1 haled CO2 to induce an acidosis and activate
acid sensing ion channels.
2 t, is essential for proton activation of the
acid-sensing ion channels.
3 at of previously described native and cloned
acid-sensing ion channels.
4 er subdomains in the extracellular domain of
acid-sensing ion channels.
5 mediated by the capsaicin receptor TRPV1 and
acid-sensing ion channels.
6 he extracellular thumb domain in the chicken
acid sensing ion channel 1 structure.
7 Acid-sensing ion channel 1 (ASIC1) is a H(+)-gated chann
8 Acid-sensing ion channel 1 (ASIC1) is homologous to ENaC
9 dy, we show that breast cancer cells express
acid-sensing ion channel 1 (ASIC1), a proton-gated catio
10 The resolved crystal structure of
acid-sensing ion channel 1 (ASIC1), a structurally relat
11 Targeting
acid-sensing ion channel 1 (encoded by the ASIC1 gene),
12 es to describe in detail the distribution of
acid-sensing ion channel 1 and its relationship with neu
13 lammatory lesions is unknown and, crucially,
acid-sensing ion channel 1 expression has not been deter
14 ver, the extent and cellular distribution of
acid-sensing ion channel 1 expression in neurons and gli
15 ther these findings suggest that blockade of
acid-sensing ion channel 1 has the potential to provide
16 ctivation in in vivo migraine models, via an
acid-sensing ion channel 1 mechanism.
17 The expression of
acid-sensing ion channel 1 was associated with axonal da
18 We found that
acid-sensing ion channel 1 was upregulated in axons and
19 We previously showed that the
acid-sensing ion channel 1 which, when activated under t
20 Moreover, blocking
acid-sensing ion channel 1 with amiloride protected both
21 Based on structural homology with
acid-sensing ion channel 1, gammaAsp(516) was predicted
22 Acid-sensing ion channel-
1 (ASIC-1) is a proton-gated io
23 The
acid-sensing ion channel-
1 (ASIC1) contributes to synapt
24 The neuronally expressed, proton-gated
acid-sensing ion channel-
1 (ASIC1) is permeable to Na+ a
25 SGK1.1 decreases expression of the
acid-sensing ion channel-
1 (ASIC1); thereby, SGK1.1 may
26 k examines the interaction of amiloride with
acid-sensing ion channel-
1, a protein whose structure is
27 Acid sensing ion channels 1a (ASIC1a) are of crucial imp
28 Acid-sensing ion channel 1a (ASIC1a) has been shown to p
29 Protons activate
acid-sensing ion channel 1a (ASIC1a) in the central nerv
30 Acid-sensing ion channel 1A (ASIC1A) is abundant in the
31 The
acid-sensing ion channel 1a (ASIC1a) is abundantly expre
32 Because
acid-sensing ion channel 1a (ASIC1a) is exquisitely sens
33 In CA1, the
acid-sensing ion channel 1a (ASIC1a) is known to facilit
34 Acid-sensing ion channel 1a (ASIC1a) is the primary acid
35 The
acid-sensing ion channel 1a (ASIC1a) is widely expressed
36 Acid-sensing ion channel 1a (ASIC1a) promotes neuronal d
37 ces and biolistic transfection, we found the
acid-sensing ion channel 1a (ASIC1a), localized in dendr
38 The
acid-sensing ion channel 1a (ASIC1a), which is expressed
39 e methods to prepare pure samples of chicken
acid-sensing ion channel 1a (cASIC1) and Caenorhabditis
40 are homologous to the Cl(-) binding site in
acid-sensing ion channel 1a and tested the effect of Cl(
41 imaging that the Sig1R binds to the trimeric
acid-sensing ion channel 1A with 3-fold symmetry.
