ライフサイエンスコーパス: acid-base

1 is balanced out by paracellular shunting of acid/base.

2 n the same way as through the standard amino acid based 13C MFA, and quantify the amount of informati

3 que to the conventional template based Lewis acid/base activation methods, herein, we report on a sim

4 biological approaches to catalysis-Bronsted acid/base activation-with this abundant reagent.

5 rmation proceeded via essentially one-to-one acid-base addition for all of the clusters, independent

6 rough introduction of stoichiometric boronic acid-based additives.

7 ystallization has been embodied as the Lewis acid-base adduct formed by metal halides (serve as Lewis

8 it is proposed to constitute efficient Lewis acid-base adduct in the SnI2 deposition step to modulate

9 city of an added base is suppressed by Lewis acid/base adduct formation.

10 ripping under equilibrium control with Lewis acid-base adducts of BF3.

11 results in the formation of classical Lewis acid-base adducts.

12 opharmacology, not previously seen for amino acid-based AMPA receptor antagonists, X-ray crystal stru

13 pid tests for tuberculosis including nucleic acid-based amplification tests, imaging, and breath anal

14 Microbial biomass using fatty acid-based analysis indicated that the youngest basins h

15 sults from a combination of attractive Lewis acid-base and hydrogen-bonding interactions, as well as

16 ntion was obtained on a ZrO2 column by Lewis acid-base and hydrophilic interactions with acetonitrile

17 anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in

18 ts have long known that CO2 directly affects acid-base and ion regulation, respiratory function and a

19 ins, NH4(+)/NH3 transport is used instead in acid-base and pH homeostasis in kidney or NH4(+)/NH3 (an

20 Here, we report hydroxamic acid-based and benzoic acid-based inhibitors (SH5-07 and

21 Next, the acid/base and nucleophile can be identified via classica

22 glycosidic bond hydrolysis act as catalytic acid/base and nucleophile.

23 er molecule positioned between the catalytic acid/base and the glycosidic oxygen.

24 hesized, and their photochemical reactivity, acid-base, and photophysical properties were investigate

25 tubule is critical for blood pressure (BP), acid-base, and potassium homeostasis.

26 Rate constants for acid-, base-, and water-mediated proton exchange vary by

27 ing mode not previously identified for amino acid-based antagonists.

28 Conversely, locked nucleic acid-based anti-miR-34a treatment diminished post-MI miR

29 editing and the application of other nucleic acid-based approaches to influence the coagulation syste

30 nments and exceptional chemical stability in acid/base aqueous solutions.

31 addition, the distance between the catalytic acid/base (Asp-315) and the ligand anomeric carbon is un

32 phenotypic, mass spectrometric, and nucleic acid-based assays and exhibited high-level resistance to

33 Among them immunoassays and Nucleic acid-based assays provide results within 24h, but they a

34 point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain reaction,

35 nd very low affinity was found for picolinic acid-based auxins (picloram) and quinolinecarboxylic aci

36 tidic foldamers, consisting of various amino acid based backbones, have been the most studied from a

37 Dietary contribution to acid-base balance in early life may influence subsequent

38 The optimal approach to managing acid-base balance is less well defined for patients rece

39 Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connex

40 tion and is involved in Na(+) absorption and acid-base balance.

41 urine output, osmolality, salt excretion, or acid-base balance.

42 ketone-body transport is needed to maintain acid-base balance.

43 at regulates cell volume, ion transport, and acid-base balance; mice knocked out for ClC-2 are blind

44 Several interesting examples of unexpected acid-base behavior and unanticipated proximity-induced r

45 h different ion sources and detection modes, acid/base behavior, octanol/water partitioning, retentio

46 Twenty-three BMS (3.0x12 mm) and 36 lactic acid-based bioresorbable scaffolds (BRS, 3.0x11 mm) were

47 The Absorb everolimus-eluting poly-L-lactic acid-based bioresorbable vascular scaffold (BVS) provide

48 ased pharmaceutical development, and nucleic acid based biosensor device design.

49 Functional nucleic acid-based biosensors are emerging tools that are capabl

50 Nucleic-acid-based biosensors have enabled rapid and sensitive d

51 To inhibit GBMs more effectively, polymalic acid-based blood-brain barrier crossing nanobioconjugate

52 gh-molecular-weight, amorphous poly-l-lactic acid-based BRS (Amaranth BRS).

