ライフサイエンスコーパス: acetyl-CoA synthetase

1 tudy expand the ASKHA superfamily to include acetyl-CoA synthetase.

2 M (S-adenosylmethionine) synthetases, and an acetyl-CoA synthetase.

3 istone deacetylase activity and up-regulated acetyl-coA synthetases.

4 of acetyl-CoA by the level of acetylation of acetyl-CoA synthetases.

5 -CoA by modulating the enzymatic activity of acetyl-CoA Synthetase 1 (AceCS1).

6 The expression of acetyl-CoA synthetase 1, another cytosolic enzyme for pr

7 values with the native acetylated substrate acetyl-CoA synthetase-1; measurement of Sirt1, Sirt2, an

8 at these processes require acetate-dependent acetyl CoA synthetase 2 (ACSS2).

9 We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matr

10 genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer ce

11 Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) directly regulates histo

12 AMP-activated protein kinase (AMPK)-mediated acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659,

13 ining acetyl lysine of its natural substrate acetyl-CoA synthetase 2, a reaction intermediate structu

14 Knockdown of the acetyl-coA synthetases abrogated the effect of ethanol o

15 We demonstrate that mammalian Acetyl-CoA synthetases (AceCSs) are regulated by reversi

16 yltransferase protein and is responsible for acetyl-CoA synthetase acetylation.

17 resent here mutations to Salmonella enterica acetyl-CoA synthetase (Acs) and test the ability of the

18 enzyme A (acetyl-CoA) by means of the enzyme acetyl-CoA synthetase (Acs) and utilize it to generate e

19 obB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase (Acs) at an active site lysine to

20 R2 function was required for activity of the acetyl-CoA synthetase (Acs) enzyme.

21 The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that a

22 own to contain an unusual acetyl coenzyme A (acetyl-CoA) synthetase (ACS) which catalyzes the formati

23 AMP-forming acetyl-CoA synthetase [ACS; acetate:CoA ligase (AMP-form

24 Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, a

25 ressing the expression of acetyl coenzyme A (acetyl-CoA) synthetase (Acss), leading to decreased acet

26 Acetyl-CoA synthetases (ACSS1, ACSS2) are involved in th

27 response to acetyl-CoA and the regulation of acetyl-CoA synthetase activity by the acetylation level.

28 acetylation of AceCS2 by SIRT3 activates the acetyl-CoA synthetase activity of AceCS2.

29 ular acetate levels resulting from decreased acetyl-CoA synthetase activity.

30 The gene coding for the acetyl-CoA synthetase (ADP-forming) from the amitochondr

31 The presence of homologs of acetyl-CoA synthetase (ADP-forming) in such human pathog

32 This gene codes for a 726 residue long acetyl-CoA synthetase (ADP-forming).

33 th of a strain of S. enterica devoid of Acs (acetyl-CoA synthetase; AMP-forming) activity on 10 mm ac

34 tylates SlAacS more efficiently than it does acetyl-CoA synthetase, an enzyme known to be under acety

35 abidopsis seeds, we isolated cDNA clones for acetyl-CoA synthetase and for the ptE1alpha- and ptE1bet

36 rophosphate generated by reactions involving acetyl-CoA synthetase and luciferase can be readily dete

37 but two enzymes are thought to be involved: acetyl-CoA synthetase and plastidic pyruvate dehydrogena

38 s regulation of acetyl-CoA by acetylation of acetyl-CoA synthetase and raises the possibility that pr

39 tion, control of p53 activity, regulation of acetyl-CoA synthetase, and aging.

40 Knockdown of acetyl-coA synthetases by short hairpin RNA (shRNA) was

41 We also show that acetyl-CoA synthetase can be a significant contributor t

42 ve determined the X-ray crystal structure of acetyl-CoA synthetase complexed with adenosine-5'-propyl

43 In contrast, the level of mRNA for acetyl-CoA synthetase does not correlate in time and spa

44 ighest level of accumulation of the mRNA for acetyl-CoA synthetase during silique development is with

45 inhibitors (lithium, allicin and sodium) of acetyl CoA synthetase (EC 6.2.1.1 acetate: CoA ligase),

46 tients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2.

47 and further develop a model to simulate the acetyl-CoA synthetase enzyme reaction network using the

48 Here, we show that the nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key sour

49 cell eukaryotes relies on acetyl coenzyme A (acetyl-CoA) synthetase enzymes that use acetate to produ

50 diauxic shift, along with expression of both acetyl-CoA synthetase genes ACS1 and ACS2 We conclude th

51 ess elevated levels of ATP citrate lyase and acetyl-CoA synthetase genes, both of which are involved

52 Mxr1p is a key regulator of ACS1 encoding acetyl-CoA synthetase in cells cultured in YPA.

53 The central metabolic enzyme acetyl-CoA synthetase is regulated in both bacteria and

54 nthesis of acetyl-coenzyme A (acetyl-CoA) by acetyl-CoA synthetase is used here as a case study for t

55 of acs, the gene encoding acetyl coenzyme A (acetyl-CoA) synthetase, leading to uptake of the excrete

56 c activity of key metabolic enzymes, such as acetyl-CoA synthetase, long-chain acyl-CoA dehydrogenase

57 They also suggest that the enzyme acetyl CoA synthetase mediates extracellular acetate upt

58 Here, genes encoding malic enzyme and acetyl-CoA synthetase (nucleoside diphosphate forming) w

59 yl-CoA was mainly produced from acetate (via acetyl-CoA synthetase) or citrate (via ATP citrate lyase

60 The Arabidopsis acetyl-CoA synthetase preprotein has a calculated mass o

61 esulting structural features in AMP- and ADP-acetyl-CoA synthetase proteins in this study expand the

62 To our knowledge, this is the first reported acetyl-CoA synthetase sequence from a plant source.

63 N- and C-terminal parts of the G. lamblia acetyl-CoA synthetase sequence were found to be homologo

64 CLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2

65 more closely related to the Giardia lamblia acetyl-CoA synthetase than to those of archaea.

66 The activity of acetyl-CoA synthetase, the first enzymatic step in aceta

67 embers of this enzyme family (exemplified by acetyl-CoA synthetase) use a large domain rotation to ca

68 coding these enzymes, as well as AMP-forming acetyl-CoA synthetase, were expressed at increased level

69 The E. histolytica acetyl-CoA synthetase, which converts acetyl-CoA to acet

70 of ethanol and acetate on acetyl-coenzyme A (acetyl-coA) synthetases, which convert acetate to acetyl