ライフサイエンスコーパス: acetylcarnitine

1 e conversion of acetyl-coenzyme A (CoA) into acetylcarnitine.

2 2 of beta-hydroxybutyrate, malonyl-CoA, and acetylcarnitine.

3 was no detectable current in the presence of acetylcarnitine.

4 transport carnitine, propionylcarnitine and acetylcarnitine.

5 anges in [(13)C]bicarbonate (-48%), [1-(13)C]acetylcarnitine (+113%), and [5-(13)C]glutamate (-63%),

6 The observed enrichment of (13)C in acetylcarnitine (19%), M+6 stearoylcarnitine (16.2%), an

7 ce of M+2 myristoylcarnitine (95.7%) and M+2 acetylcarnitine (19.4%) is evidence for beta-oxidation o

8 ylglycine, 1-methylnicotinamide, methionine, acetylcarnitine, 2-oxoglutarate, choline, and creatine.

9 Treatment with acetylcarnitine (AcCN) increases the activity of cytochr

10 Whereas (+)-acetylcarnitine also failed to influence CACT, both (+)-

11 release of 2 specific acylcarnitine species, acetylcarnitine and 3-hydroxybutyryl-carnitine.

12 eased tissue efflux and urinary excretion of acetylcarnitine and improvement of whole body glucose to

13 Because of this channeling, the labeling of acetylcarnitine and ketone bodies released by the heart

14 the release of small excess acetyl groups as acetylcarnitine and ketone bodies, and (iii) the channel

15 Cycling of acetyl-CoA through acetylcarnitine appears key to matching instantaneous ac

16 drogenase complex activation, acetyl-CoA and acetylcarnitine by approximately 20-fold (P < 0.01), app

17 Acetylcarnitine (C2), showing a late response pattern an

18 enzymatic conversion of pyruvate to lactate, acetylcarnitine, citrate, and glutamate with 1 s tempora

19 (P < 0.01), when there was a 47% decrease in acetylcarnitine concentration (P < 0.05), and a 24-fold

20 showed a reciprocal distribution, with mean acetylcarnitine concentration correlating with mean insu

21 Skeletal muscle acetylcarnitine concentration showed a reciprocal distri

22 omic analysis showed a 2.2 times increase in acetylcarnitine concentrations (p=0.002).

23 nterest, noninvasive alternatives to measure acetylcarnitine concentrations could facilitate our unde

24 troscopy (1H-MRS) to measure skeletal muscle acetylcarnitine concentrations on a clinical 3T scanner.

25 min of passive recovery, muscle lactate and acetylcarnitine concentrations were elevated above basal

26 These results demonstrate that measuring acetylcarnitine concentrations with 1H-MRS is feasible o

27 ate dehydrogenase complex (PDC) activity and acetylcarnitine content at rest, it has also been establ

28 irst 3 min of infusion, the concentration of acetylcarnitine declined (pre-infusion = 3.8 +/- 0.3 vs.

29 derivatives, rose from virtual absence, and acetylcarnitines fell.

30 The effect on each of (+)-acetylcarnitine, (+)-hexanoylcarnitine, (+)-octanoylcarn

31 quantitative determination of carnitine and acetylcarnitine in analytical standard solutions as well

32 We applied long-TE 1H-MRS to measure acetylcarnitine in endurance-trained athletes, lean and

33 ategy to the quantification of carnitine and acetylcarnitine in rat liver is shown.

34 umulation of glucose-6-phosphate (G-6-P) and acetylcarnitine in resting canine skeletal muscle.

35 14C]acetyl-CoA, which is converted to [2-14C]acetylcarnitine in the presence of excess L-carnitine an

36 for successful detection of skeletal muscle acetylcarnitine in these individuals.

37 Because current methods to detect acetylcarnitine involve biopsy of the tissue of interest

38 Acetylcarnitine is produced by the mitochondrial matrix

39 The positively charged radiolabeled product, acetylcarnitine, is separated from negatively charged ex

40 The acetylating agent L-acetylcarnitine (LAC), a well-tolerated drug, behaves as

41 production by 35% and increased the overall acetylcarnitine pool size by 33%.

42 arnitine production by 37% and decreased the acetylcarnitine pool size by 40%.

43 between pyruvate-derived acetyl-CoA and the acetylcarnitine pool.

44 re characterized by a decreased formation of acetylcarnitine, possibly underlying decreased insulin s

45 chloroacetate increased the rate of [1-(13)C]acetylcarnitine production by 35% and increased the over

46 Dobutamine decreased the rate of [1-(13)C]acetylcarnitine production by 37% and decreased the acet

47 Animal models suggest that acetylcarnitine production is essential for maintaining

48 Carnosine and 3 acylcarnitines (acetylcarnitine, propionylcarnitine, and 2-methylbutyryl

49 tic resonance spectroscopy has revealed that acetylcarnitine provides a route of disposal for excess

50 zed [2-(13)C]pyruvate infusion, the [1-(13)C]acetylcarnitine resonance was saturated with a radiofreq

51 In the perfused heart, [1-(13)C]acetylcarnitine saturation reduced the [1-(13)C]citrate

52 5% decrease in short-chain acylcarnitine and acetylcarnitine secretion.

53 , with strong trends for both acetyl-CoA and acetylcarnitine to actually decline (indicating the exis

54 13)C-label flux into citrate, glutamate, and acetylcarnitine, which correlated with the degree of car

55 ous distribution of 1-methylnicotinamide and acetylcarnitine, which mostly colocalized with hypoxic t

56 esulted in the biphasic changes in G-6-P and acetylcarnitine with infusion time.