53 igh molecular weight amorphous poly-l-lactic acid-based BRS (APTITUDE, Amaranth Medical [AMA]) to Abs

54 The acid/base-catalysed Kemp elimination of 5-nitro-benzisox

55 The large majority of enzymes utilize acid-base catalysis and proton-transfer mechanisms, wher

56 esidues H50, H63, D67 and H87 participate in acid-base catalysis during mRNA hydrolysis and further s

57 demonstrate which residues are critical for acid-base catalysis of mRNA cleavage.

58 ows the same catalyst-acceptor adduct driven acid-base catalysis reaction course.

59 te, thus suggesting a direct role in general acid-base catalysis, the function of A32 is less clear.

60 showing the power of this gold(III) chloride acid-base catalysis.

61 the distinction between general and specific acid-base catalysis.

62 One outcome of the acid-based catalysis is that 1-phenylalkanes cannot be p

63 selectivity that is opposite to traditional acid-based catalysis.

64 In this Review, a simple analogy between acid/base catalysis and redox catalysis is presented.

65 tic hypothesis involves a bifunctional Lewis acid/base catalysis strategy involving the combination o

66 ribute to stabilization of the TS in general acid/base catalysis together with other preorganized fea

67 the rational design of selective and robust acid-base catalyst for C-C coupling via aldolization rea

68 e catalytically competent orientation of the acid/base catalyst Glu-496.

69 ve site explains why histidine is used as an acid/base catalyst in place of the anionic glutamate see

70 ey finding is a chiral bifunctional Bronsted acid/base catalyst that can deliver beta-amino-alpha-flu

71 The mechanism involves a histidine as acid/base catalyst, which is unique for glycosidases.

72 tive catalytic activity of such bifunctional acid-base catalysts.

73 s to transcript backtracking, rather than as acid-base catalysts.

74 e three histidines with the inverse roles of acid/base catalysts.

75 We also found that this enzyme follows an acid-base catalytic mechanism similar to the bacterial D

76 mitting this residue to serve as the general acid/base catalytic residue.

77 Both reactions were acid/base catalyzed, and rate constants were characteriz

78 capable of plasticity in response to extreme acid-base challenges.

79 ly, we show that it is possible to use Lewis acid-base chemistry as a bridge to connect molecules to

80 The acid-base chemistry that drives catalysis in pyridoxal-5

81 Oxygen is an essential participant in the acid-base chemistry that takes place within many enzyme

82 raphene to the other side where they undergo acid-base chemistry with the silica hydroxyl groups.

83 erve polar interactions but are incapable of acid-base chemistry, had little effect on either phospho

84 Besides their obvious importance in acid-base chemistry, these ions play an important role i

85 le of the conserved glutamate on active site acid-base chemistry, we mutated the putative proton dono

86 profile strongly influenced by the redox and acid-base chemistry.

87 uch analyte selectivity spectrum for nucleic acid-based chiral separation tools.

88 We find that atmospheric ions and small acid-base clusters, which are not generally accounted fo

89 explored, and the nature and range of Lewis acid/base combinations capable of effecting such activat

90 ubsequently exhibited the greatest degree of acid-base compensation ever observed in an aquatic chord

91 used and on the concentrations of the major acid-base components of each buffer.

92 auto-inductive protocol employs a Meldrum's-acid-based conjugate acceptor (1) as a latent source of

93 e specifically functionalized by a myriad of acid-base conjugation strategies for applications rangin

94 An alpha-amino acid-based core structure, derived from a hydantoin core

95 rison to the chrysin, indole, and barbituric acid based COX-2 inhibitors, the new compounds have disp

96 ameters, we report a poly(lactic-co-glycolic acid) based curcumin nanoparticle formulation (Nano-CUR)

97 Microarray-based multiplexing and nucleic-acid-based deep-sequencing methods allow simultaneous de

98 redox-robust thorium compounds engage in an acid-base/dehydrocoupling route.

99 is of tularemia by blood culture and nucleic acid-based diagnostic tests is insufficiently sensitive.

100 atform for rapid field deployment of nucleic acid-based diagnostics using consumer-class quadcopter d

101 dichotomy polar/nonpolar matches the nucleic acid base dichotomy purine/pyrimidine at the second posi

102 bolic acidosis with that of patients without acid-base disorders.

