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1 to epoxypropane followed by carboxylation to acetoacetate.
2 evels ( approximately 10% yield) relative to acetoacetate.
3 secondary product formed by the reduction of acetoacetate.
4 of the carbon nucleophilic lipid metabolite acetoacetate.
5 were identified as beta-hydroxybutyrate and acetoacetate.
6 of the enamine or an imine tautomer produces acetoacetate.
7 ding an allene (2,3-butadienoate) to produce acetoacetate.
8 similarly to rat islets but formed much more acetoacetate.
9 ates acetone and HCO3(-) to form the product acetoacetate.
10 uctive cleavage and carboxylation to produce acetoacetate.
11 ardial oxidation of beta-hydroxybutyrate and acetoacetate.
12 results in the conversion of epoxypropane to acetoacetate.
13 leavage of HMG-CoA to produce acetyl-CoA and acetoacetate.
14 e is dependent on the presence of Mg(2+) and acetoacetate.
15 ading capacity in the presence or absence of acetoacetate.
16 t cleavage of HMG-CoA to form acetyl-CoA and acetoacetate.
17 he condensation of acetone and CO(2) to form acetoacetate.
18 oxide ring opening and carboxylation to form acetoacetate.
19 oxylation to form acetone and CO(2); and (4) acetoacetate/(14)CO(2) exchange to form (14)C(1)-acetoac
20 ated increased acetate, adenosine, xanthine, acetoacetate, 3-hydroxybutyrate and betaine in alcohol-f
21 emonstrated that high glucose (25 mm) and/or acetoacetate (4 mm) increased reactive oxygen species, d
22 se plus insulin (40 microU/ml), glucose plus acetoacetate (5 mM), or glucose plus insulin and acetoac
23 tate 4a, N-tosyl carbamate 5a, TBDMS 6a, and acetoacetate 7a) undergo metathesis without competing si
24 counter elevated levels of the ketone bodies acetoacetate (AA), beta-hydroxybutyrate (BHB), and aceto
25 U937 cells were cultured with ketone bodies (acetoacetate [AA] and beta-hydroxybutyrate [BHB]) in the
28 ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during st
30 biotinylated capture probe, the Friedlander-acetoacetate adduct can be trapped and purified directly
31 d the labeling of the ketone bodies [1-(13)C]acetoacetate and [1-(13)C]beta-hydroxybutyryate, without
32 erized and demonstrated to cleave HMG-CoA to acetoacetate and acetyl-CoA with catalytic and affinity
33 oduction from glycine and conversion between acetoacetate and B-OH-butyrate, were assigned higher wei
35 T1D is associated with both hyperketonemia (acetoacetate and beta-hydroxybutyrate) and hyperglycemia
37 esis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky react
39 topropylthio)ethanesulfonate; 2-KPC] to form acetoacetate and coenzyme M (CoM) in the bacterial pathw
41 nd carboxylation of 2-ketopropyl-CoM to form acetoacetate and CoM according to the reaction: 2-ketopr
43 oacetyl-CoA synthetase to synthesize and use acetoacetate and suggests human islets may use this path
44 least two redundant pathways, one involving acetoacetate and the other citrate, for the synthesis SC
45 er a longer fast and with severer ketonemia, acetoacetate and total ketone-body production and oxidat
47 ld ketonemia and minimal ketonuria, rates of acetoacetate and total ketone-body production and oxidat
48 ed of three compounds (beta-hydroxybutyrate, acetoacetate, and acetone) that circulate during starvat
50 output of 13C-labeled beta-hydroxybutyrate, acetoacetate, and CO2, indicating stimulated fatty acid
51 gen content in hearts perfused with glucose, acetoacetate, and insulin suggests increased glycogen tu
52 for a series of ketones (2-butanone, methyl acetoacetate, and N,N-dimethylacetoacetamide) and alkyl
55 in fumarylacetoacetate to yield fumarate and acetoacetate as the final step of Phe and Tyr degradatio
58 networks and signals through the Oct-1-HMGCL-acetoacetate axis to selectively promote BRAF V600E-depe
59 sured using NMR, reveals intact oxidation to acetoacetate but no contribution of ketone bodies to the
60 ding on the medium, and was not derived from acetoacetate by nonenzymatic decarboxylation in the medi
61 enesis (production of beta-hydroxybutyrate + acetoacetate), C(5) ketogenesis (production of beta-hydr
62 t metabolites (3-D-hydroxybutyrate, acetone, acetoacetate, citrate, lactate, creatine, creatinine, an
63 the physiological products of the reaction, acetoacetate, coenzyme M, and NADP, and reduction of the
64 tructure demonstrates reduced coenzyme A and acetoacetate covalently bound to the active site cystein
66 e include the upregulated adc gene, encoding acetoacetate decarboxylase (EC 4.1.1.4), and the downreg
67 of enzymes in the acetone-formation pathway (acetoacetate decarboxylase [AADC] and coenzyme A-transfe
69 a high degree of structural similarity with acetoacetate decarboxylase, though the respective quater
70 previously uncharacterized family within the acetoacetate decarboxylase-like superfamily (ADCSF) and
71 mologues, identify a novel family within the acetoacetate decarboxylase-like superfamily with diverge
74 sing 2-ketopropyl-CoM but did not inactivate acetoacetate decarboxylation or (14)CO(2) exchange react
75 siologically important forward reaction; (3) acetoacetate decarboxylation to form acetone and CO(2);
80 phosphono allylic carbonates with tert-butyl acetoacetate followed by hydrolysis and decarboxylation,
81 for acetone carboxylation of 0.225 micromol acetoacetate formed min-1.mg-1 at 30 degrees C and pH 7.
