ライフサイエンスコーパス: acetylated histone

1 trated association of the IL-4 promoter with acetylated histone.

2 ivation, and resulted in increased levels of acetylated histones.

3 to active euchromatin structures containing acetylated histones.

4 by the limited availability of homogeneously acetylated histones.

5 ind that both are found at active genes with acetylated histones.

6 RNA genes on, in order to enrich the pool of acetylated histones.

7 or an increase in the ratio of methylated to acetylated histones.

8 and Bdf1, an SWR1 complex member that binds acetylated histones.

9 RD3 isoforms display differential binding to acetylated histones.

10 HDACIs, but not RA, induced accumulation of acetylated histones.

11 ed binding of the transcription activator or acetylated histones.

12 omatin formation, and decreased occupancy of acetylated histones.

13 bate and BETi blocked the binding of BRD4 to acetylated histones.

14 osomal DNA is dominant over interaction with acetylated histones.

15 coding regions and the incorporation of new acetylated histones.

16 egion (+665/+2068) in intron 1 enriched with acetylated histone 3 (H3) and H3 methylated at lysine 4,

17 and gp130 genes correlates with the level of acetylated histone 3 associated with the receptor promot

18 of NFkappaB p65 to and reduced the levels of acetylated histone 3 at promoters of monocyte chemotacti

19 BP at the MMP-9 promoter, inhibits levels of acetylated histone 3 at the MMP-9 promoter, and subseque

20 results in reduced Gcn5 occupancy, decreased acetylated histone 3 levels, lower globin and erythroid-

21 rait loci, disease-associated polymorphisms, acetylated histone 3 lysine 27 (H3K27ac) and transcripti

22 Using acetylated histone 3 lysine 27 chromatin immunoprecipita

23 We have generated acetylated histone 3 lysine 27 profiles from primary int

24 -methylated histone 3 lysine 4 (H3K4me3) and acetylated histone 3 lysine 9 (H3K9ac) at the HER2 promo

25 We show that the presence of acetylated histone 3 N-terminal tail peptides stabilizes

26 additional repressive histone modifications, acetylated histone 3 on lysine 9 and 14 deacetylation, a

27 tone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 methylation.

28 y by sodium butyrate enhances recruitment of acetylated histone 3 to the IL-10 promoter and increases

29 I inhibitor etoposide induces association of acetylated histone 3 with the promoter of IRF-7 gene, in

30 22 alone minimally increased p21 (waf1) and acetylated histones 3 and 4 but caused dose-dependent in

31 d but only modestly increased p21 (waf1) and acetylated histones 3 and 4, suggesting that 17 selectiv

32 We found that genistein increased acetylated histones 3, 4, and H3/K4 at the p21 and p16 t

33 Additionally, IFNgamma reduced p300 and acetylated histone-3 binding in both smooth muscle alpha

34 An increase in acetylated histone 4 (ac-H4; p < 0.01) was found in curr

35 acterized by the absence of coactivators and acetylated histone 4, and the presence of corepressors a

36 In the absence of Set2, H3K36 or Rpd3S acetylated histones accumulate on open reading frames (O

37 ling-deficient plants have altered levels of acetylated histones after the UV-B treatment, demonstrat

38 thesis of a variety of proteins including an acetylated histone and a site-specifically modified mono

39 present a challenge for the future study of acetylated histone and non-histone proteins.

40 is unmethylated and the promoter region has acetylated histones and an accessible chromatin structur

41 Acetylated histones and apoptosis-associated proteins we

42 gulator that localizes to DNA via binding to acetylated histones and controls the expression of thera

43 enetic signaling factors that associate with acetylated histones and facilitate transcription of targ

44 p65 phosphorylation, p300, and the levels of acetylated histones and H3-Me3K4, while enhancing the le

45 Brd4 binds acetylated histones and has been observed to diffusely c

46 ited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin

47 nal domain (BET) protein family, which binds acetylated histones and is a critical regulator of trans

48 of BRD4, a bromodomain protein that binds to acetylated histones and is a key transcriptional coactiv

49 ilarly important roles in the recognition of acetylated histones and JQ1.

