ライフサイエンスコーパス: acetylation

1 haride O-acetyltransferase involved in xylan acetylation.

2 s that are controlled predominantly by H3K27 acetylation.

3 chromatin and enhanced by p300 mediated TET2 acetylation.

4 virulence in maize through altering protein acetylation.

5 y of HIPK2 can be regulated by p300-mediated acetylation.

6 elated metabolites and cyclic global protein acetylation.

7 er, it is unknown whether NO affects histone acetylation.

8 induces nucleosome displacement and histone acetylation.

9 TopA from inactivation by such non-enzymatic acetylation.

10 cer activation, indicated by increased H3K27 acetylation.

11 s that display putative NO-regulated histone acetylation.

12 vity measured by histone 3 lysine 27 (H3K27) acetylation.

13 tb is capable of regulating ICDH activity by acetylation.

14 alization of KAT5, thereby stimulating H4K16 acetylation.

15 versed by SIRT3, which deacetylates lys(101) acetylation.

16 frequently among pneumococcal capsules is O-acetylation.

17 AF up-regulates CXCR4 expression via histone acetylation.

18 ion, possibly involving cross-talk with H3K9 acetylation.

19 ic modifications targeting histone H4 lysine acetylation.

20 retinas, VPA treatment increased histone H3 acetylation.

21 ion a targeted lysine in the active site for acetylation.

22 ice while CR robustly rescues global protein acetylation.

23 Sas3 and Ada2(Gcn5)-dependent histone H3K14 acetylation.

24 , which we clustered based on their rates of acetylation.

25 to be affected by the negative charge by K65 acetylation.

26 on is associated with broad scale histone de-acetylation.

27 , a cognitive process that relies on histone acetylation.

28 s identified gtr-dependent glucosylation and acetylation.

29 ete, as the reported structure contains no O-acetylation.

30 deacetylation producing enhanced microtubule acetylation.

31 ted tau aggregation inhibitor, modulates tau acetylation, a novel mechanism of action for this class

32 dence times on chromatin requires C-terminal acetylation-a classical mark for transcriptionally activ

33 f influences on Arc, including promoting its acetylation-a previously uncharacterized post-translatio

34 3, lysine 4 (H3K4) monomethylation, and H3K9 acetylation, accompanied by decreased H3K9 di/trimethyla

35 yl-lysines and recruits proteins to sites of acetylation across the genome.

36 CBP interaction domain reduces Nr4a promoter acetylation after learning.

37 etylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acetylation i

38 We find that tubulin acetylation alone does not directly affect kinesin-1 mot

39 ypertension showed 2.6-fold increase in SOD2 acetylation and 1.4-fold decrease in Sirt3 levels, where

40 sferase Brd2, which results in histone H3K27 acetylation and a robust activation of neuron-specific g

41 cells (GSCs), EGFR signaling promotes H3K23 acetylation and association with TRIM24.

42 Changes in histone acetylation and class IIa histone deacetylases expressio

43 SKI controls histone acetylation and deacetylation of the Rorc locus and TH17

44 yamine metabolism is regulated by reversible acetylation and dysregulated polyamine metabolism is ass

45 we elucidated the temporal order of histone acetylation and gene activation, as well as the stabilit

46 and acetate uptake is important for histone acetylation and gene expression.

47 ribitol connectivity, as well as variable O-acetylation and glycosylation of GlcNAc contribute to th

48 difications (PTMs), such as phosphorylation, acetylation and glycosylation, regulate numerous cellula

49 Peripheral blood histone acetylation and HDAC2 gene expression were associated wi

50 was associated with decreased histone 3 (H3) acetylation and increased Bcl-xL expression: the latter

51 with concomitant global reduction of histone acetylation and increased sensitivity of leukemia cells

52 s approach, we demonstrated that both lysine acetylation and lysine succinylation can be installed se

53 P300/CBP-associated factor (PCAF)-dependent acetylation and lysosomal degradation of the pyruvate ki

54 ots in mice harbor several histone H3 and H4 acetylation and methylation marks that are typical of op

55 post-translational modifications, including acetylation and methylation.

56 types of lung injuries showed increased p53 acetylation and miR-34a expression with reduction in Sir

57 ine the molecular connection between histone acetylation and Nr4a gene expression after learning.

