ライフサイエンスコーパス: acetogenin

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1 library of the adjacent bis-THF Annonaceous acetogenins.

2 the key fragment of the bis-THF Annonaceous acetogenins.

3 vities among these asimicin type annonaceous acetogenins.

4 fragment common to murisolin and many other acetogenins.

5 nd marilzabicycloallene D as halogenated C15-acetogenin 12-membered bicyclic and tricyclic ether brom

6 thesis of the bistetrahydrofuran Annonaceous acetogenins 30(S)-hydroxybullatacin, uvarigrandin A, and

7 Annonaceous acetogenins (AAGs) are neurotoxins possibly responsible

8 IC50 values for the four aforementioned acetogenins against H-116 human colon cancer cells were

9 Putative protein targets of the acetogenins are membrane-associated proteins, including

10 rane diffusion, controls the conformation of acetogenins as they diffuse to an active site.

11 A synthesis of four Annonaceous acetogenins, asiminocin, asimicin, asimin, and bullanin,

12 ynthesis of the nonadjacently linked bis-THF acetogenin bullatanocin (squamostatin C) is described.

13 observations indicate that an asimicin-type acetogenin can be in either sickle-shaped or U-shaped co

14 af extracts of Rollinia mucosa, is the first acetogenin containing a hydroxylated trisubstituted tetr

15 analogues constitute a class of Annonaceous acetogenins containing two tetrahydrofuran (THF) rings w

16 The depth of membrane penetration of acetogenins, coupled to membrane diffusion, controls the

17 core subunits of members of the Annonaceous acetogenin family of natural products.

18 none, a natural product from the Annonaceous acetogenins group.

19 Compounds 1-4 represent the asimicin type of acetogenins; however, the locations of the adjacent bis-

20 elucidating the conformation of Annonaceous acetogenins in membranes.

21 Mucoxin, an annonaceous acetogenin isolated from bioactive leaf extracts of Roll

22 solation of four novel bioactive annonaceous acetogenins: longimicins A-D (1-4).

23 The acetogenins may, thus, have chemotherapeutic potential,

24 he constitutional isomeric halogenated C(15)-acetogenin medium-ring ether natural products from Laure

25 urated biosynthetic precursor of the bis-THF acetogenin membranacin, was examined.

26 THF rings are located near the center of the acetogenin molecules and the lactone ring is terminal to

27 rary of 28 of the 64 possible isomers of the acetogenin murisolin, including 24 of the 32 possible di

28 such that any of the C30, C10, or C4 natural acetogenins or stereoisomers thereof could be prepared.

29 Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-

30 rhauser effects (NOEs), the THF rings of all acetogenins studied reside near the polar interfacial he

31 Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-tra

32 is-THF lactones, syntheses of two nonnatural acetogenins were achieved.

33 Several bioactive acetogenins were selective against 1A9 (ovarian cancer)

34 to the family Annonaceae produce Annonaceous acetogenins, which are a unique class of long-chain fatt

35 permopsis raciborskii, indicate that 1 is an acetogenin with guanidinoacetic acid serving as the star

36 iola pulp extract (GPE) that contains unique acetogenins with strong anti-cancer effects.

37 ey are the first examples among this type of acetogenins with the placements of the ring systems alte

38 The cytotoxicity of the asimicin-type of acetogenins would seem to be strongly related to the mem

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