42 of Held synapse express functional homomeric
Acid-sensing ion channel-
1a (ASIC-1as) that can be activ
43 Acid-sensing ion channel-
1a (ASIC1a) contributes to mult
44 Acid-sensing ion channel-
1a (ASIC1a) is a potential ther
45 The
acid-sensing ion channel-
1a (ASIC1a) is composed of 3 su
46 Acid-sensing ion channel-
1a (ASIC1a) is localized in bra
47 Acid-sensing ion channel-
1a (ASIC1a) mediates H(+)-gated
48 these models to test the hypothesis that the
acid-sensing ion channel-
1a (ASIC1a) might be targeted t
49 Because the amygdala expresses
acid-sensing ion channel-
1a (ASIC1a), and ASIC1a is requ
50 and anxiety-related behaviors and expresses
acid-sensing ion channel-
1A (ASIC1A), we hypothesized th
51 the role of the vertebrate DEG-ENaC protein,
acid-sensing ion channel 2 (ASIC2), in auditory transduc
52 The acid-sensitive cation channel
acid-sensing ion channel-
2 (ASIC2) is widely believed to
53 , GFRalpha2-expressing sensory neurons), the
acid-sensing ion channel 2a, and transient receptor pote
54 d to correlate with significant increases in
acid-sensing ion channels 2A and 2B and transient recept
55 ly through regulating membrane expression of
acid sensing ion channel 3.
56 Through its location on nociceptors,
acid-sensing ion channel 3 (ASIC-3) is activated by decr
57 t receptor potential vanilloid 1 (TRPV1) and
acid-sensing ion channel 3 (ASIC3) are peripheral mechan
58 In rodent sensory neurons,
acid-sensing ion channel 3 (ASIC3) has recently emerged
59 Acid-sensing ion channel 3 (ASIC3) is highly expressed o
60 Acid-sensing ion channel 3 (ASIC3) is involved in acid n
61 ouse model by altering the expression of the
acid-sensing ion channel 3 (ASIC3) which we had identifi
62 Acid-sensing ion channel 3 (ASIC3), a proton-gated ion c
63 Here we show that
acid-sensing ion channel 3 (ASIC3), but no other known a
64 and IV muscle afferents via upregulation of
acid-sensing ion channel 3 (ASIC3), leading not only to
65 t receptor potential vanilloid 1 (TRPV1) and
acid-sensing ion channel 3 (ASIC3), on development of be
66 APETx2 is a potent and selective blocker of
acid-sensing ion channel 3 (ASIC3).
67 was found exclusively in neurons expressing
acid-sensing ion channel 3, where SP enhances M-channel-
68 The
acid-sensing ion channel-
3 (ASIC3) is a degenerin/epithe
69 at a specific cation conductance composed of
acid-sensing ion channels and ENaC subunits regulates mi
70 Acid-sensing ion channels are cation channels activated
71 Acid-sensing ion channels are proton-activated ion chann
72 Acid-sensing ion channels are proton-activated, sodium-s
73 Acid-sensing ion channels are proton-gated Na(+) channel
74 ASICs (
acid-sensing ion channels)
are proton-gated channels tha
75 oral artery is attenuated by blockade of the
acid sensing ion channel (
ASIC) 3.
76 We found that eliminating the
acid sensing ion channel (
ASIC) abolished H(+)-gated cur
77 Acid sensing ion channel (
ASIC)2 belongs to the amilorid
78 ation, and to investigate the involvement of
acid-sensing ion channel (
ASIC) -3 in the response.
79 Interestingly,
acid-sensing ion channel (
ASIC) 1, 2a, 2b, and 3 mRNAs w
80 Acid-sensing ion channel (
ASIC) 1a and ASIC2a are acid-s
81 Acid-sensing ion channel (
ASIC) 1a subunit is expressed
82 release and a low extracellular pH, leads to
acid-sensing ion channel (
ASIC) activation and reflexive
83 nt in glomus cells that was inhibited by the
acid-sensing ion channel (
ASIC) blocker amiloride, absen
84 Other types of
acid-sensing ion channel (
ASIC) channels were intact to
85 modulate the proton-sensitive members of the
acid-sensing ion channel (
ASIC) family.
86 date transducer molecules are members of the
acid-sensing ion channel (
ASIC) family; nerve fibre reco
87 ude the epithelial sodium channel (ENaC) and
acid-sensing ion channel (
ASIC) members of the DEG/ENaC
88 oresis of acid, suggesting an involvement of
acid-sensing ion channel (
ASIC) receptors.