50 eins are epigenetic "readers" that recognize acetylated histones and mark areas of the genome for tra

51 gulation remain obscure, although changes in acetylated histones and methylated CpG dinucleotides may

52 altered chromatin, marked by a depletion of acetylated histones and methylated histone 3-lysine 4 an

53 s IkappaB alpha and GAPDH had high levels of acetylated histones and no trimethylated histones.

54 t with SFN in the diet resulted in levels of acetylated histones and p21(WAF1) in the ileum, colon, p

55 ssayed in vitro, Hpa2 and Hpa3 (from Met-19) acetylated histones and polyamines.

56 " proteins (BRD2, BRD3, BRD4, and BRDT) bind acetylated histones and serve as a scaffold for the recr

57 visualize the spatiotemporal distribution of acetylated histones and thus the tumor-selective pharmac

58 ctions both to suppress the incorporation of acetylated histones and to signal for the deacetylation

59 ks to chromatin functions that interact with acetylated histones, and proteins that participate in RN

60 the dissociation of the SWI/SNF complex from acetylated histones, and reduces its association with pr

61 two N-terminal bromodomains, which recognize acetylated histones, and the C-terminal protein-protein

62 romatin immunoprecipitation assays with anti-acetylated-histone antibodies revealed that unliganded T

63 We have previously shown that acetylated histones are associated with unmethylated DNA

64 Acetylated histones are associated with unmethylated DNA

65 mma3-Sgamma3-Cgamma3 locus demonstrated that acetylated histones are focused to the Igamma3 exon and

66 understanding of how bromodomains that bind acetylated histones are regulated, nor how the gene-spec

67 cetylated H4 decreases in late spermatids as acetylated histones are removed from the condensing nucl

68 vealed no significant change in the level of acetylated histones associated with the MMTV promoter fo

69 pitation analyses showed increased H3 and H4 acetylated histones at the core promoter in the presence

70 In contrast, p300 recruitment and acetylated histones at the promoter were not detected in

71 n spermatids revealed enrichment of BRD4 and acetylated histones at the promoters of active genes.

72 ant positive correlations between H3- and H4-acetylated histones, BET protein-binding sites and MLV-i

73 Here we report the structural mechanism of acetylated histone binding by the double PHD fingers of

74 precipitation assays revealed an increase in acetylated histones bound to the P21 promoter.

75 this promoter region becomes associated with acetylated histones by chromatin immunoprecipitation ass

76 used to compare deacetylation of chemically acetylated histones by the yeast sirtuins, Sir2 and Hst2

77 rotein interactions between bromodomains and acetylated histones can be antagonized by selective smal

78 s indicate that Brd4 specifically recognizes acetylated histone codes, and this recognition is passed

79 etylase inhibitor valproate, which increases acetylated histone content in cortical GABAergic interne

80 81X gene showed the highest association with acetylated histones, especially in the newborn.

81 ng factor chromatin assembly, which requires acetylated histones for efficient assembly.

82 e level of enrichment of VHS107 genes in the acetylated histone fractions as assayed by chromatin imm

83 end towards a dose-dependent accumulation of acetylated histones from 200 to 600 mg of oral SAHA.

84 cooperates with CBP/p300 in eviction of the acetylated histones from the chromatin template.

85 gulation of IFNGR1 and prevented the loss of acetylated histones from the ifngr1 promoter.

