ライフサイエンスコーパス: acetylase

1 titution interferes with binding to the de-N-acetylase.

2 between p300/CBP and its associated histone acetylase.

3 ortactin deacetylase and p300 as a cortactin acetylase.

4 tudied how FXR activity is regulated by p300 acetylase.

5 ral gene of the pneumococcal peptidoglycan O-acetylase.

6 t may harbor a high concentration of histone acetylases.

7 present evidence for novel roles of histone acetylases.

8 ng complex], and STAGA [SPT3-TAF(II)31-GCN5L acetylase]).

9 ay) and subsequent recruitment of histone de-acetylase 2 (HDAC2), which mediates epigenetic gene sile

10 d p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-ISRE com

11 rus E1A, which inhibits both coactivator and acetylase activities of p300.

12 RbAp48 lowered the K(m) of CBP histone acetylase activity and facilitated p300-mediated in vitr

13 ar distribution of PIG-L and Glc-NAc-PI-de-N-acetylase activity and then studied the localization of

14 logy, and that both SWI/SNF and p300 histone acetylase activity are required for hormone-dependent ac

15 thymoma cells, both PIG-L and GlcNAc-PI-de-N-acetylase activity are uniformly distributed between ER

16 signaling to Elk-1 enhances the net histone acetylase activity associated with the c-fos promoter, w

17 es to AMF-1 or E2 immunoprecipitated histone acetylase activity from cell lysates.

18 ated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes wit

19 Here we investigate the role of CBP acetylase activity in CREB-mediated gene expression.

20 a decline in coactivators containing histone acetylase activity in myometrium may contribute to the o

21 Lastly, Geminin inhibits HBO1 acetylase activity in the context of a Cdt1-HBO1 complex

22 ates the recruitment of p300 and its histone acetylase activity into complexes with E2 and represents

23 use thymoma cells showed that GlcNAc-PI de-N-acetylase activity is localized to the endoplasmic retic

24 HBO1 acetylase activity is required for licensing, because a

25 These results indicate that MCM3 acetylase activity of MCM3AP is required to inhibit init

26 However, it remains unclear whether the acetylase activity of p300 is necessary for regulating M

27 k by further examining whether the intrinsic acetylase activity of p300 is necessary for stimulating

28 ion of MDM2, on the other hand, requires the acetylase activity of p300.

29 lpha1 on Lys(22), a process dependent on the acetylase activity of p300.

30 PgaB displays de-N-acetylase activity on beta-1,6-GlcNAc oligomers but not

31 Besides histone acetylase activity on chromatin, the TIP60 complex posse

32 ells, suggesting the positive effect of p300 acetylase activity on Sp3.

33 expression of mutated TIP60 lacking histone acetylase activity results in cells with defective doubl

34 ults demonstrate that p300 does not need its acetylase activity to be a coactivator of p73.

35 The p300-acetylase activity was dispensable since expression of a

36 s ability to bind and inhibit p300's histone acetylase activity, an essential MyoD coactivator.

37 ional coactivators possess intrinsic histone acetylase activity, providing a direct link between hype

38 onent of a multiprotein complex with histone acetylase activity, scored as a significant SB hit.

39 nner dependent on HDAC activity, p300 lysine acetylase activity, the p300 bromodomain, and RB K873/K8

40 cribed c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5

41 of cyclin D1 at least partially required de-acetylase activity.

42 riptional coactivator with intrinsic histone acetylase activity.

43 iption factors through its intrinsic histone acetylase activity.

44 ne deacetylases with those that have histone acetylase activity.

45 complex has been discovered to house histone acetylase activity.

46 likely to involve inhibition of HBO1 histone acetylase activity.

47 the underlying mechanism, we found that the acetylase ACTR can be acetylated by p300/CBP.

48 using deacetylase inhibitors or the tubulin acetylase alphaTAT1 prevents association of mutant LRRK2

49 thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1; 2) iloprost

50 Importantly, manipulating histone acetylase and deacetylase activities established that hi

51 ble acetylation is executed by the intrinsic acetylase and deacetylase activities of co-regulators as

52 We thus suggest that protein acetylase and deacetylase interact with ETA in a ligand-

53 act as multifunctional regulators of p53 via acetylase and polyubiquitin ligase (E4) activities.

54 that E2F1 activity is stimulated by p300/CBP acetylase and repressed by an RB-associated deacetylase,

55 loss of Eaf3, a subunit of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes, greatl

56 Eaf3, a component of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes, is imp

57 The CBP/p300 acetylase and the CARM1 methyltransferase can positively

58 s with CREB-binding protein (CBP), a histone acetylase and transcriptional coactivator.

59 TRRAP links Myc with histone acetylases and appears to be an important mediator of it

60 ry bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict the spre

61 polymerase II but requires specific histone acetylases and chromatin remodelers.