89 to test the hypothesis that a member of the
acid-sensing ion channel (
ASIC) subfamily of the DEG/ENa
90 Acid-sensing ion channel (
ASIC) subunits associate to fo
91 id channel composed of a mixture of ENaC and
acid-sensing ion channel (
ASIC) subunits.
92 ions, dramatically increases activity of an
acid-sensing ion channel (
ASIC) that is highly expressed
93 Acid-sensing ion channel (
ASIC)-1a, the major ASIC subun
94 ns exhibited transient, amiloride-sensitive,
acid-sensing ion-channel (
ASIC) currents.
95 Hippocampal neurons express subunits of the
acid-sensing ion channel (
ASIC1 and ASIC2) and exhibit l
96 pha subunit and the resolved structure of an
acid-sensing ion channel (
ASIC1) have conserved acidic p
97 The
acid-sensing ion channel,
ASIC1, contributes to synaptic
98 osensing of acidosis in the amygdala via the
acid-sensing ion channel ASIC1a.
99 ently of VR1, has characteristics similar to
acid sensing ion channels (
ASICs) and is found in the ai
100 Acid sensing ion channels (
ASICs) are cation-selective m
101 Although thin fibre muscle afferents possess
acid sensing ion channels (
ASICs), their contribution to
102 Because acidosis can activate
acid sensing ion channels (
ASICs), we also studied ASIC1
103 Acid-sensing ion channels (
ASICs) act as neurotransmitte
104 Neuronal
acid-sensing ion channels (
ASICs) act as sensors for ext
105 The
acid-sensing ion channels (
ASICs) are a family of ion ch
106 Acid-sensing ion channels (
ASICs) are a group of trimeri
107 Acid-sensing ion channels (
ASICs) are cation-selective p
108 Acid-sensing ion channels (
ASICs) are expressed in skele
109 Acid-sensing ion channels (
ASICs) are H(+)-gated members
110 Acid-sensing ion channels (
ASICs) are highly expressed i
111 Acid-sensing ion channels (
ASICs) are neuronal Na(+)-sel
112 Acid-sensing ion channels (
ASICs) are neuronal non-volta
113 Acid-sensing ion channels (
ASICs) are neuronal proton-ga
114 Acid-sensing ion channels (
ASICs) are neuronal receptors
115 Acid-sensing ion channels (
ASICs) are neuronal, voltage-
116 Acid-sensing ion channels (
ASICs) are proton-activated c
117 Acid-sensing ion channels (
ASICs) are proton-activated N
118 The
acid-sensing ion channels (
ASICs) are proton-gated catio
119 Acid-sensing ion channels (
ASICs) are proton-gated catio
120 Acid-sensing ion channels (
ASICs) are proton-gated catio
121 Acid-sensing ion channels (
ASICs) are proton-gated Na(+)
122 The
acid-sensing ion channels (
ASICs) are proton-gated, volt
123 Acid-sensing ion channels (
ASICs) are sodium channels ga
124 Acid-sensing ion channels (
ASICs) are trimeric cation ch
125 Acid-sensing ion channels (
ASICs) are trimeric cation-se
126 Acid-sensing ion channels (
ASICs) are trimeric cation-se
127 Acid-sensing ion channels (
ASICs) are voltage-independen
128 Acid-sensing ion channels (
ASICs) are voltage-independen
129 Acid-sensing ion channels (
ASICs) are voltage-independen
130 Acid-sensing ion channels (
ASICs) are widely expressed p
131 Peripheral sensitization depended on
acid-sensing ion channels (
ASICs) because treatment of s
132 Acid-sensing ion channels (
ASICs) constitute a family of
133 tion in response to inflammatory conditions,
acid-sensing ion channels (
ASICs) contribute to the path
134 ility of neuronal networks via activation of
acid-sensing ion channels (
ASICs) could have therapeutic
135 Acid-sensing ion channels (
ASICs) detect extracellular p
136 Acid-sensing ion channels (
ASICs) form both homotrimeric
137 In central and peripheral neurons,
acid-sensing ion channels (
ASICs) have emerged as key re
138 The exact roles of
acid-sensing ion channels (
ASICs) in synaptic plasticity
139 The role of
acid-sensing ion channels (
ASICs) in the ventrolateral m
140 t receptor potential V1 (TRPV1) channels and
acid-sensing ion channels (
ASICs) is that their ion cond
141 Acid-sensing ion channels (
ASICs) mediate chemosensitivi
142 The
acid-sensing ion channels (
ASICs) open in response to ex
143 Acid-sensing ion channels (
ASICs) open when extracellula
144 Acid-sensing ion channels (
ASICs) regulate synaptic acti
145 mba venom that specifically inhibit a set of
acid-sensing ion channels (
ASICs) to relieve pain.
