex and the nucleus accumbens shell, and moderately to medial amygdala, locu
282 C neurons that project to the medial nucleus accumbens shell, confirming that these neurons are respo
283 ress-induced relapse, comprising the nucleus accumbens shell, the dorsal raphe nucleus and the medial
288 ortex, hippocampus, caudate-putamen, nucleus accumbens, thalamus, and hypothalamus) of BAC aldh1l1-tr
290 ne to elevate dopamine levels in the nucleus accumbens, the ability of cocaine to establish a conditi
291 ated with reward responsivity in the nucleus accumbens, the default mode network, and the cingulo-ope
292 ithin the striatum, the shell of the nucleus accumbens, the hippocampal projection zone, and the amyg
293 ontinue to grow ectopically from the nucleus accumbens to the PFC and profoundly change PFC structura
294 , in cross-sectional analyses, right nucleus accumbens volume was inversely related to anhedonia seve
295 ilateral hippocampus, amygdala, thalamus and accumbens volumes as well as intracranial volume, but la
296 nnabinoid/mGlu5-mediated LTD in the mPFC and accumbens was abolished in adult n-3-deficient mice.
298 ticular brain regions, including the nucleus accumbens, where oxytocin receptor signaling facilitates
299 duce stable synaptic rewiring in the nucleus accumbens, which will likely influence responses to subs
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