ライフサイエンスコーパス: acid catalysis

1 ol by chiral BINOL-phosphoric acid (Bronsted acid catalysis).

2 low-energy pathways under water or sulfuric acid catalysis.

3 blished as a new activation mode in Bronsted acid catalysis.

4 e ester was studied with and without general-acid catalysis.

5 PT is likely to involve general base-general acid catalysis.

6 ue Trp354 to Ala completely disables general acid catalysis.

7 aC excision, which involves solvent-mediated acid catalysis.

8 rahydrothiophene derivatives with phosphinic acid catalysis.

9 metal photoredox catalysis with chiral Lewis acid catalysis.

10 nted phenomenon in enantioselective Bronsted acid catalysis.

11 ctivity and position the metal ion for Lewis acid catalysis.

12 indolines using silver(I)/chiral phosphoric acid catalysis.

13 , and its rate is not markedly influenced by acid catalysis.

14 reaction merges aerobic oxidation and Lewis acid catalysis.

15 ons brings about unusual reactivity in Lewis acid catalysis.

16 mical cycles that define energy relations in acid catalysis.

17 ither under thermal conditions or with Lewis acid catalysis.

18 ate is subject to both specific- and general-acid catalysis.

19 metals such as Zn(2+) for mediating nucleic acid catalysis.

20 solid HF equivalents for similar alkylation acid catalysis.

21 hydrolysis of mNBP, consistent with general acid catalysis.

22 rates and a His-Glu pair involved in general acid catalysis.

23 e on the leaving group and efficient general acid catalysis.

24 at these reactions involve only weak general acid catalysis.

25 eviously been unavailable using chiral Lewis acid catalysis.

26 gen bonding plays a crucial role in Bronsted acid catalysis.

27 n transition state stabilization and general acid catalysis.

28 sted plot that was characteristic of general acid catalysis.

29 e phosphatase conformation, enabling general acid catalysis.

30 clearly indicated the involvement of general acid catalysis, a hallmark of protein-tyrosine phosphata

31 that ligate RNA expand the scope of nucleic acid catalysis and allow preparation of site-specificall

32 Classical SNAr methods using acid catalysis and elevated temperatures could not be ex

33 ansition-state stabilization through general-acid catalysis and freeing of three water molecules trap

34 is acids in stoichiometric reactivity, Lewis acid catalysis and frustrated Lewis pair (FLP) reactivit

35 ities for metal carbene generation and Lewis acid catalysis and in the cost of the precious metal rho

36 ize N3-protonated forms of caC to facilitate acid catalysis and suggesting that N191A-TDG could poten

37 olysis; this reaction is subject to specific acid catalysis and to nucleophilic catalysis by 1-hydrox

38 f biomass-derived levulinic acid under solid acid catalysis and treatment of the resulting angelica l

39 ammonium ion activates the enone by Bronsted acid catalysis, and the catalyst's hydroxyl group orient

40 dings and their relevance to chiral Bronsted acid catalysis are discussed.

41 en bond mechanism as well as hidden Bronsted acid catalysis are frequently discussed as possible expl

42 nt of the flexible loop that enables general acid catalysis are presented.

43 ther enzymatic KIEs with and without general acid catalysis, are consistent with a loose transition s

44 t a role for rescuing nucleobases in general acid catalysis, because a nucleobase that contributes ge

45 ition state for cleavage of 1-F from general acid catalysis by 0.80 M cyanoacetate buffer at pH 1.7.

46 de support for a mechanism involving general-acid catalysis by a conserved adenine residue in the act

47 Acid catalysis by hydronium ions is ubiquitous in aqueou

48 ntal investigations rule out hidden Bronsted acid catalysis by partial decomposition of I2 to HI and

49 ion of fructose and HMF compared to Bronsted acid catalysis by promoting side reactions.

50 e was the major product as a result of Lewis acid catalysis by Sn(2+).

51 p of the substrate in conjunction with Lewis acid catalysis by the bound zinc.

52 te the individual rate constants for general-acid catalysis by the diacid and monoacid forms of succi

53 aving group (Cys-35) via an enforced general acid catalysis by trapping mechanism.

54 the catalytic diad which strengthens general acid catalysis by Tyr-14.

55 Cleavage of BPA in HTW occurs by specific acid catalysis, by specific base catalysis, and by gener

56 inia, we have examined the effect on general acid catalysis caused by mutations to two conserved resi

57 Application of the new acid catalysis conditions has afforded diverse bacterioc

58 urvey of >20 acids identified four promising acid catalysis conditions of which TMSOTf/2,6-di-tert-bu

59 The prior acid-catalysis conditions [BF(3) x O(Et)(2) in CH(3)CN a

60 he huge success of enantioselective Bronsted acid catalysis, experimental data about structures and a

61 e applicability of enantioselective Bronsted acid catalysis, experimental insight into transition sta

62 We established the requirement of general acid catalysis for E-P formation in reactions with high

63 yl, and benzyl moieties are found to require acid catalysis for efficient hydrolysis.

