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2 ger for no medication than for standard-dose aciclovir (13 h vs 7 h; p=0.01) and for standard-dose va
4 rd-dose valaciclovir (22.6) versus high-dose aciclovir (20.2; p=0.54), and standard-dose valaciclovir
5 her for no medication than for standard dose aciclovir (3.3 vs 2.9; p=0.02), and for standard-dose va
6 signed by block randomisation to twice daily aciclovir 400 mg (n=1637) or matching placebo (n=1640) f
7 numbers in blocks of four to receive either aciclovir 400 mg orally twice daily or placebo; particip
8 ss-over studies comparing no medication with aciclovir 400 mg twice daily (standard-dose aciclovir),
10 0 mg daily (standard-dose valaciclovir) with aciclovir 800 mg three times daily (high-dose aciclovir)
11 tiretrovirals, such as the anti-herpes drugs Aciclovir and Ganciclovir and the anti-cancer drug Clofa
12 ciclovir 800 mg three times daily (high-dose aciclovir), and standard-dose valaciclovir with valacicl
13 se with CD4 counts >or=350 cells per microL, aciclovir delayed risk of CD4 cell counts falling to <35
14 4, 18.1% of swabs) than in the standard-dose aciclovir group (25, 1.2%; incidence rate ratio [IRR] 0.
15 of HIV-1 was 3.9 per 100 person-years in the aciclovir group (75 events in 1935 person-years of follo
17 rence to dispensed study drug was 94% in the aciclovir group and 94% in the placebo group, and 85% of
21 t suppressive therapy with standard doses of aciclovir is not effective in reduction of HIV-1 acquisi
23 investigated the effect of daily suppressive aciclovir on HIV-1 disease progression in Rakai, Uganda.
24 onsisted of cotrimoxazole, itraconazole, and aciclovir (or valganciclovir for asymptomatic cytomegalo
27 aciclovir 400 mg twice daily (standard-dose aciclovir), valaciclovir 500 mg daily (standard-dose val
29 investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition.
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