103 These findings suggest that acid-base disturbances may affect the CaR-mediated contr

104 ickly compensate to environmentally relevant acid-base disturbances using baseline cellular machinery

105 logies for large-scale production of nucleic acid-based drugs have been exploited for various therape

106 catalyzing the oxygen evolution reaction in acid-based electrolyzers must be guided by the proper ba

107 calculated for exclusive feeding with amino acid-based elemental formulas, allergy test result-direc

108 s employed identical LC settings with formic-acid-based eluents in the last dimension.

109 Herein, an acid-base engineered foam is employed for separation of

110 ransfer of analyte into the vesicle based on acid-base equilibria is developed to predict the concent

111 rent pH values in order to determine its (i) acid-base equilibria, (ii) coordination equilibria, (iii

112 We additionally identified the internal acid-base equilibrium as a key determinant of the GCaMP

113 00) x 10(9) M(-1) s(-1), which correspond to acid-base equilibrium dissociation constants (Ka) in exc

114 lude molecular details as exemplified by the acid-base equilibrium of the detailed distribution of am

115 Acid-base features are analyzed for catalysts from chrom

116 alkyne dehydrocarbation with a carbon Lewis acid based FLP to form the new C-C bond.

117 has been devoted to the development of amino acid-based fluorophores that do not require a specific e

118 ereas beta-epoxide ABPs require a protonated acid/base for irreversible inhibition of retaining beta-

119 sonide, or dietary strategies, such as amino acid-based formulas, allergy test-directed elimination d

120 ode extension and the development of nucleic acid-based functional nanodevices, DNA duplexes containi

121 or catalytic processes by installing pendant acid-base functionalities in the close vicinity of the r

122 37 very polar model chemicals with different acid/base functionalities.

123 The presence of the pendant acid-base functions pushes the redox chemistry of the az

124 trast the efficacies of a wide range nucleic acid-based gene silencing reagents in the skin of live a

125 active site of FgFCO1 with flexible general acid/base Glu, a common feature shared by several bacter

126 catalysis by orienting the conserved general acid/base Glu-288 nearest the predicted glycosidic posit

127 sor is constructed of a fluorescent, boronic-acid based glucose indicating polymer coated onto a mini

128 as examples of the possible role of pendant acid-base groups in molecular catalysis.

129 Our results suggest that hydroxamic acid-based HDAC inhibitors may mediate neuroprotection v

130 e to the metallic character of RuO2, and the acid-base heterogeneity of the oxide surface.

131 '-phosphohistidyl intermediate and a general acid/base His (His(gab)), which resolves the Tdp1-DNA li

132 ear fluid and regulation of electrolytes and acid-base homeostasis in the collecting duct system of t

133 Acid-base homeostasis is essential for life.

134 retion, playing an essential role in ion and acid-base homeostasis.

135 with apical proton pumps to maintain normal acid-base homeostasis.

136 mplex could participate in the regulation of acid-base homeostasis.

137 abolic acid load and may adversely influence acid-base homeostasis.

138 llecting duct of the kidney are critical for acid-base homeostasis.

139 are best known for their role in modulating acid-base homeostasis.

140 e (V-ATPase) and are extensively involved in acid-base homeostasis.

141 where it functions to maintain normal bodily acid-base homeostasis.

142 structed a ROS sensor comprising an ascorbic-acid-based hydrogel encapsulating luminescent amphiphili

143 ted the biophysical properties of hyaluronic acid-based hydrogels to support the differentiation of w

144 RGD (arginylglycylaspartic acid)-based imaging tracers allow specific imaging of in

145 cent hydrophilic reagent zone containing the acid-base indicator 3-nitrophenol or bromothymol blue.

146 retion might be a better and perhaps earlier acid-base indicator of risk than serum bicarbonate, part

147 we report hydroxamic acid-based and benzoic acid-based inhibitors (SH5-07 and SH4-54, respectively)

148 is, and evaluation of a series of hydroxamic acid-based inhibitors and demonstrate the compounds to b

149 n on Neu5Ac2en in the design of novel sialic acid-based inhibitors that target human parainfluenza ty

150 n, and biological activity of new hydroxamic acid-based inhibitors with nanomolar affinity for human

151 onal monomers preventing the favorable Lewis acid base interaction.

