ライフサイエンスコーパス: acetylglucosaminyltransferase

1 synthesizing enzyme GCNT3 (core 2 beta-1,6 N-acetylglucosaminyltransferase).

2 l fringe is also a fucose-specific beta1,3-N-acetylglucosaminyltransferase.

3 mster ovary cells expressing core2 beta1,6-N-acetylglucosaminyltransferase.

4 ich is synthesized by I-branching beta1, 6-N-acetylglucosaminyltransferase.

5 , which are synthesized by core 2 beta-1,6-N-acetylglucosaminyltransferase.

6 network included alpha-dystroglycan and like-acetylglucosaminyltransferase.

7 olyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.

8 n, a proposed substrate of Fringe beta-1,3-N-acetylglucosaminyltransferases.

9 icient for the glycosyltransferase beta1,3-N-acetylglucosaminyltransferase 1 (beta3GnT1), a key enzym

10 Core 2 N-acetylglucosaminyltransferase 1 (C2GnT1) is a key enzyme

11 atively, protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) catalyzes the

12 sease, mice deficient in O-mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1).

13 ease, mice deficient in O-mannose beta31,2-N-acetylglucosaminyltransferase 1 (POMGnT1).

14 fukutin, protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 and the fukutin-related

15 G was increased by co-expression of core 2 N-acetylglucosaminyltransferase 1 with Large.

16 s of an enzyme (protein O-mannose beta-1,2-N-acetylglucosaminyltransferase 1) that modifies O-mannosy

17 ing protein O-mannosyltransferase 1, beta3-N-acetylglucosaminyltransferase 1, and like-acetylglucosam

18 sed by co-expression of protein:O-mannosyl N-acetylglucosaminyltransferase 1.

19 ted with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 (beta3GnT1).

20 ands elaborated by LSST and core 2 beta1,6-N-acetylglucosaminyltransferase-1 (Core2GlcNAcT) have been

21 85 targets UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT1) and

22 Protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the

23 Core 2 N-acetylglucosaminyltransferase 2/M (C2GnT-M) synthesizes

24 Core2 beta1,6-N-acetylglucosaminyltransferase-2 (C2GnT-2) was markedly i

25 yltransferase (C1GalT1) and core 2 beta1,6-N-acetylglucosaminyltransferase-2 or mucus type (C2GnT-M),

26 , beta1,4-galactosyltransferase-I, beta1,3-N-acetylglucosaminyltransferase-2, hCGn6ST, and keratan su

27 In this study, we first show that beta1,3-N-acetylglucosaminyltransferase-3 (beta3GlcNAcT-3) is almo

28 in C2GnT-2 knock-out mice but not in core2 N-acetylglucosaminyltransferase-3 (C2GnT-3) nulls.

29 and LNCaP prostate cancer cells with beta3-N-acetylglucosaminyltransferase-6 (core3 synthase) require

30 EM domain nuclear lamina component by beta-N-acetylglucosaminyltransferase, a nutrient sensor that re

31 n in vitro glycosylation assay to evaluate N-acetylglucosaminyltransferase activity after bacterial e

32 residues that are known to be critical for N-acetylglucosaminyltransferase activity of yeast chitin s

33 proteins possess a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that initiates el

34 The mutant had normal levels of N-acetylglucosaminyltransferase activity, and the partiall

35 The former mutant lacks the Golgi N-acetylglucosaminyltransferase activity, whereas the latt

36 We conclude that beta-N-acetylglucosaminyltransferase, an essential enzyme, cont

37 poly-N-acetyllactosamines, while beta1, 3-N-acetylglucosaminyltransferase and beta4Gal-TI efficientl

38 nt cellular proteins catalyzed by O-linked N-acetylglucosaminyltransferase and O-linked N-acetylgluco

39 esence of the enzymes for addition (O-beta-N-acetylglucosaminyltransferase) and removal (O-beta-N-ace

40 The Fringe family of beta1,3-N-acetylglucosaminyltransferases are regulators of this pa

41 Golgi poly-LacNAc extension enzyme beta1,3-N-acetylglucosaminyltransferase (B3GNT).

42 Fringe is a beta 3N-acetylglucosaminyltransferase (beta 3GlcNAcT) that trans

43 gene encoding the K. lactis Golgi membrane N-acetylglucosaminyltransferase by complementation of the

44 the alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C) gene on 12q21.3

45 ized with the Golgi enzyme core 2 beta-1,6-N-acetylglucosaminyltransferase (C2 GlcNAcT).

