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1 cells treated with an inhibitor of lysosomal acid lipase.
2 owing cholesteryl esters to be hydrolyzed by acid lipase.
3 uence derived from the propiece of lysosomal acid lipase.
4 Castor bean endosperm contains a well known acid lipase activity that is associated with the oil bod
6 tudies indicate that administrated lysosomal acid lipase affects the atherogenesis by at least two me
7 that one of the early compartments contains acid lipase (AL), the enzyme required for liberating cho
9 s we have previously described, in lysosomal acid lipase and glucocerebrosidase, and localizes to str
10 eview will focus on the role(s) of lysosomal acid lipase and its use as an enzyme therapy to reduce a
11 LDL-CE hydrolysis is catalyzed by lysosomal acid lipase; (b) neither scavenger receptors nor the LDL
12 NPC1 and NPC2 and several digestive enzymes (acid lipase, beta-glucuronidase, and cathepsins B and D)
13 d cell growth and emphysema during lysosomal acid lipase deficiency are partially caused by peroxisom
14 broblasts from patients with WD (a lysosomal acid lipase deficiency characterized by excessive lipid
17 herapy in children and adults with lysosomal acid lipase deficiency, an underappreciated cause of cir
18 Fabry's disease, Pompe's disease, lysosomal acid lipase deficiency, and five types of mucopolysaccha
22 ter and triglyceride metabolism in lysosomal acid lipase gene knockout mice (lal-/-) results in sever
23 stem was used to reintroduce human lysosomal acid lipase (hLAL) expression into LAL gene knockout (la
24 or NPC2 protein in NPC disease or lysosomal acid lipase in Wolman disease results in defective cellu
28 The underlying mechanisms that lysosomal acid lipase (LAL) deficiency causes infiltration of myel
40 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of el
42 (CESD), an inherited deficiency of lysosomal acid lipase (LAL), is an underappreciated cause of progr
44 the effect of lalistat, a specific lysosomal acid lipase (LAL/Lipa) inhibitor on LD degradation in HS
46 rganelles, which in turn indirectly inhibits acid lipase, leading to a subsequent accumulation of cho
47 by mutations in the gene encoding lysosomal acid lipase (LIPA) that result in reduced or absent acti
48 e maintenance of AT; deficiency in lysosomal acid lipase (Lipa), the enzyme required for lysosome lip
49 e worm Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear translocalization o
50 mice, genomic clones for the mouse lysosomal acid lipase (mLAL) gene were isolated and characterized.
51 on of the lysosomal hydrolase LAL (lysosomal acid lipase) to mobilize FA for FAO and memory T cell de
53 with sham-treated mice, the human lysosomal acid lipase-treated mice also have reduced levels of pla
55 t involves two lysosomal proteins, lysosomal acid lipase, which hydrolyzes C esters, and NPC1 (Nieman
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