58 regulation of protein function by reversible acetylation and offer insight into the complex immune re

59 This interplay of acetylation and phosphorylation also regulated cell deat

60 te, for the first time, the effect of lysine acetylation and phosphorylation, as well as the crosstal

61 etylase inhibitor treatment increased IQGAP1 acetylation and reduced IQGAP1 cleavage.

62 This study examined whether acetylation and S574 phosphorylation act independently o

63 for producing paCOS with defined patterns of acetylation and specific bioactivities.

64 phosphorylation and demonstrate that histone acetylation and STAT3 tyrosine705 phosphorylation cooper

65 cyte differentiation is regulated by histone acetylation and the binding protein bromodomain containi

66 eneration 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes.

67 nal modifications (e.g., phosphorylation and acetylation) and can also be part of mixed polymers with

68 ordination of nutrient availability, protein acetylation, and cellular lipid metabolic responses.

69 of epigenetic modification including histone acetylation, and DNA methylation.

70 dies highlight the dynamic nature of protein acetylation, and how metabolism plays a central role in

71 dent deacetylase activity, increased protein acetylation, and impaired mitochondrial integrity.

72 ion depends on chromatin remodeling, histone acetylation, and methylation, which all affect Schwann c

73 ally reduces H3K36 tri-methylation and H3K36 acetylation, and mutants show partial transcriptional ov

74 those genes correlated with decreased H3K27 acetylation, and nearly 80% of these regions with affect

75 d Sirt3 S-glutathionylation, diminished SOD2 acetylation, and reduced blood pressure in wild-type but

76 S2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of

77 t mitochondrial metabolism regulates cardiac acetylation, and that signals derived from alterations i

78 ands include PI-3 kinase activation, histone acetylation, and the integrated stress response.

79 n-enzymatic acetyl phosphate mediated lysine acetylation, and the presence of purified CobB protects

80 We found that loss of WcjE-mediated O-acetylation appears not to affect cell wall shielding, s

81 ted that the main determinants of N-terminal acetylation are contained within the first five residues

82 challenged the prevailing view of N-terminal acetylation as a co-translational ribosome-associated pr

83 Our study identifies alpha-synuclein acetylation as a key regulatory mechanism governing alph

84 Here we provide evidence supporting TDP-43 acetylation as a trigger for disease pathology.

85 ts activation loop, which could explain self-acetylation as an important feedback mechanism to regula

86 Although the in vitro acetylation assays revealed that HDAC5 decreased LSD1 pr

87 bundance of 3,636 proteins and the levels of acetylation at 2,791 sites in maize plants treated with

88 However, serotype 42 has only O-acetylation at 3-beta-galactofuranose, an observation co

89 on and aberrant patterns of histone H3 Lys27 acetylation at enhancers and promoters, suggesting a cro

90 However, mimicking NP hyper-acetylation at K77 and K229 severely diminishes viral po

91 These results suggest that NP acetylation at K77, K113 and K229 impacts multiple steps

92 2 directly activates Tip60 for its catalyzed acetylation at p53 K120.

93 48 h after activation and the levels of H3K9 acetylation at the 2-cell to 8-cell stages, meanwhile, s

94 iG functionality, which is associated with O-acetylation at the 2-position and subsequent reaction wi

95 polymerase activity, while mimicking NP hypo-acetylation at these sites has no effect on viral replic

96 ficiency is also observed mimicking constant acetylation at this site (K229Q), whereas virus encoding

97 s that NEDD4 regulates glucose-induced H3 K9 acetylation at transcription starting site and enhancer

98 r cells show widespread increases in histone acetylation at transcriptionally enhanced genes, implica

99 of transcriptionally active chromatin marks (acetylation) at its proximal promoter region as well as

100 ased pS81 enhances p300 recruitment, histone acetylation, BRD4 binding and subsequent further recruit

101 psule of the WciG-deficient isolate lacked O-acetylation but was otherwise identical to serotype 35B.

102 nal MAP tau is also not sensitive to tubulin acetylation, but enriches preferentially on highly curve

103 n KRAS can be modified by ubiquitylation and acetylation, but the role of this residue in intrinsic K

104 , S10 phosphorylation is not dependent on K9 acetylation by PCAF.

105 These data suggest that NO affects histone acetylation by targeting and inhibiting HDAC complexes,

106 In the absence of APE1 acetylation, cells accumulated AP sites in the genome an

107 olar type II cells have increased MnSOD(K68) acetylation compared with controls.