46 lation of the expression of core-2 beta1,6-N-acetylglucosaminyltransferase (C2GnT) 1, a key enzyme re

47 ferase VII (Fuc-T VII) and core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) are critical for b

48 sgenic mice overexpressing core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) in T cells, and de

49 is synthesized only when core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GnT) is present, and th

50 BW5147 T cells lacking the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT) were resistant to

51 fucosyltransferase-VII, and core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT).

52 use they do not express the core 2 beta1 6-N-acetylglucosaminyltransferase (C2GnT).

53 s for galectin-1 created by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT-I).

54 Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GnT, is a key enzyme in

55 we engineered mice lacking core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT), an enzyme predict

56 d Nod2 agonists upregulated core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT; an important enzym

57 cinoma AGS cells transfected with alpha1,4-N-acetylglucosaminyltransferase cDNA.

58 ions mediated by UDP-GlcNAc:GlcNAc-P-P-Dol N-acetylglucosaminyltransferase (chitobiosyl-P-P-lipid syn

59 irst demonstrate that I-branching beta1, 6-N-acetylglucosaminyltransferase cloned from human PA-1 emb

60 ne of the protein subunits of the alpha1-6-N acetylglucosaminyltransferase complex, which catalyses a

61 The four known mucin beta1,6-N-acetylglucosaminyltransferases contain nine conserved cy

62 d activity of glycosylating enzyme [beta]1,6 acetylglucosaminyltransferase (core 2 GlcNAc-T) is respo

63 The core 2 beta-1, 6-N-acetylglucosaminyltransferase (core 2 GnT) creates a bra

64 cloning of a HEV-expressed core1-beta 1,3-N-acetylglucosaminyltransferase (Core1-beta 3GlcNAcT) enab

65 f glycoproteins by leukocyte core2 beta1,6-N-acetylglucosaminyltransferase (Core2GlcNAcT-I).

66 ce sites SS#2 or SS#4 mostly via LARGE (like-acetylglucosaminyltransferase)-dependent glycans attache

67 roduced glycosyltransferases including key N-acetylglucosaminyltransferases (e.g., GnTI, GnTII, and G

68 The Golgi N-acetylglucosaminyltransferases encoded by Mgat1, Mgat2,

69 y non-conserved residue within the beta1,6-N-acetylglucosaminyltransferase family, Cys235, is also a

70 gation of O-fucose on Notch by the beta1,3-N-acetylglucosaminyltransferase Fringe modulates the abili

71 Upon expression of the beta3-N-acetylglucosaminyltransferase Fringe with Notch, we obse

72 lactosyltransferase or beta1-2- or beta1-6-N-acetylglucosaminyltransferase genes have been found in t

73 thesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.

74 es glycolipids is catalyzed by the beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4

75 GlcNAc transfer is mediated by a distinct N-acetylglucosaminyltransferase (GlcNAc-T) activity.

76 f the glycosylating enzyme core 2 beta 1,6-N-acetylglucosaminyltransferase (GlcNAc-T) through protein

77 of the regulatory enzyme lactosylceramide N-acetylglucosaminyltransferase (GlcNAc-Tr) with age in vi

78 lucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substr

79 A paralog of GnT-Vb, N-acetylglucosaminyltransferase (GnT-V), is expressed in m

80 Our previous studies on a beta1,6-N-acetylglucosaminyltransferase, GnT-IX (GnT-Vb), a homolo

81 ts of the multisubunit enzyme complex, GPI-N-acetylglucosaminyltransferase (GPI-GnT), involved in the

82 iaA), and the undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase homolog (wecA) produced si

83 gnificantly lower levels of core 2 beta1,6 N-acetylglucosaminyltransferase I (C2GlcNAcT-I), but no di

84 Core 2 beta1,6-N-acetylglucosaminyltransferase I (C2GnT-I) plays a pivota

85 ose of transcripts encoding core 2 beta1,6-N-acetylglucosaminyltransferase I (Core2GlcNAcT-I).