62 Targeted acetylases and deacetylases can locally perturb this equ

63 dification of chromatin structure by histone acetylases and deacetylases is an important mechanism in

64 proteins, suggesting that the action of both acetylases and deacetylases is important in the regulati

65 inhibitors and activators of various lysine acetylases and deacetylases offer a new potential strate

66 ng activators and repressors recruit histone acetylases and deacetylases to promoters, thereby genera

67 ss involving chromatin remodeling by histone acetylases and deacetylases, yet the role of this proces

68 This mechanism is regulated by histone acetylases and deacetylases.

69 ynamic equilibrium between competing histone acetylases and deacetylases.

70 maturation together with competition between acetylases and deacetylases.

71 n modification activities, including histone acetylases and enhancer- and insulator-associated factor

72 hat Myc can interact indirectly with histone acetylases and have suggested that Myc mediates transcri

73 y coordinating the functions of both histone acetylases and HDACs.

74 cent studies demonstrated the effect histone acetylases and histone deacetylases (HDACs) have on fine

75 eraction of two families of enzymes: histone acetylases and histone deacetylases (HDACs).

76 the human HAT complex STAGA (SPT3-TAF9-GCN5-acetylase) and a "core" form of the Mediator complex dur

77 ack the NatA N(alpha)-terminal acetylase (Nt-acetylase) and therefore cannot N-terminally acetylate a

78 ced an interaction between KLF5 and the p300 acetylase, and acetylation of KLF5 was necessary for Sma

79 a member of the STAGA [SPT3-TAF(II)31-GCN5L acetylase] and TFTC (GCN5 and TRRAP) chromatin remodelin

80 It is well known that histone acetylases are important chromatin modifiers and that th

81 Acetylases are now known to modify a variety of proteins

82 The characterization of GlcNAc-PI de-N-acetylase as a zinc metalloenzyme will facilitate the ra

83 s and cofactors, including the TIP60 histone acetylase-associated proteins transactivation/transforma

84 keratin RE (KRE), co-activators and histone acetylase become co-repressors of the RA/T3 receptors in

85 es Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex.

86 inds to this new site and recruits its H3K27 acetylase-binding partner CBP, as well as core component

87 erridden not only by ablation of the NatA Nt-acetylase but also by overexpression of the Arg/N-end ru

88 ction in chromatin remodelers and histone(de)acetylases but they have not previously been found in nu

89 ee system and recombinant rat GlcNAc-PI de-N-acetylase by divalent metal cation chelators demonstrate

90 (ii) The Plasmodium de-N-acetylase can act on analogues containing N-benzoyl, Gal

91 Acetylases can also target other proteins such as transc

92 A de-N-acetylase capable of hydrolyzing the N-acetyl group of L

93 otein screen by interaction with the histone acetylase CBP.

94 on domain-induced recruitment of the histone acetylase CBP/p300.

95 l functional interaction between the protein acetylases CBP and p300, and deacetylases, is essential

96 similar results were observed with a related acetylase, CBP, GCN5 did not enhance FXR transactivation

97 es have shown that Sp1, Sp3, and the histone acetylase co-activator p300 are components of the comple

98 xpression via the recruitment of the histone acetylase coactivator paralogs CREB binding protein (CBP

99 n domain with the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.

100 chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex.

101 tone acetyltransferase 1 (HAT1)-RBBP7 lysine acetylase complex as an interaction partner of the Lsm4

102 The Esa1-containing NuA4 histone acetylase complex can interact with activation domains i

103 plex, whereas liganded TR recruits a histone acetylase complex for gene activation.

104 g protein (TBP), TFIIB, and the SAGA histone acetylase complex in vivo.

105 e transcription factor TFIID and the histone acetylase complex PCAF/SAGA.

106 the catalytic subunit of a novel histone H3 acetylase complex that harbors a histone chaperone subun

107 7, which is also present in the SAGA histone acetylase complex, causes a decrease in transcription of

108 ent of the human PCAF (human Gcn5 homologue) acetylase complex.

109 ome-remodeling complex, and the SAGA histone acetylase complex.

110 II holoenzyme/mediator and the SAGA histone acetylase complex.

111 f chromatin remodeling complex, Gcn5 histone acetylase complexes Ada and SAGA, and Rad6, which ubiqui

112 ompletely understood; the SAGA (Spt-Ada-Gcn5 acetylase) complexes from yeast to Drosophila that are m

113 hereafter as the STAGA (SPT3-TAF9-GCN5/PCAF acetylase) complexes.