86 lel to nuclear accumulation of cytochrome c, acetylated histone H2A, but not unmodified H2A, was rele

87 SAHA treatment caused an accumulation of acetylated histones (H2B, H3, and H4), an increase of p2

88 occupancy by RNA polymerase II (RNA pol II), acetylated histone H3 (Ac-H3), and acetylated histone H4

89 The increases in acetylated histone H3 (AcH3) and AcH4 in NaB-treated NB4

90 ere significant cocaine-induced increases in acetylated histone H3 (AcH3) and phospho-cAMP response e

91 e sequence-specific recognition of lysine-14-acetylated histone H3 (H3K14ac).

92 racts with mitotic chromosomes by binding to acetylated histone H3 and H4 and is thought to play a ro

93 nes were associated with a moderate level of acetylated histone H3 and H4 and trimethylated histone H

94 on and could be correlated to an increase of acetylated histone H3 and H4 at the PLOD2 promoter.

95 itation, we show that the levels of multiply acetylated histone H3 and H4 in chromatin are decreased

96 tein 2 (MeCP2) and increased the bindings of acetylated histone H3 and H4 in the cyclin A promoter.

97 We find that acetylated histone H3 and H4 proteins are associated wit

98 Peaks of acetylated histone H3 and H4, together with tri-methyl K

99 or containing tandem bromodomains binding to acetylated histone H3 and H4.

100 treatment in parallel with observed loss of acetylated histone H3 and H4.

101 ia markedly reduced global levels of CBP and acetylated histone H3 and increased the expression of hi

102 tic genes is correlated with the presence of acetylated histone H3 and phosphorylated RNA polymerase

103 In addition, both acetylated histone H3 and total H3 decreased at the Il2

104 Sug1 binds to acetylated histone H3 and, in the absence of Sug1, histo

105 ells treated with 8-bromo-cAMP had increased acetylated histone H3 associated with the proximal (but

106 rified the increased enrichment of lysine-27 acetylated histone H3 at discrete loci, accompanied by e

107 marks (dimethylated histone H3 at lysine 4, acetylated histone H3 at lysine 14, and acetylated H4) a

108 e significantly increased the association of acetylated histone H3 at lysine 9 with the SRE-containin

109 and WRKY53 in P(1) plants are enriched with acetylated histone H3 at lysine 9, a chromatin mark asso

110 -induced c-Fos was co-localized with phospho-acetylated histone H3 in a majority of c-Fos-positive ce

111 higher levels of the permissive histone mark acetylated histone H3 in both the human and mouse IL10 l

112 s directly to histones, reduces the level of acetylated histone H3 in cultured cells and inhibits ace

113 the levels of LiCl-induced c-Fos and phospho-acetylated histone H3 in the CeA.

114 lowed by a persistent increase, in levels of acetylated histone H3 in the nucleus accumbens, an impor

115 scence microscopy to show that immunostained acetylated histone H3 is relatively absent from peri-cen

116 association of active RNA polymerase II and acetylated histone H3 just upstream of Mef2c exon 4, pro

117 Increased CAR, alpha(v) integrin, and acetylated histone H3 levels were observed in PBMCs from

118 l proliferation, p21(waf1) upregulation, and acetylated histone H3 levels.

119 deposition of histone H2B on preexisting non-acetylated histone H3 Lys(56) at GAL1 in Deltartt109 is

120 HDAC8 selectively targeted acetylated histone H3 lysine 27 (H3K27Ac), which is know

121 structure alteration, targeting reduction of acetylated histone H3 lysine 9 and increased dimethylate

122 apping of translocation breakpoints using an acetylated histone H3 lysine 9 chromatin immunoprecipita

123 Through evaluation of genes associated with acetylated histone H3 marks, and global expression analy

124 associated with a switch from methylated to acetylated histone H3 on p21(WAF-1) promoter.

125 d tubulin peptide as a substrate relative to acetylated histone H3 peptide.

126 In this study, we found that K27-acetylated histone H3 specifically recruited Super Elong

127 nhibits binding of the second bromodomain to acetylated histone H3 tails.

128 oters increases binding of IRF-3, IRF-7, and acetylated histone H3 to this promoter region.