86 The Mgat1 gene encodes N-acetylglucosaminyltransferase I (Glc-NAc-TI; EC 2.4.1.10

87 ylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GlcNAc-TI, EC 2.4.1.101

88 lted in a marked and specific reduction in N-acetylglucosaminyltransferase I (GlcNAcT-I) activity and

89 ssion of erythropoietin (EPO) in a HEK293S N-acetylglucosaminyltransferase I (GnT I)(-/-) cell line r

90 N-acetylglucosaminyltransferase I (GNT-I) contributes to b

91 glycosylation caused by a mutation in the N-acetylglucosaminyltransferase I (GnT1) gene.

92 bryonic kidney 293 (HEK293S) cells lacking N-acetylglucosaminyltransferase I (GnTI(-)), and was recen

93 It was shown to lack N-acetylglucosaminyltransferase I (GnTI) activity, and con

94 e alpha-1,2-mannosidase and human beta-1,2-N-acetylglucosaminyltransferase I (GnTI) in the secretory

95 nt to the NH2-terminal retention signal of N-acetylglucosaminyltransferase I (NAGT I).

96 we identified a highly divergent T. brucei N-acetylglucosaminyltransferase I (TbGnTI) among a set of

97 dent UDP-GlcNAc:alpha3-D-mannoside beta1-2-N-acetylglucosaminyltransferase I activity (TbGnTI).

98 e O-glycan branching enzyme core 2 beta1,6-N-acetylglucosaminyltransferase I and its independent regu

99 and siRNA-mediated knockdown of the Golgi N-acetylglucosaminyltransferase I gene (MGAT1) induce part

100 nhibition of glycosylation in the Golgi by N-acetylglucosaminyltransferase I gene inactivation nor PN

101 s organism, no homologues of the canonical N-acetylglucosaminyltransferase I or II genes can be found

102 a-mannosidase I, Nicotiana tabacum beta1,2-N-acetylglucosaminyltransferase I, Arabidopsis Golgi alpha

103 the lowest levels, partial deficiencies in N-acetylglucosaminyltransferase I, II, and V (i.e. Mgat1,

104 lyltransferase, galactosyltransferase, and N-acetylglucosaminyltransferase I, was dramatically disrup

105 the protease was efficiently secreted from N-acetylglucosaminyltransferase I-deficient Lec1 Chinese h

106 te baculovirus, transduce HEK293S GnTI(-) (N-acetylglucosaminyltransferase I-negative) cells in suspe

107 expressed alpha-2,6-sialyltransferase and N-acetylglucosaminyltransferase-I (NAGT-I), both C-termina

108 electin ligands derived from core2 beta1,6-N-acetylglucosaminyltransferase-I null mice.

109 ly homologous to the I branching beta-1, 6-N-acetylglucosaminyltransferase (IGnT).

110 paucimannosidic N-glycans or elongated by N-acetylglucosaminyltransferase II (GNT-II) to produce com

111 erase family, encodes an equally divergent N-acetylglucosaminyltransferase II (TbGnTII) activity.

112 sect cell lines lacked adequate endogenous N-acetylglucosaminyltransferase II activity for biantennar

113 ng UDP-GlcNAc:alpha-6-d-mannoside beta-1,2-N-acetylglucosaminyltransferase II enzyme exhibit deficien

114 mammalian glycosyltransferases, including N-acetylglucosaminyltransferase II.