114 Most importantly, we show that the histone acetylase components of TFIID and SAGA (TAF(II)145 and G

115 E1a's interactions with the nuclear acetylases conferred epithelial morphologies but did not

116 those inactivating the SAS-I histone H4 K16 acetylase, consist of cells all with an intermediate lev

117 We asked whether the acetylase CREB-binding protein (CBP) could acetylate pro

118 leosomes or covalently modify histones (e.g. acetylases, deacetylases, methyltransferases, and kinase

119 p300, but not its acetylase-defective mutant AT2, stimulated p63gamma-depe

120 Also, an acetylase-defective mutant p300 named p300AT2 was able t

121 Finally, both wild type and acetylase-defective mutant p300 proteins associated with

122 Similarly, the acetylase-defective p300 AT2 mutant stabilized the MDM2

123 n and methylation of R17 in vivo, whereas an acetylase-deficient CBP mutant is unable to induce these

124 Both wild type and acetylase-deficient mutant MCM3AP, however, can bind to

125 show here that wild type MCM3AP, but not the acetylase-deficient mutant, inhibits initiation of DNA r

126 efore confused in databases because the MCM3 acetylase DNA sequence is contained entirely within the

127 AMP-response element-binding protein histone acetylase domain reduced ligand-dependent AR function.

128 ithout either the MSL complex or MOF histone acetylase, dosage compensation is retained but autosomal

129 Overexpression of P/CAF acetylase drives DEK into IGCs, and addition of a newly

130 promoted the recruitment of the p300 histone acetylase (EP300) and, in turn, induced histone H3 acety

131 on has been established, it is not clear how acetylases function in the nucleus of the cell and how t

132 s HDACs are associated with PCAF and another acetylase, GCN5, in HeLa cells.

133 An insertion mutation in a putative PG acetylase gene (designated pacA) resulted in loss of PG

134 A role for histone acetylase has been implicated in leukemias and developme

135 frican sleeping sickness, and GlcNAc-PI de-N-acetylase has previously been validated as a drug target

136 c patients (D-CMSC), identifying the histone acetylase (HAT) activator pentadecylidenemalonate 1b (SP

137 is the catalytic subunit of the NuA4 histone acetylase (HAT) complex that acetylates histone H4, and

138 xpression via their association with histone acetylase (HAT) or deacetylase complexes.

139 Histone deacetylase (HDAC), histone acetylase (HAT), and intracellular cAMP levels were meas

140 is required for licensing, because a histone acetylase (HAT)-defective mutant of HBO1 bound at origin

141 ITA ubiquitination was controlled by histone acetylases (HATs) and deacetylases (HDACs), indicating t

142 aving opposing enzymatic activities, histone acetylases (HATs) and deacetylases affect chromatin and

143 show that blockade of corepressor histone de-acetylase (HDAC) activity reverses the differential inhi

144 SPT10 gene, which encodes a putative histone acetylase implicated in regulation at core promoters.

145 s sequence is acetylated by the related Nat3 acetylase in eukarya.

146 onists, suggesting functional specificity of acetylases in FXR signaling.

147 ndicate a new but undefined role for nuclear acetylases in maintaining the transformed phenotype.

148 regulators, such as ARA24 or PCAF, a histone acetylase, in an additive manner.

149 and the mof gene product, a putative histone acetylase, in msl mutant males returns to a uniform geno

150 iption of DNA methyltransferases and histone acetylases including p300, contributing to regulation of

151 nnot interact with Sirt1, or p300, a histone acetylase, increased acetylation of FoxO1 and inhibited

152 ich results in the accumulation of p53 in an acetylase-independent manner.

153 Histone acetylase inhibition in the hippocampus during consolida

154 nger than the synergistic effects of histone acetylase inhibitors or additive effects of doxorubicin

155 The acetylase inhibitors sodium butyrate and trichostatin A

156 (iv) Three GlcNR-PI analogues are de-N-acetylase inhibitors, one of which is a suicide inhibito

157 roup of the GlcN is dispensable for the de-N-acetylase, inositol acyltransferase, all four of the man

158 ntial for substrate recognition for the de-N-acetylase, inositol acyltransferase, and first mannosylt

159 BF1 and the related Chameau and HBO1 histone acetylases interact with distinct subgroups of bZIP prot

160 HBO1 histone acetylase is a coactivator both for AP-1 transcription f

161 PCAF histone acetylase is found in a complex with more than 20 associ

162 HBO1 histone acetylase is important for DNA replication licensing.

163 HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication licen

164 MCM3 acetylase (MCM3AP) and germinal-centre associated nuclea

165 cells, which lack the NatA N(alpha)-terminal acetylase (Nt-acetylase) and therefore cannot N-terminal

166 homologue of oafA, a putative O-antigen LPS acetylase of Salmonella typhimurium, that was present in

167 of E1A, an inhibitor of the CBP/p300 histone acetylase, on LCR function.

