ライフサイエンスコーパス: acetylhydrolase

1 oinflammatory actions are antagonized by PAF acetylhydrolase.

2 paraoxonase 1 and platelet activating factor acetylhydrolase.

3 ogical actions, and it is inactivated by PAF acetylhydrolase.

4 terase from Streptomyces scabies and a brain acetylhydrolase.

5 of intracellular platelet-activating factor acetylhydrolase.

6 hydrolyzed and inactivated by the enzyme PAF-acetylhydrolase.

7 vating factor (PAF) and is also known as PAF acetylhydrolase.

8 residues of PAF, as a candidate for aspirin acetylhydrolase.

9 t after pretreatment of the extract with PAF acetylhydrolase.

10 )), also known as platelet-activating factor acetylhydrolase.

11 nit of the enzyme platelet-activating factor acetylhydrolase.

12 te of degradation, which is catalyzed by PAF acetylhydrolase.

13 hydrolyzed and inactivated by the enzyme PAF acetylhydrolase.

14 tive cells now contained an abundance of PAF acetylhydrolase.

15 -treated animals contained no detectable PAF acetylhydrolase.

16 PAF acetylhydrolase 1b (PAFAH1B) hydrolyzes PAF and is compo

17 Platelet-activating factor acetylhydrolase 1B1 (LIS1), a critical mediator of neuro

18 s of type I platelet-activating factor (PAF) acetylhydrolase, a phospholipase A(2) with selectivity f

19 Plasma PAF-acetylhydrolase activity increased 2-fold by 24 h follow

20 rates that plasma platelet-activating factor acetylhydrolase activity increases in men and women with

21 Miwa et al. reported that PAF acetylhydrolase activity is absent in 4% of the Japanese

22 ing that baseline platelet-activating factor acetylhydrolase activity levels are related to the sever

23 al antibody (MAb), 2B11, neutralized the PAF acetylhydrolase activity of SsE.

24 O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity was not observed.

25 oteins, increased platelet-activating factor acetylhydrolase activity, and secretory phospholipase A(

26 PAF levels and a concurrent decrease in PAF acetylhydrolase activity.

27 was observed for platelet activating factor acetylhydrolase alpha (Paf-AHalpha), and, in mammalian c

28 Plasma PAF acetylhydrolase, an enzyme that hydrolyzes PAF and struc

29 of a brain platelet-activating factor (PAF) acetylhydrolase, an enzyme that inactivates PAF by hydro

30 PAF acetylhydrolase, an oxidized phospholipid phospholipase

31 Enzymes associated with HDL such as PAF acetylhydrolase and paraoxonase can participate in the e

32 t determining whether SsE(M28) is also a PAF acetylhydrolase and participates in innate immune evasio

33 receptor 2/CD21, platelet-activating factor acetylhydrolase, and oxidized low-density lipoprotein re

34 The platelet-activating factor acetylhydrolases are enzymes that were initially charact

35 ot associate with LDL), the mutant mouse PAF acetylhydrolase associated with lipoproteins.

36 Plasma platelet-activating factor acetylhydrolase becomes progressively activated as ather

37 PAF acetylhydrolase catalyzes the degradation of PAF and rel

38 s of paraoxonase, platelet-activating factor acetylhydrolase, ceruloplasmin, and apoJ in HDL occur du

39 ith a recombinant platelet-activating factor acetylhydrolase completely abolishes the proapoptotic ef

40 ssociation defines the physical state of PAF acetylhydrolase, confers a long half-life, and is a majo

41 We asked if PAF acetylhydrolase deficiency correlates with the incidence

42 We found that the prevalence of PAF acetylhydrolase deficiency is higher in Japanese asthmat

43 Recombinant PAF-acetylhydrolase degrades PAF generated by NMDA-receptor

44 lasma samples from subjects deficient in PAF acetylhydrolase do not release F2-isoprostanes from este

45 In human plasma, PAF acetylhydrolase (EC 3.1.1.47) circulates in a complex wi

46 m, using acetylcholinesterase (acetylcholine acetylhydrolase; EC 3.1.1.7; abbreviated herein AChE) as

47 ulated in oxLDL with a recombinant human PAF acetylhydrolase eliminated the inhibitory effects of oxL

48 We examined the regulation of PAF acetylhydrolase expression and demonstrated the administ

49 pffer cells were established in culture, PAF-acetylhydrolase expression became constitutively activat

50 The up-regulation of the plasma-type PAF acetylhydrolase expression constitutes an important mech

51 B 2170, inhibited by 50% the increase in PAF acetylhydrolase expression in response to LPS.

52 Alterations in plasma-type PAF-acetylhydrolase expression may constitute an important m

53 ssues examined, the greatest increase in PAF acetylhydrolase expression was observed in lung followed

54 uman plasma platelet-activating factor (PAF) acetylhydrolase functions by reducing PAF levels as a ge

55 ng the 5' genomic sequence of the plasma PAF acetylhydrolase gene and further characterized the promo

56 nor with an inactivating mutation in the PAF acetylhydrolase gene did not hydrolyze oxidized phosphol

57 Finally, deletion of the oxaloacetate acetylhydrolase gene in H915-1 eliminated oxalate format

58 We conclude that the PAF acetylhydrolase gene is a modulating locus for the sever

59 A missense mutation (V279F) in the PAF acetylhydrolase gene results in the complete loss of act

60 ined the regulation of expression of the PAF acetylhydrolase gene.