115 Mice lacking N-acetylglucosaminyltransferase III (GlcNAc-TIII) exhibit

116 N-acetylglucosaminyltransferase III (GlcNAc-TIII) is encod

117 N-Acetylglucosaminyltransferase III (GlcNAc-TIII), the pro

118 ene transfection of U373 MG cells with the N-acetylglucosaminyltransferase III (GnT-III).

119 gene expression of the responsible enzyme N-acetylglucosaminyltransferase III (GnT-III).

120 polylactosamine elongation by knockdown of N-acetylglucosaminyltransferase III or V had no effect on

121 Addition of O-GlcNAc by O-beta-N-acetylglucosaminyltransferase increased InsP(3)R-3 singl

122 chocystis sp. strain PCC6803, which encode N-acetylglucosaminyltransferases involved in peptidoglycan

123 on, suggesting developmental regulation of N-acetylglucosaminyltransferases IV and V and alpha6-fucos

124 ermore, the mRNA and protein expression of N-acetylglucosaminyltransferase IVa (GnT-IVa), which was r

125 f this capsular polysaccharide involves in N-acetylglucosaminyltransferase (KfiA) and d-glucuronyltra

126 The N-acetylglucosaminyltransferase known as GnT-Vb or -IX is

127 , which encodes an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase known to modify epidermal

128 ing as a result of the silencing of the like-acetylglucosaminyltransferase (LARGE) gene in a cohort o

129 Like-acetylglucosaminyltransferase (LARGE) is a bifunctional

130 Like-acetylglucosaminyltransferase (LARGE) is a key molecule

131 of alpha-dystroglycan (alpha-DG) by the like-acetylglucosaminyltransferase (LARGE) is required for it

132 se-alpha1,3-glucuronic acid-beta1-]n by like-acetylglucosaminyltransferase (LARGE) is required for th

133 at this modification is mediated by the like-acetylglucosaminyltransferase (LARGE) protein.

134 (myd) mice as a result of a mutation in like-acetylglucosaminyltransferase (LARGE), a glycosyltransfe

135 synaptic strength, as does knockdown of like-acetylglucosaminyltransferase (LARGE)--a glycosyltransfe

136 2 branching enzyme, termed core 2 beta-1,6-N-acetylglucosaminyltransferase-leukocyte type (C2GnT-L),

137 Bovine core 2 beta1,6-N-acetylglucosaminyltransferase-M (bC2GnT-M) catalyzes the

138 (hexosamine pathway) and in turn to Golgi N-acetylglucosaminyltransferases Mgat1, -2, -4, and -5.

139 le to interact with four different mannoside acetylglucosaminyltransferases (Mgat1, Mgat2, Mgat4B, an

140 n of beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) (P < 0.001) and ot

141 annosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (Mgat4) with UDP-GlcNAc.

142 annosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Mgat5) in the Golgi membr

143 annosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (Mgat5).

144 Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferases modulate Notch signaling

145 ue of the cellular core 2 protein beta-1,6-N-acetylglucosaminyltransferase-mucin type (C2GnT-M), whic

146 reased mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (ncOGT).

147 mutation in the gene encoding the alpha1-6-N-acetylglucosaminyltransferase necessary for the formatio

148 gosaccharides on the physiology of plants, N-ACETYLGLUCOSAMINYLTRANSFERASE (NodC) of Azorhizobium cau

149 GnT1IP-L inhibits other N-glycan branching N-acetylglucosaminyltransferases of the medial Golgi.

150 O-Linked N-acetylglucosaminyltransferase (OGT) catalyzes the transf

151 r, the mRNA for nucleocytoplasmic O-linked N-acetylglucosaminyltransferase (OGT) increases 3.4-fold w

152 er did not have a soluble inhibitor of the N-acetylglucosaminyltransferase or a hexosaminidase that c

153 ligand-synthesizing enzymes core-2 beta1,6-N-acetylglucosaminyltransferase or fucosyltransferases IV/

154 n is evident in protein O-mannose beta-1,2-N-acetylglucosaminyltransferase (POMGnT1) knockout mouse,

155 an glycans, the protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, POMGnT1.