108 tem cells Myst2 is part of H3 and H4 histone acetylation complexes similar to those described in soma

109 rly 80% of these regions with affected H3K27 acetylation contained a bona fide TRbeta1-binding site.

110 We propose that CRP K100 acetylation could be a mechanism by which the cell downw

111 ulate epigenetic mechanisms, such as histone acetylation/deacetylation balance, in part via histone d

112 n approach inspired by the posttranslational acetylation/deacetylation of lysine residues, in which a

113 The acetylation decreased the tensile strength and increased

114 of lysine 68 to glutamine (K68Q), mimicking acetylation, decreased MnSOD activity in SNc dopaminergi

115 , whereas Nav1.5 with K1479 mutated to mimic acetylation decreases INa.

116 denovirus-mediated expression of SIRT3 or an acetylation-defective SIRT3-K57R mutant in diet-induced

117 omatin regulator gene BRPF1 cause histone H3 acetylation deficiency and a previously unrecognized int

118 by epigenetic mechanisms, including histone-acetylation dependant pathways.

119 thway choice through its ability to regulate acetylation-dependent control of 53BP1 localization.

120 rt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the oxidati

121 a potential "two-hit" mechanism in which tau acetylation disengages tau from MTs and also promotes ta

122 We show that O-acetylation driven by Adr protects the peptidoglycan of

123 ndogenous plant enzymes can modulate protein acetylation during an immune response.

124 proportional to the degree of in vivo lysine acetylation during growth transition and growth arrest.

125 Thus, the study of protein acetylation dynamics is critical for understanding of ho

126 Sirt3 depletion increased SOD2 acetylation, elevated mitochondrial O2(. -), and diminis

127 deacetylase 6 (HDAC6) increase alpha-tubulin acetylation, endoplasmic reticulum (ER)-mitochondrial ov

128 ETS1 chromatin occupancy and increases ETS1 acetylation, enhancing its binding to BRD4, which recrui

129 clei results in an attenuation of HIF-1alpha acetylation, enhancing the stabilization and transcripti

130 Strikingly, mutants blocking acetylation exacerbate alpha-synuclein toxicity in vivo,

131 nt DLBCL clones exhibited reduced histone H3 acetylation, expressed significantly less MHCII, and gre

132 e degree of polymerization (DP), fraction of acetylation (FA), or pattern of acetylation (PA).

133 several sequence determinants of N-terminal acetylation for proteins lacking (i)Met, some of which h

134 e explored the mechanistic details of PatB's acetylation function and determined that PatB has substr

135 rrelated with decreased histone H3 lysine 27 acetylation (H3K27Ac) in the FBP1 enhancer.

136 ruits p300, which is associated with histone acetylation (H3K27ac) indicative of an active enhancer.

137 taining ATAC complex co-localizes with H3K27 acetylation (H3K27ac) on the promoters of actively trans

138 4 monomethylation, and histone H3 lysine 27 acetylation (H3K4me3, H3K4me1, and H3K27ac) and define,

139 romatin accessibility and histone 3 lysine 9 acetylation (H3K9ac) enrichment in young seedling and hu

140 insufficiency suppressed histone H3 lysine 9 acetylation (H3K9ac) overall and particularly reduced H3

141 sine 4 trimethylation (H3K4me3) and lysine 9 acetylation (H3K9ac), co-localize on active gene promote

142 However, how H4 acetylation (H4Ac) recruits repair proteins and reorgani

143 Tau acetylation has recently emerged as a dominant post-tran

144 inothricin (also known as glufosinate) via N-acetylation, have been globally used in basic plant rese

145 C6-responsive sites in tau and determine how acetylation in a site-specific manner affects tau's biop

146 mical screen platform to quantify PGC-1alpha acetylation in cells and identified small molecules that

147 r previous work demonstrated reduced tubulin acetylation in CF cell models and tissue that is correct

148 trikingly, a ketogenic diet increased lysine acetylation in Cpt2M(-/-) hearts 2.3-fold compared with

149 corroborate the importance of histone H4K16 acetylation in CRC.

150 These findings identify perturbed chromatin acetylation in irinotecan resistance and establish HDAC

151 ouse cervix confirmed large scale histone de-acetylation in labor.

152 lative analyses showed enhanced histone (H3) acetylation in peripheral blood mononuclear cells and re

153 e acetylation, allowing for rapid changes in acetylation in response to a learning event.