152 the spectroscopic assessment of the dynamic acid-base interaction, for the first time the putative P

153 a bridging oxygen of the support via a Lewis acid-base interaction.

154 ems that possess no obvious frustrated Lewis acid-base interaction.

155 ular hydrogen bonding and Bronsted and Lewis acid-base interactions can drastically influence both th

156 ubstrate selectivity is achieved by means of acid-base interactions.

157 bonding, possibly strengthened by d-electron acid/base interactions, appear to stabilize Rh(OH)3, Rh2

158 ion via weak dispersion rather than residual acid/base interactions.

159 g the last universal ancestor of all nucleic-acid-based life.

160 Aptamers are nucleic acid-based ligands that exhibit promising features inclu

161 pment of amplified DNA sensors using nucleic acid-based machineries, involving the isothermal autonom

162 This reaction is thought to occur by an acid-base mechanism involving the glucosamine-6-phosphat

163 of a simple but computationally intractable acid-base mechanism.

164 se studies highlight that optimizing nucleic acid-based medicines for safety in humans presents chall

165 lidocaine provided superior cardiovascular, acid-base, metabolic, and renal recoveries following sev

166 cate that A-ICs, which are known to regulate acid-base metabolism, are also critical for urinary defe

167 to identify in vivo functions of non-nucleic acid-based metabolites beyond their metabolic roles.

168 H3iPr2-2,6) is accessible via a tandem Lewis acid-base metathesis protocol employing (THF)2Li[B(NArCH

169 ecificity of the potassium dichromate/acetic acid-based method used.

170 up identifications were confirmed by nucleic acid-based methods and included nine group A and 12 grou

171 Other nucleic acid-based methods were expensive and required trained p

172 is article explores the use of SDS-salicylic acid based micellar systems for their potential use in f

173 Nucleic acid-based molecular diagnostics are particularly well s

174 of the major obstacles to implement nucleic acid-based molecular diagnostics at the point-of-care (P

175 creation of a stunning diversity of nucleic acid-based nanodevices.

176 ely, when DOX was encapsulated in hyaluronic acid-based nanoparticles (HAC/DOX) and intravenously adm

177 will impact our understanding of how nucleic acid-based nanostructures, and SNAs in particular, funct

178 ond section, the characterization of nucleic acid-based nanostructures, nucleic acid-functionalized n

179 We report on the use of nucleic acid bases (NBs) in organic light emitting diodes (OLEDs

180 s of a linear motor type, which is fueled by acid-base neutralization.

181 orrosion, ash hydration and carbonation, and acid-base neutralization.

182 rticle, we describe a poly-lactic-coglycolic acid-based NP platform, wherein avidin-decorated NPs can

183 vibrational frequencies for the monoboronic acid base of our bisboronic acids, glucose and fructose.

184 A carboxylic acid based on a second generation l-lysine dendron inter

185 AuNPs facilitated the detection of ascorbic acid based on fluorescence enhancement effects in wide r

186 alysed the relevance of each energetic amino acid based on gene/protein expression data and the obtai

187 o perform in situ determination of salicylic acid based on its electrocatalytic oxidation.

188 dic sensor to specifically quantify ascorbic acid based on the immobilization of ascorbate oxidase, a

189 ionalized (Z)-6-hetaryl-2,4-dioxo-5-hexenoic acids based on acid-catalyzed alkenylation of indoles an

190 sensitive and selective detection of nucleic acids based on an ionic diode feature of an anion exchan

191 one correspondences between subsets of amino acids based on atomic coordinates).

192 o from sulfonamides and aliphatic carboxylic acids based on reactions with TMMS and one or two CAD ex

193 transformation does not require an exogenous acid, base, or transition metal catalyst; instead the ad

194 Previously, we found that an amino acid-based oral rehydration solution (AA-ORS) improved g

195 um by a linear molecular pump are induced by acid-base oscillations.

196 on of dithienylethene, Z/E isomerization and acid-base oxazolidine change cause selective addressabil

197 ulting aryl bioconjugates are stable towards acids, bases, oxidants and external thiol nucleophiles.

198 ture of being stable in the presence of many acids, bases, oxidants and reductants.

199 erse CNTs rely on tedious and time-consuming acid-based oxidation.