156 ve identified an enzyme, polypeptide alpha-N-acetylglucosaminyltransferase (pp alpha-GlcNAc-T2), that

157 ZP3 and huZP3 affect the ability of core 2 N-acetylglucosaminyltransferase(s) to extend the core 1 se

158 up-regulated miRNAs, alpha-dystroglycan/like-acetylglucosaminyltransferase, spectrin, and myotrophin,

159 -N-acetylglucosaminyltransferase 1, and like-acetylglucosaminyltransferase that are required to synth

160 essed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthes

161 We demonstrate that MGAT4A, an N-acetylglucosaminyltransferase that installs the beta-1,4

162 ucosyltransferase-1) and Fringe, a beta1,3-N-acetylglucosaminyltransferase that modifies O-fucose in

163 Fringe is a fucose-specific beta1,3-N-acetylglucosaminyltransferase that modifies O-fucose moi

164 ge proteins are O-fucose-specific beta-1,3 N-acetylglucosaminyltransferases that glycosylate the extr

165 Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch recepto

166 Fringe proteins are beta3-N-acetylglucosaminyltransferases that modulate Notch activ

167 Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modulate signaling t

168 t in milk and the recently cloned beta-1,3-N-acetylglucosaminyltransferase, the formation of poly-N-a

169 ure of beta4Gal-TI and i-extension beta1,3-N-acetylglucosaminyltransferase, the major product was the

170 beta-1,6-N-Acetylglucosaminyltransferase V (EC 2.4.1.155) catalyzes

171 tivity and mRNA transcript levels encoding N-acetylglucosaminyltransferase V (GlcNAc-T V).

172 Changes in the levels of N-acetylglucosaminyltransferase V (GnT-V) can alter the fu

173 Beta1,6-acetylglucosaminyltransferase V (GnT-V) forms beta1,6 br

174 N-Acetylglucosaminyltransferase V (GnT-V) is an enzyme inv

175 The expression of N-acetylglucosaminyltransferase V (GnT-V) mRNA, which is r

176 mall interfering RNA-directed knockdown of N-acetylglucosaminyltransferase V (GnT-V), a glycosyltrans

177 man clinical samples, we demonstrated that N-acetylglucosaminyltransferase V (GnT-V)-mediated glycosy

178 eta(1,6)-linked GlcNAc, synthesized by the N-acetylglucosaminyltransferase V (GnT-V).

179 ycans caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).

180 rides caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).

181 including branched N-glycans generated by N-acetylglucosaminyltransferase V (Mgat5) activity, forms

182 N-Acetylglucosaminyltransferase V (MGAT5) mediates beta1,6

183 that beta1,6GlcNAc-branched complex-type (N-acetylglucosaminyltransferase V (Mgat5)) N-glycans on TC

184 cancer cells, galectin-3 binding to beta1,6-acetylglucosaminyltransferase V (Mgat5)-modified N-glyca

185 tylglucosamine:alpha-6-D-mannoside beta1,6-N-acetylglucosaminyltransferase V (MGAT5)-modified N-glyca

186 c4 and Lec13 cells, which are defective in N-acetylglucosaminyltransferase V and GDP-fucose synthesis

187 aberrant N-glycosylation caused by altered N-acetylglucosaminyltransferase V(GnT-V, GnT-Va, and Mgat5

188 periments indicated that HG-CD147 contains N-acetylglucosaminyltransferase V-catalyzed, beta1,6-branc

189 A glycosyltransferase that branches O-Man, N-acetylglucosaminyltransferase Vb (GnT-Vb), is highly exp

190 ther Fringe, an O-fucose specific beta 1,3-N-acetylglucosaminyltransferase, was capable of modifying

191 over, beta4Gal-TIV, together with beta-1,3-N-acetylglucosaminyltransferase, was capable of synthesizi

192 identified one glycosyltransferase, core 2 N-acetylglucosaminyltransferase, which is down-regulated i

193 C2) is a protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase whose product could be ext

194 re we report this enzyme is not a beta-1,3-N-acetylglucosaminyltransferase with catalytic activity to