146 Recently,
acid-sensing ion channels (
ASICs) were shown to act as n
147 Acid-sensing ion channels (
ASICs), a novel class of liga
148 -inflammatory drug (NSAID) pharmacology with
acid-sensing ion channels (
ASICs), a small family of exc
149 Acid-sensing ion channels (
ASICs), activated by a decrea
150 Acid-sensing ion channels (
ASICs), activated by lowering
151 Acid-sensing ion channels (
ASICs), expressed in thin mus
152 show that acidosis activates Ca2+ -permeable
acid-sensing ion channels (
ASICs), inducing glutamate re
153 Our previous results have shown that the
acid-sensing ion channels (
ASICs), members of the epithe
154 Potential receptors for protons are
acid-sensing ion channels (
ASICs), Na(+)- and Ca(2+)-per
155 Acid-sensing ion channels (
ASICs), newly discovered memb
156 potent, persistent and selective agonist for
acid-sensing ion channels (
ASICs), showing equal or grea
157 ar approach was used to open and close human
acid-sensing ion channels (
ASICs), which are also trimer
158 The activation of
acid-sensing ion channels (
ASICs), which are highly perm
159 n brain sodium channel family, also known as
acid-sensing ion channels (
ASICs).
160 teractions between extracellular protons and
acid-sensing ion channels (
ASICs).
161 are converted to excitatory sodium influx by
acid-sensing ion channels (
ASICs).
162 Analysis of the known ASIC1 (
acid-sensing ion channel)
crystal structure suggested th
163 ere we present the structure of a functional
acid-sensing ion channel in a desensitized state at 3 A
164 sensing ion channel (ASIC) 1a and ASIC2a are
acid-sensing ion channels in central and peripheral neur
165 opagation, probably via mechanisms involving
acid-sensing ion channels in the pilocarpine model of te
166 Hyperactivation of the
acid-sensing ion channels including degenerin/epithelial
167 39 had no effect on the structurally related
acid-sensing ion channels,
indicating specificity for EN
168 s support the possibility that modulation of
acid-sensing ion channels may have therapeutic potential
169 These results suggest that
acid-sensing ion channels may integrate multiple extrace
170 n neuronal DEG/ENaC channels known as ASICs (
acid-sensing ion channels)
mediate sensory perception an
171 also found that down-regulation of Nach, an
acid sensing ion channel,
mitigates SCA3 pathogenesis in
172 ith acid by increasing the pH sensitivity of
acid-sensing ion channel number 3 (ASIC3), the molecule
173 Acid-sensing ion channels,
or ASICs, are members of the
174 Acid-sensing ion channels,
or ASICs, are proton-gated ca
175 eract with the epithelial sodium channel and
acid-sensing ion channel proteins, as well as sodium/hyd
176 ng ion channel 3 (ASIC3), but no other known
acid-sensing ion channel,
reproduces the functional feat
177 Comparison of the
acid-sensing ion channel structure with the ATP-gated P2
178 Studies further demonstrate that
acid-sensing ion channel subtype 3 (ASIC(3)) in thin-fib
179 loride, a potent and nonselective blocker of
acid-sensing ion channels,
suppresses generalized seizur