84 exosamine pathway including glucose, GlcNAc, acetoacetate, glutamine, ammonia, or uridine but not by
89 ient mice (specifically mice lacking fumaryl acetoacetate hydrolase [Fah], recombination activating g
90 ed the carboxylation of epoxypropane to form acetoacetate in a reaction that was dependent on the add
93 release indicating formation of SC-CoAs from acetoacetate in the cytosol is important for insulin sec
94 toacid-CoA transferase, an enzyme that forms acetoacetate in the mitochondria, and acetoacetyl-CoA sy
97 uction in the absence of acetoacetate, while acetoacetate inhibited the uptake of glucose and the oxi
98 beta-hydroxybutyrate formaton indicate that acetoacetate is the primary product of propylene oxide c
99 ruvate) and mitochondrial (3-hydroxybutyrate/acetoacetate) NADH redox states were elevated by at leas
101 media with serum and without serum; however, acetoacetate only induced proteolysis in cells maintaine
104 tion with the metabolic substrates pyruvate, acetoacetate, or hydroxybutyrate also prevented mitochon
105 earrangement of nonracemic phosphono allylic acetoacetates, or the intermolecular allylic substitutio
106 HMG-CoA reductase reaction and/or cleaved to acetoacetate plus acetyl-CoA by HMG cleavage enzyme.
107 elds a markedly reduced beta-hydroxybutyrate:acetoacetate ratio of 1:3, compared with 3:1 in Oxct1(+)
108 ns of ketone bodies (beta-hydroxybutyrate or acetoacetate) reduced the spontaneous firing rate of neu
111 t synthesis of 2-ketopropyl-CoM from CoM and acetoacetate, the reverse of the physiologically importa
112 observed in condensations of 16 with benzyl acetoacetate to afford Biginelli adduct 29 supports the
114 generated succinyl-CoA initially reacts with acetoacetate to yield acetoacetyl-CoA plus succinate in
115 nary complex with NAD(+) and 3-ketobutyrate (acetoacetate) to 1.4 A resolution, and as a ternary comp
116 uccinate esters or generated by succinyl-CoA-acetoacetate transferase is metabolized to malate follow
118 oacetate (5 mM), or glucose plus insulin and acetoacetate, using a three tracer (3H, 14C, and 13C) te
124 reated with high glucose alone or along with acetoacetate, was prevented by vitamin D supplementation
125 the product of reductive decarboxylation of acetoacetate, was revealed in this structure in addition
126 P, Krebs cycle intermediates, glutamate, and acetoacetate were investigated as candidate stimulus-cou
128 not alter the stereochemistry at C-2 of [2-D]acetoacetate when the reaction is conducted in D2O.
129 s-CaaD and the T34 mutant generate (2R)-[2-D]acetoacetate, whereas Cg10062 generates mostly the 2S is
130 n release caused large relative increases in acetoacetate, which is a precursor of pathways to short
131 eased intracellular levels of HMGCL product, acetoacetate, which selectively enhances binding of BRAF
132 nd promotes the formation of the ketone body acetoacetate, which subsequently enhances BRAF(V600E)/ME
133 ake and lactate production in the absence of acetoacetate, while acetoacetate inhibited the uptake of
134 ensation of 2-hydroxybenzaldehydes and ethyl acetoacetate with 1:1 acetylenecarboxylate-isocyanides i
135 se catalyzes the carboxylation of acetone to acetoacetate with concomitant hydrolysis of ATP to AMP a
136 he ATP-dependent carboxylation of acetone to acetoacetate with the concomitant production of AMP and
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