61 d that both the intracellular and plasma PAF acetylhydrolases have high affinity for esterified F2-is

62 FAH1B2, but not its family member plasma PAF acetylhydrolase, hydrolyzed aspirin, and PAF competitive

63 man gene encoding platelet-activating factor acetylhydrolase IB subunit alpha (Pafah1b1), also called

64 atelet-activating factor metabolizing enzyme acetylhydrolase II blunted alpha-toxin-induced arachidon

65 The intracellular PAF acetylhydrolase II, which shares homology to the plasma

66 f paraoxonase and platelet-activating factor acetylhydrolase in HDL decreased after infection and rea

67 ing did not reveal detectable amounts of PAF acetylhydrolase in PON1 preparations, although very low

68 LPS resulted in increased expression of PAF acetylhydrolase in several tissues.

69 In addition, this enzyme acted as a PAF-acetylhydrolase in the absence of lipid acceptor molecul

70 tumor cells with platelet-activating factor acetylhydrolase inhibited tumor growth at the site of im

71 or PAFAH1B3, and the competitive type I PAF acetylhydrolase inhibitor NaF reduced erythrocyte hydrol

72 y of plasma platelet-activating factor (PAF) acetylhydrolase is an autosomal recessive syndrome that

73 paraoxonase 1 or platelet-activating factor acetylhydrolase is responsible for the antioxidant activ

74 We conclude that intracellular type I PAF acetylhydrolase is the major aspirin hydrolase of human

75 We show that inherited deficiency of PAF acetylhydrolase is the result of a point mutation in exo

76 We conclude that PAF acetylhydrolase is the sole phospholipase A(2) of HDL an

77 A2, also known as platelet-activating factor acetylhydrolase, is a new risk factor that may have the

78 in zeta-1 (FEZ1), platelet-activating factor acetylhydrolase, isoform Ib, PAFAH1B1 or lissencephaly 1

79 These data on the molecular basis of the PAF acetylhydrolase-LDL association provide a new level of u

80 otein (apo) B100 in the formation of the PAF acetylhydrolase-LDL complex, we tested the ability of PA

81 important mechanism for elevating plasma PAF-acetylhydrolase levels and an important component in min

82 olipids turnover in vivo and the role of PAF acetylhydrolase/Lp-PLA(2) in this process.

83 eparations, although very low amounts of PAF acetylhydrolase might still account for PON1 phospholipa

84 osure with the production of plasma-type PAF acetylhydrolase mRNA and protein expression specifically

85 ed the tissue distribution of the plasma PAF acetylhydrolase mRNA in humans.

86 Additionally, the expression of PAF acetylhydrolase mRNA increased in circulating leukocytes

87 cells were responsible for the increased PAF-acetylhydrolase mRNA levels.

88 tration had no effect on the increase in PAF-acetylhydrolase mRNA seen at 24 h.

89 onstrated very low levels of plasma-type PAF-acetylhydrolase mRNA transcripts in the livers of saline

90 ing LPS exposure, a 20-fold induction of PAF-acetylhydrolase mRNA was detected.

91 In Kupffer cells, plasma-type PAF-acetylhydrolase mRNA was induced by 12 h, peaked at 24 h

92 barely detectable levels of plasma-type PAF-acetylhydrolase mRNA, when Kupffer cells were establishe

93 Oxalacetate acetylhydrolase (OAH), a member of the phosphoenolpyruva

94 different biochemical pathways, oxaloacetate acetylhydrolase (OAH)-catalyzed hydrolytic cleavage of o

95 grates with platelet-activating factor (PAF) acetylhydrolase on KBr density gradients.

96 an also be blocked by co-incubation with PAF acetylhydrolase, or a PAF receptor antagonist.

97 ng whether plasma platelet-activating factor acetylhydrolase, or lipoprotein-associated phospholipase

98 he plasma form of platelet-activating factor acetylhydrolase (PAF AH) in tissue macrophages.

99 ymes paraoxonase, platelet activating factor acetylhydrolase (PAF), and glutathione peroxidase.

100 lved to target PAF by characterizing the PAF acetylhydrolase (PAF-AH) activity and substrate specific

101 PAF acetylhydrolase (PAF-AH) degrades PAF and regulates its

102 Platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 that inac

103 PAF acetylhydrolase (PAF-AH) is a recently isolated naturall

104 The enzyme platelet-activating factor acetylhydrolase (PAF-AH) rapidly degrades PAF and oxidiz

105 ine hydrolysis or platelet-activating factor acetylhydrolase (PAF-AH) treatment.