129 YEATS2 binds to acetylated histone H3 via its YEATS domain.

130 that on the myosin VI promoter, the level of acetylated histone H3 was markedly decreased, whereas th

131 Increased immunoreactivity for acetylated histone H3 was observed in the nuclei of Nogo

132 In both human and mouse, the levels of acetylated histone H3 were also decreased in uterine tis

133 ), and there was an increased association of acetylated histone H3 with Bdnf promoters in only the ma

134 In addition, the association of acetylated histone H3 with Bdnf promoters was increased

135 tinal-specific association of CRX, GCN5, and acetylated histone H3 with CRX target genes.

136 of Pre-Ac CD4(+) T cells, whereas increased acetylated histone H3 with no change in total H3 was obs

137 expression through increased association of acetylated histone H3 with the CK2alpha gene promoter.

138 ling process characterized by an increase in acetylated histone H3 within a 968-bp region 5' of the A

139 on in leukemic cells, with reduced levels of acetylated histone H3 within the MYC gene associated wit

140 ation to the nucleus and colocalization with acetylated histone H3, a hallmark of active transcriptio

141 photoreceptor nuclei, Hmgb1 colocalized with acetylated histone H3, a marker of euchromatin.

142 quencing analyses revealed that ENL binds to acetylated histone H3, and co-localizes with H3K27ac and

143 ociated with NFAT and GATA4, as well as with acetylated histone H3, following agonist stimulation.

144 , Patz1(+/-) MEFs displayed higher levels of acetylated histone H3, H3K4me2, H3K4me3, H3K36me3 and lo

145 However, neither acetylated histone H3, H4 nor dimethylated histone H3/K4

146 A large fraction of acetylated histone H3, including possibly all tetra- and

147 the conserved YEATS domain, which recognizes acetylated histone H3.

148 nt of the CCN1 promoter with both MRTF-A and acetylated histone H3.

149 r of treatment and a concomitant decrease in acetylated histone H3.

150 ells and mediates incorporation of lysine 56 acetylated histone H3.3 (H3acK56) at the chromatin domai

151 substrate with preferential activity toward acetylated histone H3; mutagenesis of the catalytic doma

152 Whereas Hpa2 acetylated histones H3 and H4 (at H3 Lys-14, H4 Lys-5, a

153 Acetylated histones H3 and H4 accumulated in TSA-treated

154 ifferent: over P1, histone activation marks (acetylated histones H3 and H4 and H3 trimethylated at K4

155 By measuring levels of acetylated histones H3 and H4 and of dimethylated H3 (K4

156 SF1 physically interacts with amino-terminal acetylated histones H3 and H4 and with acetyltransferase

157 pitation assays of the H4/n gene reveal that acetylated histones H3 and H4 are maintained at the same

158 of activated RNA polymerase II (pol II) and acetylated histones H3 and H4 at the ifngr1 promoter and

159 lly immunoprecipitated by antibodies against acetylated histones H3 and H4 in shear-stressed but not

160 associated with an increased accumulation of acetylated histones H3 and H4 in total cellular chromati

161 MS-275 caused an accumulation of acetylated histones H3 and H4 in total cellular chromati

162 istribution of Fs(1)h-S and various forms of acetylated histones H3 and H4 suggest a preference for b

163 An increase in the accumulation of acetylated histones H3 and H4 was detected in the TbetaR

164 Accumulation of acetylated histones H3 and H4 was observed in the SAHA-t

165 Cac2p, Msi1p and Rlf2p) and RCAF (Asf1p plus acetylated histones H3 and H4).

166 oprecipitation assays revealed enrichment of acetylated histones H3 and H4, and H3 di- and tri-methyl

167 p in cultured cells reduces the level of the acetylated histones H3 and H4, and this reduction can be

168 IL-12 stimulation and transiently increases acetylated histones H3 and H4, patterns of histone acety

169 thylated regulatory regions and excludes the acetylated histones H3 and H4, resulting in a localized

170 munoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control

171 cluding H3 di- and trimethylated at Lys4 and acetylated histones H3 and H4, while their silent counte

172 aB increases the recruitment of HAT p300 and acetylated histones H3 and H4.

