1 yseal dysplasia, atelosteogenesis type 2 and achondrogenesis 1B (ACG-1B).

2 tified, we find that individuals with severe achondrogenesis 1B phenotype have null mutations on both

3 skeletal dysplasia in humans, suggested that achondrogenesis type 1A may be caused by GMAP-210 defici

4  mutations in the 10 unrelated patients with achondrogenesis type 1A whom we studied.

5 pes in these mice and those in patients with achondrogenesis type 1A, a neonatal lethal form of skele

6 t a third even more severe chondrodysplasia, achondrogenesis type IB, is also caused by mutations in

7                                 They include achondrogenesis type II, hypochondrogenesis, spondyloepi