154 Loss of WciG-mediated O-acetylation in serotypes 33X1 and 33X2, however, resulte

155 We hypothesized that targeting PGC-1alpha acetylation in the liver, a chemical modification known

156 regation, revealing a potential role for tau acetylation in the propagation of tau pathology.

157 arallel, Mof loss also impaired global H4K16 acetylation in the tumor cell genome.

158 the impact of diet on acetyl-CoA and histone acetylation in these tissues remains unknown.

159 demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diabetic va

160 , increased N-deacetylation, and increased O-acetylation in VRE when grown in the presence of vancomy

161 eas, HFD also impacted the levels of histone acetylation; in particular, histone H3 lysine 23 acetyla

162 Thus, acetylation increases mechanical resilience to ensure th

163 uppression of cell proliferation, suggesting acetylation-induced HIPK2 stabilization contributed to t

164 Histone acetylation is a fundamental epigenetic mechanism that i

165 Lysine acetylation is a key posttranslational modification that

166 onum Analyses of these data demonstrate that acetylation is a widespread posttranslational modificati

167 Strikingly, this oscillation in acetylation is absent in old mice while CR robustly resc

168 The results demonstrate that histone H4 acetylation is absolutely dependent on CA-induced AhR an

169 Our study reveals that APE1 acetylation is an integral part of the BER pathway for m

170 Although most Smc3 acetylation is Esco1 dependent, inactivation of the ESCO

171 investigated to what extend peptidoglycan O-acetylation is involved in cell wall biosynthesis and ce

172 kappaB signaling through phosphorylation and acetylation is not fully understood.

173 N-terminal acetylation is one of the most common protein modificati

174 These results reveal that acetylation is permissive for generation of the apoptoti

175 One challenge for studying protein acetylation is to get purely acetylated proteins at spec

176 rs in the cytoplasm and the function of this acetylation is typically ascribed to roles in either his

177 )-mediated HDAC5 knockdown did not alter the acetylation level of LSD1 in MDA-MB-231 cells.

178 diet can impact tissue acyl-CoA and histone acetylation levels and that acetyl-CoA abundance correla

179 ted genes, most likely due to decreased H3K9 acetylation levels at the corresponding loci.

180 Furthermore, PGK1 K388 acetylation levels correlate with Beclin1 S30 phosphoryl

181 he nucleus and cytosol and regulates histone acetylation levels in many cell types.

182 Endogenous ERK1/2 acetylation levels increased upon treatment with a pan-H

183 cytes also suppressed acetyl-CoA and histone acetylation levels.

184 , validating the importance of this specific acetylation mark for PBRM1 binding.

185 ) increased the abundance of several histone acetylation marks in Arabidopsis (Arabidopsis thaliana),

186 Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associate

187 ated inside their lumen and that microtubule acetylation may modify microtubule mechanics.

188 hondrial SIRT3 functions by inhibiting SIRT3 acetylation may offer a new therapeutic approach for obe

189 As such, PsAvh23 suppresses H3K9 acetylation mediated by the ADA2/GCN5 module and increas

190 (within a KCGS motif) is both essential for acetylation-mediated inhibition of tau aggregation in vi

191 Acetylation-mediated neutralization of the positive char

192 mal structures featuring all of the reported acetylation/methylation patterns associated with Bp and

193 104Q mutant has recently been employed as an acetylation mimetic, we conducted a series of studies to

194 beneficial effects were not observed with an acetylation-mimic SIRT3-K57Q mutant.

195 Full-length acetylation-mimic tau showed increased propensity to und

196 Interestingly, an acetylation-mimicking ERK1 mutant (K72Q) exhibited less

197 d mouse skeletal muscle, we show that TDP-43 acetylation-mimics promote TDP-43 phosphorylation and ub

198 erse both enzymatic and non-enzymatic lysine acetylation modification in E. coli.

199 e proteolytic cleavage and posttranslational acetylation modification of CREBH are regulated by the c

200 ansferase D (NatD) mediates N-alpha-terminal acetylation (Nt-acetylation) of histone H4 known to be i

201 lase sirtuin 1 (SIRT1) correlated with lower acetylation occupancy and lower levels of ribosomal prot

202 cetylated lysine residues mainly exhibit low acetylation occupancy, but challenges in sample preparat

203 erevisiae or Escherichia coli cells, require acetylation of APE1 for the efficient repair of AP sites

204 that lymphocyte activation triggers massive acetylation of chromatin.