173 cant decrease in promoter bound Sp1, Sp3 and acetylated histones H3 and H4.

174 oprecipitation assay with antibodies against acetylated histones H3 and H4.

175 oid receptor coactivator proteins (SRC), and acetylated histones H3/H4 (AcH) at estrogen-regulated pr

176 of HDACs and HATs, responsible for decreased acetylated histone-H3 and -H4, and increased HDAC activi

177 ion of class I HDAC protein, accumulation of acetylated histone-H3 in total cellular chromatin, resul

178 The presence of acetylated histone H3K56 (H3K56ac) in human ES cells (ES

179 he Kcc2 promoter, and decrease in binding of acetylated histone H3K9 surrounding the transcriptional

180 pol II), acetylated histone H3 (Ac-H3), and acetylated histone H4 (Ac-H4) but did not significantly

181 which resulted in acquisition of H3K4me1 and acetylated histone H4 (H4Ac).

182 erved low levels of tetra-acetylated and K16 acetylated histone H4 (H4K16Ac) at centromeres.

183 (ChIP) assay showed increased association of acetylated histone H4 and lysine 9 (K9)-acetyl H3 with t

184 H4 dimethylated at lysine (K) 20, and N-term acetylated histone H4 dimethylated at K20 and acetylated

185 g these, two peaks were identified as N-term acetylated histone H4 dimethylated at lysine (K) 20, and

186 panied by relocation of the MSL proteins and acetylated histone H4 from the X chromosome to autosomal

187 ound by TATA-binding protein and enriched in acetylated histone H4 in cultured human 293 cells.

188 genomic deposition of MacroH2A, H3TrimK9 and acetylated histone H4 modifications on the Xi at higher

189 n revealed that METH decreased enrichment of acetylated histone H4 on GluA1, GluA2, and GluN1 promote

190 m molecular dynamics simulations of a doubly acetylated histone H4 peptide bound to the bromodomain o

191 , assayed using mixed acetylated histones or acetylated histone H4 peptide.

192 Bromodomains bind acetylated histone H4 peptides in vitro.

193 HDAC inhibitors increased acetylated histone H4 protein expression in NHA cells.

194 decrease in HDAC activity and an increase in acetylated histone H4 protein.

195 cooperate to ensure that only appropriately acetylated histone H4 proteins are imported into the nuc

196 comparison, the acetyl transferase p300 and acetylated histone H4 remain localized with DNA througho

197 ted that these sequences are associated with acetylated histone H4 specifically in endothelial cells.

198 The bromodomains of Bdf2 recognize acetylated histone H4 tails and antagonize Sir2-mediated

199 s been linked to Bdf1, which binds TFIID and acetylated histone H4 tails, but no linkage between TAF1

200 tin immunoprecipitation with an antibody for acetylated histone H4 that discriminates between constit

201 However, acetylated histone H4 transiently associated with the Il

202 in the association of TbetaRII promoter with acetylated histone H4 was detected in the TSA-treated ce

203 markedly decreased, whereas that of p53 and acetylated histone H4 was slightly increased in MCF7 cel

204 ctively expressed, whereas genes depleted in acetylated histone H4 were non-transcribed or expressed

205 Maximal and specific association of acetylated histone H4 with the PCNA promoter also depend

206 o the VWF promoter, increased association of acetylated histone H4 with the VWF promoter and subseque

207 uclear Hat1p/Hat2p/Hif1p complex is bound to acetylated histone H4, as well as histone H3.

208 specifically increased levels of endogenous acetylated histone H4, but not histone H3, strongly sugg

209 Bdf1 binds preferentially to acetylated histone H4.

210 experiments using antibodies that recognised acetylated histone H4.

