ライフサイエンスコーパス: acentric

1 The DNA break-induced missegregation of acentric and centric chromosome fragments provides a nov

2 er replication arrest, and are resolved into acentric and dicentric chromosomes in G2.

3 blation studies demonstrate that segregating acentrics are mechanically associated with microtubules.

4 resulting in an increase in the frequency of acentric-bearing, lamin-coated micronuclei.

5 Unlike other acentric carbonate fluorides, in this example, the inclu

6 uct of assembly is a holo-apoptosome with an acentric CARD-CARD disk and tethered pc-9 catalytic doma

7 Fragmentation with an acentric CFV directed in a centromere-proximal orientati

8 The acentric chromatid poleward movement is mediated through

9 Polo facilitate the accurate segregation of acentric chromatids by maintaining the integrity of the

10 Our live studies reveal that acentric chromatids segregate efficiently to opposite po

11 function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome t

12 in cancer cells is often mediated by paired acentric chromatin bodies called double minute chromosom

13 the roles of mitotic proteins in segregating acentric chromatin.

14 ning bodies were formed through both loss of acentric chromosome fragments and by chromosome missegre

15 romosome condensation, an increased yield of acentric chromosome fragments at the first postirradiati

16 ules play a key role in poleward movement of acentric chromosome fragments generated in Drosophila me

17 This behavior of acentric chromosome fragments on anastral plant spindles

18 clei were CREST-negative, reflective of lost acentric chromosome fragments.

19 gation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in

20 determine the behavior of kinetochore-free "acentric" chromosome fragments and "monocentric" chromos

21 polyploid, they naturally accumulate broken acentric chromosomes but do not apoptose/arrest the cell

22 lear envelope through which late-segregating acentric chromosomes enter the telophase daughter nucleu

23 We used the endonuclease I-CreI to generate acentric chromosomes in Drosophila larvae.

24 e dynamics of NEF in the presence of lagging acentric chromosomes in Drosophila neuroblasts.

25 While I-CreI expression produces acentric chromosomes in the majority of neuronal stem ce

26 Through live analysis, we show that acentric chromosomes induce highly localized delays in t

27 Although poleward segregation of acentric chromosomes is well documented, the underlying

28 Acentric chromosomes often exhibit delayed but ultimatel

29 ng the integrity of the tethers that connect acentric chromosomes to their centric partners.

30 ents that lack centromeric DNA (structurally acentric chromosomes) are usually not inherited in mitos

31 To survive mitosis with acentric chromosomes, papillar cells require Fanconi ane

32 equently fuse to form unstable dicentric and acentric chromosomes.

33 cle morphology characterized by a spherical, acentric core and a crescent-shaped, electron-dense shel

34 e benzothiazolium crystals consisting of new acentric core HMB (2-(4-hydroxy-3-methoxystyryl)-3-methy

35 During activation an acentric disk is formed on the central hub of the apopto

36 attempted to characterize MN with centric or acentric DNA fragments for the presence or absence of fr

37 ases to promote alignment and segregation of acentric DNA produced by double-strand breaks, thus avoi

38 In klp3a mutants, acentrics fail to localize and segregate along the perip

39 ormation: following a double-strand break an acentric fragment forms, during either meiosis or mitosi

40 The acentric fragment is lost when cells divide and the dice

41 The open DNA end of the acentric fragment is stabilized by the formation of an i

42 a- or metaphase were cut with the laser, the acentric fragments (lacking kinetochores) that were gene

43 chromosome fragmentation at metaphase I, and acentric fragments and chromatin bridges in meiosis I an

44 Etoposide induced mostly acentric fragments and deletions, types of aberrations e

45 Acentric fragments and monocentric chromosomes generated

46 When this occurred, we found that the acentric fragments cosegregated into either the mother o

47 it is unknown whether these late-segregating acentric fragments influence NEF to ensure their inclusi

48 At anaphase, control acentric fragments typically remained unoriented between

49 When acentric fragments were generated in taxol-treated sperm

50 broken chromosome (rejoining the centric and acentric fragments) occurred in either the mother or dau

51 or during prometaphase/metaphase II, whereas acentric fragments, also generated by afd1, fail to alig

52 aphase cells with lagging chromosomes and/or acentric fragments.

53 al fragments, albeit to a lesser extent than acentric fragments.

54 zed from the vapour phase into intrinsically acentric, high-quality, micrometre-scale films.

55 re squamous epithelial cells that contain an acentric, hyperchromatic nucleus that is displaced by a

56 pe that facilitates the inclusion of lagging acentrics into telophase daughter nuclei.

57 a new general mechanism is proposed for the acentric inv dup marker formation: following a double-st

58 the previously suggested model by which the acentric inv dup markers form through inter-chromosomal

59 Acentric inverted duplication (inv dup) markers, the lar

60 The achiral nonpolar acentric material is second harmonic generation (SHG) ac

61 The chiral nonpolar acentric material shows second-harmonic generation (SHG)

62 irst-order hyperpolarizabilities (beta) into acentric microstructures for electro-optic (EO) applicat

63 Here we report that these acentric mini-chromosomes bind the centromere-specific p

64 rmally non-centromeric DNAs present in these acentric mini-chromosomes have acquired centromere funct

65 elanogaster mini-chromosome, of structurally acentric mini-chromosomes that display efficient mitotic

66 The sequences in these acentric mini-chromosomes were derived from the tip of t

67 inversions, translocations, and formation of acentric minichromosomes.

68 to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of bo

69 Such inherently acentric networks exhibit intensive nonlinear optical pr

70 normal virion maturation; virions containing acentric nucleoid structures comprised 90 to 99% of all

71 matter material system, leading to increased acentric order and EO activity.

72 ivate new experimental approaches to achieve acentric order in both bulk-phase and thin film structur

73 l role of the small potassium cations in the acentric packing of the [NbOF5]2- anion.

74 Normally, acentric poleward segregation occurs at the periphery of

75 that from the X-ray crystal structure of the acentric racemic (+/-)-(1pR,1' 'R)(1pS,1' 'S)-[Cr(CO)(3)

76 The local symmetry of acentric regions present in BaTiO(3) nanocrystals, parti

77 Acentrics segregate with either telomeres leading or lag

78 Finally, we show that successful acentric segregation requires the chromokinesin Klp3a.

79 role for interpolar microtubules in driving acentric segregation.

80 both, consistent with a model in which both acentric sister chromatid fragments are passaged into th

81 The acentric structure is described by a superposition of 16

82 at the nanoscale can be utilized to produce acentric structures markedly different than their consti

83 e formation of a dicentric chromosome and an acentric, telomere-bearing, chromosome fragment in somat

84 se via directed hydrogen-bond networks, into acentric thin films.

85 Two acentric vector arms were utilized; these carry autonomo