64 e ion on the scissile phosphate, and general acid catalysis for protonation of the leaving 3'-O anion

65 revious studies that Cdc25A utilizes general acid catalysis for substrates with a leaving group pK(a)

66 system reacted by means of concerted general acid catalysis (found to be a so-called D(N)A(N)A(H)D(xh

67 d sodium hypophosphite (peroxide initiators, acid catalysis, heat), the method proceeds under neutral

68 ivity of various types of lignin linkages in acid catalysis in conjunction with stabilization of reac

69 uction cascade using TEMPO-BAIB-HEH-Bronsted acid catalysis in DMPU as solvent and a stoichiometric a

70 The role of acid catalysis in oxacalix[3]arene synthesis has been in

71 General acid catalysis in protein tyrosine phosphatases (PTPases

72 ted by TFA and is a rare example of Bronsted acid catalysis in radical addition reactions.

73 ew general approach to accelerating Bronsted acid catalysis in solution.

74 ecause a nucleobase that contributes general acid catalysis in the cleavage pathway should provide ge

75 a general base mechanism with likely general acid catalysis in the oxidative decarboxylation of D-mal

76 ssess the functional significance of general acid catalysis in the system.

77 Our results show that the process of general acid catalysis is complex and suggest that Lys-167 and A

78 the alkane peroxyflavin intermediate, while acid catalysis is needed for the protonation of the FMNO

79 y clearly corroborating that hidden Bronsted acid catalysis is not operating with our Lewis acid.

80 In the Phe mutant, general acid catalysis is partially effective, but the proton is

81 General acid catalysis is rendered inoperative by the Lys mutati

82 Diarylborinic acid catalysis is shown to be an efficient and general m

83 igh and low pH, indicating that general base/acid catalysis is the rate-limiting step.

84 alkane C-H bond activation in heterogeneous acid catalysis is unknown.

85 Biochemical experiments suggest that general acid catalysis may occur through the N3 position, which

86 Furthermore, the prediction that general acid catalysis may only be effective in low dielectric m

87 This unique acid-catalysis mechanism had been ascribed to the nucleo

88 ides an explanation for the impaired general acid catalysis observed in kinetic experiments with Trp

89 acid and the imidazolium ion showed general acid catalysis of 18.5 and 1.5 M-1 sec-1, respectively,

90 the native protein, this H(2)O could provide acid catalysis of dioxygen reduction at the reduced trin

91 the conclusion that Glu-461 provides general acid catalysis of leaving group departure, which is most

92 sion with the alkyl substrate, while general acid catalysis of pNPP by YopH is more synchronous with

93 4 on the scissile phosphodiester and general-acid catalysis of the expulsion of the 5'-deoxyribose ox

94 is observation supports Glu19-CO(2)H general acid catalysis of the formation of mutant.III.

95 HN) and CHI.TS, we found: (i) Lys-97-general-acid catalysis of the O2'(-) nucleophilic addition; (ii)

96 tial abstraction of the 2-proton by Lys 220, acid catalysis of the vinylogous beta-elimination of the

97 gly catalyzed by the hydroxide ion but shows acid catalysis only at pH < 1.

98 ical reaction (carbonyl reduction) by either acid catalysis or by a propinquity effect and where thes

99 btained cleanly from the Cl(9) compound with acid catalysis or by reduction with mercury.

100 phosphodiester cleavage, either for general acid catalysis or for electrostatic stabilization.

101 synthetic xanthone targets it was found that acid catalysis promoted their isomerization to thermodyn

102 chemical experiments are indicative of Lewis-acid catalysis rather than a metal template-controlled p

103 ed with Fe(III) imparting activity for Lewis acid catalysis (regioselective methanolysis ring-opening

104 rs to incorporate a lesser degree of general-acid catalysis, relative to the 2,3-isomer.

105 We address here the manner in which acid catalysis senses the strength of solid acids.

106 to study the proton-transfer step in general acid catalysis that is facilitated by the catalytic Mg2+

107 Even without general acid catalysis, the D262N mutant reaction is activated b

108 d 1,3-hydroxyalkyl azides with ketones under acid catalysis; the initial reaction affords an iminium

109 allylidene-indenedione derivatives and under acid-catalysis they are additionally transformed to 2-(1

110 riegee intermediates and H2 S under water or acid catalysis, thioladehydes could be detected in a hyd

111 We have shown that, under Bronsted acid catalysis, this reaction is reversible and therefor

112 data that points to a novel mode of general acid catalysis through the N3 position of an adenine nuc

113 bvious path from an interest in chiral Lewis acid catalysis to a project focused on the development o

114 thers 1a-e reacted with styrenes under Lewis acid catalysis to give novel polysubstituted thiochroman

115 their detailed understanding of chiral Lewis acid catalysis to stereocontrol in reactions involving e

116 nd the proton field is postulated to provide acid catalysis to the conjugation reaction.

117 levels of endo addition attained from Lewis acid catalysis translate to trans hydrindene junctions u

118 f the substrates are polarized through Lewis acid catalysis via complexation with the beta-metal ion,

119 Acid catalysis was a factor when there was reduced react

120 Finally an acid catalysis was used to break down proanthocyanidin c

121 Acid catalysis, which is often employed in Schiff base s

122 A1 performs general acid catalysis while G33 acts as a general base.

123 that activates the electrophile by Bronsted acid catalysis, while the urea group binds the nucleophi