211 tes with the Sir2 deacetylase for binding to acetylated histone H4.

212 inding pocket by JQ1 prevents recognition of acetylated histone H4.

213 Accumulation of acetylated histones has been used as a marker of the bio

214 In addition to stabilization of acetylated histones, HDAC inhibitors stabilize the acety

215 l (BET) proteins are epigenetic "readers" of acetylated histones in chromatin and have been identifie

216 pecific primers indicated an accumulation of acetylated histones in chromatin associated with the RI

217 ing proteins recognize different patterns of acetylated histones in intact nuclei of living cells.

218 e further show that the MIEP associates with acetylated histones in permissive cells, and that in per

219 or, trichostatin A, rescued the reduction of acetylated histones in the CBP cKO cortex but failed to

220 inistration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal corte

221 ve effect of HDAC evident in the presence of acetylated histones in the immediate-early promoter regi

222 Apc(min) mice, and there was an increase in acetylated histones in the polyps, including acetylated

223 there were only modest changes in levels of acetylated histones in the skin of ODC transgenic mice.

224 es the Adipoq gene by recruiting P-TEFb onto acetylated histones in the transcribed region of the gen

225 lly active genes display enhanced binding of acetylated histones in their promoters.

226 inhibit the association of BRD7 and BRD9 to acetylated histones in vitro and in cells.

227 TAF(II)250 and PCAF recognized H3 and other acetylated histones, indicating fine specificity of hist

228 genome, whereas most CGBP co-localizes with acetylated histones, indicating that CGBP is localized t

229 oth HSS-9 and HSS+3 inducibly associate with acetylated histones, indicative of chromatin remodeling,

230 fashion, selective disruption of bromodomain:acetylated histone interactions with chemical probes ser

231 dues in histone H3 enables deposition of pre-acetylated histones into cellular chromatin, via a pathw

232 ns contain two bromodomains whose binding to acetylated histones is required for the blockade of diff

233 modomain protein capable of interacting with acetylated histones, is implicated in transmitting epige

234 ally associated with an increase in the mono-acetylated histone isoform H4K16.

235 tive chromatin within the promoter; that is, acetylated histone K9/K14 and histone H4K5 as well as tr

236 nd their recruitment to the SHP promoter and acetylated histone levels at the promoter were increased

237 After HDAC inhibitor treatment, acetylated histone levels increased, particularly at ups

238 f p300 by siRNA decreased acetylated FXR and acetylated histone levels, and occupancy of FXR at the p

239 monstrates that despite no change in overall acetylated histone levels, histone H3 is hypo-acetylated

240 ecialized binding modules that interact with acetylated histones, linking chromatin recognition to ge

241 T) proteins, which are epigenetic readers of acetylated histone lysine tail residues.

242 teins (BET) are chromatin adapters that bind acetylated histone marks via two tandem BDs, BD1 and BD2

243 ET proteins to chromatin by engaging cognate acetylated histone marks, and the extraterminal (ET) dom

244 ower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and N

245 Nucleosome-like particles and acetylated histones occur near active promoters and enha

246 t indicating that SEC recruitment to certain acetylated histones on a subset of genes stimulates the

247 the paternal allele, was not associated with acetylated histones on either allele.

248 In contrast, we found that the extent of acetylated histones on the p21 promoter, especially the

249 pocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.

250 of deacetylase activity, assayed using mixed acetylated histones or acetylated histone H4 peptide.

251 malignant T cell apoptosis and modulation of acetylated histones, p21(WAF1), bax, Stat6, and caspase-

252 1 alters the direct association of BRD4 with acetylated histone-packaged promoters and reduces the tr

253 ound, I-BET-762, that inhibits binding of an acetylated histone peptide to proteins of the bromodomai

254 minal fragment of Brd4 binds to both DNA and acetylated histone peptides, allowing it to bind tightly

255 eeper residue and binds relatively weakly to acetylated histone peptides.

