ライフサイエンスコーパス: acid ceramidase

1 min reduced transcriptional up-regulation of acid ceramidase.

2 D2646, to inhibit the hydrolytic activity of acid ceramidase.

3 ped to produce and purify recombinant, human acid ceramidase.

4 These data indicate that ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzym

5 In this study, we identified acid ceramidase (A-CDase) as a general transcription tar

6 The expression of acid ceramidase (AC) - a cysteine amidase that hydrolyse

7 (e) whether physiological hypoxia increased acid ceramidase (AC) expression; and (f) the effect of t

8 Acid ceramidase (AC) hydrolyzes ceramides, which are cen

9 s regulating ulcerative colitis, the role of acid ceramidase (AC) in intestinal inflammation is yet t

10 Acid ceramidase (AC) is a key regulatory enzyme involved

11 Acid ceramidase (AC) is a lysosomal cysteine amidase tha

12 Acid ceramidase (AC) is a lysosomal cysteine hydrolase t

13 Acid ceramidase (AC) is an intracellular cysteine amidas

14 Acid ceramidase (AC) is the lysosomal enzyme that degrad

15 Autoproteolytic cleavage of the inactive acid ceramidase (AC) precursor into the active heterodim

16 In addition, the acid ceramidase (AC) was also upregulated by Ca2+(o); an

17 demonstrate that ceramide-deacylating enzyme acid ceramidase (AC) was preferentially upregulated in i

18 C12 myotubes that constitutively overexpress acid ceramidase (AC), an enzyme that catalyzes the lysos

19 ons revealed that desipramine down-regulated acid ceramidase (AC), but not sphingosine kinase, at the

20 The cysteine amidase, acid ceramidase (AC), hydrolyzes these substances into s

21 show that the ceramide-metabolizing enzyme, acid ceramidase (AC), is expressed in human cumulus cell

22 in the gene (Asah1) encoding one ceramidase, acid ceramidase (AC), lead to the lysosomal storage diso

23 h cDNA and genomic sequences encoding murine acid ceramidase (AC; E.C. 3.5.1.23) have been isolated a

24 Herein we report the mechanism of human acid ceramidase (AC; N-acylsphingosine deacylase) cleava

25 Interestingly, cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5

26 cumulation of ceramide through inhibition of acid ceramidase (aCDase).

27 Acid ceramidase activities in skin fibroblasts and EBV-t

28 e detected, providing an accurate measure of acid ceramidase activity as low as 0.1 pmol/mg protein/h

29 phages revealed rapid internalization of the acid ceramidase activity from the hamster cell media but

30 s study reports a new assay method to detect acid ceramidase activity in vitro using Bodipy or lissam

31 be useful wherever the in vitro detection of acid ceramidase activity is of importance.

32 A deficiency of acid ceramidase activity results in the lipid storage di

33 ctate, perinuclear distribution, although no acid ceramidase activity was detected in the transfected

34 id, and highly sensitive method to determine acid ceramidase activity, and that it could be useful wh

35 Using mouse kidney extracts as the source of acid ceramidase activity, this new method was compared w

36 er disease patient to the same extent as the acid ceramidase activity.

37 a provide important new information on human acid ceramidase and further document its central role in

38 s no effect on transcriptional activation of acid ceramidase and that CerS2 slightly but significantl

39 These studies provide new insights into acid ceramidase and the related lipid hydrolase, acid sp

40 se analysis of sequences homologous to human acid ceramidase (ASAH) revealed a 1233-bp cDNA (previous

41 Acid ceramidase (ASAH1) plays a pivotal role in regulati

42 CR analysis revealed that only expression of acid ceramidase (ASAH1) was increased.

43 Moreover, suppression of expression of acid ceramidase (ASAH1), an enzyme that produces SPH, in

44 we report detailed characterization of this acid ceramidase-associated "reverse activity" and provid

45 Blocking acid ceramidase but not sphingosine kinase activity in a

46 rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as earl

47 Acid ceramidase, expressed in a recombinant SV, decrease

48 beta1-integrins downregulate acid ceramidase expression, resulting in further accumul

49 -(alpha) and 40 (beta)-kDa subunits as human acid ceramidase from natural sources, had an acidic pH o

50 or in cells, and it was a poor inhibitor of acid ceramidase (IC50>500 microM).

51 S6 can mediate transcriptional activation of acid ceramidase in a JNK-dependent manner that is indepe

52 Loss of acid ceramidase in myeloid cells suppresses intestinal n

53 Overexpression of acid ceramidase in normal human skin fibroblasts also le

54 ure (renamed human ASAHL since it is a human acid ceramidase-like sequence), chromosomal location, pr

55 macrophages have high constitutive levels of acid ceramidase mRNA, protein, and activity.

56 Acid ceramidase (N-acylsphingosine amidohydrolase) is th

57 morpholino-1-propanol (PDMP), which inhibits acid ceramidase or glucosylceramide synthase and then in

58 Using an acid ceramidase promoter driven luciferase reporter plas

59 s method utilizes purified human recombinant acid ceramidase to completely hydrolyze ceramide to sphi

60 this activity could be co-precipitated with acid ceramidase using anti-ceramidase antibodies.

61 The increase in acid ceramidase was confirmed by expression and activity

62 tigated sphingolipid pathways and found that acid ceramidase was constitutively overexpressed in leuk

63 Human acid ceramidase was overexpressed in Chinese hamster ova

64 The high levels of acid ceramidase were specific to alveolar macrophages, b