168 Strains lacking Sas2 histone acetylase or the histone methylases that modify lysines

169 acetylation, and had identified the histone acetylase P/CAF and the transcription factor NF-Y as the

170 ascade involving HSF1 binding to the histone acetylase p300 and positive translation elongation facto

171 oxygen through its interaction with histone acetylase p300 and the hypoxia-inducible factor (HIF)1 p

172 Mechanistically, TGFbeta recruited acetylase p300 to acetylate KLF5, and acetylation in tur

173 d to the Trx promoter, recruited the histone acetylase p300 to the Trx promoter, and formed a transcr

174 n gene expression, interact with the histone acetylase p300, suggesting a role for histone acetylatio

175 wn substrates of CBP and the closely related acetylase p300, we identified G/SK (in the single-letter

176 e Lys residues are acetylated by the nuclear acetylase p300.

177 The histone acetylases p300 and P/CAF directly acetylate the AR in v

178 E1a protein interacts with the nuclear acetylases p300, CBP and P/CAF, and also with the co-rep

179 multaneous interactions with the host lysine acetylases p300/CBP and the tumor suppressor RB.

180 (garcinol and antisense against the histone acetylase, p300) or activators of histone deacetylase (t

181 REB is acetylated by CBP, but not by another acetylase, p300/CBP-associated factor.

182 he orchiectomy-induced expression of histone acetylases, p300 and CBP, which are AR cofactors.

183 y enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300).

184 transfer analysis, we demonstrated that the acetylase PCAF and histone deacetylase 1 (HDAC1) are in

185 Whereas the histone acetylase PCAF has been suggested to be part of a coacti

186 stability by counteracting the action of the acetylases PCAF/GCN5.

187 d to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding protein an

188 Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-alpha-st

189 PCAF histone acetylase plays a role in regulation of transcription, c

190 We report that Gcn5, a histone H3 acetylase, plays a central role in initiation of meiosis

191 etween the RXR/RAR heterodimer and a histone acetylase presented elsewhere.

192 s by p300 indicates a mechanism in which the acetylase promotes formation of longer flaps in the cell

193 The TIP60 histone acetylase purifies as a multimeric protein complex.

194 Remodeling ATPases or histone acetylases release some of the negative supercoiling pre

195 sly reported cases identified PIGL, the de-N-acetylase required for glycosylphosphatidylinositol (GPI

196 ex of a related protein, dihydrolipoyl trans-acetylase, reveals that both substrates localize to the

197 e chromatin remodeller, Rsc, and the histone acetylase, Rtt109, to generate a histone-depleted region

198 The histone acetylases, SAS-I and NuA4, functioned in insulation, in

199 (i) The de-N-acetylases show little specificity for the lipid moiety

200 p nor TAF65p are associated with the histone acetylase Spt-Ada-Gcn5 complex or other non-TFIID TBF.TA

201 ctivator AceI, and also requires the histone acetylase Spt10 for full induction.

202 access or function of an H4-specific histone acetylase such as Esa1.

203 tic mechanism similar to metalloprotein de-N-acetylases such as LpxC.

204 in part, due to an interaction with histone acetylases, such as CREB-binding protein (CBP).

205 wo analogues with the known nonspecific de-N-acetylase suicide inhibitor, GalNCONH(2)-PI and GlcNCONH

206 YopP is a protein acetylase that inhibits mitogen-activated protein kinase

207 pha)(x) barrel domains: a metal-binding de-N-acetylase that is a member of the family 4 carbohydrate

208 , ARD1 is recently described as a HIF-1alpha acetylase that regulates its stability.

209 These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA r

210 is histone deacetylase or recruits a histone acetylase to allow the formation of a functional transcr

211 incides with recruitment of the Esa1 histone acetylase to RP gene promoters.

212 pecific to males, which sequesters a histone acetylase to the X.

213 Here, we recruit histone deacetylases and acetylases to a well-defined yeast promoter in a regulat

214 mbers of a Myb protein complex in recruiting acetylases to the origin.

215 bly by preventing the recruitment of histone acetylases to the promoter.

216 Their association with histone acetylases, to mediate activation, or deacetylases, to m

217 with chromatin modification (methylases and acetylases), transcription (RNA polymerase II), translat

218 acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-co

219 ed that expression of PCAF and other histone acetylases was markedly induced in U937 cells upon phorb

220 al antibodies raised against p300, a histone acetylase, well-known as a marker of active enhancers, f

221 osoma brucei and human (HeLa) GlcNAc-PI de-N-acetylases were determined using 24 substrate analogues.

222 Histone acetylases were originally identified because of their a

223 ociated commonly with recruitment of histone acetylases, while repression involves histone deacetylas

224 Reconstitution of metal-free GlcNAc-PI de-N-acetylase with divalent metal cations restores activity