256 rom PBMNCs showed consistent accumulation of acetylated histones post-therapy, and enzyme-linked immu

257 nucleosomal arrays reconstituted with highly acetylated histones prepared from butyrate-treated HeLa

258 the interaction between its YEATS domain and acetylated histones reduces the ATAC complex-dependent p

259 t sites exhibited stronger allelic bias than acetylated histone residues in general.

260 nal domain-containing proteins (Brd) bind to acetylated histone residues, resulting in recruitment of

261 ith transcription factors and recognition of acetylated histone residues, the chromatin remodeling ac

262 Although both BD1 and BD2 bind acetylated histone residues, they may independently regu

263 MMTV arrays containing highly acetylated histones show diminished intramolecular compa

264 However, highly acetylated histones show reduced loading tendencies on 5

265 unoblotting with specific antibodies against acetylated histones shows that Alp5 is required for hist

266 acetylated histones in the polyps, including acetylated histones specifically associated with the pro

267 s that 'read' chromatin states by binding to acetylated histones strongly suppresses osteoclastogenes

268 owever, that repression by dSir2 requires an acetylated histone substrate.

269 c acetyl antibodies in that they prefer poly-acetylated histone substrates.

270 d SNRPN expression, but not association with acetylated histones, suggesting that histone acetylation

271 fer resistance to the drug map to the likely acetylated histone tail binding domain of the protein.

272 We also find that bromodomain/acetylated histone tail interactions can contribute to t

273 sessed SIRT6 enzymatic activity on synthetic acetylated histone tails (H3K9Ac) by measuring products

274 rs controlling transcription through reading acetylated histone tails and recruiting transcription co

275 BD1 mutants and analyzed their affinities to acetylated histone tails and to the BET inhibitor JQ1 us

276 ate, suggesting that domains recognizing the acetylated histone tails reside at the interface between

277 It binds to acetylated histone tails via its tandem bromodomains BD1

278 BET proteins bind acetylated histone tails via their bromodomain, bringing

279 Since the BET proteins are known to bind acetylated histone tails, these results also suggest a r

280 aining bromodomains read the code by binding acetylated histone tails.

281 utant MLLT1 protein shows altered binding to acetylated histone tails.

282 ntly blocks the interaction of BET BRDs with acetylated histone tails.

283 tibody reveal that this aptamer binds to the acetylated histone target with similar affinity to a com

284 -forward loops of acetylation and binding of acetylated histones that drive transcription of underlyi

285 ondensin II chromatin remodelling complex to acetylated histones through bromodomain interactions.

286 Besides P-TEFb, BRD4 binds to acetylated histones through the bromodomain.

287 ncreased P-Rex1 promoter activity and caused acetylated histones to accumulate and associate with the

288 Histone deacetylase inhibitors cause acetylated histones to accumulate in both tumor and peri

289 BRD7 simultaneously binds to acetylated histones to promote Smad-chromatin associatio

290 protein that has been shown to interact with acetylated histones to regulate transcription by recruit

291 Bromodomain proteins bind acetylated histones to regulate transcription.

292 changes in recruitment of RNA polymerase and acetylated histones to viral promoters.

293 Interaction with acetylated histone was essential for Brd2 to amplify tra

294 T) proteins, inhibiting them from binding to acetylated histones, which occurs preferentially at supe

295 inhibitor treatment increases association of acetylated histones with downregulated genes and correct

296 Lsh resulted in an increased association of acetylated histones with repeat sequences and transcript

297 In support of this, increased association of acetylated histones with the promoter loci of granzyme B

298 ur finding of allele-specific association of acetylated histones with the SNRPN exon 1 region, which

299 ved to be reasonably specific at recognizing acetylated histones, with recognition efficiencies of 60

300 Vorinostat induced the accumulation of acetylated histones within 30 min, which could alter chr