205 imulates RNAPII pause release by stimulating acetylation of ETS1, a master endothelial cell transcrip

206 hermore, SDHD-G12S/H50R-mediated increase in acetylation of FOXO3a further enhances AKT-associated ph

207 This combination of phosphorylation and acetylation of FOXO3a results in its nuclear export for

208 Furthermore, p300/CBP are important for the acetylation of H3K27 at loci downregulated in Hnf1alpha-

209 ecruitment of P300 acetyltransferase and the acetylation of H3K27 at precise gene loci in cells.

210 We also observed that DNA damage induced acetylation of HIPK2 along with an increase in the prote

211 ogether, our data suggest that p300-mediated acetylation of HIPK2 increases the protein stability of

212 ing BRPF1 variants are pathogenic and impair acetylation of histone H3 at lysine 23, an abundant but

213 We found that Nt-acetylation of histone H4 antagonizes histone H4 serine

214 ase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is

215 tion (H4S1ph), and that downregulation of Nt-acetylation of histone H4 facilitates CK2alpha binding t

216 trate for direct binding of the SEC, as does acetylation of histone H4 lysine 5 to a lesser extent.

217 Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the pho

218 Lysine acetylation of histone proteins is a fundamental post-tr

219 istone deacetylases (HDACs) not only induced acetylation of histones in the respective promoter regio

220 The simultaneous pseudo-acetylation of hTau at lysines 163, 280, 281 and 369 dra

221 tether sister chromatids together depends on acetylation of its Smc3 subunit by members of the Eco1 f

222 on of lysine 36 in histone H3 (H3K36me3) and acetylation of lysine 16 in histone H4 (H4K16ac) have im

223 The RelA NF-kappaB subunit is activated by acetylation of lysine 310.

224 say was developed and used to determine that acetylation of lysines 19 and 26 of MPC2 is enhanced in

225 mutant in diet-induced obese mice decreased acetylation of mitochondrial long-chain acyl-CoA dehydro

226 vate transport activity, mediated in part by acetylation of MPC2, is a contributor to metabolic infle

227 ted repression on the erm enhancer, enabling acetylation of multiple histone proteins and activating

228 s and by chemical modifications, including O-acetylation of MurNAc residues that occurs in most Gram-

229 ferase 10 protein (Naa10p) catalyzes N-alpha-acetylation of nascent proteins, and mutation of human N

230 ty or expression results in decreased lysine acetylation of Nav1.5, which promotes the trafficking of

231 The acetylation of newly synthesized H4 occurs in the cytopl

232 one acetyltransferase 1 (Hat1) catalyzes the acetylation of newly synthesized histone H4 at lysines 5

233 lcNAcylation affects the phosphorylation and acetylation of NF-kappaB subunit p65/RelA.

234 tone deacetylases) can be modulated to alter acetylation of nonhistone proteins during an immune resp

235 ding protein (CBP)/p300-dependent activating acetylation of p65 at Lys-310, contributing to NF-kappaB

236 High glucose-stimulated lysine acetylation of p66Shc facilitates its phosphorylation on

237 ine deacetylase (Sirt1), and Sirt1-regulated acetylation of p66Shc governs its capacity to induce ROS

238 We show that O-acetylation of peptidoglycan, a mechanism utilized by S.

239 O-acetyltransferase B (PatB) catalyzes the O-acetylation of PG in Gram (-) bacteria, which aids in ba

240 nd that acetyl-CoA abundance correlates with acetylation of specific histone lysines in WAT but not i

241 C646 treatment blocked acetylation of specific lysine residues that regulate p5

242 Furthermore, RA triggers GCN5-mediated acetylation of TACC1, which results in dissociation of T

243 del in which IQGAP1 cleavage is regulated by acetylation of the cleavage sites.

244 interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providin

245 Exposure to FA dramatically decreased the acetylation of the N-terminal tails of cytosolic histone

246 s indicated that PAF-treatment activated the acetylation of the p21 promoter.

247 Here the authors show that acetylation of the protein triggers TDP-43 pathology in

248 SMAD4: ectopic SKI expression inhibits H3K9 acetylation of the Rorc locus, Rorc expression, and TH17

249 We have previously shown that acetylation of the SUMO E2 conjugase enzyme, Ubc9, at K6

250 sferase EP300, which increases histone H3K27 acetylation of vasopressin-responsive genes (confirmed b

251 D) mediates N-alpha-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell

252 this new model to investigate the effects of acetylation on hTau toxicity in vivo.