200 Stress degradation studies (acid, base, oxidation, heat and UV light) of curcumin we

201 e particles by metal ions which modify Lewis acid/base oxide properties and possibly strongly modify

202 uded that the catalytic cooperativity of the acid-base pair can be affected by two factors: (1) the c

203 work not only demonstrates a balanced Lewis acid-base pair for the highly active and selective casca

204 This Lewis acid-base pair is initiated and preserved by disrupting

205 With these main-group element Lewis acid base pairs, it is not only possible to polymerize s

206 alently connected linear sequence of nucleic acid base pairs.

207 isotopically labeled molecules confirm that acid-base pairs in the Si-O-M framework ensemble promote

208 ctive and selective nature of balanced Lewis acid-base pairs was masked by the coexisting Bronsted ac

209 a result, ZnxZryOz catalysts with only Lewis acid-base pairs were discovered, on which nearly a theor

210 of relevant intracellular and extracellular acid-base parameters in a coral reef fish exposed to ele

211 on toward downstream applications in nucleic acid based pathogen detection.

212 ical insights into nuclear crowding, nucleic acid based pharmaceutical development, and nucleic acid

213 r, an important requirement toward a nucleic-acid-based point-of-care diagnostic system.

214 study, structurally different ionic phthalic acid based polyesters (the number-average molecular weig

215 the early application and success of hydroxy acid based polyesters as degradable sutures and controll

216 Furthermore, because these nucleic acid-based polymeric nanoparticles exhibited enhanced ce

217 ng blocks have been combined to form nucleic acid-based polymeric nanoparticles without the need for

218 rs classified as polyacids (e.g., carboxylic acid based polymers, sulfonamides, anionic polysaccharid

219 In acidic or basic environments, acid-base polymers acquire surface charge due to protona

220 locondensation reactions using the hard-soft acid-base principle, quantum chemical calculations (dens

221 (SELEX) method, which can generate a nucleic acid-based probe (aptamer) that possess numerous advanta

222 tional effect in an o-hydroxydihydrocinnamic acid based prodrug design.

223 Speciation studies provide an acid-base profile that helps define the scope and limita

224 In particular, we show that the Lewis acid-base properties of the solvents, in addition to the

225 urface properties including the wettability, acid-base properties, adsorption, electric conductivity

226 can be controlled to greatly tune catalytic acid/base properties and consequently the reaction selec

227 The acid/base properties of a molecule are among the most fu

228 The design is based on the dual acid-base property and tautomerization of indazole.

229 on of miRNA was determined by locked nucleic acid-based quantitative real-time polymerase chain react

230 Existing fluorine-18-labeled amino acid-based radiotracers predominantly visualize amino ac

231 y showed that A1120 (3), a potent carboxylic acid based RBP4 antagonist, can significantly reduce lip

232 sign CO2 resistant membranes using the Lewis acid-base reaction concept and thermodynamics perspectiv

233 tionic ruthenium catalyst generated upon the acid-base reaction of H2Ru(CO)(PPh3)3 and 2,4,6-(2-Pr)3P

234 eport a functionalization method via a Lewis acid-base reaction that does not alter the host structur

235 e results show that the reaction is a simple acid-base reaction.

236 co-workers have implicated an excited-state acid/base reaction as the source of the nonradiative dec

237 ,4-diyl)dinitramidate anion were prepared by acid-base reactions and fully characterized by infrared,

238 rather than preparing the salts of 1 through acid-base reactions, an alternative route through the ni

239 the proton-transfer reactions underlying the acid/base reactivity at the interface.

240 e precisely, a calix[6]arene tris-carboxylic acid-based receptor bearing three azido groups at the la

241 subtly different analytes for which nucleic acid-based receptors exist.

242 ortho-Aminomethylphenylboronic acid-based receptors with appended fluorophores are comm

243 old electrodes were generated using an amino acid based recognition element, N-methacryloyl-L-histidi

244 Apart from Lewis acid-base recognition, hydrogen bonding recognition is a

245 sessing the energetic demand associated with acid-base regulation by examining ion movement and O2 co

246 alated cells of the collecting duct impaired acid-base regulation by the kidney.

247 Energetic costs associated with ion and acid-base regulation in response to ocean acidification

248 es crucial for normal inner ear function and acid-base regulation in the kidney.

249 chins than mussels, suggesting that internal acid-base regulation in urchins may substantially modera

250 may be compromised, while genes involved in acid-base regulation were up-regulated.