106 sma form of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-asso

107 tivity represents platelet-activating factor acetylhydrolase (PAF-AH), an esterase that co-purifies w

108 ontains secretory platelet-activating factor acetylhydrolase (PAF-AH), the enzyme capable of hydrolyz

109 PAF acetylhydrolase (PAF-AH), which is known to hydrolyze po

110 These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH).

111 active metabolite lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH).

112 active lyso-PAF by cellular and secreted PAF-acetylhydrolase (PAF-AH).

113 Platelet-activating factor acetylhydrolases (PAF-AHs) are a group of enzymes that h

114 Platelet-activating factor acetylhydrolases (PAF-AHs) play an important role in the

115 ied out by specific intra- and extracellular acetylhydrolases (PAF-AHs), a subfamily of phospholipase

116 enzyme activity (platelet-activating factor acetylhydrolase [PAF-AH] and superoxide dismutase) were

117 A single enzyme (plasma PAF acetylhydrolase [PAF-AH] or lipoprotein-associated phosp

118 PAF-CPT), and its main catabolic enzyme (PAF acetylhydrolase; PAF-AH), on U937 cells, in cell free an

119 We report that platelet-activating factor acetylhydrolase (PAFAH) Ib, comprised of two phospholipa

120 2) enzyme complex platelet-activating factor acetylhydrolase (PAFAH) Ib, which consists of alpha1, al

121 reduced turnover due to lower levels of PAF acetylhydrolase (PAFAH), the enzyme that catabolizes PAF

122 ng was restored by HDL or HDL-associated PAF acetylhydrolase (PAFAH), which mediates inactivation of

123 inished levels of platelet-activating factor acetylhydrolase (PAFAH).

124 alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) at the chromosomal breakpoint

125 e beta subunit of platelet-activating factor acetylhydrolase (PAFAH1B1, also known as LIS1) in humans

126 acellular form of platelet-activating factor acetylhydrolase, PAFAH1b2.

127 Platelet-activating factor acetylhydrolase (PLA2G7) is a potent pro- and anti-infla

128 Our results suggested that PAF acetylhydrolases play key roles in the hydrolysis of F2-

129 LA2), also called platelet-activating factor acetylhydrolase, plays in atherosclerosis.

130 Human plasma platelet activating factor acetylhydrolase (pPAF-AH) is a phospholipase A(2) that s

131 (PAF)-like lipids in L5 by a recombinant PAF acetylhydrolase prevented both FGF-2 downregulation and

132 The abundance of PAF acetylhydrolase production in the liver lobule likely li

133 There are multiple regions in the PAF acetylhydrolase promoter that contain responsive element

134 A2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylch

135 A crystal structure is also presented of PAF acetylhydrolase reacted with the organophosphate compoun

136 termination of PAF action by recombinant PAF-acetylhydrolase (rPAF-AH) were investigated.

137 ammatory activities of recombinant human PAF-acetylhydrolase (rPAF-AH), which converts PAF to biologi

138 rats were treated with human recombinant PAF acetylhydrolase (rPAF-AH), which efficiently inactivates

139 LA(2)) and plasma platelet-activating factor acetylhydrolase (rPAF-AH).

140 determine whether platelet-activating factor acetylhydrolase Sse and streptolysin S (SLS) have synerg

141 The platelet-activating factor (PAF) acetylhydrolase SsE produced by GAS is required for inva

142 for SpeB and the platelet-activating factor acetylhydrolase Sse, and a new type of variant that had

143 1 copurifies with platelet-activating factor acetylhydrolase subunits alpha 1 and alpha 2 [12], and w

144 ernalized, and overexpression of PLA2g7 (PAF acetylhydrolase) that specifically hydrolyzes such oxidi

145 phospholipase A2 (platelet-activating factor acetylhydrolase), the expression of which is regulated b

146 ctive metabolite, lysoPAF, by the enzyme PAF acetylhydrolase, the activity of which has shown to corr

147 h can be prevented by co-incubation with PAF acetylhydrolase, the enzyme that catabolizes PAF in the

148 se-LDL complex, we tested the ability of PAF acetylhydrolase to bind to lipoproteins containing trunc

149 1 purification by first depleting HDL of PAF acetylhydrolase to find PON1 purified in this way no lon

150 Studies using PAF acetylhydrolase transgenic mice indicated that these ani

151 ins within the primary sequence of human PAF acetylhydrolase, tyrosine 205 and residues 115 and 116,

152 When residues 115 and 116 from human PAF acetylhydrolase were introduced into mouse PAF acetylhyd

153 PS) significantly inhibited synthesis of PAF acetylhydrolase, whereas other cytokines, including IFNa

154 etylhydrolase were introduced into mouse PAF acetylhydrolase (which normally does not associate with

155 h lower levels of platelet activating factor acetylhydrolase, which may contribute to the loss of ant

156 is effectively and tightly regulated by PAF acetylhydrolases, which convert PAF back to lysoPAF.

157 B plays a key role in the association of PAF acetylhydrolase with LDL.