253 ites in tau are responsive to HDAC6 and that acetylation on Lys-321 (within a KCGS motif) is both ess

254 associated with epigenetic memory histone H3 acetylation on the transcribed region of the gene.

255 tid cohesion is established by Eco1-mediated acetylation on two conserved tandem lysines in the cohes

256 fraction of acetylation (FA), or pattern of acetylation (PA).

257 monocytes induced a rapid increase of FOXO3 acetylation, partly by suppression of SIRT1 and SIRT7.

258 These properties likely arise from different acetylation patterns, but determining the sequences of p

259 These findings uncover a novel acetylation-phosphorylation switch at Lys-321/Ser-324 th

260 Protein acetylation plays a critical role in biological processe

261 Protein acetylation plays important roles in many biological pro

262 There has long been evidence that acetylation promotes FOXO3-driven apoptosis and recently

263 achieve significant fold changes observed by acetylation proteomics methods.

264 iated changes in gene expression and histone acetylation require TRbeta1.

265 Control of CIDEC acetylation required the conversion of FAs to triacylgly

266 ation, suggested a putative role for histone acetylation signaling in the altered hypertrophy respons

267 spectrometry analysis indicated Lys-72 as an acetylation site in the ERK1 N terminus, adjacent to Lys

268 JNK1, and a mutant FOXO3 lacking four known acetylation sites (K242, 259, 290 and 569R) abolished JN

269 lterations in individual phosphorylation and acetylation sites in full-length Htt constructs.

270 in vitro Our findings indicate that several acetylation sites in tau are responsive to HDAC6 and tha

271 Here we identify several acetylation sites of the influenza A virus nucleoprotein

272 s revealed that HDAC5 decreased LSD1 protein acetylation, small interfering RNA (siRNA)-mediated HDAC

273 We show that acetylation specifically at residues K280/K281 impairs t

274 The acetylation state of GlcNAc did not affect linkage.

275 Lys-71, which binds to ATP, suggesting that acetylation status of Lys-72 may affect ERK1 ATP binding

276 As the occurrence of N-terminal acetylation strongly depends on the context of protein s

277 linking function, ID3 can also interact with acetylation substrates of CBP.

278 ied small molecules that increase PGC-1alpha acetylation, suppress gluconeogenic gene expression, and

279 In the absence of H3K14 acetylation, Swi-Snf recruitment and histone eviction pr

280 Paxillin, by modulating microtubule acetylation through HDAC6 regulation, was shown to contr

281 icetin treatment led to decreased PGC-1alpha acetylation through SIRT1 activation.

282 X-MLL4 complex enhances p300-dependent H3K27 acetylation through UTX-dependent stimulation of p300 re

283 Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene expressi

284 nd 1,000 sites with significantly increasing acetylation trends, which we clustered based on their ra

285 SMP enhancer region was decreased by histone acetylation under hypoxic conditions in cancer cells.

286 ositive charge of K100 can be neutralized by acetylation using the central metabolite acetyl phosphat

287 We also observed that DSB-induced H4K16 acetylation was abolished in cells upon depletion of the

288 The degree of acetylation was generally higher in the soluble complexe

289 ylation; in particular, histone H3 lysine 23 acetylation was lower in HFD-fed mice.

290 tand the sequence determinants of N-terminal acetylation were conducted initially by simply examining

291 tional modifications including oxidation and acetylation were detected.

292 DNA hypomethylation and histone 3 acetylation were found on the p66(Shc) promoter of patie

293 -resistant microtubules lost upon removal of acetylation were largely restored by either pharmacologi

294 the liver, no significant effects on histone acetylation were observed with a HFD despite lower acety

295 e activity of TIP60, promoting histone H4K16 acetylation, which facilities 53BP1 displacement from DS

296 a myosin-independent increase in microtubule acetylation, which increases podosome rosette stability

297 Histone acetylation, which is an important mechanism to regulate

298 Pharmacologically, modulating histone acetylation with acetyl-L-carnitine (LAC) or acetyl-N-cy

299 Predictor, can be used to predict N-terminal acetylation with an accuracy of more than 80%.

300 edictor, accurately predicted the N-terminal acetylation, with an overall performance comparable or s