251 iological function of the ancestral gill was acid-base regulation, and that the gill was later co-opt

252 be associated with a tremendous capacity for acid-base regulation.

253 ve molarity measurements, in which exogenous acids/bases rescue the reaction in mutants lacking these

254 A) to serve directly as a general catalytic acid/base residue and thereby facilitate cleavage of the

255 several mutants with mutation at the general acid/base residue E274 of the Lactobacillus casei alpha1

256 ine but not beta-epoxide ABPs identifies the acid/base residue in mutagenized enzyme, as only the bet

257 the enzyme, however, the proposed catalytic acid/base residue was found to be too distant from the g

258 d in a signature sequence as their catalytic acid/base residue.

259 e-based respiration is decreased while fatty acid-based respiration is increased, reflecting a fuel s

260 A carboxylic acid based reversible additionfragmentation transfer (RA

261 leobase interactions in the genesis of amino acid-based ribosomal components.

262 Using a well-known boronic acid-based saccharide sensor (3), this work reveals a ne

263 e a new drug-free fully bioresorbable lactic acid-based scaffold designed to allow early dismantling

264 ion with routine chlamydia/gonorrhea nucleic acid-based screening are likely to have the most impact

265 Also included is a section on Lewis acid-base secondary coordination sphere interactions, wh

266 We propose that a sialic acid-based "self-associated molecular pattern" on erythr

267 ated in other ortho-aminomethylphenylboronic acid-based sensors.

268 rted binding site for synthetic, non-nucleic-acid-based, sequence-specific DNA-binding molecules.

269 prove tractable as an alternative to nucleic-acid based sequencing for the multiplexed identification

270 identified a novel hydroxyindole carboxylic acid-based SHP2 inhibitor 11a-1, with an IC50 value of 2

271 opurity and are prone to undergo deleterious acid-base side-reactions under the reaction conditions f

272 orrelations between the catalytically active acid-base sites and reactants, it is concluded that the

273 ogen ions expelled from the membrane undergo acid-base solution chemistry and protonate available bas

274 le of pH on ED was further studied by adding acid/base solutions to biosolids prior to ED.

275 hock, we measured hemodynamics, blood gases, acid-base status, metabolism, organ function, cytokine p

276 to both optical (UV-vis light) and chemical (acid/base) stimuli.

277 Herein, we developed hyaluronic acid-based substrates capable of sequential photodegrada

278 tter's high-melting fraction, with the oleic acid-based surfactants and canola oil showing little inf

279 cocoa butter crystal size whereas the oleic acid-based surfactants and canola showed no notable effe

280 lized RNA-binding protein is a novel nucleic-acid-based surveillance mechanism of RQC.

281 The acid-base switching of complexes formed from anti-electr

282 Control of protein levels by nucleic-acid-based technologies has proven to be a useful resear

283 apacity lies at the heart of several nucleic acid-based technologies that are finding applications in

284 Nucleic acid-based tests for infectious diseases currently used

285 s to evaluate three FDA-approved HPV nucleic acid-based tests for the ability to predict high-grade c

286 t microscopy, culture, serology, and nucleic acid-based tests.

287 we find can be explained using the hard/soft acid-base theory.

288 umber of chemotherapeutic agents and nucleic acid-based therapies are rapidly being synthesized and t

289 edictions of the best available experimental acid-base titration data.

290 Compared to the traditional acid-base titration method, the error of this improved m

291 ntified via diffuse layer modeling of the GO acid/base titrations.

292 18)F-labeled alpha,alpha-disubstituted amino acid-based tracer, 2-amino-5-[(18)F]fluoro-2-methylpenta

293 lated cells (ICs), which are specialized for acid-base transport.

294 s demonstrate a selective CA facilitation of acid/base transporters in the ventricular myocyte, imply

295 e report a new family of chiral bifunctional acid/base type organocatalysts, 2-aminoDMAP/Squaramides,

296 ormation that includes analyte pK(a), log P, acid/base type, and PSA are sufficient to accurately pre

297 Electrostatic stabilization of the general acid/base TyrL36 by TrpH103, SerH100, and AsnL34 enabled

298 Establishing tautomerism of nucleic acid bases under physiological conditions has been chall

299 ia for metabolic acidosis and 145 had normal acid-base values.

300 nitriles can be readily isolated by a simple acid-base workup.